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The map label for this gene is trxA [H]

Identifier: 220932648

GI number: 220932648

Start: 1934318

End: 1934638

Strand: Reverse

Name: trxA [H]

Synonym: Hore_18120

Alternate gene names: 220932648

Gene position: 1934638-1934318 (Counterclockwise)

Preceding gene: 220932649

Following gene: 220932647

Centisome position: 75.04

GC content: 39.88

Gene sequence:

>321_bases
ATGAGTAGACCAGTGGATGTAACTGATGGTAATTTTAGCAGGGAGGTTTTAAAGTCCGATAAACCTGTGGTGGTTGATTT
CTGGGCTGAATGGTGTGCCCCCTGCCGGATGTTAACACCGGTTATAAAAAAGATTGCCAGGGAATACAGTGATAAAGTTA
AGGTTTGCAAACTGAATGTTGATGAAAATCAGTCGACCGCAAGCCGTTATGGGGTTATGAGCATACCGACAATAATTCTC
TTTGAAAATGGTAAGGTAAAAAAACAGGTTACCGGTTATATGCCAAAAAACACCCTTGTAAAAAAACTGGGTATAGAATA
A

Upstream 100 bases:

>100_bases
GGTTATTTTTTGACTGGCATTTGTTCATATTTGCGCAATGTCAGGTAGTAAAGACCATTTTTAATAGAGATAATAAAAAT
CTAAAAGGGGAGGAATTTAA

Downstream 100 bases:

>100_bases
AATGGTAGGCAGGGGATGGTAATTCCCTGCTTATTGTTTTATCCAGGGTTTTTTTATAGTTAATTTTTCTGGTTTCAGGC
CCTGTTTTATAGCAACTATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MSRPVDVTDGNFSREVLKSDKPVVVDFWAEWCAPCRMLTPVIKKIAREYSDKVKVCKLNVDENQSTASRYGVMSIPTIIL
FENGKVKKQVTGYMPKNTLVKKLGIE

Sequences:

>Translated_106_residues
MSRPVDVTDGNFSREVLKSDKPVVVDFWAEWCAPCRMLTPVIKKIAREYSDKVKVCKLNVDENQSTASRYGVMSIPTIIL
FENGKVKKQVTGYMPKNTLVKKLGIE
>Mature_105_residues
SRPVDVTDGNFSREVLKSDKPVVVDFWAEWCAPCRMLTPVIKKIAREYSDKVKVCKLNVDENQSTASRYGVMSIPTIILF
ENGKVKKQVTGYMPKNTLVKKLGIE

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=40, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=34.7368421052632, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=47.3684210526316, Blast_Score=112, Evalue=5e-27,
Organism=Escherichia coli, GI1788936, Length=82, Percent_Identity=46.3414634146341, Blast_Score=93, Evalue=3e-21,
Organism=Escherichia coli, GI87081747, Length=96, Percent_Identity=30.2083333333333, Blast_Score=66, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=89, Percent_Identity=34.8314606741573, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=92, Percent_Identity=40.2173913043478, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=39.7435897435897, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=75, Percent_Identity=36, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=94, Percent_Identity=35.1063829787234, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=97, Percent_Identity=36.0824742268041, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=42.3529411764706, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=80, Percent_Identity=42.5, Blast_Score=73, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=82, Percent_Identity=34.1463414634146, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639826, Length=92, Percent_Identity=40.2173913043478, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=36.4583333333333, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921434, Length=94, Percent_Identity=41.4893617021277, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17648013, Length=88, Percent_Identity=35.2272727272727, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=88, Percent_Identity=35.2272727272727, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639068, Length=88, Percent_Identity=32.9545454545455, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358065, Length=89, Percent_Identity=34.8314606741573, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17530795, Length=73, Percent_Identity=36.986301369863, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664269, Length=65, Percent_Identity=40, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12009; Mature: 11878

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPVDVTDGNFSREVLKSDKPVVVDFWAEWCAPCRMLTPVIKKIAREYSDKVKVCKLNV
CCCCCCCCCCCCHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEC
DENQSTASRYGVMSIPTIILFENGKVKKQVTGYMPKNTLVKKLGIE
CCCCCHHHHCCCCCCCEEEEECCCCCCHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SRPVDVTDGNFSREVLKSDKPVVVDFWAEWCAPCRMLTPVIKKIAREYSDKVKVCKLNV
CCCCCCCCCCCHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEC
DENQSTASRYGVMSIPTIILFENGKVKKQVTGYMPKNTLVKKLGIE
CCCCCHHHHCCCCCCCEEEEECCCCCCHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9795152; 10671452; 12000953 [H]