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The map label for this gene is mtbA [H]

Identifier: 220932369

GI number: 220932369

Start: 1639603

End: 1640949

Strand: Reverse

Name: mtbA [H]

Synonym: Hore_15330

Alternate gene names: 220932369

Gene position: 1640949-1639603 (Counterclockwise)

Preceding gene: 220932370

Following gene: 220932368

Centisome position: 63.65

GC content: 44.62

Gene sequence:

>1347_bases
ATGAATGGTAAAGAAAAGATATACAATGTTTTTAAAAACGGATCCCAGAAAGAAGTTCCCTGGGTGCCTTTTGCCGGTGT
TCATGCCGGTAAGCTTAAAGGGTATACGGCCCGGGAGGTACTGACAGATGAAAATAAACTGTTTGAGTCCCTGAAGGAGG
TCAACAAGATATACCGGCCCGATGGGCAGCCGGTTACCTTTGATCTCCAGATTGAGGCTGAAATACTGGGGTGTGAACTA
AAGTGGTCCGAGGATTCACCGCCAACCGTAATCTCCCATCCTTTATCCGGGAGTGAAGAAGTTCCGGACAGGATTCCTGC
CCGGGATGAAGGCAGAATCCCCCTTGTCCTCAATGTTATGAAGAAAATGAAAGAAGAGGTAGGGGAAAAAACAGCCCTTT
ACGGGTTACTCTGTGGGCCCTTTACCCTGGCATCCCATTTACGGGGGACCAACCTGTTTATGGATATGGTCTTAAATCCA
GATTATGTAAAGAAACTTATGGCCTATACCACTGAAGTGGCCAGGGCCATAGCCAGTTATTATATTGAAGCGGGGATGGA
TGTTATCGCTGCCGTGGACCCCATGGTTTCCCAGATTTCACCTGAACATTTTAAGGAGTTTCTCAACAGATCATATACCG
AACTATTTGCCTTTATCCGGGATGAGGGTGCCTTTTCTTCTTTCTTTGTCTGTGGGAATGCCAGCAAAAACATTGAAGAG
ATGTGCCTGACAGAGCCTGATAGTATTTCAGTTGACGAAAATGTCTCTTTGCCTGAAGCCAAGGAGATTACCGATAAACA
TGGCATAGTTATTGGAGGAAATATCCCCCTGACGACTGTAATGTTACACGGAAATCAGCAGGACAATATGAAATATACCG
TTGATTTACTTAATTCAGTTAGTCGGGATAATCTAATTATTTCACCCGGGTGTGATATGCCCTATGATACCCCGGTAGAA
AATACTGTGGCAGTTGAACAGGCCGTTCATGAGACAGAAAAGGTCAGGGAGATGGTTAAAAATTATGAGGTCAGGGAAGA
GGACATAGAGGTAGAATTACCTGATTATGATGCCCTGGAGAAGCCATTAATTGAGGTATTTACCCTTGATTCTGATACCT
GTGCTGCCTGTACCTATATGAAGGCAGCGGCAGTTGAGGCCGGCAAACACTTCGGCGATAAAGTCGAGGTGGTGGAGTAT
AAGTATACTACCCCGGAAAATATTGCCCGGATCAAGAAAATGGGGGTTGAAAAACTACCGAGTATTTATATAAATGGTGA
ATTGAAGTTTTCATCAATTGTCCCCAACCGCAGGGAACTCTTAGAGGAGGTTGAAAAATGCCTGTAA

Upstream 100 bases:

>100_bases
CAGGTTTCTATGATCCGAATTCCTACATGTGGCCGGAGTAAATTATTAAAATTCTCAACTCAGCAAAAAATTTTATTGTA
AAAAAGGGGAGGTTAATAAA

Downstream 100 bases:

>100_bases
CAGGGCCTGGTAAACAGATTGATATGTTTTTTATAACTGGATTTCTGGGTTCGGGGAAGACAACCTTTTTAAATAACCTG
CTCAAAAATAATAGTGGAAA

Product: methylamine-specific methylcobalamin coenzyme M methyltransferase

Products: NA

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNGKEKIYNVFKNGSQKEVPWVPFAGVHAGKLKGYTAREVLTDENKLFESLKEVNKIYRPDGQPVTFDLQIEAEILGCEL
KWSEDSPPTVISHPLSGSEEVPDRIPARDEGRIPLVLNVMKKMKEEVGEKTALYGLLCGPFTLASHLRGTNLFMDMVLNP
DYVKKLMAYTTEVARAIASYYIEAGMDVIAAVDPMVSQISPEHFKEFLNRSYTELFAFIRDEGAFSSFFVCGNASKNIEE
MCLTEPDSISVDENVSLPEAKEITDKHGIVIGGNIPLTTVMLHGNQQDNMKYTVDLLNSVSRDNLIISPGCDMPYDTPVE
NTVAVEQAVHETEKVREMVKNYEVREEDIEVELPDYDALEKPLIEVFTLDSDTCAACTYMKAAAVEAGKHFGDKVEVVEY
KYTTPENIARIKKMGVEKLPSIYINGELKFSSIVPNRRELLEEVEKCL

Sequences:

>Translated_448_residues
MNGKEKIYNVFKNGSQKEVPWVPFAGVHAGKLKGYTAREVLTDENKLFESLKEVNKIYRPDGQPVTFDLQIEAEILGCEL
KWSEDSPPTVISHPLSGSEEVPDRIPARDEGRIPLVLNVMKKMKEEVGEKTALYGLLCGPFTLASHLRGTNLFMDMVLNP
DYVKKLMAYTTEVARAIASYYIEAGMDVIAAVDPMVSQISPEHFKEFLNRSYTELFAFIRDEGAFSSFFVCGNASKNIEE
MCLTEPDSISVDENVSLPEAKEITDKHGIVIGGNIPLTTVMLHGNQQDNMKYTVDLLNSVSRDNLIISPGCDMPYDTPVE
NTVAVEQAVHETEKVREMVKNYEVREEDIEVELPDYDALEKPLIEVFTLDSDTCAACTYMKAAAVEAGKHFGDKVEVVEY
KYTTPENIARIKKMGVEKLPSIYINGELKFSSIVPNRRELLEEVEKCL
>Mature_448_residues
MNGKEKIYNVFKNGSQKEVPWVPFAGVHAGKLKGYTAREVLTDENKLFESLKEVNKIYRPDGQPVTFDLQIEAEILGCEL
KWSEDSPPTVISHPLSGSEEVPDRIPARDEGRIPLVLNVMKKMKEEVGEKTALYGLLCGPFTLASHLRGTNLFMDMVLNP
DYVKKLMAYTTEVARAIASYYIEAGMDVIAAVDPMVSQISPEHFKEFLNRSYTELFAFIRDEGAFSSFFVCGNASKNIEE
MCLTEPDSISVDENVSLPEAKEITDKHGIVIGGNIPLTTVMLHGNQQDNMKYTVDLLNSVSRDNLIISPGCDMPYDTPVE
NTVAVEQAVHETEKVREMVKNYEVREEDIEVELPDYDALEKPLIEVFTLDSDTCAACTYMKAAAVEAGKHFGDKVEVVEY
KYTTPENIARIKKMGVEKLPSIYINGELKFSSIVPNRRELLEEVEKCL

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: NA

Molecular weight: Translated: 50263; Mature: 50263

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGKEKIYNVFKNGSQKEVPWVPFAGVHAGKLKGYTAREVLTDENKLFESLKEVNKIYRP
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCC
DGQPVTFDLQIEAEILGCELKWSEDSPPTVISHPLSGSEEVPDRIPARDEGRIPLVLNVM
CCCEEEEEEEEEEEEEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHH
KKMKEEVGEKTALYGLLCGPFTLASHLRGTNLFMDMVLNPDYVKKLMAYTTEVARAIASY
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YIEAGMDVIAAVDPMVSQISPEHFKEFLNRSYTELFAFIRDEGAFSSFFVCGNASKNIEE
HHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
MCLTEPDSISVDENVSLPEAKEITDKHGIVIGGNIPLTTVMLHGNQQDNMKYTVDLLNSV
HHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHCC
SRDNLIISPGCDMPYDTPVENTVAVEQAVHETEKVREMVKNYEVREEDIEVELPDYDALE
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHH
KPLIEVFTLDSDTCAACTYMKAAAVEAGKHFGDKVEVVEYKYTTPENIARIKKMGVEKLP
HCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCHHHCC
SIYINGELKFSSIVPNRRELLEEVEKCL
CEEECCEEEEHHCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MNGKEKIYNVFKNGSQKEVPWVPFAGVHAGKLKGYTAREVLTDENKLFESLKEVNKIYRP
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCC
DGQPVTFDLQIEAEILGCELKWSEDSPPTVISHPLSGSEEVPDRIPARDEGRIPLVLNVM
CCCEEEEEEEEEEEEEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHH
KKMKEEVGEKTALYGLLCGPFTLASHLRGTNLFMDMVLNPDYVKKLMAYTTEVARAIASY
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YIEAGMDVIAAVDPMVSQISPEHFKEFLNRSYTELFAFIRDEGAFSSFFVCGNASKNIEE
HHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
MCLTEPDSISVDENVSLPEAKEITDKHGIVIGGNIPLTTVMLHGNQQDNMKYTVDLLNSV
HHCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHCC
SRDNLIISPGCDMPYDTPVENTVAVEQAVHETEKVREMVKNYEVREEDIEVELPDYDALE
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHH
KPLIEVFTLDSDTCAACTYMKAAAVEAGKHFGDKVEVVEYKYTTPENIARIKKMGVEKLP
HCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCHHHCC
SIYINGELKFSSIVPNRRELLEEVEKCL
CEEECCEEEEHHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]