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The map label for this gene is yeiR [C]

Identifier: 220932368

GI number: 220932368

Start: 1638695

End: 1639612

Strand: Reverse

Name: yeiR [C]

Synonym: Hore_15320

Alternate gene names: 220932368

Gene position: 1639612-1638695 (Counterclockwise)

Preceding gene: 220932369

Following gene: 220932367

Centisome position: 63.6

GC content: 39.65

Gene sequence:

>918_bases
ATGCCTGTAACAGGGCCTGGTAAACAGATTGATATGTTTTTTATAACTGGATTTCTGGGTTCGGGGAAGACAACCTTTTT
AAATAACCTGCTCAAAAATAATAGTGGAAAAAACCTCGGGGTTATTGTCAATGAGTTCGGGGAAATAAATGTAGATGTCA
AATTGTTAGACAGTGATACAGATATGAAGGTAACCGAAATAAATAATGGCTCAATATTTTGCAGCTGTCTTTCCGGTTCC
TTTGTGGAAAGCATTATCTCCTATCAAGATTTACCCGTCGATTGTCTCTTTGTAGAGAGTACCGGAATGGCCCGACCCTC
AAGCCTTGATAACATTTTAGAAGATGTTAATAAACTGGCTCCGGGGAGGTTTAACTACCACGGTATGGTCTGTGTGGTTG
ATGCCTCCAGTTTTATGGTCCTCAGCCAGTCAGTTAATGCAGTGAGGGAACAGATCCAGTACAGTGATATTGTTTTAATT
AACAAGATAGACCTAGTTGAAGCAGATTTAATAAAGGTTATAGAAGAAAAAGTAAAAGGTTTAAACCCTCAGGCAGAAAT
CATTAAGACCAGTTACGGCAGGTCAGATTTACCATTTTTTGAGGTTAAGACCGGAAGCAGCTGTACATGTAATTGTTCCT
GCTCTTTGACCTGTGATGAACTGACTTCAGATAGACCTCAATGTTATTTTTTAAAGCCTGACGGGGAAGTCAGCAAAGAC
AGATTGGTAGAATTTCTCGAGGAAGTTGCCAGTAAAACCTACCGGATTAAAGGCTTTATCAAGACCGGGGAAGGGTATAT
CCGGGTAGACTGTGTCGGGGATAGTATTAATTTTGAAAGGACAGAGGAAAGTTCTCCTGAAGAAGGGCTTGTTATTTTTG
CCCCTGAAGATGTAAGTGATAAAGATTTAATATTATGA

Upstream 100 bases:

>100_bases
AAATGGGGGTTGAAAAACTACCGAGTATTTATATAAATGGTGAATTGAAGTTTTCATCAATTGTCCCCAACCGCAGGGAA
CTCTTAGAGGAGGTTGAAAA

Downstream 100 bases:

>100_bases
CTGGATTAAATGCGACTGGGTTAAAGCCTCCATATTCCGGGGGCTTTTTTTTATGTTTAACTATTTTTTATGTTTAACTA
TAGTATGTTTAACCATAAAT

Product: cobalamin synthesis protein P47K

Products: NA

Alternate protein names: P47K [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MPVTGPGKQIDMFFITGFLGSGKTTFLNNLLKNNSGKNLGVIVNEFGEINVDVKLLDSDTDMKVTEINNGSIFCSCLSGS
FVESIISYQDLPVDCLFVESTGMARPSSLDNILEDVNKLAPGRFNYHGMVCVVDASSFMVLSQSVNAVREQIQYSDIVLI
NKIDLVEADLIKVIEEKVKGLNPQAEIIKTSYGRSDLPFFEVKTGSSCTCNCSCSLTCDELTSDRPQCYFLKPDGEVSKD
RLVEFLEEVASKTYRIKGFIKTGEGYIRVDCVGDSINFERTEESSPEEGLVIFAPEDVSDKDLIL

Sequences:

>Translated_305_residues
MPVTGPGKQIDMFFITGFLGSGKTTFLNNLLKNNSGKNLGVIVNEFGEINVDVKLLDSDTDMKVTEINNGSIFCSCLSGS
FVESIISYQDLPVDCLFVESTGMARPSSLDNILEDVNKLAPGRFNYHGMVCVVDASSFMVLSQSVNAVREQIQYSDIVLI
NKIDLVEADLIKVIEEKVKGLNPQAEIIKTSYGRSDLPFFEVKTGSSCTCNCSCSLTCDELTSDRPQCYFLKPDGEVSKD
RLVEFLEEVASKTYRIKGFIKTGEGYIRVDCVGDSINFERTEESSPEEGLVIFAPEDVSDKDLIL
>Mature_304_residues
PVTGPGKQIDMFFITGFLGSGKTTFLNNLLKNNSGKNLGVIVNEFGEINVDVKLLDSDTDMKVTEINNGSIFCSCLSGSF
VESIISYQDLPVDCLFVESTGMARPSSLDNILEDVNKLAPGRFNYHGMVCVVDASSFMVLSQSVNAVREQIQYSDIVLIN
KIDLVEADLIKVIEEKVKGLNPQAEIIKTSYGRSDLPFFEVKTGSSCTCNCSCSLTCDELTSDRPQCYFLKPDGEVSKDR
LVEFLEEVASKTYRIKGFIKTGEGYIRVDCVGDSINFERTEESSPEEGLVIFAPEDVSDKDLIL

Specific function: The presence of P47K is critical for the expression of the nitrile hydratase genes. May stabilize or activate the nitrile hydratase proteins [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=206, Percent_Identity=28.6407766990291, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI126722884, Length=206, Percent_Identity=28.6407766990291, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI148727351, Length=206, Percent_Identity=28.6407766990291, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI146231952, Length=206, Percent_Identity=28.6407766990291, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI223941779, Length=206, Percent_Identity=28.6407766990291, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI223941776, Length=190, Percent_Identity=27.3684210526316, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87082430, Length=227, Percent_Identity=26.431718061674, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788499, Length=302, Percent_Identity=23.5099337748344, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324356, Length=217, Percent_Identity=23.963133640553, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 33600; Mature: 33468

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTGPGKQIDMFFITGFLGSGKTTFLNNLLKNNSGKNLGVIVNEFGEINVDVKLLDSDT
CCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCC
DMKVTEINNGSIFCSCLSGSFVESIISYQDLPVDCLFVESTGMARPSSLDNILEDVNKLA
CEEEEEECCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHC
PGRFNYHGMVCVVDASSFMVLSQSVNAVREQIQYSDIVLINKIDLVEADLIKVIEEKVKG
CCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHC
LNPQAEIIKTSYGRSDLPFFEVKTGSSCTCNCSCSLTCDELTSDRPQCYFLKPDGEVSKD
CCCHHHHEEECCCCCCCCEEEEECCCCEEEEEEEEEEHHHHCCCCCCEEEECCCCCCCHH
RLVEFLEEVASKTYRIKGFIKTGEGYIRVDCVGDSINFERTEESSPEEGLVIFAPEDVSD
HHHHHHHHHHHCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCC
KDLIL
CCCCC
>Mature Secondary Structure 
PVTGPGKQIDMFFITGFLGSGKTTFLNNLLKNNSGKNLGVIVNEFGEINVDVKLLDSDT
CCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEECCCC
DMKVTEINNGSIFCSCLSGSFVESIISYQDLPVDCLFVESTGMARPSSLDNILEDVNKLA
CEEEEEECCCCEEEEECCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHC
PGRFNYHGMVCVVDASSFMVLSQSVNAVREQIQYSDIVLINKIDLVEADLIKVIEEKVKG
CCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHC
LNPQAEIIKTSYGRSDLPFFEVKTGSSCTCNCSCSLTCDELTSDRPQCYFLKPDGEVSKD
CCCHHHHEEECCCCCCCCEEEEECCCCEEEEEEEEEEHHHHCCCCCCEEEECCCCCCCHH
RLVEFLEEVASKTYRIKGFIKTGEGYIRVDCVGDSINFERTEESSPEEGLVIFAPEDVSD
HHHHHHHHHHHCEEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCC
KDLIL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2013568 [H]