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The map label for this gene is dapL

Identifier: 220931995

GI number: 220931995

Start: 1248344

End: 1249513

Strand: Reverse

Name: dapL

Synonym: Hore_11560

Alternate gene names: 220931995

Gene position: 1249513-1248344 (Counterclockwise)

Preceding gene: 220931996

Following gene: 220931994

Centisome position: 48.47

GC content: 38.12

Gene sequence:

>1170_bases
ATGGAAAATGCTGATAGAATTAAAAACCTGCCGCCATATTTATTCGCAGAAATTGATAAAATGATTGCCAGAGCAAAAAA
AGAGGGAGTAGATGTAATCAGTTTCGGAATTGGAGATCCGGATCAACCAACACCTGATAATATAATAAATAAAATGATAG
AGGCTGTTAAAGACCCTTCTACTCACAGTTACCCCTCTTATGAAGGGATGTATGAATACCGTAAAACAGTTGCTGACTGG
TATAAAAATAACTATGGTAGGGAGTTAGATCCTGATAAAGAGGTTGTTTCTTTAATTGGTTCTAAAGAGGGGATAGCCCA
TCTTCCTTTTTGTTATATAAACCCCGGTGATATAGCCCTTGTACCTGATCCCGGGTATCCTGTCTATAAGACTTCAGTTT
TGCTGGCAGGAGGAAAACCGGTTCAGGTTCCATTAGTTGAAGAAAATAATTTCCTACCTGACCTTAAAGCAATCGATGAA
GATATCGCCAGAAAAGCTAAACTCTTTTTTATAAACTATCCCAACAATCCGACCGGGGCAATTGCTCCTGAGGAGTTTTA
TGAAGAATTGATTGATTTTGCCGATAAATATGATATAATAATTGCCCATGATGCCGCCTATAGTGAAATTGGCCTTGATG
GATATAATCCTCCCAGTTTTATGCAGTTTGAAGGAGCAAAAAAGGTTGGCATCGAATTTAATTCTCTTTCCAAACCCTTT
AATATGACCGGCTGGAGAGTAGGCTGGGCAGTTGGTCGTTCTGATGTGATAGAATCTTTAGGAAGAATCAAAACAAACAT
TGATTCCGGTATATTTGAAGCTATTCAGTATGCTGGAATTGAAGCCCTGACAGGCCCTGAAGATAATATTGAAAAAATGA
CAGAATTATATTCTAAAAGGAGAGACTTACTGGTAGAAGGCCTGCGTGAACTGGGCTGGGAAGTCCCTGTAAATAAAGCC
ACCTTCTATATCTGGGCTAAAGTACCTGAAGGCTATAATTCCACTGAATTCTCCACACATGTTTTTGAAAAAACCGGGAT
ATTCTTTACACCCGGTAATGGTTACGGGGAATTCGGTGAAGGGTATGTCAGAATTGCATTAACAGTAACAGAAGAGCGTA
TAAAAGAAGCTTTAGAAAGACTTAAAAATAGTGATATAAAATTTAAATAA

Upstream 100 bases:

>100_bases
GGGAGACCTTAATATTGAATGGCAGGAACAGGATGTATTTATGACAGGTCCTGCAGAGAGTGTTTACACAGGAAAAATCG
TAATACAGGAGGGATAAGCA

Downstream 100 bases:

>100_bases
AACTTTAAGTAAAATAAAGACCTGTCCCTTTATCTGTAATTTTACAGATTCTCTGTTAACTGACACAGAGGGGACAGGTT
TTTTAAATTTTAAAACGGTT

Product: LL-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MENADRIKNLPPYLFAEIDKMIARAKKEGVDVISFGIGDPDQPTPDNIINKMIEAVKDPSTHSYPSYEGMYEYRKTVADW
YKNNYGRELDPDKEVVSLIGSKEGIAHLPFCYINPGDIALVPDPGYPVYKTSVLLAGGKPVQVPLVEENNFLPDLKAIDE
DIARKAKLFFINYPNNPTGAIAPEEFYEELIDFADKYDIIIAHDAAYSEIGLDGYNPPSFMQFEGAKKVGIEFNSLSKPF
NMTGWRVGWAVGRSDVIESLGRIKTNIDSGIFEAIQYAGIEALTGPEDNIEKMTELYSKRRDLLVEGLRELGWEVPVNKA
TFYIWAKVPEGYNSTEFSTHVFEKTGIFFTPGNGYGEFGEGYVRIALTVTEERIKEALERLKNSDIKFK

Sequences:

>Translated_389_residues
MENADRIKNLPPYLFAEIDKMIARAKKEGVDVISFGIGDPDQPTPDNIINKMIEAVKDPSTHSYPSYEGMYEYRKTVADW
YKNNYGRELDPDKEVVSLIGSKEGIAHLPFCYINPGDIALVPDPGYPVYKTSVLLAGGKPVQVPLVEENNFLPDLKAIDE
DIARKAKLFFINYPNNPTGAIAPEEFYEELIDFADKYDIIIAHDAAYSEIGLDGYNPPSFMQFEGAKKVGIEFNSLSKPF
NMTGWRVGWAVGRSDVIESLGRIKTNIDSGIFEAIQYAGIEALTGPEDNIEKMTELYSKRRDLLVEGLRELGWEVPVNKA
TFYIWAKVPEGYNSTEFSTHVFEKTGIFFTPGNGYGEFGEGYVRIALTVTEERIKEALERLKNSDIKFK
>Mature_389_residues
MENADRIKNLPPYLFAEIDKMIARAKKEGVDVISFGIGDPDQPTPDNIINKMIEAVKDPSTHSYPSYEGMYEYRKTVADW
YKNNYGRELDPDKEVVSLIGSKEGIAHLPFCYINPGDIALVPDPGYPVYKTSVLLAGGKPVQVPLVEENNFLPDLKAIDE
DIARKAKLFFINYPNNPTGAIAPEEFYEELIDFADKYDIIIAHDAAYSEIGLDGYNPPSFMQFEGAKKVGIEFNSLSKPF
NMTGWRVGWAVGRSDVIESLGRIKTNIDSGIFEAIQYAGIEALTGPEDNIEKMTELYSKRRDLLVEGLRELGWEVPVNKA
TFYIWAKVPEGYNSTEFSTHVFEKTGIFFTPGNGYGEFGEGYVRIALTVTEERIKEALERLKNSDIKFK

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Homo sapiens, GI56713254, Length=342, Percent_Identity=24.2690058479532, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI56713256, Length=342, Percent_Identity=24.2690058479532, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI95147551, Length=312, Percent_Identity=22.7564102564103, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169881279, Length=312, Percent_Identity=22.7564102564103, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4507369, Length=371, Percent_Identity=23.1805929919137, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI169881281, Length=223, Percent_Identity=21.0762331838565, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI7705897, Length=317, Percent_Identity=25.5520504731861, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI33469970, Length=317, Percent_Identity=25.5520504731861, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788722, Length=380, Percent_Identity=38.9473684210526, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1788627, Length=254, Percent_Identity=29.1338582677165, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786816, Length=368, Percent_Identity=20.1086956521739, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994476, Length=352, Percent_Identity=26.4204545454545, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71994472, Length=352, Percent_Identity=26.4204545454545, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17567369, Length=325, Percent_Identity=22.4615384615385, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17567663, Length=373, Percent_Identity=24.3967828418231, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322401, Length=392, Percent_Identity=22.7040816326531, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28573069, Length=384, Percent_Identity=20.8333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24646114, Length=384, Percent_Identity=20.8333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28573067, Length=384, Percent_Identity=20.8333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28573065, Length=384, Percent_Identity=20.8333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859735, Length=371, Percent_Identity=25.6064690026954, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641770, Length=383, Percent_Identity=22.7154046997389, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641760, Length=383, Percent_Identity=22.7154046997389, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641768, Length=383, Percent_Identity=22.7154046997389, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641766, Length=383, Percent_Identity=22.7154046997389, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641764, Length=383, Percent_Identity=22.7154046997389, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551451, Length=383, Percent_Identity=22.7154046997389, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_HALOH (B8CX89)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508903.1
- ProteinModelPortal:   B8CX89
- SMR:   B8CX89
- GeneID:   7312901
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_11560
- HOGENOM:   HBG645860
- OMA:   EHHRYPS
- ProtClustDB:   PRK09276
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03540

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 43768; Mature: 43768

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 38-38 BINDING 67-67 BINDING 126-126 BINDING 176-176 BINDING 176-176 BINDING 204-204 BINDING 207-207 BINDING 235-235 BINDING 237-237 BINDING 246-246 BINDING 364-364

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENADRIKNLPPYLFAEIDKMIARAKKEGVDVISFGIGDPDQPTPDNIINKMIEAVKDPS
CCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCC
THSYPSYEGMYEYRKTVADWYKNNYGRELDPDKEVVSLIGSKEGIAHLPFCYINPGDIAL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEECCEEEECCCCEEE
VPDPGYPVYKTSVLLAGGKPVQVPLVEENNFLPDLKAIDEDIARKAKLFFINYPNNPTGA
ECCCCCCEEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCC
IAPEEFYEELIDFADKYDIIIAHDAAYSEIGLDGYNPPSFMQFEGAKKVGIEFNSLSKPF
CCHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCEEECCCCEECEEHHCCCCCC
NMTGWRVGWAVGRSDVIESLGRIKTNIDSGIFEAIQYAGIEALTGPEDNIEKMTELYSKR
CCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RDLLVEGLRELGWEVPVNKATFYIWAKVPEGYNSTEFSTHVFEKTGIFFTPGNGYGEFGE
HHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCC
GYVRIALTVTEERIKEALERLKNSDIKFK
CEEEEEEEECHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MENADRIKNLPPYLFAEIDKMIARAKKEGVDVISFGIGDPDQPTPDNIINKMIEAVKDPS
CCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCC
THSYPSYEGMYEYRKTVADWYKNNYGRELDPDKEVVSLIGSKEGIAHLPFCYINPGDIAL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEECCEEEECCCCEEE
VPDPGYPVYKTSVLLAGGKPVQVPLVEENNFLPDLKAIDEDIARKAKLFFINYPNNPTGA
ECCCCCCEEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCC
IAPEEFYEELIDFADKYDIIIAHDAAYSEIGLDGYNPPSFMQFEGAKKVGIEFNSLSKPF
CCHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCEEECCCCEECEEHHCCCCCC
NMTGWRVGWAVGRSDVIESLGRIKTNIDSGIFEAIQYAGIEALTGPEDNIEKMTELYSKR
CCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
RDLLVEGLRELGWEVPVNKATFYIWAKVPEGYNSTEFSTHVFEKTGIFFTPGNGYGEFGE
HHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCEEEECCCCCCCCCC
GYVRIALTVTEERIKEALERLKNSDIKFK
CEEEEEEEECHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA