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The map label for this gene is rnr [H]

Identifier: 220932409

GI number: 220932409

Start: 1684322

End: 1686442

Strand: Reverse

Name: rnr [H]

Synonym: Hore_15730

Alternate gene names: 220932409

Gene position: 1686442-1684322 (Counterclockwise)

Preceding gene: 220932410

Following gene: 220932408

Centisome position: 65.41

GC content: 42.34

Gene sequence:

>2121_bases
ATGAGCGCTAGAGATAAAATTATGGAATTTATGGCCGATAAGGCCGAACGGCCTATGTCGGCCGCCGAATTAATGAAAGT
ATTTAAAATTGAAAAGGATCAGAAGGGGATATTTATTAACCTTTTAAAAAAACTGGTTAAAGAGGGTCTTCTTTTTAAAA
CCCAGGATGGTAAATACGGTATTCCCGAGAAAATGGACCTGATTCCCGGTCGTATTGAGGGTAACCCCAGGGGATTTGCG
TTTTTAATCCCTGATGACCCGACCCGGGATGATATATTTATTAGCCTTGAAAATCTAAAAGGGGCCATGCATAATGACCG
GGTCTTTGTCAGACTTCTTTCAAGGCAAAAGGGTAAAAACAGAGAGGGAGAAGTTGTAAAAATCATAGAACGGGCCAACC
ACCAGGTGGTCGGCAACCTGGAGAAAAGCAAGTACTTTGGCTTTGTAGTCCCTGATAATAAAAGAATTTTTTATGATGTT
TTTATTCCGAAAGAGGAATTAAACGGGGCCAGGCAAAACCAGAAAGTGGTTGCTGAAATAACCAGATGGCCTGAAAAAAA
GAGAAACCCTGAAGGTAAGATAATTAAAATCCTGGGCTCCCGGGGAGAACGGGGAGTAGACATAGAGGGGATAATTTATC
AGCTGGGTCTTCCCCAGGAGTTTGATTATGAGGTCCTTGAGGAAGCAAAGTCTATTCCCCTTGAAATAAGTAAAGGTGAC
TTAAAGGGAAGAAGGGACCTTAGAGCTATGCCCATGGTTACAATTGACGGGGCTGATGCTAAGGACCTTGATGATGCTGT
ATCCATTGAAGAGGTGGATGATAACCAGGTACGCCTGGGGGTCCATATTGCCGATGTCTCCCATTATGTAAAAGAAGATA
GTGCCCTTGATCGGGAGGCTCTGAAGAGGGGAACCAGTATTTATCTGGTGGACCGGGTTATTCCGATGCTTCCTGAGAGG
CTTTCCAATGGTATCTGTAGCCTTAACCCCAATCAGGACCGGTTAACCATGTCGGTCTTTATTACTTATCAGCTGGAACC
CTTTAAACTGATGGAGTATGAGATCGTTCCCAGTGTTATCAAAACCAATTACCGTTTAACCTATGATGAGGTCAGAGAAA
TCCTTGTTCATAAAAATAAAGCGGCAATTCAAAAATACAGGGATTTTGTTCCCTATTTAAAGTTAATGAATAAGCTCAGG
AAAAGATTAAGGGAAGAAAGGGTAGCCCGGGGTAGCATTGATTTTGATATGCCCGAGGTAAAGGTTATCCTTAATGAAGA
TGGTAAGCCGGTTGATATTATAAACAGAGTTCATGGTATTCCTGAACAGCTTATTGAGGAATTTATGATTGCAGCCAATC
GGGTAGTTGCTGAAGATATGTACTGGCGACAGATACCCTTTATCTACAGGGTTCATGATCAGCCTGATCACGGCAGGATG
GCTGACTTTAATGAATTTATCCATAATTTTGGCTACCATTTAAAGGGGGTTAATAATGAGATACACCCCCGGGAATTACA
GGAACTGCTTCAACTGGTGGAAGGGAGACCGGAAGAACGCTTGATTACCAGAATACTTTTAAGGTCCATGAAACAGGCAG
TCTACTCAGACCAGAATATTGGCCATTTTGGACTGGCTCTCGATTATTATACCCACTTTACATCCCCAATAAGGCGGTAT
CCCGACCTTATGATTCACCGGATTATTAAAGAGGTTATTAAAAAAGGTTATCTACCAGCCCGGAGGCAGGAAGAACTGGA
AGAGAAATTATTTGAAGTTGCTGAACACAGCTCCCTCCAGGAAAGAAAAGCCATGGAAGCTGAACGGGACTCTGTTGATT
TGAAGAAGGTTGAATATATGAAGGATAAAACTGGAGAAGAGTATGAAGGTATTATTAACGGGGTTACCAATTTTGGCTTC
TTTGTTGAACTGGATAATACTGTTGAGGGGCTTATCCATGTTGAAAATCTGGAGGATGATTACTATCATTATGTGGAAGA
ACAGCATGCTTTAATTGGTGAGAGGACCCGGAAGACTTACCGGTTTGGTGACAGGGTAAGGGTCAGGGTTGAACGGGTCA
ATCTAGATGAAAGACAGATAGATTTTAGCCTCATCGAGTAG

Upstream 100 bases:

>100_bases
TACTTAAATCCAACGTTAATCCAGTTTTACTATAATTGATTTTTCTGGTGGAAAAGCCAGGCGATAATTAAAATAAAATG
ATAATTTAGGAATGGTGACT

Downstream 100 bases:

>100_bases
AGGAGGGATAAAATGGGACAGGATAATATAAAGGTTATAGCCCGGAATAAAAAGGCAAGACATGATTTTTTCATCGAAGA
AACCTATGAATCTGGTATCA

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MSARDKIMEFMADKAERPMSAAELMKVFKIEKDQKGIFINLLKKLVKEGLLFKTQDGKYGIPEKMDLIPGRIEGNPRGFA
FLIPDDPTRDDIFISLENLKGAMHNDRVFVRLLSRQKGKNREGEVVKIIERANHQVVGNLEKSKYFGFVVPDNKRIFYDV
FIPKEELNGARQNQKVVAEITRWPEKKRNPEGKIIKILGSRGERGVDIEGIIYQLGLPQEFDYEVLEEAKSIPLEISKGD
LKGRRDLRAMPMVTIDGADAKDLDDAVSIEEVDDNQVRLGVHIADVSHYVKEDSALDREALKRGTSIYLVDRVIPMLPER
LSNGICSLNPNQDRLTMSVFITYQLEPFKLMEYEIVPSVIKTNYRLTYDEVREILVHKNKAAIQKYRDFVPYLKLMNKLR
KRLREERVARGSIDFDMPEVKVILNEDGKPVDIINRVHGIPEQLIEEFMIAANRVVAEDMYWRQIPFIYRVHDQPDHGRM
ADFNEFIHNFGYHLKGVNNEIHPRELQELLQLVEGRPEERLITRILLRSMKQAVYSDQNIGHFGLALDYYTHFTSPIRRY
PDLMIHRIIKEVIKKGYLPARRQEELEEKLFEVAEHSSLQERKAMEAERDSVDLKKVEYMKDKTGEEYEGIINGVTNFGF
FVELDNTVEGLIHVENLEDDYYHYVEEQHALIGERTRKTYRFGDRVRVRVERVNLDERQIDFSLIE

Sequences:

>Translated_706_residues
MSARDKIMEFMADKAERPMSAAELMKVFKIEKDQKGIFINLLKKLVKEGLLFKTQDGKYGIPEKMDLIPGRIEGNPRGFA
FLIPDDPTRDDIFISLENLKGAMHNDRVFVRLLSRQKGKNREGEVVKIIERANHQVVGNLEKSKYFGFVVPDNKRIFYDV
FIPKEELNGARQNQKVVAEITRWPEKKRNPEGKIIKILGSRGERGVDIEGIIYQLGLPQEFDYEVLEEAKSIPLEISKGD
LKGRRDLRAMPMVTIDGADAKDLDDAVSIEEVDDNQVRLGVHIADVSHYVKEDSALDREALKRGTSIYLVDRVIPMLPER
LSNGICSLNPNQDRLTMSVFITYQLEPFKLMEYEIVPSVIKTNYRLTYDEVREILVHKNKAAIQKYRDFVPYLKLMNKLR
KRLREERVARGSIDFDMPEVKVILNEDGKPVDIINRVHGIPEQLIEEFMIAANRVVAEDMYWRQIPFIYRVHDQPDHGRM
ADFNEFIHNFGYHLKGVNNEIHPRELQELLQLVEGRPEERLITRILLRSMKQAVYSDQNIGHFGLALDYYTHFTSPIRRY
PDLMIHRIIKEVIKKGYLPARRQEELEEKLFEVAEHSSLQERKAMEAERDSVDLKKVEYMKDKTGEEYEGIINGVTNFGF
FVELDNTVEGLIHVENLEDDYYHYVEEQHALIGERTRKTYRFGDRVRVRVERVNLDERQIDFSLIE
>Mature_705_residues
SARDKIMEFMADKAERPMSAAELMKVFKIEKDQKGIFINLLKKLVKEGLLFKTQDGKYGIPEKMDLIPGRIEGNPRGFAF
LIPDDPTRDDIFISLENLKGAMHNDRVFVRLLSRQKGKNREGEVVKIIERANHQVVGNLEKSKYFGFVVPDNKRIFYDVF
IPKEELNGARQNQKVVAEITRWPEKKRNPEGKIIKILGSRGERGVDIEGIIYQLGLPQEFDYEVLEEAKSIPLEISKGDL
KGRRDLRAMPMVTIDGADAKDLDDAVSIEEVDDNQVRLGVHIADVSHYVKEDSALDREALKRGTSIYLVDRVIPMLPERL
SNGICSLNPNQDRLTMSVFITYQLEPFKLMEYEIVPSVIKTNYRLTYDEVREILVHKNKAAIQKYRDFVPYLKLMNKLRK
RLREERVARGSIDFDMPEVKVILNEDGKPVDIINRVHGIPEQLIEEFMIAANRVVAEDMYWRQIPFIYRVHDQPDHGRMA
DFNEFIHNFGYHLKGVNNEIHPRELQELLQLVEGRPEERLITRILLRSMKQAVYSDQNIGHFGLALDYYTHFTSPIRRYP
DLMIHRIIKEVIKKGYLPARRQEELEEKLFEVAEHSSLQERKAMEAERDSVDLKKVEYMKDKTGEEYEGIINGVTNFGFF
VELDNTVEGLIHVENLEDDYYHYVEEQHALIGERTRKTYRFGDRVRVRVERVNLDERQIDFSLIE

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014625, Length=617, Percent_Identity=28.8492706645057, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI190014623, Length=617, Percent_Identity=28.8492706645057, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI134288890, Length=574, Percent_Identity=28.397212543554, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI19115966, Length=525, Percent_Identity=27.047619047619, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI219521928, Length=525, Percent_Identity=27.047619047619, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI156105695, Length=546, Percent_Identity=25.6410256410256, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI156105693, Length=210, Percent_Identity=31.9047619047619, Blast_Score=104, Evalue=3e-22,
Organism=Escherichia coli, GI87082383, Length=713, Percent_Identity=38.7096774193548, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1787542, Length=642, Percent_Identity=27.2585669781931, Blast_Score=163, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17553506, Length=502, Percent_Identity=29.4820717131474, Blast_Score=195, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI212645896, Length=552, Percent_Identity=28.804347826087, Blast_Score=194, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6324552, Length=627, Percent_Identity=28.8676236044657, Blast_Score=187, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320499, Length=474, Percent_Identity=24.6835443037975, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323943, Length=430, Percent_Identity=24.1860465116279, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24649634, Length=542, Percent_Identity=30.0738007380074, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI19922976, Length=483, Percent_Identity=30.2277432712215, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24654597, Length=483, Percent_Identity=30.2277432712215, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24654592, Length=483, Percent_Identity=30.2277432712215, Blast_Score=184, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 82397; Mature: 82266

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARDKIMEFMADKAERPMSAAELMKVFKIEKDQKGIFINLLKKLVKEGLLFKTQDGKYG
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCC
IPEKMDLIPGRIEGNPRGFAFLIPDDPTRDDIFISLENLKGAMHNDRVFVRLLSRQKGKN
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHCCCC
REGEVVKIIERANHQVVGNLEKSKYFGFVVPDNKRIFYDVFIPKEELNGARQNQKVVAEI
CCCHHHHHHHHCCCCEEECCCCCCEEEEEEECCCEEEEEEECCHHHHCCCHHHHHHHHHH
TRWPEKKRNPEGKIIKILGSRGERGVDIEGIIYQLGLPQEFDYEVLEEAKSIPLEISKGD
HHCHHHCCCCCCCEEEEEECCCCCCCCHHHEEEECCCCCCCCHHHHHHHHCCCEEEECCC
LKGRRDLRAMPMVTIDGADAKDLDDAVSIEEVDDNQVRLGVHIADVSHYVKEDSALDREA
CCCCCCCCCCCEEEECCCCCCCCHHCCCCEECCCCEEEEEEEEHHHHHHHHHCCCCCHHH
LKRGTSIYLVDRVIPMLPERLSNGICSLNPNQDRLTMSVFITYQLEPFKLMEYEIVPSVI
HHCCCEEEEHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEEEEECCCEEHHHHHHHHHH
KTNYRLTYDEVREILVHKNKAAIQKYRDFVPYLKLMNKLRKRLREERVARGSIDFDMPEV
HCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
KVILNEDGKPVDIINRVHGIPEQLIEEFMIAANRVVAEDMYWRQIPFIYRVHDQPDHGRM
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
ADFNEFIHNFGYHLKGVNNEIHPRELQELLQLVEGRPEERLITRILLRSMKQAVYSDQNI
CHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
GHFGLALDYYTHFTSPIRRYPDLMIHRIIKEVIKKGYLPARRQEELEEKLFEVAEHSSLQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHH
ERKAMEAERDSVDLKKVEYMKDKTGEEYEGIINGVTNFGFFVELDNTVEGLIHVENLEDD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCHH
YYHYVEEQHALIGERTRKTYRFGDRVRVRVERVNLDERQIDFSLIE
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHCCCEECC
>Mature Secondary Structure 
SARDKIMEFMADKAERPMSAAELMKVFKIEKDQKGIFINLLKKLVKEGLLFKTQDGKYG
CHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCC
IPEKMDLIPGRIEGNPRGFAFLIPDDPTRDDIFISLENLKGAMHNDRVFVRLLSRQKGKN
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHCCCC
REGEVVKIIERANHQVVGNLEKSKYFGFVVPDNKRIFYDVFIPKEELNGARQNQKVVAEI
CCCHHHHHHHHCCCCEEECCCCCCEEEEEEECCCEEEEEEECCHHHHCCCHHHHHHHHHH
TRWPEKKRNPEGKIIKILGSRGERGVDIEGIIYQLGLPQEFDYEVLEEAKSIPLEISKGD
HHCHHHCCCCCCCEEEEEECCCCCCCCHHHEEEECCCCCCCCHHHHHHHHCCCEEEECCC
LKGRRDLRAMPMVTIDGADAKDLDDAVSIEEVDDNQVRLGVHIADVSHYVKEDSALDREA
CCCCCCCCCCCEEEECCCCCCCCHHCCCCEECCCCEEEEEEEEHHHHHHHHHCCCCCHHH
LKRGTSIYLVDRVIPMLPERLSNGICSLNPNQDRLTMSVFITYQLEPFKLMEYEIVPSVI
HHCCCEEEEHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEEEEECCCEEHHHHHHHHHH
KTNYRLTYDEVREILVHKNKAAIQKYRDFVPYLKLMNKLRKRLREERVARGSIDFDMPEV
HCCCEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
KVILNEDGKPVDIINRVHGIPEQLIEEFMIAANRVVAEDMYWRQIPFIYRVHDQPDHGRM
EEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
ADFNEFIHNFGYHLKGVNNEIHPRELQELLQLVEGRPEERLITRILLRSMKQAVYSDQNI
CHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
GHFGLALDYYTHFTSPIRRYPDLMIHRIIKEVIKKGYLPARRQEELEEKLFEVAEHSSLQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHH
ERKAMEAERDSVDLKKVEYMKDKTGEEYEGIINGVTNFGFFVELDNTVEGLIHVENLEDD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCHH
YYHYVEEQHALIGERTRKTYRFGDRVRVRVERVNLDERQIDFSLIE
HHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]