Click here to switch to the map view.

The map label for this gene is pgcA [H]

Identifier: 220932577

GI number: 220932577

Start: 1858876

End: 1860621

Strand: Reverse

Name: pgcA [H]

Synonym: Hore_17410

Alternate gene names: 220932577

Gene position: 1860621-1858876 (Counterclockwise)

Preceding gene: 220932578

Following gene: 220932574

Centisome position: 72.17

GC content: 38.2

Gene sequence:

>1746_bases
TTGAATTATATGTCTCGCTATAAAGAATGGCTTTTAAGTGATTATTTCGATGAGGAAACTAAAGCTGAACTGGAGAGTAT
TAAAGATGATAAAAAAGAAATTGAAGACAGATTTTATAAAGACCTCAATTTTGGGACCGGTGGTTTGCGGGGTATAATTG
GAGCCGGGACAAACAGAATGAACAAATATACAGTTCAGAAAGCTACCCAGGGTCTGGCCAATTATATTATTAACTATAGT
GAGAATGGAAAGGATCGCGGGGTTGTAATAGCTTATGATTCCCGCCACAAATCACCTGAATTTGCTTTAGAGGCTGCTCT
TGTTTTAAATGGAAATGGGATAAAGGCCTACCTTTTTGATGAACTAAGACCAACTCCTGAGCTTTCATTTGCTGTCAGGG
ACTTAAATGCAATCGGTGGTATTGTTATTACTGCCAGCCATAACCCCCCTGAATACAATGGTTATAAAGTTTACTGGGAA
GATGGGGGACAGGTAGTACCTGACCAGGCCCGGGAAATTATAGCGGAAATTGAAGAAATTGATGATTTTGAACTTGTTAA
AAGAATAGATGAAAAAGAAGCCCGGAGTCAGGGATTACTGAAAACAATAGGTGAGGAAATAGATAAGCGATATATCGAGG
AAATGCTAAAAGTCCTGCCTAATAAGGAACTGGCCTCAAAAAAGGGTAAAGATTTTTCAATAATTTATACCCCCCTTCAC
GGTACTGGAAACAAACCAGTTCGCCGTGTTTTAAAAGAATTAGGTTTTAATAATGTTCATGTTGTTGAAGAACAGGCCAA
ACCTGACCCTGAGTTTTCAACAGTAGAAAGCCCCAATCCTGAAGAATTTTCAGCTTTTAAAATGGCATTAGACCTGGCCG
GGGAATATGAACCGGAGTTAATTATCGGAACAGATCCTGATTGTGATAGAATGGGTATAGTAGTAAAGAACAATGAGGGT
GAGTATGTCGGATTAAATGGTAACCAGGTTGGTGTCTTAATGGCTGATTATCTCTTAAGTCAGATGAAAGAACAGGGTGA
GTTGCCTGATAACGGGGTTATCATCAAAACTATAGTTACCACTGAAATGGTGAGAAAAGTTGCAGCTGACTATGGCGTAG
AAGTAATGGATGTTCTCACCGGGTTTAAATTTATCGGTGAAAAGATAAAGGAATTTAAAAAGACCGGTGACCACACCTTC
ATATTTGGATTTGAGGAAAGCTATGGGTACTTAGCAGGGACCTATTGTCGGGATAAGGATGCGGTTATAGCATCTGCCCT
TATAGCCACTATGGCTCTTTATTACCGGGAACAGGGGTTTAGCATTTATGAAAAGCTTATAGATCTTATGGAGAAATATG
GCTACTATAAAGAAAAGCTGTCAGCCATAAAATTAGAAGGAAAGGAAGGTCAGGATAAGATTAAAAACACCCTGGCTACC
ATCAGGGAAGATAGGCCAGATAGTATTTCCGGTATTAAAGTAGAAGTATTTAAGGATTACAAAGAAAAGAAAAGTTATAA
TAATAAAACCGGTGAAATAGAAGATATTGATTTACCGGAATCCAATGTACTCCAGTTTAAACTGGAAGATGACAGTATGT
TGACGATACGTCCTTCAGGAACCGAACCGAAACTAAAGATTTACTTTGCTGTCAGGGGAGAAAATGAAGAAGATGCTGAA
AGAAAGATTAATGCTTTGAAAGAGAACTTTTTAGCCGAGGTTAATAAAATTATAGATGAATCTTAA

Upstream 100 bases:

>100_bases
TAATTGTTTGACTGGAATTATATTAATTATACATTTTAATAAATTTTACTACTGGTAATGGATTTAATCATTAAACTTTT
AAAGGAAGGGATGATTTCTC

Downstream 100 bases:

>100_bases
CTATGGTCTTTAATAATTGATTTTCCGTTCCAAAAACAGAGCGTAAGACGAACAGTTTTTAAGTTCCCGTTTACAACTAA
TTATCATACATTTTTATTAT

Product: alpha-phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MNYMSRYKEWLLSDYFDEETKAELESIKDDKKEIEDRFYKDLNFGTGGLRGIIGAGTNRMNKYTVQKATQGLANYIINYS
ENGKDRGVVIAYDSRHKSPEFALEAALVLNGNGIKAYLFDELRPTPELSFAVRDLNAIGGIVITASHNPPEYNGYKVYWE
DGGQVVPDQAREIIAEIEEIDDFELVKRIDEKEARSQGLLKTIGEEIDKRYIEEMLKVLPNKELASKKGKDFSIIYTPLH
GTGNKPVRRVLKELGFNNVHVVEEQAKPDPEFSTVESPNPEEFSAFKMALDLAGEYEPELIIGTDPDCDRMGIVVKNNEG
EYVGLNGNQVGVLMADYLLSQMKEQGELPDNGVIIKTIVTTEMVRKVAADYGVEVMDVLTGFKFIGEKIKEFKKTGDHTF
IFGFEESYGYLAGTYCRDKDAVIASALIATMALYYREQGFSIYEKLIDLMEKYGYYKEKLSAIKLEGKEGQDKIKNTLAT
IREDRPDSISGIKVEVFKDYKEKKSYNNKTGEIEDIDLPESNVLQFKLEDDSMLTIRPSGTEPKLKIYFAVRGENEEDAE
RKINALKENFLAEVNKIIDES

Sequences:

>Translated_581_residues
MNYMSRYKEWLLSDYFDEETKAELESIKDDKKEIEDRFYKDLNFGTGGLRGIIGAGTNRMNKYTVQKATQGLANYIINYS
ENGKDRGVVIAYDSRHKSPEFALEAALVLNGNGIKAYLFDELRPTPELSFAVRDLNAIGGIVITASHNPPEYNGYKVYWE
DGGQVVPDQAREIIAEIEEIDDFELVKRIDEKEARSQGLLKTIGEEIDKRYIEEMLKVLPNKELASKKGKDFSIIYTPLH
GTGNKPVRRVLKELGFNNVHVVEEQAKPDPEFSTVESPNPEEFSAFKMALDLAGEYEPELIIGTDPDCDRMGIVVKNNEG
EYVGLNGNQVGVLMADYLLSQMKEQGELPDNGVIIKTIVTTEMVRKVAADYGVEVMDVLTGFKFIGEKIKEFKKTGDHTF
IFGFEESYGYLAGTYCRDKDAVIASALIATMALYYREQGFSIYEKLIDLMEKYGYYKEKLSAIKLEGKEGQDKIKNTLAT
IREDRPDSISGIKVEVFKDYKEKKSYNNKTGEIEDIDLPESNVLQFKLEDDSMLTIRPSGTEPKLKIYFAVRGENEEDAE
RKINALKENFLAEVNKIIDES
>Mature_581_residues
MNYMSRYKEWLLSDYFDEETKAELESIKDDKKEIEDRFYKDLNFGTGGLRGIIGAGTNRMNKYTVQKATQGLANYIINYS
ENGKDRGVVIAYDSRHKSPEFALEAALVLNGNGIKAYLFDELRPTPELSFAVRDLNAIGGIVITASHNPPEYNGYKVYWE
DGGQVVPDQAREIIAEIEEIDDFELVKRIDEKEARSQGLLKTIGEEIDKRYIEEMLKVLPNKELASKKGKDFSIIYTPLH
GTGNKPVRRVLKELGFNNVHVVEEQAKPDPEFSTVESPNPEEFSAFKMALDLAGEYEPELIIGTDPDCDRMGIVVKNNEG
EYVGLNGNQVGVLMADYLLSQMKEQGELPDNGVIIKTIVTTEMVRKVAADYGVEVMDVLTGFKFIGEKIKEFKKTGDHTF
IFGFEESYGYLAGTYCRDKDAVIASALIATMALYYREQGFSIYEKLIDLMEKYGYYKEKLSAIKLEGKEGQDKIKNTLAT
IREDRPDSISGIKVEVFKDYKEKKSYNNKTGEIEDIDLPESNVLQFKLEDDSMLTIRPSGTEPKLKIYFAVRGENEEDAE
RKINALKENFLAEVNKIIDES

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=604, Percent_Identity=31.4569536423841, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI63055049, Length=593, Percent_Identity=30.185497470489, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1786904, Length=410, Percent_Identity=26.5853658536585, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71993870, Length=576, Percent_Identity=30.7291666666667, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71993878, Length=317, Percent_Identity=33.7539432176656, Blast_Score=161, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6323934, Length=577, Percent_Identity=32.5823223570191, Blast_Score=231, Evalue=2e-61,
Organism=Drosophila melanogaster, GI20129809, Length=573, Percent_Identity=31.064572425829, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24651977, Length=490, Percent_Identity=31.8367346938775, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24653722, Length=603, Percent_Identity=28.5240464344942, Blast_Score=238, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 65852; Mature: 65852

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYMSRYKEWLLSDYFDEETKAELESIKDDKKEIEDRFYKDLNFGTGGLRGIIGAGTNRM
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCC
NKYTVQKATQGLANYIINYSENGKDRGVVIAYDSRHKSPEFALEAALVLNGNGIKAYLFD
HHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCEEEEEEC
ELRPTPELSFAVRDLNAIGGIVITASHNPPEYNGYKVYWEDGGQVVPDQAREIIAEIEEI
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCEECCHHHHHHHHHHHHC
DDFELVKRIDEKEARSQGLLKTIGEEIDKRYIEEMLKVLPNKELASKKGKDFSIIYTPLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECC
GTGNKPVRRVLKELGFNNVHVVEEQAKPDPEFSTVESPNPEEFSAFKMALDLAGEYEPEL
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCE
IIGTDPDCDRMGIVVKNNEGEYVGLNGNQVGVLMADYLLSQMKEQGELPDNGVIIKTIVT
EECCCCCCCCEEEEEECCCCCEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
TEMVRKVAADYGVEVMDVLTGFKFIGEKIKEFKKTGDHTFIFGFEESYGYLAGTYCRDKD
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEECCCCCH
AVIASALIATMALYYREQGFSIYEKLIDLMEKYGYYKEKLSAIKLEGKEGQDKIKNTLAT
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCHHHHHHHHHH
IREDRPDSISGIKVEVFKDYKEKKSYNNKTGEIEDIDLPESNVLQFKLEDDSMLTIRPSG
HHCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEEECCCCEEEEECCC
TEPKLKIYFAVRGENEEDAERKINALKENFLAEVNKIIDES
CCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYMSRYKEWLLSDYFDEETKAELESIKDDKKEIEDRFYKDLNFGTGGLRGIIGAGTNRM
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCCC
NKYTVQKATQGLANYIINYSENGKDRGVVIAYDSRHKSPEFALEAALVLNGNGIKAYLFD
HHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCCEEEEEEEEECCCEEEEEEC
ELRPTPELSFAVRDLNAIGGIVITASHNPPEYNGYKVYWEDGGQVVPDQAREIIAEIEEI
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEECCCCEECCHHHHHHHHHHHHC
DDFELVKRIDEKEARSQGLLKTIGEEIDKRYIEEMLKVLPNKELASKKGKDFSIIYTPLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECC
GTGNKPVRRVLKELGFNNVHVVEEQAKPDPEFSTVESPNPEEFSAFKMALDLAGEYEPEL
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCE
IIGTDPDCDRMGIVVKNNEGEYVGLNGNQVGVLMADYLLSQMKEQGELPDNGVIIKTIVT
EECCCCCCCCEEEEEECCCCCEEECCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEHHHH
TEMVRKVAADYGVEVMDVLTGFKFIGEKIKEFKKTGDHTFIFGFEESYGYLAGTYCRDKD
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEECCCCCH
AVIASALIATMALYYREQGFSIYEKLIDLMEKYGYYKEKLSAIKLEGKEGQDKIKNTLAT
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCHHHHHHHHHH
IREDRPDSISGIKVEVFKDYKEKKSYNNKTGEIEDIDLPESNVLQFKLEDDSMLTIRPSG
HHCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEEECCCCEEEEECCC
TEPKLKIYFAVRGENEEDAERKINALKENFLAEVNKIIDES
CCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]