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The map label for this gene is celR [H]

Identifier: 220932287

GI number: 220932287

Start: 1541059

End: 1542060

Strand: Reverse

Name: celR [H]

Synonym: Hore_14510

Alternate gene names: 220932287

Gene position: 1542060-1541059 (Counterclockwise)

Preceding gene: 220932288

Following gene: 220932286

Centisome position: 59.81

GC content: 40.22

Gene sequence:

>1002_bases
ATGGATAAAATAACAATGAAAGATATAGCAAAAGCTGCCAAAGTATCTAAATCAACGGTTTCCAGGGCCCTGAGTAATGA
TCCCCGGGTTAATGAAGAAACCAGAAAAAAGGTTGTTAAGATAGCCAGGGAAATGAATTATCGTCCCCATCAGGTTGCTC
AGGCTCTGGCCAAAAAGAATACCAATATAATAGGGGTTGTACTACCAACTTTCCCCAGAACAGTAGCTGACCCCTTTTTC
CTGGAATTCCTCCAGGGAATAGGAGAAATAGCTGTTGAAAAGGGATATAGCCTGACCCTCCCCAATCTTGCCAGGAAGGA
AATTCAAAACCTTGGTCAGGTTATAAACAAAAATACGGTCGACGGGGTAATTTTGACTGAACCAAAAATCGATGACCCCA
GGATTAAATACTTAAAAGAAAAGGAAATTCCCTTTGTGTTTCTGGGAAATCCCATGGATAAAGACGATGTTTACTGGGTA
GAAACTGATAATATAAGGGGATCCTATCTTGCAATGGAATACTTGATTAAGTCCGGTCATAAAAAAATAGCTACTGTTGC
CGGGTCTCCCGACCTGGTGGCCGGTAAATACAGGTATTTAGGTTATAAAAAAGCCCTGGAAAATTACGGTTTAACCATTG
ATAAAAATCTAGTCTGTTATGCTGATTTTACCGAAGAGGGGGCCTATTCTGCTGTTCTAAAGTTATTGGAAAAGAGGAAC
GATTTTACAGCTATTTTTGTAGCCAATGATTTGATGGCCTTCGGGGTTATAAAGGCTCTGAAGGAAAAAGGCCTCTCAAT
ACCGGAAGATATAGCGGTTATGGGATATGATGGTATTAAGCTGGGGGAATTTATTGAACCTCCTTTAAGTACCATAAAAA
TACCCAGCCGGCAGATGGGAAGGGTGGCTTTAAATCTTCTTATTAAGTTGATTAATGGTGAAAATGTCAAGGATAAACAT
GTCTTACTACCACCGGAGTTAATGGTGAGAGAGTCAGCTTAA

Upstream 100 bases:

>100_bases
GTAAGTAAATTTATATTGAAATAAAATGTTGTTAACACTATCAAAATATATTTAATTGAATTTTTTAGTAAAATTATGTA
TAATATTCTGGGTGGTATCT

Downstream 100 bases:

>100_bases
ATTAATCATAAGTAATCCTGAATTTAGATAAAATAAAACCCATATTTGGAAACCTCTATTGGTTTATAAAAATGAAATTC
TGTTGGTCTGTAAAAATTAA

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MDKITMKDIAKAAKVSKSTVSRALSNDPRVNEETRKKVVKIAREMNYRPHQVAQALAKKNTNIIGVVLPTFPRTVADPFF
LEFLQGIGEIAVEKGYSLTLPNLARKEIQNLGQVINKNTVDGVILTEPKIDDPRIKYLKEKEIPFVFLGNPMDKDDVYWV
ETDNIRGSYLAMEYLIKSGHKKIATVAGSPDLVAGKYRYLGYKKALENYGLTIDKNLVCYADFTEEGAYSAVLKLLEKRN
DFTAIFVANDLMAFGVIKALKEKGLSIPEDIAVMGYDGIKLGEFIEPPLSTIKIPSRQMGRVALNLLIKLINGENVKDKH
VLLPPELMVRESA

Sequences:

>Translated_333_residues
MDKITMKDIAKAAKVSKSTVSRALSNDPRVNEETRKKVVKIAREMNYRPHQVAQALAKKNTNIIGVVLPTFPRTVADPFF
LEFLQGIGEIAVEKGYSLTLPNLARKEIQNLGQVINKNTVDGVILTEPKIDDPRIKYLKEKEIPFVFLGNPMDKDDVYWV
ETDNIRGSYLAMEYLIKSGHKKIATVAGSPDLVAGKYRYLGYKKALENYGLTIDKNLVCYADFTEEGAYSAVLKLLEKRN
DFTAIFVANDLMAFGVIKALKEKGLSIPEDIAVMGYDGIKLGEFIEPPLSTIKIPSRQMGRVALNLLIKLINGENVKDKH
VLLPPELMVRESA
>Mature_333_residues
MDKITMKDIAKAAKVSKSTVSRALSNDPRVNEETRKKVVKIAREMNYRPHQVAQALAKKNTNIIGVVLPTFPRTVADPFF
LEFLQGIGEIAVEKGYSLTLPNLARKEIQNLGQVINKNTVDGVILTEPKIDDPRIKYLKEKEIPFVFLGNPMDKDDVYWV
ETDNIRGSYLAMEYLIKSGHKKIATVAGSPDLVAGKYRYLGYKKALENYGLTIDKNLVCYADFTEEGAYSAVLKLLEKRN
DFTAIFVANDLMAFGVIKALKEKGLSIPEDIAVMGYDGIKLGEFIEPPLSTIKIPSRQMGRVALNLLIKLINGENVKDKH
VLLPPELMVRESA

Specific function: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=333, Percent_Identity=33.9339339339339, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1790194, Length=334, Percent_Identity=34.7305389221557, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=30.6306306306306, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789068, Length=318, Percent_Identity=32.3899371069182, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1787580, Length=314, Percent_Identity=30.5732484076433, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789202, Length=294, Percent_Identity=28.2312925170068, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788474, Length=326, Percent_Identity=28.2208588957055, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786540, Length=336, Percent_Identity=29.4642857142857, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1787906, Length=341, Percent_Identity=26.6862170087977, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI48994940, Length=326, Percent_Identity=29.1411042944785, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1790715, Length=315, Percent_Identity=26.984126984127, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1789456, Length=336, Percent_Identity=27.3809523809524, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790192, Length=260, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786268, Length=320, Percent_Identity=22.1875, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37217; Mature: 37217

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKITMKDIAKAAKVSKSTVSRALSNDPRVNEETRKKVVKIAREMNYRPHQVAQALAKKN
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
TNIIGVVLPTFPRTVADPFFLEFLQGIGEIAVEKGYSLTLPNLARKEIQNLGQVINKNTV
CCEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCC
DGVILTEPKIDDPRIKYLKEKEIPFVFLGNPMDKDDVYWVETDNIRGSYLAMEYLIKSGH
CCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCC
KKIATVAGSPDLVAGKYRYLGYKKALENYGLTIDKNLVCYADFTEEGAYSAVLKLLEKRN
CEEEEECCCCCCEECHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCHHHHHHHHHHCCC
DFTAIFVANDLMAFGVIKALKEKGLSIPEDIAVMGYDGIKLGEFIEPPLSTIKIPSRQMG
CEEEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHCCCHHHEECCCHHHH
RVALNLLIKLINGENVKDKHVLLPPELMVRESA
HHHHHHHHHHHCCCCCCCCEEECCHHHHHCCCC
>Mature Secondary Structure
MDKITMKDIAKAAKVSKSTVSRALSNDPRVNEETRKKVVKIAREMNYRPHQVAQALAKKN
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
TNIIGVVLPTFPRTVADPFFLEFLQGIGEIAVEKGYSLTLPNLARKEIQNLGQVINKNTV
CCEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCC
DGVILTEPKIDDPRIKYLKEKEIPFVFLGNPMDKDDVYWVETDNIRGSYLAMEYLIKSGH
CCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCC
KKIATVAGSPDLVAGKYRYLGYKKALENYGLTIDKNLVCYADFTEEGAYSAVLKLLEKRN
CEEEEECCCCCCEECHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCHHHHHHHHHHCCC
DFTAIFVANDLMAFGVIKALKEKGLSIPEDIAVMGYDGIKLGEFIEPPLSTIKIPSRQMG
CEEEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHCCCHHHEECCCHHHH
RVALNLLIKLINGENVKDKHVLLPPELMVRESA
HHHHHHHHHHHCCCCCCCCEEECCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224066 [H]