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The map label for this gene is argD [H]

Identifier: 220932314

GI number: 220932314

Start: 1571996

End: 1573309

Strand: Reverse

Name: argD [H]

Synonym: Hore_14780

Alternate gene names: 220932314

Gene position: 1573309-1571996 (Counterclockwise)

Preceding gene: 220932315

Following gene: 220932313

Centisome position: 61.02

GC content: 45.66

Gene sequence:

>1314_bases
GTGGGTGAGAAAAATTATATTGGTCCCGATGCCATAATTGACAAGAAAAAGGAGTATCTGATTCCCTGTGTTTACCATTT
TTATAAAAACCCAATGCAGCTGGTGAGGGCTAAAGGAAAATATTTTTATGACCAGGCAGGTAAAGAGTATTTAGATCTTT
TTGCCGGGGTTTCGGTGATGAACGCCGGTCACTGTCACCCTGAAATTACAGACAGGGTCTGTGAGCAGGTTAAGACCTTG
CAGCACACCTGTACTATTTATTTGAACCAGCCTATTGTTGACCTGGCTGAGAAATTGGCTGAAGTTACACCCGGCAACTT
AAAGAAGAGCTTTTTTGTCAATAGTGGTACTGAAGCCAATGAGGGTGCTTTACTCCTGGCCAAGTTGTATACGGGGAATT
CTGAGTATATTGCCTTAAAGCAGGGGCTTCATGGTAGAACTCATTTAACCATGAGTATTACCGGGTTATCTTTCTGGAGA
ACAGACCCCAACCCGGCCGGTGGAATAAGTTTTGCCCCTGATGCATACTGCTATCGTTGTCCTTATGGACTTGAATACCC
GGGGTGTGACCTCAAATGTGCCCGGGCCATAAGGGATGTAATTGAAACTTCAACTTCAAAACAGGTGGCAGCCCTGATTG
CTGAACCGATTCAGGGTAACGGTGGTATAATTACCCCACCCCCGGAGTACTTTAAAGTCGTCAGGGATATCCTCGATGAA
TATGGGGCGTTATTAATAATTGATGAAGTTCAGACCGGGTTTGGGCGGACCGGTAAAATGTTTGCCATTGAAAACTGGGG
GGTTACCCCTGATATTATGACCATGGCCAAGGCCCTCGGTAATGGTGTCCCCATTGGTGCTTTTACAGCCACTGAAGAGG
TTGCTGATGTCTATACCCGCCCCGGGGCTTCAACCCTGGGAGGAAACCCAGTAAGCGCTACAGCCGGTCTGGCTACACTG
AAGGTTATCGAAGAGGAAAAACTGACAGAAAATGCAGCTGAAGTTGGTTTATATTTTAAAAATGGTCTGGAAAACCTGGC
CAAAAGACACAGGATAATTGGTGATGTCCGGGGTCTGGGTCTCATGCTGGGAGCAGAGCTGGTAAAAGAAAATAAAGAGC
CTGCCCCTGATGAAACAGATCTGGTTCTTGAAAAGATGAAGGACCGCGGTATTTTAATTGGTAAAAATGGTCCTTCCCGG
AATGTTCTCGCCTTCCAGCCTCCTTTGATTATTAATAAAAAAGATGTGGAGCAGGTTATTGCTACCCTCGATGAAGTCCT
GAATGAAGTAGAAAAAGAAGCTGGCCTTGACTAG

Upstream 100 bases:

>100_bases
GCCTACGAGAAAGGGGTCCTGGGGACCGGTACTTAATCCACAAAACTGTTATGATAGTTTGTTTTAAAAAATTTGCTTAA
AAATTAAAAGGAGGGGTAAT

Downstream 100 bases:

>100_bases
AGGAGGGTTATGGAACCATGTTTAAAAACATGTTTAAAAAATTGTCGTTATATCTATTAAGTATCTTTTTACTGACAGGC
ATTTTTACTTTGCCAGCCGG

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MGEKNYIGPDAIIDKKKEYLIPCVYHFYKNPMQLVRAKGKYFYDQAGKEYLDLFAGVSVMNAGHCHPEITDRVCEQVKTL
QHTCTIYLNQPIVDLAEKLAEVTPGNLKKSFFVNSGTEANEGALLLAKLYTGNSEYIALKQGLHGRTHLTMSITGLSFWR
TDPNPAGGISFAPDAYCYRCPYGLEYPGCDLKCARAIRDVIETSTSKQVAALIAEPIQGNGGIITPPPEYFKVVRDILDE
YGALLIIDEVQTGFGRTGKMFAIENWGVTPDIMTMAKALGNGVPIGAFTATEEVADVYTRPGASTLGGNPVSATAGLATL
KVIEEEKLTENAAEVGLYFKNGLENLAKRHRIIGDVRGLGLMLGAELVKENKEPAPDETDLVLEKMKDRGILIGKNGPSR
NVLAFQPPLIINKKDVEQVIATLDEVLNEVEKEAGLD

Sequences:

>Translated_437_residues
MGEKNYIGPDAIIDKKKEYLIPCVYHFYKNPMQLVRAKGKYFYDQAGKEYLDLFAGVSVMNAGHCHPEITDRVCEQVKTL
QHTCTIYLNQPIVDLAEKLAEVTPGNLKKSFFVNSGTEANEGALLLAKLYTGNSEYIALKQGLHGRTHLTMSITGLSFWR
TDPNPAGGISFAPDAYCYRCPYGLEYPGCDLKCARAIRDVIETSTSKQVAALIAEPIQGNGGIITPPPEYFKVVRDILDE
YGALLIIDEVQTGFGRTGKMFAIENWGVTPDIMTMAKALGNGVPIGAFTATEEVADVYTRPGASTLGGNPVSATAGLATL
KVIEEEKLTENAAEVGLYFKNGLENLAKRHRIIGDVRGLGLMLGAELVKENKEPAPDETDLVLEKMKDRGILIGKNGPSR
NVLAFQPPLIINKKDVEQVIATLDEVLNEVEKEAGLD
>Mature_436_residues
GEKNYIGPDAIIDKKKEYLIPCVYHFYKNPMQLVRAKGKYFYDQAGKEYLDLFAGVSVMNAGHCHPEITDRVCEQVKTLQ
HTCTIYLNQPIVDLAEKLAEVTPGNLKKSFFVNSGTEANEGALLLAKLYTGNSEYIALKQGLHGRTHLTMSITGLSFWRT
DPNPAGGISFAPDAYCYRCPYGLEYPGCDLKCARAIRDVIETSTSKQVAALIAEPIQGNGGIITPPPEYFKVVRDILDEY
GALLIIDEVQTGFGRTGKMFAIENWGVTPDIMTMAKALGNGVPIGAFTATEEVADVYTRPGASTLGGNPVSATAGLATLK
VIEEEKLTENAAEVGLYFKNGLENLAKRHRIIGDVRGLGLMLGAELVKENKEPAPDETDLVLEKMKDRGILIGKNGPSRN
VLAFQPPLIINKKDVEQVIATLDEVLNEVEKEAGLD

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI24119277, Length=421, Percent_Identity=36.104513064133, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=35, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI13994255, Length=455, Percent_Identity=33.1868131868132, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI226442705, Length=440, Percent_Identity=34.0909090909091, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI226442709, Length=383, Percent_Identity=35.7702349869452, Blast_Score=248, Evalue=7e-66,
Organism=Homo sapiens, GI4557809, Length=430, Percent_Identity=30.6976744186047, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=31.4984709480122, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI188536080, Length=465, Percent_Identity=24.3010752688172, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679950, Length=465, Percent_Identity=24.3010752688172, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679946, Length=465, Percent_Identity=24.3010752688172, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=35.609756097561, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=33.9108910891089, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1788044, Length=407, Percent_Identity=35.3808353808354, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI145693181, Length=437, Percent_Identity=35.2402745995423, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1787560, Length=394, Percent_Identity=34.7715736040609, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786349, Length=342, Percent_Identity=31.2865497076023, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1786991, Length=416, Percent_Identity=26.9230769230769, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=430, Percent_Identity=39.0697674418605, Blast_Score=285, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71992977, Length=446, Percent_Identity=32.0627802690583, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25144271, Length=426, Percent_Identity=32.1596244131455, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25144274, Length=264, Percent_Identity=35.2272727272727, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=441, Percent_Identity=25.8503401360544, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71992985, Length=145, Percent_Identity=30.3448275862069, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=424, Percent_Identity=32.311320754717, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=425, Percent_Identity=31.7647058823529, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321456, Length=446, Percent_Identity=25.7847533632287, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324386, Length=436, Percent_Identity=24.0825688073394, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161085790, Length=444, Percent_Identity=38.7387387387387, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI28574759, Length=450, Percent_Identity=37.7777777777778, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=35.8974358974359, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21357415, Length=408, Percent_Identity=29.9019607843137, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI281366494, Length=437, Percent_Identity=27.0022883295195, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667139, Length=437, Percent_Identity=27.0022883295195, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667143, Length=437, Percent_Identity=27.0022883295195, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 47718; Mature: 47587

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKNYIGPDAIIDKKKEYLIPCVYHFYKNPMQLVRAKGKYFYDQAGKEYLDLFAGVSVM
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHCHHHH
NAGHCHPEITDRVCEQVKTLQHTCTIYLNQPIVDLAEKLAEVTPGNLKKSFFVNSGTEAN
CCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCCC
EGALLLAKLYTGNSEYIALKQGLHGRTHLTMSITGLSFWRTDPNPAGGISFAPDAYCYRC
CCCEEEEEEECCCCCEEEEECCCCCCEEEEEEEECEEEECCCCCCCCCCCCCCCCEEEEC
PYGLEYPGCDLKCARAIRDVIETSTSKQVAALIAEPIQGNGGIITPPPEYFKVVRDILDE
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHH
YGALLIIDEVQTGFGRTGKMFAIENWGVTPDIMTMAKALGNGVPIGAFTATEEVADVYTR
CCCEEEEECHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
PGASTLGGNPVSATAGLATLKVIEEEKLTENAAEVGLYFKNGLENLAKRHRIIGDVRGLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLGAELVKENKEPAPDETDLVLEKMKDRGILIGKNGPSRNVLAFQPPLIINKKDVEQVI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEECCCEEECHHHHHHHH
ATLDEVLNEVEKEAGLD
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GEKNYIGPDAIIDKKKEYLIPCVYHFYKNPMQLVRAKGKYFYDQAGKEYLDLFAGVSVM
CCCCCCCCHHHHCCCHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHCHHHH
NAGHCHPEITDRVCEQVKTLQHTCTIYLNQPIVDLAEKLAEVTPGNLKKSFFVNSGTEAN
CCCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCCC
EGALLLAKLYTGNSEYIALKQGLHGRTHLTMSITGLSFWRTDPNPAGGISFAPDAYCYRC
CCCEEEEEEECCCCCEEEEECCCCCCEEEEEEEECEEEECCCCCCCCCCCCCCCCEEEEC
PYGLEYPGCDLKCARAIRDVIETSTSKQVAALIAEPIQGNGGIITPPPEYFKVVRDILDE
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHH
YGALLIIDEVQTGFGRTGKMFAIENWGVTPDIMTMAKALGNGVPIGAFTATEEVADVYTR
CCCEEEEECHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
PGASTLGGNPVSATAGLATLKVIEEEKLTENAAEVGLYFKNGLENLAKRHRIIGDVRGLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMLGAELVKENKEPAPDETDLVLEKMKDRGILIGKNGPSRNVLAFQPPLIINKKDVEQVI
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCEEEECCCEEECHHHHHHHH
ATLDEVLNEVEKEAGLD
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]