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The map label for this gene is ywlC [H]

Identifier: 220932631

GI number: 220932631

Start: 1919641

End: 1920735

Strand: Reverse

Name: ywlC [H]

Synonym: Hore_17950

Alternate gene names: 220932631

Gene position: 1920735-1919641 (Counterclockwise)

Preceding gene: 220932632

Following gene: 220932630

Centisome position: 74.5

GC content: 43.74

Gene sequence:

>1095_bases
TTGAGGATGGAATATAAAACCAGAATCGGCAGGGTCAATCGGGACCTTATTAAAAAACAGGATATACTTAAACTGAAAGA
GAATGATGCTATCAGGGAAGGGGCCTCCCTTTTGCAAAAAGGGGAGGTTGTTGCTTTTCCTACAGAGACGGTATACGGGT
TAGGGGCAGATGCTACCAGTGAAAGTGCTGTCAAAAAAATTTTTAAAGCCAAAGGTCGGCCCCGGGATAACCCTCTAATT
GTTCATATCGGTGAGATGGATCAGCTTTACGACATTATAAAAAACCCCCTCTCCGATACGACCCGTAGATTAATAAAACA
TTTCTGGCCCGGACCCCTGACCCTTATTTTTGAAAAAAAAGAGACGATTCCCGGGGTGACTACAGCCGGTCTTGAGAGTG
TAGCGGTCAGGTTTCCGGACAACCCGGTAGCAAGGGCATTAATTGGTTTGAGCTCTGTCCCGGTTGCTGCCCCCAGTGCC
AATCTCTCGGGATCACCGAGTCCTACCAGGGCTGAGCATGTTTTTAAAGATTTAAAGGGTAGGATTCCCTTTATAATTGA
TGGTGGACCGTCCTCTGTCGGAGTAGAATCGACTGTGATTGATATCAGGAGTGGGAACCCTGTTATTCTCCGCCCCGGTG
GTGTTACCAGGGAGGAGATAGCTGAAGTAACCGGGTTTAGCCCGGAAAATCCTGATAATGAAGATAGAAAAAAGCCCCTG
TCACCAGGTATGAAGTACCGCCATTATTCCCCCCGGACCCCCTTGTATTTAATTGAAATCAGAGATTTTGATAAAATTAG
AGACGTTGGAGAAAAATATAAAGGATACAATCTTGCCCTCGTAATTACTTCAGAAACGGATATGGTTTTAAAAGAAAGCC
TGAAAAGTTTTTCAACTACAGGTATTAAAAAGGTTGTAATTGGTTCCAGGAATGATTTTAAAAAGATTGCAGCCTGCATG
TTCGATATCTTAAGGAATCTGGATACTGATAATATTGATCTTATTTTCTTTGAAACCATTCCGGAGAAGGGACTGGGGGA
GGCTATAATGAATAGACTGGCCAAAGCAGCAACGGGGAAAATTGTTGTTGAGTGA

Upstream 100 bases:

>100_bases
TTTTGTCAGGCCTGCCCTGGGGTGATATCAGGGTTTTACAGGATTATTCTGGCCTGGACCGGGTTGTTATTGCCCGCAAA
AAATAAAACAGGGAAGGAAA

Downstream 100 bases:

>100_bases
TCATTAAAAATCTTCAATATCAGTAGTGAAATCTTGTAGTGAAATCTTGATTTTAATATCAGGTTATTGAGACGTTTTTT
ACTTTTAAAAGATTATGGCC

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MRMEYKTRIGRVNRDLIKKQDILKLKENDAIREGASLLQKGEVVAFPTETVYGLGADATSESAVKKIFKAKGRPRDNPLI
VHIGEMDQLYDIIKNPLSDTTRRLIKHFWPGPLTLIFEKKETIPGVTTAGLESVAVRFPDNPVARALIGLSSVPVAAPSA
NLSGSPSPTRAEHVFKDLKGRIPFIIDGGPSSVGVESTVIDIRSGNPVILRPGGVTREEIAEVTGFSPENPDNEDRKKPL
SPGMKYRHYSPRTPLYLIEIRDFDKIRDVGEKYKGYNLALVITSETDMVLKESLKSFSTTGIKKVVIGSRNDFKKIAACM
FDILRNLDTDNIDLIFFETIPEKGLGEAIMNRLAKAATGKIVVE

Sequences:

>Translated_364_residues
MRMEYKTRIGRVNRDLIKKQDILKLKENDAIREGASLLQKGEVVAFPTETVYGLGADATSESAVKKIFKAKGRPRDNPLI
VHIGEMDQLYDIIKNPLSDTTRRLIKHFWPGPLTLIFEKKETIPGVTTAGLESVAVRFPDNPVARALIGLSSVPVAAPSA
NLSGSPSPTRAEHVFKDLKGRIPFIIDGGPSSVGVESTVIDIRSGNPVILRPGGVTREEIAEVTGFSPENPDNEDRKKPL
SPGMKYRHYSPRTPLYLIEIRDFDKIRDVGEKYKGYNLALVITSETDMVLKESLKSFSTTGIKKVVIGSRNDFKKIAACM
FDILRNLDTDNIDLIFFETIPEKGLGEAIMNRLAKAATGKIVVE
>Mature_364_residues
MRMEYKTRIGRVNRDLIKKQDILKLKENDAIREGASLLQKGEVVAFPTETVYGLGADATSESAVKKIFKAKGRPRDNPLI
VHIGEMDQLYDIIKNPLSDTTRRLIKHFWPGPLTLIFEKKETIPGVTTAGLESVAVRFPDNPVARALIGLSSVPVAAPSA
NLSGSPSPTRAEHVFKDLKGRIPFIIDGGPSSVGVESTVIDIRSGNPVILRPGGVTREEIAEVTGFSPENPDNEDRKKPL
SPGMKYRHYSPRTPLYLIEIRDFDKIRDVGEKYKGYNLALVITSETDMVLKESLKSFSTTGIKKVVIGSRNDFKKIAACM
FDILRNLDTDNIDLIFFETIPEKGLGEAIMNRLAKAATGKIVVE

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=193, Percent_Identity=32.6424870466321, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI2367210, Length=160, Percent_Identity=35.625, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081864, Length=188, Percent_Identity=26.5957446808511, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17537239, Length=212, Percent_Identity=31.1320754716981, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193205175, Length=128, Percent_Identity=35.15625, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321269, Length=376, Percent_Identity=40.9574468085106, Blast_Score=230, Evalue=2e-61,
Organism=Drosophila melanogaster, GI78707274, Length=200, Percent_Identity=29.5, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 40216; Mature: 40216

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMEYKTRIGRVNRDLIKKQDILKLKENDAIREGASLLQKGEVVAFPTETVYGLGADATS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCHHHEECCCCCCH
ESAVKKIFKAKGRPRDNPLIVHIGEMDQLYDIIKNPLSDTTRRLIKHFWPGPLTLIFEKK
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECC
ETIPGVTTAGLESVAVRFPDNPVARALIGLSSVPVAAPSANLSGSPSPTRAEHVFKDLKG
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
RIPFIIDGGPSSVGVESTVIDIRSGNPVILRPGGVTREEIAEVTGFSPENPDNEDRKKPL
CCCEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCCC
SPGMKYRHYSPRTPLYLIEIRDFDKIRDVGEKYKGYNLALVITSETDMVLKESLKSFSTT
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHC
GIKKVVIGSRNDFKKIAACMFDILRNLDTDNIDLIFFETIPEKGLGEAIMNRLAKAATGK
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCC
IVVE
EEEC
>Mature Secondary Structure
MRMEYKTRIGRVNRDLIKKQDILKLKENDAIREGASLLQKGEVVAFPTETVYGLGADATS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCHHHEECCCCCCH
ESAVKKIFKAKGRPRDNPLIVHIGEMDQLYDIIKNPLSDTTRRLIKHFWPGPLTLIFEKK
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECC
ETIPGVTTAGLESVAVRFPDNPVARALIGLSSVPVAAPSANLSGSPSPTRAEHVFKDLKG
CCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
RIPFIIDGGPSSVGVESTVIDIRSGNPVILRPGGVTREEIAEVTGFSPENPDNEDRKKPL
CCCEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCCC
SPGMKYRHYSPRTPLYLIEIRDFDKIRDVGEKYKGYNLALVITSETDMVLKESLKSFSTT
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHC
GIKKVVIGSRNDFKKIAACMFDILRNLDTDNIDLIFFETIPEKGLGEAIMNRLAKAATGK
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCC
IVVE
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]