Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 220932459

GI number: 220932459

Start: 1743481

End: 1745499

Strand: Reverse

Name: uvrB [H]

Synonym: Hore_16230

Alternate gene names: 220932459

Gene position: 1745499-1743481 (Counterclockwise)

Preceding gene: 220932460

Following gene: 220932458

Centisome position: 67.7

GC content: 45.37

Gene sequence:

>2019_bases
TTGAAAACAGAGAAGAAATTTAAACTGGTTTCCTCATATTCGCCAAAAGGAGACCAGCCCCAGGCCATTGAAAAACTGGT
TAAAGGGGTAAATAAGGGTTACAGGCATCAGACCCTGCTGGGGGCAACAGGGACAGGTAAAACCTATACCATGGCAGCGG
TAATCGAAAAGCTGAACAAGCCTACCCTGGTAATTGCCCACAATAAAACACTGGCGGCTCAACTCTGTAGTGAATTCCGG
GAATTTTTTCCTGAAAATGCTGTTCATTACTTTGTCAGCTATTATGATTATTATCAACCGGAAGCTTATGTCCCCCAGAC
AGATACCTATATTGAGAAAGATGCTTCTATAAATGAGGATATAGATAAGCTACGCCTGGCAGCTACCAGTTCTCTCTTTG
AGAGACGGGATGTGCTGATTGTGGCCAGTGTTTCCTGTATTTATGGCCTCGGTAATCCAGAGGATTACCTGGATCTATCC
TGCCACCTTAAGGTTGGGGATTTGAAGGAAAGGAATACAATCCTCCAGGAACTTATTTTTATGCAATATAGCCGCAATGA
TATTGATCTGTCCCGGGGTCATTTCCGGGTAAAAGGTGATGTTATCGATATTTTTCCTGCATACAGGGATGAGGCAATAA
GGGTTGAATTGTTCGGGGATGAAATAGATCGTATCACTAAAATCAATACAGTGACTGGAGAGGTTCTACAGGAGATTGAT
GAGATTACTATTTATCCAGCGAGCCATTTTGTTACCCCTGAAGATAAAATAAAGAGGGCACTAAAAACAATTCAGGTAGA
GCTGGAAGAAAGGTTAAAGGAGCTTAAAAAACAGAATCGATTGGTAGAGGCCCAACGCCTTGAACAGAGGACCCGCTACG
ACATGGAGATGCTGGAACAGATGGGGTACTGTACCGGGATTGAAAATTATTCCCGTCACCTGGAGGGGCGACCGCCCGGT
TCCAGGCCCAACACCTTACTTGACTATTTCCCCGATGATGATTTTCTGGTGATTATCGATGAATCCCACATGACAATACC
CCAGATCGGGGGCATGTATGCCGGAGACAGGTCCCGTAAGGAAAAACTGGTTGAATATGGATTCAGGTTGCCGTCAGCCC
TGGATAACAGGCCCCTGAACTTTGAAGAATTTGAAAAACTCGTGCCCCGGGCGATTTATGTGTCTGCCACCCCGGGCCCT
TATGAGTTGAAACACAGCCAGCAGGTAGTTGAGCAGATTATAAGGCCGACCGGTCTGGTTGACCCGGTGGTTATCGTTAA
ACCTACCGAAGGTCAGATAGATGACCTGATGGATGAAATTCAACAGGTTATTGAAAGGGAAGAAAGGGTCCTGGTAACAA
CTTTAACCAAACGGATGGCAGAGGATTTGACCGAGTTTCTGGCTGAAGCAGGAATCAGGGTTAGATACCTCCATTCTGAT
ATTGATACCCTGGAACGGTCCGAAATTATAAGGGATTTGAGGCTCGGCGAGTTTGATGTTCTGGTCGGGATAAATTTGCT
CCGGGAAGGCCTTGATTTACCCGAGGTATCGCTGGTAGCCATCCTGGATGCTGATAAGGAGGGTTATTTGCGTTCTGAAC
GTTCCCTGATACAGACCATTGGGCGGGCTGCCCGTAATGTTAACGGGCGGGTCGTTATGTATGCTGATAAGATTACAGAA
TCAATGGAAAAGGCCATAGATGAGACCGAAAGAAGGAGAAAAATTCAGCTTGAATTTAATAAAAAACATGGGATTACACC
CACGACCATCGTAAAACCGGTCAGAAAAGTGCTCAGGCCTGAAGATATGATTATTAAAGATGTAGATGAAATAGACTATT
CTGTTAAGTCGGGTGAAGGGGAGGAGATTAAGAACCTGTCTCCTTCTGAAATACGCCACCGGATTCTGGAACTTGAGGAA
GAGATGAAAGAGGCGGCCGATAACCTGGAGTTTGAACTGGCAGCCCAGATAAGGGATGAAATAAAGGAACTGGAAGAAGA
GCTGGAAAAGATGAGGTGA

Upstream 100 bases:

>100_bases
TGGATTTAATTATAGTTCTTATTTTACTGGTTTATATTGCATTATGTTTATATTAAATTATATTTATGATTTATATTACT
CACCGAAAGGGGTGGGTTGG

Downstream 100 bases:

>100_bases
AAAGATAATGGTCAAGGAAATGATTTATGTTAAGGGAGCCCAGGAGCATAATTTAAAGAATATTGATGTCAGGATTCCAA
GGGATAAACTTATAGTTATA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MKTEKKFKLVSSYSPKGDQPQAIEKLVKGVNKGYRHQTLLGATGTGKTYTMAAVIEKLNKPTLVIAHNKTLAAQLCSEFR
EFFPENAVHYFVSYYDYYQPEAYVPQTDTYIEKDASINEDIDKLRLAATSSLFERRDVLIVASVSCIYGLGNPEDYLDLS
CHLKVGDLKERNTILQELIFMQYSRNDIDLSRGHFRVKGDVIDIFPAYRDEAIRVELFGDEIDRITKINTVTGEVLQEID
EITIYPASHFVTPEDKIKRALKTIQVELEERLKELKKQNRLVEAQRLEQRTRYDMEMLEQMGYCTGIENYSRHLEGRPPG
SRPNTLLDYFPDDDFLVIIDESHMTIPQIGGMYAGDRSRKEKLVEYGFRLPSALDNRPLNFEEFEKLVPRAIYVSATPGP
YELKHSQQVVEQIIRPTGLVDPVVIVKPTEGQIDDLMDEIQQVIEREERVLVTTLTKRMAEDLTEFLAEAGIRVRYLHSD
IDTLERSEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRSERSLIQTIGRAARNVNGRVVMYADKITE
SMEKAIDETERRRKIQLEFNKKHGITPTTIVKPVRKVLRPEDMIIKDVDEIDYSVKSGEGEEIKNLSPSEIRHRILELEE
EMKEAADNLEFELAAQIRDEIKELEEELEKMR

Sequences:

>Translated_672_residues
MKTEKKFKLVSSYSPKGDQPQAIEKLVKGVNKGYRHQTLLGATGTGKTYTMAAVIEKLNKPTLVIAHNKTLAAQLCSEFR
EFFPENAVHYFVSYYDYYQPEAYVPQTDTYIEKDASINEDIDKLRLAATSSLFERRDVLIVASVSCIYGLGNPEDYLDLS
CHLKVGDLKERNTILQELIFMQYSRNDIDLSRGHFRVKGDVIDIFPAYRDEAIRVELFGDEIDRITKINTVTGEVLQEID
EITIYPASHFVTPEDKIKRALKTIQVELEERLKELKKQNRLVEAQRLEQRTRYDMEMLEQMGYCTGIENYSRHLEGRPPG
SRPNTLLDYFPDDDFLVIIDESHMTIPQIGGMYAGDRSRKEKLVEYGFRLPSALDNRPLNFEEFEKLVPRAIYVSATPGP
YELKHSQQVVEQIIRPTGLVDPVVIVKPTEGQIDDLMDEIQQVIEREERVLVTTLTKRMAEDLTEFLAEAGIRVRYLHSD
IDTLERSEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRSERSLIQTIGRAARNVNGRVVMYADKITE
SMEKAIDETERRRKIQLEFNKKHGITPTTIVKPVRKVLRPEDMIIKDVDEIDYSVKSGEGEEIKNLSPSEIRHRILELEE
EMKEAADNLEFELAAQIRDEIKELEEELEKMR
>Mature_672_residues
MKTEKKFKLVSSYSPKGDQPQAIEKLVKGVNKGYRHQTLLGATGTGKTYTMAAVIEKLNKPTLVIAHNKTLAAQLCSEFR
EFFPENAVHYFVSYYDYYQPEAYVPQTDTYIEKDASINEDIDKLRLAATSSLFERRDVLIVASVSCIYGLGNPEDYLDLS
CHLKVGDLKERNTILQELIFMQYSRNDIDLSRGHFRVKGDVIDIFPAYRDEAIRVELFGDEIDRITKINTVTGEVLQEID
EITIYPASHFVTPEDKIKRALKTIQVELEERLKELKKQNRLVEAQRLEQRTRYDMEMLEQMGYCTGIENYSRHLEGRPPG
SRPNTLLDYFPDDDFLVIIDESHMTIPQIGGMYAGDRSRKEKLVEYGFRLPSALDNRPLNFEEFEKLVPRAIYVSATPGP
YELKHSQQVVEQIIRPTGLVDPVVIVKPTEGQIDDLMDEIQQVIEREERVLVTTLTKRMAEDLTEFLAEAGIRVRYLHSD
IDTLERSEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRSERSLIQTIGRAARNVNGRVVMYADKITE
SMEKAIDETERRRKIQLEFNKKHGITPTTIVKPVRKVLRPEDMIIKDVDEIDYSVKSGEGEEIKNLSPSEIRHRILELEE
EMKEAADNLEFELAAQIRDEIKELEEELEKMR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=673, Percent_Identity=60.7726597325409, Blast_Score=798, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 77403; Mature: 77403

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTEKKFKLVSSYSPKGDQPQAIEKLVKGVNKGYRHQTLLGATGTGKTYTMAAVIEKLNK
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCC
PTLVIAHNKTLAAQLCSEFREFFPENAVHYFVSYYDYYQPEAYVPQTDTYIEKDASINED
CEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHH
IDKLRLAATSSLFERRDVLIVASVSCIYGLGNPEDYLDLSCHLKVGDLKERNTILQELIF
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHH
MQYSRNDIDLSRGHFRVKGDVIDIFPAYRDEAIRVELFGDEIDRITKINTVTGEVLQEID
HHHCCCCCCCCCCEEEEECCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
EITIYPASHFVTPEDKIKRALKTIQVELEERLKELKKQNRLVEAQRLEQRTRYDMEMLEQ
HEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGYCTGIENYSRHLEGRPPGSRPNTLLDYFPDDDFLVIIDESHMTIPQIGGMYAGDRSRK
CCCCCCHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHH
EKLVEYGFRLPSALDNRPLNFEEFEKLVPRAIYVSATPGPYELKHSQQVVEQIIRPTGLV
HHHHHHHCCCCHHHCCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
DPVVIVKPTEGQIDDLMDEIQQVIEREERVLVTTLTKRMAEDLTEFLAEAGIRVRYLHSD
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
IDTLERSEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRSERSLIQTI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
GRAARNVNGRVVMYADKITESMEKAIDETERRRKIQLEFNKKHGITPTTIVKPVRKVLRP
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHCC
EDMIIKDVDEIDYSVKSGEGEEIKNLSPSEIRHRILELEEEMKEAADNLEFELAAQIRDE
CHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IKELEEELEKMR
HHHHHHHHHHCC
>Mature Secondary Structure
MKTEKKFKLVSSYSPKGDQPQAIEKLVKGVNKGYRHQTLLGATGTGKTYTMAAVIEKLNK
CCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCC
PTLVIAHNKTLAAQLCSEFREFFPENAVHYFVSYYDYYQPEAYVPQTDTYIEKDASINED
CEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCHH
IDKLRLAATSSLFERRDVLIVASVSCIYGLGNPEDYLDLSCHLKVGDLKERNTILQELIF
HHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHH
MQYSRNDIDLSRGHFRVKGDVIDIFPAYRDEAIRVELFGDEIDRITKINTVTGEVLQEID
HHHCCCCCCCCCCEEEEECCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
EITIYPASHFVTPEDKIKRALKTIQVELEERLKELKKQNRLVEAQRLEQRTRYDMEMLEQ
HEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGYCTGIENYSRHLEGRPPGSRPNTLLDYFPDDDFLVIIDESHMTIPQIGGMYAGDRSRK
CCCCCCHHHHHHHCCCCCCCCCCCCCEECCCCCCEEEEECCCCCCCCCCCCCCCCCHHHH
EKLVEYGFRLPSALDNRPLNFEEFEKLVPRAIYVSATPGPYELKHSQQVVEQIIRPTGLV
HHHHHHHCCCCHHHCCCCCCHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCC
DPVVIVKPTEGQIDDLMDEIQQVIEREERVLVTTLTKRMAEDLTEFLAEAGIRVRYLHSD
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
IDTLERSEIIRDLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGYLRSERSLIQTI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHH
GRAARNVNGRVVMYADKITESMEKAIDETERRRKIQLEFNKKHGITPTTIVKPVRKVLRP
HHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHCC
EDMIIKDVDEIDYSVKSGEGEEIKNLSPSEIRHRILELEEEMKEAADNLEFELAAQIRDE
CHHHHHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
IKELEEELEKMR
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]