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The map label for this gene is waaA [H]

Identifier: 220932724

GI number: 220932724

Start: 2017908

End: 2020247

Strand: Reverse

Name: waaA [H]

Synonym: Hore_18890

Alternate gene names: 220932724

Gene position: 2020247-2017908 (Counterclockwise)

Preceding gene: 220932725

Following gene: 220932723

Centisome position: 78.36

GC content: 43.38

Gene sequence:

>2340_bases
ATGTTTATATTTTACTTAATCTATAATCTGCTCTTAATAACTGTACTCATATTATATCTACCTTTTTTGATCTACAATTT
TATAAAAGGTAAATACCGGGAGGGTTTTCTGGAGAGACTGGCTCTCTATCAAAAGTCTTTTATAGAGATGGTTAAGCTAC
ATCCTGTTATCTGGATCCATGCTGCTTCAGTGGGGGAAACTATGGCTGCAGAACCCCTTGTCAGAGAATTGAGGGAACAG
TATCCCCACGTTAAGCTTATATTTTCGACAGTTTCCAGTACAGGAAGGCAGACTGCCCGTAAATTTTATAAAAAAGAGGT
TGATGCCATAATATATTTTCCGATAGATTTAGGGTTTATTATTAAAAGGGCTATAAAACTGATTAATCCCCGTCTCGTTA
TTATGATTGAAACCGAGTTATGGCCCAATTTTATACGTTATGCTGATAAATCTGGTTCAAGAATTATGGTCGCCAGTGGC
CGTATCAGTGATAAAGGATACAAAAATTTTAGATACCTGGGTCCCCTTTTAAGAGATATGCTGAAAAGGGTAGATGTTTT
CAGTATGCAGTCTGACCTTGATGTTCAGCGAATAGTGGCTCTGGGGGCTAAGGAAGACAGGGTATACCGGAATGGCAACA
TTAAGTTTGATAAAGAATATTCTGTTTCTCCCCTGGAGGTTAATAAACTAAGACAGGAGTTTAACCTTGATGAAAACCAG
CCGGTGATGGTAGCTGGAAGTACCCATGCCGGTGAGGAAGAGAAGTTGATAACTGTTTTTGAAAGGGTTAATAAAGAGCT
TCCTGACTTTGTCATGATTATTGCCCCCCGTTATATTGAGAGGGTGGAACAGGTAGAAAAGCTATTTACGAGTAAGGGAA
TTAAAACAATCAGGCGGAGTGAACTGGAGGGTTATAAACGGCGGGAGCAGGTTATTCTGGTTGACACCTTCGGGGAACTG
GCCCTGATTTATAAACTGGCTTCTCTGGTTTTTGTGGGTGGAAGTTTAATCCCCAGGGGGGGTCATAACATTATTGAACC
GGCTGCCCAGGGAAAGCTGGTTTTATTTGGTCCCCATATGTTTAACTTTAAGGAAGAGACTAAATTTCTCCTGGGACAGG
AGGCTGCAGTACAGGTAGGTAATACCGACGGATTGGGAGATAAGGTCCTATATTATTTGAAAAATCAGGACAGCCTCCGG
GAAAAAAGTGAGCGGGCCCGGCAGATAATTACGGAAAACCGGGGAGCGACAATCAGAAATTTAAAACTGGTATCGGAACT
GTTACAGAAAAAGTCACGACTCAACATGCTTATTATACGCCTCAGTGCTATCGGGGATGTTATTCATGCCCTGCCGGTAG
CCTATGCTGTCAGGCAAAGCTATCCTGAGGCTGAAATAACCTGGATAGTTGAGGATAAAGCCAGTGATCTAGTCCTGGAC
AATCCTTATCTGGACCGGGTTATTATTATGCCCAGAAAGAAATGGAAAGAAGTTTTTAAAGCTGATAAATTAAAAGCCCT
GGGGCAAGTAAGGTCTTTTGTTAAGGAGTTAAAAAAATATAATTTTGATATGGCCCTTGATGTTCATGGCCTTTTTAAAA
GTGCTATAACCGCTCTATGGAGCGGGGCCAGAGTAAGGTATGGACCTGGCGATGGACGGGAGGGGAGCAAATTTTTTTAT
ACAGACAAATTGACTCCCCCGTCTACTCGCGTTCATATGATTGATAGAAATCTGGAGCTGGCCCGGGGAATCGGCGCCAG
GACCGGGGAAATCAGGTATGGGATTGTCACCGGTGAAAAAGAAGTCACTAAAGTCGACAGGCTTTTAGGCCAATTTGATG
GTAAGGGTAAGTTCATGGTATGTATCAATCCCTATACCACCTGGAAATCAAAGAACTGGCTTGAGGAAAGGTATGCCCGA
CTGGCTGACCTCCTTATAAAGAGAAATGGTTGTATCGTTATATTTACCGGTGGTCCCGGTGATAAAGAAGGTATTGAAAG
AATACAGGCCTTAATGGAAGAACAGGCCCTGAACCTGGCCGGGCAGACAAATTTAAAGGAACTGGCAGAGCTTTATAAAC
GGACTCACCTTTTTATCGGTGGAGATACAGGCCCCATGCATCTGGCAGCAGCGGTAGGTAGCAGGGTAGTGGCCCTGATG
GGGCCCACTGATCCTGTAACTCATGGTCCTTACGGAGATGGCCATATTGTAATCCAGCACCAGGACCTTGATTGTATTAA
ATGCTGGAAACGGGAATGCCCGGCCAGTCATAGTTGTATGAAAAATATCAGGGTGGACGAAGTTCTGTCAGCAGCAGAAA
GAATTCTGGGGGTGACCTGA

Upstream 100 bases:

>100_bases
CACTGGCTATGGCTACACCGTCGCTGGAAAACTTATTAAGCTTTAGAAGGTGTTTATCATTTGAAGGTTTATCAAATGAG
TAAAGGGGGGCTGGATCCAG

Downstream 100 bases:

>100_bases
ATAATGACCGGACAGAAACCATCGATACCAGACCATATCCAGAAAGCTAAAAGAATCCTTATCATAGATTTGCTCTACCT
GGGTGATTTAATCTTTGCCA

Product: Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MFIFYLIYNLLLITVLILYLPFLIYNFIKGKYREGFLERLALYQKSFIEMVKLHPVIWIHAASVGETMAAEPLVRELREQ
YPHVKLIFSTVSSTGRQTARKFYKKEVDAIIYFPIDLGFIIKRAIKLINPRLVIMIETELWPNFIRYADKSGSRIMVASG
RISDKGYKNFRYLGPLLRDMLKRVDVFSMQSDLDVQRIVALGAKEDRVYRNGNIKFDKEYSVSPLEVNKLRQEFNLDENQ
PVMVAGSTHAGEEEKLITVFERVNKELPDFVMIIAPRYIERVEQVEKLFTSKGIKTIRRSELEGYKRREQVILVDTFGEL
ALIYKLASLVFVGGSLIPRGGHNIIEPAAQGKLVLFGPHMFNFKEETKFLLGQEAAVQVGNTDGLGDKVLYYLKNQDSLR
EKSERARQIITENRGATIRNLKLVSELLQKKSRLNMLIIRLSAIGDVIHALPVAYAVRQSYPEAEITWIVEDKASDLVLD
NPYLDRVIIMPRKKWKEVFKADKLKALGQVRSFVKELKKYNFDMALDVHGLFKSAITALWSGARVRYGPGDGREGSKFFY
TDKLTPPSTRVHMIDRNLELARGIGARTGEIRYGIVTGEKEVTKVDRLLGQFDGKGKFMVCINPYTTWKSKNWLEERYAR
LADLLIKRNGCIVIFTGGPGDKEGIERIQALMEEQALNLAGQTNLKELAELYKRTHLFIGGDTGPMHLAAAVGSRVVALM
GPTDPVTHGPYGDGHIVIQHQDLDCIKCWKRECPASHSCMKNIRVDEVLSAAERILGVT

Sequences:

>Translated_779_residues
MFIFYLIYNLLLITVLILYLPFLIYNFIKGKYREGFLERLALYQKSFIEMVKLHPVIWIHAASVGETMAAEPLVRELREQ
YPHVKLIFSTVSSTGRQTARKFYKKEVDAIIYFPIDLGFIIKRAIKLINPRLVIMIETELWPNFIRYADKSGSRIMVASG
RISDKGYKNFRYLGPLLRDMLKRVDVFSMQSDLDVQRIVALGAKEDRVYRNGNIKFDKEYSVSPLEVNKLRQEFNLDENQ
PVMVAGSTHAGEEEKLITVFERVNKELPDFVMIIAPRYIERVEQVEKLFTSKGIKTIRRSELEGYKRREQVILVDTFGEL
ALIYKLASLVFVGGSLIPRGGHNIIEPAAQGKLVLFGPHMFNFKEETKFLLGQEAAVQVGNTDGLGDKVLYYLKNQDSLR
EKSERARQIITENRGATIRNLKLVSELLQKKSRLNMLIIRLSAIGDVIHALPVAYAVRQSYPEAEITWIVEDKASDLVLD
NPYLDRVIIMPRKKWKEVFKADKLKALGQVRSFVKELKKYNFDMALDVHGLFKSAITALWSGARVRYGPGDGREGSKFFY
TDKLTPPSTRVHMIDRNLELARGIGARTGEIRYGIVTGEKEVTKVDRLLGQFDGKGKFMVCINPYTTWKSKNWLEERYAR
LADLLIKRNGCIVIFTGGPGDKEGIERIQALMEEQALNLAGQTNLKELAELYKRTHLFIGGDTGPMHLAAAVGSRVVALM
GPTDPVTHGPYGDGHIVIQHQDLDCIKCWKRECPASHSCMKNIRVDEVLSAAERILGVT
>Mature_779_residues
MFIFYLIYNLLLITVLILYLPFLIYNFIKGKYREGFLERLALYQKSFIEMVKLHPVIWIHAASVGETMAAEPLVRELREQ
YPHVKLIFSTVSSTGRQTARKFYKKEVDAIIYFPIDLGFIIKRAIKLINPRLVIMIETELWPNFIRYADKSGSRIMVASG
RISDKGYKNFRYLGPLLRDMLKRVDVFSMQSDLDVQRIVALGAKEDRVYRNGNIKFDKEYSVSPLEVNKLRQEFNLDENQ
PVMVAGSTHAGEEEKLITVFERVNKELPDFVMIIAPRYIERVEQVEKLFTSKGIKTIRRSELEGYKRREQVILVDTFGEL
ALIYKLASLVFVGGSLIPRGGHNIIEPAAQGKLVLFGPHMFNFKEETKFLLGQEAAVQVGNTDGLGDKVLYYLKNQDSLR
EKSERARQIITENRGATIRNLKLVSELLQKKSRLNMLIIRLSAIGDVIHALPVAYAVRQSYPEAEITWIVEDKASDLVLD
NPYLDRVIIMPRKKWKEVFKADKLKALGQVRSFVKELKKYNFDMALDVHGLFKSAITALWSGARVRYGPGDGREGSKFFY
TDKLTPPSTRVHMIDRNLELARGIGARTGEIRYGIVTGEKEVTKVDRLLGQFDGKGKFMVCINPYTTWKSKNWLEERYAR
LADLLIKRNGCIVIFTGGPGDKEGIERIQALMEEQALNLAGQTNLKELAELYKRTHLFIGGDTGPMHLAAAVGSRVVALM
GPTDPVTHGPYGDGHIVIQHQDLDCIKCWKRECPASHSCMKNIRVDEVLSAAERILGVT

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=435, Percent_Identity=34.9425287356322, Blast_Score=248, Evalue=1e-66,
Organism=Escherichia coli, GI1790051, Length=310, Percent_Identity=25.4838709677419, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1790062, Length=345, Percent_Identity=24.9275362318841, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1790050, Length=304, Percent_Identity=25.9868421052632, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 88721; Mature: 88721

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIFYLIYNLLLITVLILYLPFLIYNFIKGKYREGFLERLALYQKSFIEMVKLHPVIWIH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AASVGETMAAEPLVRELREQYPHVKLIFSTVSSTGRQTARKFYKKEVDAIIYFPIDLGFI
ECCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHH
IKRAIKLINPRLVIMIETELWPNFIRYADKSGSRIMVASGRISDKGYKNFRYLGPLLRDM
HHHHHHHHCCEEEEEEECCCCHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
LKRVDVFSMQSDLDVQRIVALGAKEDRVYRNGNIKFDKEYSVSPLEVNKLRQEFNLDENQ
HHHHHHHHCCCCCCHHHHHHCCCCCCCEEECCCEEECCCCCCCCHHHHHHHHHHCCCCCC
PVMVAGSTHAGEEEKLITVFERVNKELPDFVMIIAPRYIERVEQVEKLFTSKGIKTIRRS
CEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ELEGYKRREQVILVDTFGELALIYKLASLVFVGGSLIPRGGHNIIEPAAQGKLVLFGPHM
HHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC
FNFKEETKFLLGQEAAVQVGNTDGLGDKVLYYLKNQDSLREKSERARQIITENRGATIRN
CCCHHHHHHHHCCCHHEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHH
LKLVSELLQKKSRLNMLIIRLSAIGDVIHALPVAYAVRQSYPEAEITWIVEDKASDLVLD
HHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEC
NPYLDRVIIMPRKKWKEVFKADKLKALGQVRSFVKELKKYNFDMALDVHGLFKSAITALW
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
SGARVRYGPGDGREGSKFFYTDKLTPPSTRVHMIDRNLELARGIGARTGEIRYGIVTGEK
CCCEEEECCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHCCCCCCCCEEEEEEECCH
EVTKVDRLLGQFDGKGKFMVCINPYTTWKSKNWLEERYARLADLLIKRNGCIVIFTGGPG
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
DKEGIERIQALMEEQALNLAGQTNLKELAELYKRTHLFIGGDTGPMHLAAAVGSRVVALM
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCEEEEE
GPTDPVTHGPYGDGHIVIQHQDLDCIKCWKRECPASHSCMKNIRVDEVLSAAERILGVT
CCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFIFYLIYNLLLITVLILYLPFLIYNFIKGKYREGFLERLALYQKSFIEMVKLHPVIWIH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AASVGETMAAEPLVRELREQYPHVKLIFSTVSSTGRQTARKFYKKEVDAIIYFPIDLGFI
ECCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHH
IKRAIKLINPRLVIMIETELWPNFIRYADKSGSRIMVASGRISDKGYKNFRYLGPLLRDM
HHHHHHHHCCEEEEEEECCCCHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
LKRVDVFSMQSDLDVQRIVALGAKEDRVYRNGNIKFDKEYSVSPLEVNKLRQEFNLDENQ
HHHHHHHHCCCCCCHHHHHHCCCCCCCEEECCCEEECCCCCCCCHHHHHHHHHHCCCCCC
PVMVAGSTHAGEEEKLITVFERVNKELPDFVMIIAPRYIERVEQVEKLFTSKGIKTIRRS
CEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
ELEGYKRREQVILVDTFGELALIYKLASLVFVGGSLIPRGGHNIIEPAAQGKLVLFGPHM
HHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCC
FNFKEETKFLLGQEAAVQVGNTDGLGDKVLYYLKNQDSLREKSERARQIITENRGATIRN
CCCHHHHHHHHCCCHHEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHH
LKLVSELLQKKSRLNMLIIRLSAIGDVIHALPVAYAVRQSYPEAEITWIVEDKASDLVLD
HHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEC
NPYLDRVIIMPRKKWKEVFKADKLKALGQVRSFVKELKKYNFDMALDVHGLFKSAITALW
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHH
SGARVRYGPGDGREGSKFFYTDKLTPPSTRVHMIDRNLELARGIGARTGEIRYGIVTGEK
CCCEEEECCCCCCCCCEEEEECCCCCCCCEEEEECCCHHHHHCCCCCCCCEEEEEEECCH
EVTKVDRLLGQFDGKGKFMVCINPYTTWKSKNWLEERYARLADLLIKRNGCIVIFTGGPG
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
DKEGIERIQALMEEQALNLAGQTNLKELAELYKRTHLFIGGDTGPMHLAAAVGSRVVALM
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCEEEEE
GPTDPVTHGPYGDGHIVIQHQDLDCIKCWKRECPASHSCMKNIRVDEVLSAAERILGVT
CCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]