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The map label for this gene is epsC [H]

Identifier: 220932534

GI number: 220932534

Start: 1816782

End: 1818245

Strand: Reverse

Name: epsC [H]

Synonym: Hore_16980

Alternate gene names: 220932534

Gene position: 1818245-1816782 (Counterclockwise)

Preceding gene: 220932535

Following gene: 220932533

Centisome position: 70.53

GC content: 30.87

Gene sequence:

>1464_bases
ATGAAAAATTTATTAATTATAGGAGCTGGAAGTGCCGGTAAGCTTGTTCTTGAGGAAATTTTAAAAAATAACGAGAGCTA
TAATTATAATATAATTGGTTTTTTAGACGCTGATATTAATAAGCATGGGACAAGCATTCATGGCTATAAAGTTTTAGGTC
ATCATGATAATATTTCCTTTTATATTGATCAATACAGTGTTGATGAAGTTATAGTAGCCACTACAGAAATTGACCGTGCT
GGATTAGAAAAAATATACCAAAACACAAAGAAATTTCAAATTGGGATAAAAGTTTTACCAACCCTTCAAGAGTTACTTAT
GGAAGAACCTTTCACTAAACAATTGAGAGAAGTAAGGGTAGAAGATTTATTAGGTAGAGAGCCTGTAAAAATTAATAGTG
ATAACATCTATAAATATATCAATCATAAAAAGGTGTTGGTTACTGGGGCTGCTGGATCAATAGGAAGTGAACTTTGTCGC
CAGATTGCTAAATATGATCCCCGGGAGTTAATAATATTAGACATAAATGAAAATGAACTCTATTTTTTAAATCTATTTTT
AAAAAGACATTATAATTTAAATGTCAGTTTAGAAATATGTAATATAAGGGAAAAAAGCAAATTAGAATATTTATTTAACT
ATTACAAACCTCAGCTTGTATTCCATGCTGCAGCCCACAAACATGTACCATTAATGGAAAAAAATATAGATGAAGCTATA
AAAAATAATGTTTTTGGTACTAAAAACCTGCTGGATCTTTCTGACAAATATGGAGTGGAAAAGTTCGTTTTAATATCAAC
TGATAAAGCCGTTAATCCTACCAATGTTATGGGGGCTACTAAACGTTTATCAGAAATTATGTTGGAGAAGATCAATAAAT
ATTCTAAAACCCAGTACATGGCAGTAAGATTTGGAAATGTCTTAGGAAGTAATGGCAGTGTGGTACCTTTATTTAAAACT
TTAATTAAAGAGGGTAAAGATTTAACAGTTACCCATGAAGAGGCAACCCGTTACTTTATGACCATACCGGAAGCTGTCCA
ACTTGTCCTTGAAGCTGGTTTTATAGGTAAAGGGGGAGAAGTTTTTGTTCTGGATATGGGTGAACCTGTTAAAATAATAG
ATTTAGCTAAAAAGATGATTGAGTTGTCAGGTTTAACCCTGGGTAGGGATATTAATATAAAAATTACTGGTTTAAGGCCT
GGTGAAAAATTACATGAAGAACTTATGCATGATATTAACTCTTGTGAAAAGACACAGAATAAAAAAATATATATTGCAAA
GATAAGAGAAGAAAATGTAGATATAGAAAAAGGTTTACAGGATTTAAAACGATATTTGATGTCTTTTGACAGAAAAAAAC
TGGTAAAAAAGCTTAAAGAATTGGTACCTACTTATAAAGACAATAGTTATAGTGAGGAGAATATAGATGGAAGACAAACT
AAATATTCCGTTATCAGTACCTAA

Upstream 100 bases:

>100_bases
AAATTTTCTAGATAATATAAAAACTATTAACAAAATTAAAGAAGAGATATATAGTCAATAATAGAAGTTTCTCTGGTTGG
GTATAGAAAAGGTGATAATA

Downstream 100 bases:

>100_bases
TCTATCTTTAGATATACTTGATAACTTAAAAGAGTGTATTGAAACGGGGTGGGTTTCAACGGGGGGAAGATTTATAAAAG
AATTTGAGGATAAAGTGGCT

Product: nucleoside-diphosphate sugar epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKNLLIIGAGSAGKLVLEEILKNNESYNYNIIGFLDADINKHGTSIHGYKVLGHHDNISFYIDQYSVDEVIVATTEIDRA
GLEKIYQNTKKFQIGIKVLPTLQELLMEEPFTKQLREVRVEDLLGREPVKINSDNIYKYINHKKVLVTGAAGSIGSELCR
QIAKYDPRELIILDINENELYFLNLFLKRHYNLNVSLEICNIREKSKLEYLFNYYKPQLVFHAAAHKHVPLMEKNIDEAI
KNNVFGTKNLLDLSDKYGVEKFVLISTDKAVNPTNVMGATKRLSEIMLEKINKYSKTQYMAVRFGNVLGSNGSVVPLFKT
LIKEGKDLTVTHEEATRYFMTIPEAVQLVLEAGFIGKGGEVFVLDMGEPVKIIDLAKKMIELSGLTLGRDINIKITGLRP
GEKLHEELMHDINSCEKTQNKKIYIAKIREENVDIEKGLQDLKRYLMSFDRKKLVKKLKELVPTYKDNSYSEENIDGRQT
KYSVIST

Sequences:

>Translated_487_residues
MKNLLIIGAGSAGKLVLEEILKNNESYNYNIIGFLDADINKHGTSIHGYKVLGHHDNISFYIDQYSVDEVIVATTEIDRA
GLEKIYQNTKKFQIGIKVLPTLQELLMEEPFTKQLREVRVEDLLGREPVKINSDNIYKYINHKKVLVTGAAGSIGSELCR
QIAKYDPRELIILDINENELYFLNLFLKRHYNLNVSLEICNIREKSKLEYLFNYYKPQLVFHAAAHKHVPLMEKNIDEAI
KNNVFGTKNLLDLSDKYGVEKFVLISTDKAVNPTNVMGATKRLSEIMLEKINKYSKTQYMAVRFGNVLGSNGSVVPLFKT
LIKEGKDLTVTHEEATRYFMTIPEAVQLVLEAGFIGKGGEVFVLDMGEPVKIIDLAKKMIELSGLTLGRDINIKITGLRP
GEKLHEELMHDINSCEKTQNKKIYIAKIREENVDIEKGLQDLKRYLMSFDRKKLVKKLKELVPTYKDNSYSEENIDGRQT
KYSVIST
>Mature_487_residues
MKNLLIIGAGSAGKLVLEEILKNNESYNYNIIGFLDADINKHGTSIHGYKVLGHHDNISFYIDQYSVDEVIVATTEIDRA
GLEKIYQNTKKFQIGIKVLPTLQELLMEEPFTKQLREVRVEDLLGREPVKINSDNIYKYINHKKVLVTGAAGSIGSELCR
QIAKYDPRELIILDINENELYFLNLFLKRHYNLNVSLEICNIREKSKLEYLFNYYKPQLVFHAAAHKHVPLMEKNIDEAI
KNNVFGTKNLLDLSDKYGVEKFVLISTDKAVNPTNVMGATKRLSEIMLEKINKYSKTQYMAVRFGNVLGSNGSVVPLFKT
LIKEGKDLTVTHEEATRYFMTIPEAVQLVLEAGFIGKGGEVFVLDMGEPVKIIDLAKKMIELSGLTLGRDINIKITGLRP
GEKLHEELMHDINSCEKTQNKKIYIAKIREENVDIEKGLQDLKRYLMSFDRKKLVKKLKELVPTYKDNSYSEENIDGRQT
KYSVIST

Specific function: Involved in biofilm formation [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=263, Percent_Identity=26.9961977186312, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 55604; Mature: 55604

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLLIIGAGSAGKLVLEEILKNNESYNYNIIGFLDADINKHGTSIHGYKVLGHHDNISF
CCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEEEEEECCCEEE
YIDQYSVDEVIVATTEIDRAGLEKIYQNTKKFQIGIKVLPTLQELLMEEPFTKQLREVRV
EEECCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEEEHHHHHHHHHCCHHHHHHHHHHH
EDLLGREPVKINSDNIYKYINHKKVLVTGAAGSIGSELCRQIAKYDPRELIILDINENEL
HHHHCCCCEEECCCCEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCE
YFLNLFLKRHYNLNVSLEICNIREKSKLEYLFNYYKPQLVFHAAAHKHVPLMEKNIDEAI
EEEEEEEHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
KNNVFGTKNLLDLSDKYGVEKFVLISTDKAVNPTNVMGATKRLSEIMLEKINKYSKTQYM
HCCCCCCCCHHCCHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
AVRFGNVLGSNGSVVPLFKTLIKEGKDLTVTHEEATRYFMTIPEAVQLVLEAGFIGKGGE
EEEECHHCCCCCCCHHHHHHHHHCCCCEEEEHHHHHEEEEECHHHHHHHHHCCCCCCCCC
VFVLDMGEPVKIIDLAKKMIELSGLTLGRDINIKITGLRPGEKLHEELMHDINSCEKTQN
EEEEECCCCCHHHHHHHHHHHHCCCEECCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
KKIYIAKIREENVDIEKGLQDLKRYLMSFDRKKLVKKLKELVPTYKDNSYSEENIDGRQT
CEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
KYSVIST
EEEEECC
>Mature Secondary Structure
MKNLLIIGAGSAGKLVLEEILKNNESYNYNIIGFLDADINKHGTSIHGYKVLGHHDNISF
CCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEEEEEECCCEEE
YIDQYSVDEVIVATTEIDRAGLEKIYQNTKKFQIGIKVLPTLQELLMEEPFTKQLREVRV
EEECCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEEEHHHHHHHHHCCHHHHHHHHHHH
EDLLGREPVKINSDNIYKYINHKKVLVTGAAGSIGSELCRQIAKYDPRELIILDINENEL
HHHHCCCCEEECCCCEEEEECCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCE
YFLNLFLKRHYNLNVSLEICNIREKSKLEYLFNYYKPQLVFHAAAHKHVPLMEKNIDEAI
EEEEEEEHHCCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
KNNVFGTKNLLDLSDKYGVEKFVLISTDKAVNPTNVMGATKRLSEIMLEKINKYSKTQYM
HCCCCCCCCHHCCHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
AVRFGNVLGSNGSVVPLFKTLIKEGKDLTVTHEEATRYFMTIPEAVQLVLEAGFIGKGGE
EEEECHHCCCCCCCHHHHHHHHHCCCCEEEEHHHHHEEEEECHHHHHHHHHCCCCCCCCC
VFVLDMGEPVKIIDLAKKMIELSGLTLGRDINIKITGLRPGEKLHEELMHDINSCEKTQN
EEEEECCCCCHHHHHHHHHHHHCCCEECCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
KKIYIAKIREENVDIEKGLQDLKRYLMSFDRKKLVKKLKELVPTYKDNSYSEENIDGRQT
CEEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
KYSVIST
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969506; 9384377 [H]