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The map label for this gene is ribBA [H]

Identifier: 220931844

GI number: 220931844

Start: 1091911

End: 1093125

Strand: Direct

Name: ribBA [H]

Synonym: Hore_10010

Alternate gene names: 220931844

Gene position: 1091911-1093125 (Clockwise)

Preceding gene: 220931843

Following gene: 220931845

Centisome position: 42.35

GC content: 41.15

Gene sequence:

>1215_bases
ATGAACACAATTGAAGAAGCAATTGAAGATATTAAACAGGGGAAAATGGTTATAGTAGTTGATGATGAAGACAGGGAAAA
TGAAGGAGATCTGGTTATGGCTGCCGAAAAAGTAACTCCTGAAAGTATTAATTTTATGATCAGGTTTGCCCGCGGGCTGG
TCTGTGTTCCCATGGAAGAGGAAAGACTTAGAGAACTTGATTTACCTATGATGGTTGTTAATAATACCGACCCCCAAGAA
ACAGGGTTTACTCTTTCAGTAGACCACCGGGATACAACAACTGGAATCTCAGCCAGGGAACGGGCTTTGACTGTTAAAGA
ACTGGTTAGCGATAATAGTAAACATACAGATTTCAGGCGACCCGGTCATATTTTCCCCCTCCGCGCCAGGCCAGGCGGGG
TTTTAAGGAGGGCAGGACATACTGAAGCTGCAGTAGATCTGGCCAGGCTGGCTGGTCTGAAACCAGCCGGTGTTATTTGT
GAGATTATAAAAGAAGATGGTACAATGGCCAGGTTACCTGATCTGGAGGAGTTTTCTAAAAAGCATGGACTTAAAATAGT
TACAATTGAAGATTTAATAAAATATCGTAAGTCTAAAGAAAAACTTGTCAAAAAAGAGGCTGAAGCCCAACTTCCAACCA
GGTTTGGTGATTTTAAAATAAAAGTTTATAAGTCTATCATTGGTAACCAGGAACATATTGCCCTGGTAAAAGGTGAGGTA
GCTGGCAAAAAGAATGTTCTGGTAAGAGTACACTCAGAATGTTTAACAGGTGATACCTTTGGCTCTTTAAGATGTGATTG
TGGTCAACAGCTGGCCGCAGCTTTGAAAATGATTGATAAAGAAGGCCATGGTGTTTTGCTATACATGAGACAGGAGGGAA
GAGGGATTGGTCTTTTAAACAAAATAAAGGCATATGCTTTACAGGATAAGGGGATGGATACTGTTGAAGCCAATCTGGCC
CTTGGCTTTCCTCCTGATCTGAGGGATTACGGGATAGGAGCCCAGATTCTGGCAGACCTGGGGTTAACCTCTATACGTCT
TCTTACCAATAACCCACGAAAGATTATCGGACTGGAAGGGTATGGTCTTATGGTTGTAGACAGGGTTCCCATTGAAATTG
AACCCAATGAAACCAATAAATATTACCTTGAGATAAAAAGGGATAAAATGGGTCATTTATTAAATTTAGAAGAAAGGGGT
AAAAATAATGGGTAA

Upstream 100 bases:

>100_bases
TATGTGGTAAATACCCTGGAAAAGGTTTTTTTGAATAATGGTACAGGTATCAACAGGGAATTTCTACGACAGAATGGGTT
TCTATAAGGGGGGTTTTTAA

Downstream 100 bases:

>100_bases
GACTTTTGAAGGAAAATTATTAGGTGAAGGAATAAAGGTTGGAATTGTCGTCAGCAGGTTTAATGAATTTATTTCCAGTA
AACTTCTTGATGGAGCCCTG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNTIEEAIEDIKQGKMVIVVDDEDRENEGDLVMAAEKVTPESINFMIRFARGLVCVPMEEERLRELDLPMMVVNNTDPQE
TGFTLSVDHRDTTTGISARERALTVKELVSDNSKHTDFRRPGHIFPLRARPGGVLRRAGHTEAAVDLARLAGLKPAGVIC
EIIKEDGTMARLPDLEEFSKKHGLKIVTIEDLIKYRKSKEKLVKKEAEAQLPTRFGDFKIKVYKSIIGNQEHIALVKGEV
AGKKNVLVRVHSECLTGDTFGSLRCDCGQQLAAALKMIDKEGHGVLLYMRQEGRGIGLLNKIKAYALQDKGMDTVEANLA
LGFPPDLRDYGIGAQILADLGLTSIRLLTNNPRKIIGLEGYGLMVVDRVPIEIEPNETNKYYLEIKRDKMGHLLNLEERG
KNNG

Sequences:

>Translated_404_residues
MNTIEEAIEDIKQGKMVIVVDDEDRENEGDLVMAAEKVTPESINFMIRFARGLVCVPMEEERLRELDLPMMVVNNTDPQE
TGFTLSVDHRDTTTGISARERALTVKELVSDNSKHTDFRRPGHIFPLRARPGGVLRRAGHTEAAVDLARLAGLKPAGVIC
EIIKEDGTMARLPDLEEFSKKHGLKIVTIEDLIKYRKSKEKLVKKEAEAQLPTRFGDFKIKVYKSIIGNQEHIALVKGEV
AGKKNVLVRVHSECLTGDTFGSLRCDCGQQLAAALKMIDKEGHGVLLYMRQEGRGIGLLNKIKAYALQDKGMDTVEANLA
LGFPPDLRDYGIGAQILADLGLTSIRLLTNNPRKIIGLEGYGLMVVDRVPIEIEPNETNKYYLEIKRDKMGHLLNLEERG
KNNG
>Mature_404_residues
MNTIEEAIEDIKQGKMVIVVDDEDRENEGDLVMAAEKVTPESINFMIRFARGLVCVPMEEERLRELDLPMMVVNNTDPQE
TGFTLSVDHRDTTTGISARERALTVKELVSDNSKHTDFRRPGHIFPLRARPGGVLRRAGHTEAAVDLARLAGLKPAGVIC
EIIKEDGTMARLPDLEEFSKKHGLKIVTIEDLIKYRKSKEKLVKKEAEAQLPTRFGDFKIKVYKSIIGNQEHIALVKGEV
AGKKNVLVRVHSECLTGDTFGSLRCDCGQQLAAALKMIDKEGHGVLLYMRQEGRGIGLLNKIKAYALQDKGMDTVEANLA
LGFPPDLRDYGIGAQILADLGLTSIRLLTNNPRKIIGLEGYGLMVVDRVPIEIEPNETNKYYLEIKRDKMGHLLNLEERG
KNNG

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=199, Percent_Identity=51.2562814070352, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=55.440414507772, Blast_Score=218, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6320695, Length=203, Percent_Identity=48.2758620689655, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=47.9768786127168, Blast_Score=143, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 45035; Mature: 45035

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIEEAIEDIKQGKMVIVVDDEDRENEGDLVMAAEKVTPESINFMIRFARGLVCVPMEE
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCCH
ERLRELDLPMMVVNNTDPQETGFTLSVDHRDTTTGISARERALTVKELVSDNSKHTDFRR
HHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
PGHIFPLRARPGGVLRRAGHTEAAVDLARLAGLKPAGVICEIIKEDGTMARLPDLEEFSK
CCCEEEEECCCCHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCCCHHHHHH
KHGLKIVTIEDLIKYRKSKEKLVKKEAEAQLPTRFGDFKIKVYKSIIGNQEHIALVKGEV
HCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCCEEEEEECCC
AGKKNVLVRVHSECLTGDTFGSLRCDCGQQLAAALKMIDKEGHGVLLYMRQEGRGIGLLN
CCCCCEEEEEECHHCCCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
KIKAYALQDKGMDTVEANLALGFPPDLRDYGIGAQILADLGLTSIRLLTNNPRKIIGLEG
HHHHHHCCCCCCCEEEEEEEECCCCCHHHCCCCHHHHHHCCCEEEEEEECCCCEEEEECC
YGLMVVDRVPIEIEPNETNKYYLEIKRDKMGHLLNLEERGKNNG
CCEEEEECCCEEECCCCCCEEEEEEECCCCCCEECHHHCCCCCC
>Mature Secondary Structure
MNTIEEAIEDIKQGKMVIVVDDEDRENEGDLVMAAEKVTPESINFMIRFARGLVCVPMEE
CCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCEEEECCCH
ERLRELDLPMMVVNNTDPQETGFTLSVDHRDTTTGISARERALTVKELVSDNSKHTDFRR
HHHHHCCCCEEEEECCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
PGHIFPLRARPGGVLRRAGHTEAAVDLARLAGLKPAGVICEIIKEDGTMARLPDLEEFSK
CCCEEEEECCCCHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECCCCHHHHHH
KHGLKIVTIEDLIKYRKSKEKLVKKEAEAQLPTRFGDFKIKVYKSIIGNQEHIALVKGEV
HCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCCEEEEEECCC
AGKKNVLVRVHSECLTGDTFGSLRCDCGQQLAAALKMIDKEGHGVLLYMRQEGRGIGLLN
CCCCCEEEEEECHHCCCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
KIKAYALQDKGMDTVEANLALGFPPDLRDYGIGAQILADLGLTSIRLLTNNPRKIIGLEG
HHHHHHCCCCCCCEEEEEEEECCCCCHHHCCCCHHHHHHCCCEEEEEEECCCCEEEEECC
YGLMVVDRVPIEIEPNETNKYYLEIKRDKMGHLLNLEERGKNNG
CCEEEEECCCEEECCCCCCEEEEEEECCCCCCEECHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA