Click here to switch to the map view.

The map label for this gene is prsA [H]

Identifier: 220932053

GI number: 220932053

Start: 1309076

End: 1310563

Strand: Reverse

Name: prsA [H]

Synonym: Hore_12160

Alternate gene names: 220932053

Gene position: 1310563-1309076 (Counterclockwise)

Preceding gene: 220932054

Following gene: 220932052

Centisome position: 50.83

GC content: 36.16

Gene sequence:

>1488_bases
ATGTTTAAAAAATTAAGGAATTATAGTAAATACATTATCTATTTTGTGGTAGCTGCACTGGTTTTAACAGGAGCCTTTTT
AGGTTTTGGAGCTTACAGGAATAGTAGCCCGGCTGCTTCATCTGTTATAGACCCTAATTATATTGCCAGGGTAAATGATA
CCAGTATACCCCGGGAAACCTATTATCAATATTTACAGAATAATGCCCAGTTTGCCCAGTTAAGCAGAGAACAACAGGTT
CCCTATCGATTAAATTTATTAAATCAATTAATTGAACGGGAATTGCTTTTACAGGAAGCAGAAAAACTGGGTATTGAGTC
AAACCCTACTGATAAAGAGGTAAAAGAACAGATTAATAAGATGCTGGAGGCTTATAATATAACCGAAGAAAAGCTAAAGG
AATTACTGGATTCAAGGGGTATTAAATATGAAGATTTTAAAGAAGATATTAGACATAATATCAAAACCAGCAATATAATC
AGAAAAACAATAGAACACACTTATAAAGGGGTTGAGGTTTCCGAGGATGAAATCAGGGAAGCCTACGAAAAAGTTCGTCC
AGCTTTAATAGCTGTAAATATAGAAGGTGAAAAGAAAAAAGAGGCCAGAGCAAAAATTGAAAAGGCCTTAAAGGAATTAG
AAGAAGGGAAGGCCTTTGGTGAAGTAGCAGCAAAATACTCTGATCTTAAACTTAAAGACGGAGATTTAGGATTTATTGGC
AGGAACAATGGATTTTTACCCCAGGAAGTACTTGATAAAGCCTTTGAACTCGAAAAGGGCAAAACCAGTGATATTATTGA
AGGAGAAAAAGGTTATTATATTGTAAAAGTCATTGATAAAAAACTGGCCAGGGGAGAAGAATTTGAAAAGTCAAGAGAAG
AATTGAAAGACCAGCTCTTAAAGCAAAAACAGAATAGAACCTATCAGAACTGGCTCAGAGATACCAAAAAGCAGGCCGAT
ATTGAGATATATGACCCCGTATTGAATGGCTATAAAGCCTTACAGGAACAAAATTATACTGAAGCTATTAATGATTTCAA
GATAGCTTTAGATTATAATGCTGCCCCCATTGTTTATGTATACCTGGCCCGTGCTTATCATGGTAAAGGAGATGACCAGG
AGGCCATTAAGGTTTTTGAGGAGGCCCTTAAAGATAATTCGGAGAGCTGGTATCTTCATTACAATTTCGGTAATTTATAT
GCTGATATTGATAAAAAAGACCTGGCTATTAAAGAATTTAAAAAGGCTTCTGAACTGGCCGGTAAAGATATTCAGGCCCA
TTACAGGCTCTATCTTGCTCTGGCTGGACTCGGGGCTAAAGAAGAGGCCGAACATGAATCTGACATAGTTAAAAAACTAC
AAAAAGAGATTGAAGAGGCCAGAAAGGAACTTCAGGAGCAGGTAAATGAATCAAGGGATAATAATGAATTGAAATCAGAT
TCCGTTGAAAAAGCCCAGACTAATAATGGCAGAACTGAAAATAAATAA

Upstream 100 bases:

>100_bases
GTTTTAATAGGTTAAAATGATTAAAGGTTAAACTTTTCTTGTAGTAGTAAATTATGTAATGATATAGTTTTCACTTTTTA
TTTCTGAAAGGAGTGTAAGG

Downstream 100 bases:

>100_bases
TTAATTTCCCAGGCTTTTAACACATCAATGAAAATTGTAATAAAAGGGTGATAATATGGATGTAAAGGCACCACGGGGGA
CAAATGATATTTTGCCCCCC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MFKKLRNYSKYIIYFVVAALVLTGAFLGFGAYRNSSPAASSVIDPNYIARVNDTSIPRETYYQYLQNNAQFAQLSREQQV
PYRLNLLNQLIERELLLQEAEKLGIESNPTDKEVKEQINKMLEAYNITEEKLKELLDSRGIKYEDFKEDIRHNIKTSNII
RKTIEHTYKGVEVSEDEIREAYEKVRPALIAVNIEGEKKKEARAKIEKALKELEEGKAFGEVAAKYSDLKLKDGDLGFIG
RNNGFLPQEVLDKAFELEKGKTSDIIEGEKGYYIVKVIDKKLARGEEFEKSREELKDQLLKQKQNRTYQNWLRDTKKQAD
IEIYDPVLNGYKALQEQNYTEAINDFKIALDYNAAPIVYVYLARAYHGKGDDQEAIKVFEEALKDNSESWYLHYNFGNLY
ADIDKKDLAIKEFKKASELAGKDIQAHYRLYLALAGLGAKEEAEHESDIVKKLQKEIEEARKELQEQVNESRDNNELKSD
SVEKAQTNNGRTENK

Sequences:

>Translated_495_residues
MFKKLRNYSKYIIYFVVAALVLTGAFLGFGAYRNSSPAASSVIDPNYIARVNDTSIPRETYYQYLQNNAQFAQLSREQQV
PYRLNLLNQLIERELLLQEAEKLGIESNPTDKEVKEQINKMLEAYNITEEKLKELLDSRGIKYEDFKEDIRHNIKTSNII
RKTIEHTYKGVEVSEDEIREAYEKVRPALIAVNIEGEKKKEARAKIEKALKELEEGKAFGEVAAKYSDLKLKDGDLGFIG
RNNGFLPQEVLDKAFELEKGKTSDIIEGEKGYYIVKVIDKKLARGEEFEKSREELKDQLLKQKQNRTYQNWLRDTKKQAD
IEIYDPVLNGYKALQEQNYTEAINDFKIALDYNAAPIVYVYLARAYHGKGDDQEAIKVFEEALKDNSESWYLHYNFGNLY
ADIDKKDLAIKEFKKASELAGKDIQAHYRLYLALAGLGAKEEAEHESDIVKKLQKEIEEARKELQEQVNESRDNNELKSD
SVEKAQTNNGRTENK
>Mature_495_residues
MFKKLRNYSKYIIYFVVAALVLTGAFLGFGAYRNSSPAASSVIDPNYIARVNDTSIPRETYYQYLQNNAQFAQLSREQQV
PYRLNLLNQLIERELLLQEAEKLGIESNPTDKEVKEQINKMLEAYNITEEKLKELLDSRGIKYEDFKEDIRHNIKTSNII
RKTIEHTYKGVEVSEDEIREAYEKVRPALIAVNIEGEKKKEARAKIEKALKELEEGKAFGEVAAKYSDLKLKDGDLGFIG
RNNGFLPQEVLDKAFELEKGKTSDIIEGEKGYYIVKVIDKKLARGEEFEKSREELKDQLLKQKQNRTYQNWLRDTKKQAD
IEIYDPVLNGYKALQEQNYTEAINDFKIALDYNAAPIVYVYLARAYHGKGDDQEAIKVFEEALKDNSESWYLHYNFGNLY
ADIDKKDLAIKEFKKASELAGKDIQAHYRLYLALAGLGAKEEAEHESDIVKKLQKEIEEARKELQEQVNESRDNNELKSD
SVEKAQTNNGRTENK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 57186; Mature: 57186

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLRNYSKYIIYFVVAALVLTGAFLGFGAYRNSSPAASSVIDPNYIARVNDTSIPRET
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEECCCCCCCHHH
YYQYLQNNAQFAQLSREQQVPYRLNLLNQLIERELLLQEAEKLGIESNPTDKEVKEQINK
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MLEAYNITEEKLKELLDSRGIKYEDFKEDIRHNIKTSNIIRKTIEHTYKGVEVSEDEIRE
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHH
AYEKVRPALIAVNIEGEKKKEARAKIEKALKELEEGKAFGEVAAKYSDLKLKDGDLGFIG
HHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEECCCCEEEEE
RNNGFLPQEVLDKAFELEKGKTSDIIEGEKGYYIVKVIDKKLARGEEFEKSREELKDQLL
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHH
KQKQNRTYQNWLRDTKKQADIEIYDPVLNGYKALQEQNYTEAINDFKIALDYNAAPIVYV
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHCCEEEEEECCCCHHHHH
YLARAYHGKGDDQEAIKVFEEALKDNSESWYLHYNFGNLYADIDKKDLAIKEFKKASELA
HHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHC
GKDIQAHYRLYLALAGLGAKEEAEHESDIVKKLQKEIEEARKELQEQVNESRDNNELKSD
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
SVEKAQTNNGRTENK
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MFKKLRNYSKYIIYFVVAALVLTGAFLGFGAYRNSSPAASSVIDPNYIARVNDTSIPRET
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEECCCCCCCHHH
YYQYLQNNAQFAQLSREQQVPYRLNLLNQLIERELLLQEAEKLGIESNPTDKEVKEQINK
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
MLEAYNITEEKLKELLDSRGIKYEDFKEDIRHNIKTSNIIRKTIEHTYKGVEVSEDEIRE
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHH
AYEKVRPALIAVNIEGEKKKEARAKIEKALKELEEGKAFGEVAAKYSDLKLKDGDLGFIG
HHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEECCCCEEEEE
RNNGFLPQEVLDKAFELEKGKTSDIIEGEKGYYIVKVIDKKLARGEEFEKSREELKDQLL
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHHHHHH
KQKQNRTYQNWLRDTKKQADIEIYDPVLNGYKALQEQNYTEAINDFKIALDYNAAPIVYV
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHCCEEEEEECCCCHHHHH
YLARAYHGKGDDQEAIKVFEEALKDNSESWYLHYNFGNLYADIDKKDLAIKEFKKASELA
HHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCHHHHHHHHHHHHHHHC
GKDIQAHYRLYLALAGLGAKEEAEHESDIVKKLQKEIEEARKELQEQVNESRDNNELKSD
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
SVEKAQTNNGRTENK
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]