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The map label for this gene is mtnA [H]

Identifier: 220932684

GI number: 220932684

Start: 1972516

End: 1973583

Strand: Reverse

Name: mtnA [H]

Synonym: Hore_18480

Alternate gene names: 220932684

Gene position: 1973583-1972516 (Counterclockwise)

Preceding gene: 220932685

Following gene: 220932683

Centisome position: 76.55

GC content: 43.54

Gene sequence:

>1068_bases
ATGTATGACACACTTAAATTTGAGGGAGATACACTTATTTTAATTGACCAGAGAAAACTCCCCCAGAAGGTTGAGTTTTT
TAAATGTAGAGATTACCGGGATGTTGAGTTTGCTATTGCCGACATGGTTGTAAGGGGAGCACCGGCTATTGGAGCTGCCG
GGGCTTATGGGGTTTATCTGGCAGCCAGTGAATTTAAAAATAACTCTGAAGAGGTTTTCTTTAAAAAAGTTAAGGAAGCC
AATAAGGTTTTAGTTAAAGCAAGGCCCACTGCAGTTAACCTTTTCTGGGCCATAAATAGAATGGAACAGGCAATGAAAAG
AAACAGGAATAAACCCGTCTCTGAAATCCTGGAAATATTAAGGGAGGAAGCTGATAACATAGCCCGGGAGGATGTTGAAA
CTAATCAGGCGATTGGTAAGTTTGGTAATGAAGTTATCCCTCAGGGGGCTACCATATTAACCCATTGTAATGCAGGAGCT
CTGGCTACAGTTGGCTATGGTACGGCTCTCGGGGTTATCAGGGCTGCCCATGAGAGTGGTAAAAATATTAAGGTTTATGC
TGATGAAACCCGCCCCCGTCTTCAGGGAGCCCGTCTCACCGCGTTTGAGTTGGTTGAAGAGGGAATTCCGGTAACCCTTA
TTGCTGATAGTGTTGCTGCAACCCTGATCAGGGATGGGGTCATTGATGTTATAGTTGTTGGAGCTGATAGAATTGCCTCC
AATGGAGATACAGCTAATAAAATCGGGACCTTTATGCTTTCAGAACTGGCAGTCAGGTTCGGTGTTCCCTTATATATTGC
GGCTCCGGTTTCAACAATCGATTTTGATATCAATGACGGGTCAGAAATTGTTATTGAAGAACGTTCACCGGAAGAAGTAA
CCCATATCCAGGGTATCCAGATTGCTCCAGATGGGGTAGAAGTCTATAACCCCGCTTTTGATGTTACTCCGGCTGAAAAT
ATAACTGGCATTATTACTGAAAAGGGGATTATTGAGCCACCATATAAAGAGGGAATAGCCAGTTTGAAATCCAGCCAGAA
AAAGGGGGATATTGATGGCCAGTTATGA

Upstream 100 bases:

>100_bases
TATACTTGCCGGGAATAATTAAGGTGTGAGGCCATTAAACCTTTTCAAAAAAATATGAGGTAGGTCTGACATAATTATCA
AATAAAGTGGGGTGGTAATA

Downstream 100 bases:

>100_bases
GAAAATTGTTGTTTCCGCAGGTCTTGAGATGTGCCAGCGGAGTCTGACAGTGGGTACCTGGGGTAATATAAGCTGCCGGA
ACCCGGAAACCGGGGAAATT

Product: putative translation initiation factor, aIF-2BI family

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MYDTLKFEGDTLILIDQRKLPQKVEFFKCRDYRDVEFAIADMVVRGAPAIGAAGAYGVYLAASEFKNNSEEVFFKKVKEA
NKVLVKARPTAVNLFWAINRMEQAMKRNRNKPVSEILEILREEADNIAREDVETNQAIGKFGNEVIPQGATILTHCNAGA
LATVGYGTALGVIRAAHESGKNIKVYADETRPRLQGARLTAFELVEEGIPVTLIADSVAATLIRDGVIDVIVVGADRIAS
NGDTANKIGTFMLSELAVRFGVPLYIAAPVSTIDFDINDGSEIVIEERSPEEVTHIQGIQIAPDGVEVYNPAFDVTPAEN
ITGIITEKGIIEPPYKEGIASLKSSQKKGDIDGQL

Sequences:

>Translated_355_residues
MYDTLKFEGDTLILIDQRKLPQKVEFFKCRDYRDVEFAIADMVVRGAPAIGAAGAYGVYLAASEFKNNSEEVFFKKVKEA
NKVLVKARPTAVNLFWAINRMEQAMKRNRNKPVSEILEILREEADNIAREDVETNQAIGKFGNEVIPQGATILTHCNAGA
LATVGYGTALGVIRAAHESGKNIKVYADETRPRLQGARLTAFELVEEGIPVTLIADSVAATLIRDGVIDVIVVGADRIAS
NGDTANKIGTFMLSELAVRFGVPLYIAAPVSTIDFDINDGSEIVIEERSPEEVTHIQGIQIAPDGVEVYNPAFDVTPAEN
ITGIITEKGIIEPPYKEGIASLKSSQKKGDIDGQL
>Mature_355_residues
MYDTLKFEGDTLILIDQRKLPQKVEFFKCRDYRDVEFAIADMVVRGAPAIGAAGAYGVYLAASEFKNNSEEVFFKKVKEA
NKVLVKARPTAVNLFWAINRMEQAMKRNRNKPVSEILEILREEADNIAREDVETNQAIGKFGNEVIPQGATILTHCNAGA
LATVGYGTALGVIRAAHESGKNIKVYADETRPRLQGARLTAFELVEEGIPVTLIADSVAATLIRDGVIDVIVVGADRIAS
NGDTANKIGTFMLSELAVRFGVPLYIAAPVSTIDFDINDGSEIVIEERSPEEVTHIQGIQIAPDGVEVYNPAFDVTPAEN
ITGIITEKGIIEPPYKEGIASLKSSQKKGDIDGQL

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=366, Percent_Identity=40.7103825136612, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI23943880, Length=357, Percent_Identity=35.0140056022409, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI4503503, Length=225, Percent_Identity=25.7777777777778, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI78000156, Length=267, Percent_Identity=23.5955056179775, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI78000158, Length=270, Percent_Identity=24.0740740740741, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI187607323, Length=267, Percent_Identity=23.5955056179775, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=337, Percent_Identity=37.3887240356083, Blast_Score=213, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI17557123, Length=222, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=390, Percent_Identity=34.8717948717949, Blast_Score=184, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21357667, Length=362, Percent_Identity=41.4364640883978, Blast_Score=257, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24651647, Length=362, Percent_Identity=41.4364640883978, Blast_Score=257, Evalue=7e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 38624; Mature: 38624

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDTLKFEGDTLILIDQRKLPQKVEFFKCRDYRDVEFAIADMVVRGAPAIGAAGAYGVYL
CCCCEEECCCEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEE
AASEFKNNSEEVFFKKVKEANKVLVKARPTAVNLFWAINRMEQAMKRNRNKPVSEILEIL
EHHHHCCCCHHHHHHHHHHHCEEEEEECCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHH
REEADNIAREDVETNQAIGKFGNEVIPQGATILTHCNAGALATVGYGTALGVIRAAHESG
HHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHCC
KNIKVYADETRPRLQGARLTAFELVEEGIPVTLIADSVAATLIRDGVIDVIVVGADRIAS
CEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCCEEEEEECCHHHCC
NGDTANKIGTFMLSELAVRFGVPLYIAAPVSTIDFDINDGSEIVIEERSPEEVTHIQGIQ
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCEEEEECCCCCHHHHCCCEE
IAPDGVEVYNPAFDVTPAENITGIITEKGIIEPPYKEGIASLKSSQKKGDIDGQL
ECCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MYDTLKFEGDTLILIDQRKLPQKVEFFKCRDYRDVEFAIADMVVRGAPAIGAAGAYGVYL
CCCCEEECCCEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEE
AASEFKNNSEEVFFKKVKEANKVLVKARPTAVNLFWAINRMEQAMKRNRNKPVSEILEIL
EHHHHCCCCHHHHHHHHHHHCEEEEEECCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHH
REEADNIAREDVETNQAIGKFGNEVIPQGATILTHCNAGALATVGYGTALGVIRAAHESG
HHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHCC
KNIKVYADETRPRLQGARLTAFELVEEGIPVTLIADSVAATLIRDGVIDVIVVGADRIAS
CEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCCEEEEEECCHHHCC
NGDTANKIGTFMLSELAVRFGVPLYIAAPVSTIDFDINDGSEIVIEERSPEEVTHIQGIQ
CCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCEEEEECCCCCHHHHCCCEE
IAPDGVEVYNPAFDVTPAENITGIITEKGIIEPPYKEGIASLKSSQKKGDIDGQL
ECCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA