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The map label for this gene is tdh [H]

Identifier: 220932147

GI number: 220932147

Start: 1406323

End: 1407333

Strand: Reverse

Name: tdh [H]

Synonym: Hore_13100

Alternate gene names: 220932147

Gene position: 1407333-1406323 (Counterclockwise)

Preceding gene: 220932148

Following gene: 220932146

Centisome position: 54.59

GC content: 36.0

Gene sequence:

>1011_bases
TTGAAAAGTTTAGTTTTTTATGGACCAGGAAATGTAAAAATTGAAGATAAAGAGATTCCTAAAATAGATGAAAATGAAGT
ACTTGTTAAAGTTAAAGCAGCTGGTATCTGTGGTACTGATAGACATATTTACAGAGGAGAGGCACCTGCCCGGACTCAGG
TAATACTGGGGCATGAAAATGCAGGAGAGATAATTGAGACTGGACGACAGGTGCGTAGTCTCAAAAAAGGTGATAAAGTT
TGCATAGATCCCAATATATTTTGTGGTCAATGTTATTATTGTCACCGTGGAGAAGTTCATTTATGTAAAGAATTGCAGGC
AATCGGAGTTACAAGAAATGGTGGTTTTGCTGAGTATTTGGTTGCTCCTGCTACTAATGTTTATAAAGTTAAGGAGAATG
TTAGTTATAAAGAAATGGCTCTTGTAGAACCACTGGCCTGTTGCCTCCATGGGATTGACCTTGCCGGGATAAGGCCTGGA
GATTTTGTTGTGATTTTGGGGGCAGGAGCTATTGGTTTAATTTTACTTCAGCTGGCATTACATAGTGGTGCCAGTGAGGT
AATAGTTAGTGAACCAAATTCAAAAAAACGAAAACTAGCCCTGAAATTAGGGGCCAGTAAAGTATTTGATCCCTTTAATG
ATAATCTTGAAAAAGAAATTAAAATAATTAAAAGGGAAGGAGCAGATGTTGTAATAGAGGCCGTGGGTAATATCCATACT
TTTAAGCAATCTATTCAGTTAGCCCGAAAGGGAGGTAGTGTTCTTTTATTTGGTGTTCCTCCTAAAGATAAGGTTATAGA
AATTAACCCTTTTGAAATTTATAAAAGGGAATTAAAATTAAAGGGGGCATATATTAATCCCTTTGTTACTGATAGAGCTG
TTAGAATACTGGAATCAGGGATGGTTAATTTAAAAAAGTTAGTAACTTCTCAATACACACTTGAAGAGCTACCAAATGTT
TTGGACGGAAATTTAGATGAGAGTAATGTCAAATCGCTAGTTATATATTAA

Upstream 100 bases:

>100_bases
AAGATACCCTACGAACAATTAACGGTATCAGATATAACCGGGACAGAAGCCATAATCAAGTAACTAGTAAGTAAAAATTA
TCTAAATGGAGGGGGTAATC

Downstream 100 bases:

>100_bases
TATTTAATTTAAATCTGTTCAGGTTAAATCCTGAACAGATTTTTGTTTATATAATATAAATTCTGATATAATACAGATAT
CTTAATATATTTTTATCATA

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKSLVFYGPGNVKIEDKEIPKIDENEVLVKVKAAGICGTDRHIYRGEAPARTQVILGHENAGEIIETGRQVRSLKKGDKV
CIDPNIFCGQCYYCHRGEVHLCKELQAIGVTRNGGFAEYLVAPATNVYKVKENVSYKEMALVEPLACCLHGIDLAGIRPG
DFVVILGAGAIGLILLQLALHSGASEVIVSEPNSKKRKLALKLGASKVFDPFNDNLEKEIKIIKREGADVVIEAVGNIHT
FKQSIQLARKGGSVLLFGVPPKDKVIEINPFEIYKRELKLKGAYINPFVTDRAVRILESGMVNLKKLVTSQYTLEELPNV
LDGNLDESNVKSLVIY

Sequences:

>Translated_336_residues
MKSLVFYGPGNVKIEDKEIPKIDENEVLVKVKAAGICGTDRHIYRGEAPARTQVILGHENAGEIIETGRQVRSLKKGDKV
CIDPNIFCGQCYYCHRGEVHLCKELQAIGVTRNGGFAEYLVAPATNVYKVKENVSYKEMALVEPLACCLHGIDLAGIRPG
DFVVILGAGAIGLILLQLALHSGASEVIVSEPNSKKRKLALKLGASKVFDPFNDNLEKEIKIIKREGADVVIEAVGNIHT
FKQSIQLARKGGSVLLFGVPPKDKVIEINPFEIYKRELKLKGAYINPFVTDRAVRILESGMVNLKKLVTSQYTLEELPNV
LDGNLDESNVKSLVIY
>Mature_336_residues
MKSLVFYGPGNVKIEDKEIPKIDENEVLVKVKAAGICGTDRHIYRGEAPARTQVILGHENAGEIIETGRQVRSLKKGDKV
CIDPNIFCGQCYYCHRGEVHLCKELQAIGVTRNGGFAEYLVAPATNVYKVKENVSYKEMALVEPLACCLHGIDLAGIRPG
DFVVILGAGAIGLILLQLALHSGASEVIVSEPNSKKRKLALKLGASKVFDPFNDNLEKEIKIIKREGADVVIEAVGNIHT
FKQSIQLARKGGSVLLFGVPPKDKVIEINPFEIYKRELKLKGAYINPFVTDRAVRILESGMVNLKKLVTSQYTLEELPNV
LDGNLDESNVKSLVIY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=322, Percent_Identity=28.8819875776398, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI4501929, Length=353, Percent_Identity=24.6458923512748, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4501933, Length=356, Percent_Identity=25, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI34577061, Length=339, Percent_Identity=25.9587020648968, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI262073058, Length=286, Percent_Identity=25.5244755244755, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=286, Percent_Identity=25.5244755244755, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501939, Length=352, Percent_Identity=25, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI156523966, Length=352, Percent_Identity=25, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI71565154, Length=277, Percent_Identity=26.3537906137184, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI194239674, Length=335, Percent_Identity=26.2686567164179, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI13236495, Length=335, Percent_Identity=26.2686567164179, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI71565152, Length=360, Percent_Identity=23.6111111111111, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788073, Length=326, Percent_Identity=32.8220858895706, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1790045, Length=321, Percent_Identity=29.9065420560748, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI226510992, Length=320, Percent_Identity=30.625, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1787863, Length=324, Percent_Identity=30.8641975308642, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788407, Length=328, Percent_Identity=29.8780487804878, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788075, Length=355, Percent_Identity=27.6056338028169, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1790718, Length=331, Percent_Identity=25.9818731117825, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786552, Length=375, Percent_Identity=27.4666666666667, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786825, Length=266, Percent_Identity=31.5789473684211, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081918, Length=277, Percent_Identity=30.3249097472924, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082125, Length=333, Percent_Identity=27.027027027027, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787572, Length=203, Percent_Identity=30.0492610837438, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=325, Percent_Identity=32.3076923076923, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17562878, Length=323, Percent_Identity=30.030959752322, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17562584, Length=347, Percent_Identity=27.6657060518732, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=26.3768115942029, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=338, Percent_Identity=25.7396449704142, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=349, Percent_Identity=23.2091690544413, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=341, Percent_Identity=23.1671554252199, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=311, Percent_Identity=24.7588424437299, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=331, Percent_Identity=31.7220543806647, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6322619, Length=331, Percent_Identity=31.7220543806647, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6319257, Length=377, Percent_Identity=29.1777188328912, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323099, Length=328, Percent_Identity=30.1829268292683, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=384, Percent_Identity=27.6041666666667, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319621, Length=272, Percent_Identity=33.8235294117647, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=333, Percent_Identity=28.5285285285285, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=29.1793313069909, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=295, Percent_Identity=26.1016949152542, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=28.4848484848485, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737897, Length=326, Percent_Identity=32.2085889570552, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17137530, Length=325, Percent_Identity=29.8461538461538, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737895, Length=337, Percent_Identity=24.9258160237389, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221457811, Length=333, Percent_Identity=23.1231231231231, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45550770, Length=333, Percent_Identity=23.1231231231231, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45551930, Length=333, Percent_Identity=23.1231231231231, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36922; Mature: 36922

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLVFYGPGNVKIEDKEIPKIDENEVLVKVKAAGICGTDRHIYRGEAPARTQVILGHEN
CCCEEEECCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCC
AGEIIETGRQVRSLKKGDKVCIDPNIFCGQCYYCHRGEVHLCKELQAIGVTRNGGFAEYL
CCHHHHHHHHHHHHHCCCEEEECCCCEECCEEEEECCCCHHHHHHHHHEEECCCCCEEEE
VAPATNVYKVKENVSYKEMALVEPLACCLHGIDLAGIRPGDFVVILGAGAIGLILLQLAL
ECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHH
HSGASEVIVSEPNSKKRKLALKLGASKVFDPFNDNLEKEIKIIKREGADVVIEAVGNIHT
HCCCCEEEEECCCCHHHEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCCEEEEHHCCHHH
FKQSIQLARKGGSVLLFGVPPKDKVIEINPFEIYKRELKLKGAYINPFVTDRAVRILESG
HHHHHHHHHCCCCEEEEECCCCCCEEEECHHHHHHHHHEECCCEECCHHHHHHHHHHHHH
MVNLKKLVTSQYTLEELPNVLDGNLDESNVKSLVIY
HHHHHHHHHCCCCHHHCCHHHCCCCCCCCCCEEEEC
>Mature Secondary Structure
MKSLVFYGPGNVKIEDKEIPKIDENEVLVKVKAAGICGTDRHIYRGEAPARTQVILGHEN
CCCEEEECCCCEEECCCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCC
AGEIIETGRQVRSLKKGDKVCIDPNIFCGQCYYCHRGEVHLCKELQAIGVTRNGGFAEYL
CCHHHHHHHHHHHHHCCCEEEECCCCEECCEEEEECCCCHHHHHHHHHEEECCCCCEEEE
VAPATNVYKVKENVSYKEMALVEPLACCLHGIDLAGIRPGDFVVILGAGAIGLILLQLAL
ECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHH
HSGASEVIVSEPNSKKRKLALKLGASKVFDPFNDNLEKEIKIIKREGADVVIEAVGNIHT
HCCCCEEEEECCCCHHHEEEEEECCHHHCCCCCCCHHHHHHHHHHCCCCEEEEHHCCHHH
FKQSIQLARKGGSVLLFGVPPKDKVIEINPFEIYKRELKLKGAYINPFVTDRAVRILESG
HHHHHHHHHCCCCEEEEECCCCCCEEEECHHHHHHHHHEECCCEECCHHHHHHHHHHHHH
MVNLKKLVTSQYTLEELPNVLDGNLDESNVKSLVIY
HHHHHHHHHCCCCHHHCCHHHCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA