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The map label for this gene is hepT [H]

Identifier: 220932319

GI number: 220932319

Start: 1578632

End: 1579612

Strand: Reverse

Name: hepT [H]

Synonym: Hore_14830

Alternate gene names: 220932319

Gene position: 1579612-1578632 (Counterclockwise)

Preceding gene: 220932320

Following gene: 220932318

Centisome position: 61.27

GC content: 39.76

Gene sequence:

>981_bases
ATGATGAGCAAATATAGTATTGCCGAGTACAGACAGAGATTTGCTCCGGTTATTGAAAAAATAGATGAAATTATATGGGA
GATAACTAAAACCAGGGTGGGGTTAATTAATATAGCTACCAGAGACCTTGTTGAGAGTGGTGGTAAAAGGTTAAGGCCCT
TACTGGTGGTTTTGTCAGCCCGGTTGGGTGATTTTGATAAAGAGAAAATATACCATATTGCTTCAGCAATTGAACTTTTG
CATATGGCTACCCTGGTTCATGATGATATTATAGATGAAGCCAGGATAAGACGAGGGGAAATCTCAGCCCAGAGTAAATT
TGGTAAGGATGTTGCTGTCTTTCTGGGTGATTTTATGTTAAGCCGGGCCTTTGATATTTTTACCCTCTATTTAAGTCGGC
ACTCTTTACGAAAGCTAAATAAGGTTGTCGGTTTAATCTGTGAAGGGGAAATAGATCAGTATGAGGATAAATTTGAATAT
AAGGTTTCTATCCGGGAGTACCTCCGGAGAATCAGGAGGAAAACAGCCCTGCTATTTGGATTGAGTACATATATCGGGGC
CTATGAGAGTGGTGTCCGGGGGAGGAACCTGTCAAATATATATAGATTTGGTCTCAGGTTGGGAACTGCTTTTCAGATTC
AGGATGATATTCTAGATTTTGTGGCTGACCCCGAGGAGTCAGGAAAAGCAATAGGCCAGGATTTAATAAATGGGATATAT
AATCTCCCTGTAATCTACCTGGTTCAGGATGAGATTTTCAGGGACAGGGCCCGGGAGATCCTGGGTAAAGACAGGCTGTC
GGTCTCAGATGTAGTTGATATTATCAATATGGTGAATAACAGTAAGGCTATAAATCAAAGCAGAGAACTGGGTAAAAGGT
ATATTGAAAAATCTCAGAAATATGTCGAGCATTTACCTGATGAAAGGGTAAAAGAGGAGCTTAATTTTATATTATCGCTT
CAATTAAATCGACAACAATAA

Upstream 100 bases:

>100_bases
GTTATGTTTATAAATAAAGATTTAGAGATAATTCTGTCAGAAGGCCTTAAGAATAAGATTAAGGTCCTGAACCAGGATTT
TAAACTTGTAGGGAATGATA

Downstream 100 bases:

>100_bases
AGACAGGGTGATGGTATATGGCTTACCGTGATTTAAGTGACTTTATTAAGACCCTTGAAAGGGAAAATGAACTGGTGAGG
GTCGGGGTTGAAGTAGACCC

Product: heptaprenyl diphosphate synthase component II

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MMSKYSIAEYRQRFAPVIEKIDEIIWEITKTRVGLINIATRDLVESGGKRLRPLLVVLSARLGDFDKEKIYHIASAIELL
HMATLVHDDIIDEARIRRGEISAQSKFGKDVAVFLGDFMLSRAFDIFTLYLSRHSLRKLNKVVGLICEGEIDQYEDKFEY
KVSIREYLRRIRRKTALLFGLSTYIGAYESGVRGRNLSNIYRFGLRLGTAFQIQDDILDFVADPEESGKAIGQDLINGIY
NLPVIYLVQDEIFRDRAREILGKDRLSVSDVVDIINMVNNSKAINQSRELGKRYIEKSQKYVEHLPDERVKEELNFILSL
QLNRQQ

Sequences:

>Translated_326_residues
MMSKYSIAEYRQRFAPVIEKIDEIIWEITKTRVGLINIATRDLVESGGKRLRPLLVVLSARLGDFDKEKIYHIASAIELL
HMATLVHDDIIDEARIRRGEISAQSKFGKDVAVFLGDFMLSRAFDIFTLYLSRHSLRKLNKVVGLICEGEIDQYEDKFEY
KVSIREYLRRIRRKTALLFGLSTYIGAYESGVRGRNLSNIYRFGLRLGTAFQIQDDILDFVADPEESGKAIGQDLINGIY
NLPVIYLVQDEIFRDRAREILGKDRLSVSDVVDIINMVNNSKAINQSRELGKRYIEKSQKYVEHLPDERVKEELNFILSL
QLNRQQ
>Mature_326_residues
MMSKYSIAEYRQRFAPVIEKIDEIIWEITKTRVGLINIATRDLVESGGKRLRPLLVVLSARLGDFDKEKIYHIASAIELL
HMATLVHDDIIDEARIRRGEISAQSKFGKDVAVFLGDFMLSRAFDIFTLYLSRHSLRKLNKVVGLICEGEIDQYEDKFEY
KVSIREYLRRIRRKTALLFGLSTYIGAYESGVRGRNLSNIYRFGLRLGTAFQIQDDILDFVADPEESGKAIGQDLINGIY
NLPVIYLVQDEIFRDRAREILGKDRLSVSDVVDIINMVNNSKAINQSRELGKRYIEKSQKYVEHLPDERVKEELNFILSL
QLNRQQ

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=269, Percent_Identity=28.2527881040892, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789578, Length=300, Percent_Identity=31.6666666666667, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786623, Length=241, Percent_Identity=30.7053941908714, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17505681, Length=247, Percent_Identity=30.7692307692308, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319475, Length=312, Percent_Identity=25.6410256410256, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325188, Length=242, Percent_Identity=26.0330578512397, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651612, Length=285, Percent_Identity=25.9649122807018, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 37685; Mature: 37685

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSKYSIAEYRQRFAPVIEKIDEIIWEITKTRVGLINIATRDLVESGGKRLRPLLVVLSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RLGDFDKEKIYHIASAIELLHMATLVHDDIIDEARIRRGEISAQSKFGKDVAVFLGDFML
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
SRAFDIFTLYLSRHSLRKLNKVVGLICEGEIDQYEDKFEYKVSIREYLRRIRRKTALLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTYIGAYESGVRGRNLSNIYRFGLRLGTAFQIQDDILDFVADPEESGKAIGQDLINGIY
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHH
NLPVIYLVQDEIFRDRAREILGKDRLSVSDVVDIINMVNNSKAINQSRELGKRYIEKSQK
HCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YVEHLPDERVKEELNFILSLQLNRQQ
HHHHCCHHHHHHHHHHHHEEEECCCC
>Mature Secondary Structure
MMSKYSIAEYRQRFAPVIEKIDEIIWEITKTRVGLINIATRDLVESGGKRLRPLLVVLSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
RLGDFDKEKIYHIASAIELLHMATLVHDDIIDEARIRRGEISAQSKFGKDVAVFLGDFML
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHH
SRAFDIFTLYLSRHSLRKLNKVVGLICEGEIDQYEDKFEYKVSIREYLRRIRRKTALLFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSTYIGAYESGVRGRNLSNIYRFGLRLGTAFQIQDDILDFVADPEESGKAIGQDLINGIY
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHHH
NLPVIYLVQDEIFRDRAREILGKDRLSVSDVVDIINMVNNSKAINQSRELGKRYIEKSQK
HCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
YVEHLPDERVKEELNFILSLQLNRQQ
HHHHCCHHHHHHHHHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]