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The map label for this gene is fmt

Identifier: 220931833

GI number: 220931833

Start: 1080783

End: 1081733

Strand: Direct

Name: fmt

Synonym: Hore_09900

Alternate gene names: 220931833

Gene position: 1080783-1081733 (Clockwise)

Preceding gene: 220931832

Following gene: 220931834

Centisome position: 41.92

GC content: 40.48

Gene sequence:

>951_bases
ATGAATATAGTGTTTATGGGAAGTCCTGATTTTGCAGTACCCGGTCTTGAGAAATTGTATAATGAGCCCGGTATAACAAT
AAAGGCTGTGGTCACCCAGCCTGATCGAAAAAAAGGGAGGGGCCATAAGCTAAGGCCTACTCCGGTAAAACAGATGGCTC
ATAAACTGGGATTAAAGGTGCTTCAGACTGACAATATAAACCGGGAAGAATTTATTACTAATTTAAGGGATTTAAGTCCA
GAAGCTATTGTAGTTGTTGCCTTTGGACAGAAGTTGGGTAAAAAGGTTCTTGAATTACCATCTTACGGGTGTATAAACTT
ACATGCCTCTTTGCTTCCCAGATACCGGGGAGCCAGTCCGATACATCGGGCTATAATAAATGGTGATAAGGTTACTGGGG
TTACTACCATGTATATGGATGAGGGCTGGGATACAGGAGATATTATATATAAAAAAGAAGTCAAAATAAACAGAGAAGAT
ACAGCAGGTACCCTTCATGATAAACTGGCCAGTATCGGTGGGGATTTACTGGTAAAAACCCTTAATGATATTGAAAAGGG
TGTTGCTCCCAGGGAAAAACAGAGTGAAGATAAAGCCAGCTATGCTTATAAAATTGACAGAAAAATCGGGGAACTGGACT
GGTCCAGAAGTAGTGAGGATATATTTAATCTGGTCAGGGGGGTAAATCCCTGGCCCGGTGCCTATACCACCTGGAAGGGT
AAGTTGCTTAAAATCTGGTGGGTTGAACCCCTGAAGTTAACAGTGACTGAGAATGATAAAAAGATGGAAGCAGGGGAAGT
AATTACAGCCAGTCAGGAGGATGGTATAATTGTGAAAACCGGGGATGATGCTGTAAAAATTATTGAATTACAGCTGGCTG
GAAGAAAAAAAATTACTGCTGACAAATTTGTTTTAGGTTATAATATAAAAGAAGGAGATAAACTTGGCTAA

Upstream 100 bases:

>100_bases
CAGGGCCTTTCAGCATGAAATTGATCATCTAAACGGAATTTTATTTATTGATAAAGTGGTCAGGATTGGAGAAGAAATGA
TTTAAGAAGGTGGTATTGGC

Downstream 100 bases:

>100_bases
AGGAGGTATGTTTTATGTATATGCCCTTTTTCTATGATCCGACTGCCATTCTTTTGATACCGGCTATTATTATTGCCATC
TATGCTCAGGTTAAGGTTAA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNIVFMGSPDFAVPGLEKLYNEPGITIKAVVTQPDRKKGRGHKLRPTPVKQMAHKLGLKVLQTDNINREEFITNLRDLSP
EAIVVVAFGQKLGKKVLELPSYGCINLHASLLPRYRGASPIHRAIINGDKVTGVTTMYMDEGWDTGDIIYKKEVKINRED
TAGTLHDKLASIGGDLLVKTLNDIEKGVAPREKQSEDKASYAYKIDRKIGELDWSRSSEDIFNLVRGVNPWPGAYTTWKG
KLLKIWWVEPLKLTVTENDKKMEAGEVITASQEDGIIVKTGDDAVKIIELQLAGRKKITADKFVLGYNIKEGDKLG

Sequences:

>Translated_316_residues
MNIVFMGSPDFAVPGLEKLYNEPGITIKAVVTQPDRKKGRGHKLRPTPVKQMAHKLGLKVLQTDNINREEFITNLRDLSP
EAIVVVAFGQKLGKKVLELPSYGCINLHASLLPRYRGASPIHRAIINGDKVTGVTTMYMDEGWDTGDIIYKKEVKINRED
TAGTLHDKLASIGGDLLVKTLNDIEKGVAPREKQSEDKASYAYKIDRKIGELDWSRSSEDIFNLVRGVNPWPGAYTTWKG
KLLKIWWVEPLKLTVTENDKKMEAGEVITASQEDGIIVKTGDDAVKIIELQLAGRKKITADKFVLGYNIKEGDKLG
>Mature_316_residues
MNIVFMGSPDFAVPGLEKLYNEPGITIKAVVTQPDRKKGRGHKLRPTPVKQMAHKLGLKVLQTDNINREEFITNLRDLSP
EAIVVVAFGQKLGKKVLELPSYGCINLHASLLPRYRGASPIHRAIINGDKVTGVTTMYMDEGWDTGDIIYKKEVKINRED
TAGTLHDKLASIGGDLLVKTLNDIEKGVAPREKQSEDKASYAYKIDRKIGELDWSRSSEDIFNLVRGVNPWPGAYTTWKG
KLLKIWWVEPLKLTVTENDKKMEAGEVITASQEDGIIVKTGDDAVKIIELQLAGRKKITADKFVLGYNIKEGDKLG

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=318, Percent_Identity=27.6729559748428, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI21614513, Length=320, Percent_Identity=27.8125, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI238814322, Length=288, Percent_Identity=27.4305555555556, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1789683, Length=304, Percent_Identity=41.4473684210526, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788589, Length=316, Percent_Identity=28.1645569620253, Blast_Score=131, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI133930964, Length=328, Percent_Identity=28.6585365853659, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319458, Length=278, Percent_Identity=28.4172661870504, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI45550868, Length=318, Percent_Identity=30.8176100628931, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI28571984, Length=237, Percent_Identity=33.3333333333333, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585660, Length=241, Percent_Identity=27.8008298755187, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_HALOH (B8CWS7)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508741.1
- ProteinModelPortal:   B8CWS7
- SMR:   B8CWS7
- GeneID:   7314578
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_09900
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 35194; Mature: 35194

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVFMGSPDFAVPGLEKLYNEPGITIKAVVTQPDRKKGRGHKLRPTPVKQMAHKLGLKV
CEEEEECCCCCCCCCHHHHHCCCCCEEEEEEECCCHHCCCCCCCCCCHHHHHHHHHCEEE
LQTDNINREEFITNLRDLSPEAIVVVAFGQKLGKKVLELPSYGCINLHASLLPRYRGASP
EECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCH
IHRAIINGDKVTGVTTMYMDEGWDTGDIIYKKEVKINREDTAGTLHDKLASIGGDLLVKT
HHHHHHCCCCCCEEEEEEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHH
LNDIEKGVAPREKQSEDKASYAYKIDRKIGELDWSRSSEDIFNLVRGVNPWPGAYTTWKG
HHHHHHCCCCCCCCCCCHHHHEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEECCC
KLLKIWWVEPLKLTVTENDKKMEAGEVITASQEDGIIVKTGDDAVKIIELQLAGRKKITA
CEEEEEEECCEEEEEECCCCCCCCCCEEEECCCCCEEEEECCCEEEEEEEEECCCCCCCC
DKFVLGYNIKEGDKLG
CEEEEEECCCCCCCCC
>Mature Secondary Structure
MNIVFMGSPDFAVPGLEKLYNEPGITIKAVVTQPDRKKGRGHKLRPTPVKQMAHKLGLKV
CEEEEECCCCCCCCCHHHHHCCCCCEEEEEEECCCHHCCCCCCCCCCHHHHHHHHHCEEE
LQTDNINREEFITNLRDLSPEAIVVVAFGQKLGKKVLELPSYGCINLHASLLPRYRGASP
EECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCEEEEHHHHCCCCCCCCH
IHRAIINGDKVTGVTTMYMDEGWDTGDIIYKKEVKINREDTAGTLHDKLASIGGDLLVKT
HHHHHHCCCCCCEEEEEEEECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCHHHHHHH
LNDIEKGVAPREKQSEDKASYAYKIDRKIGELDWSRSSEDIFNLVRGVNPWPGAYTTWKG
HHHHHHCCCCCCCCCCCHHHHEEEEHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEECCC
KLLKIWWVEPLKLTVTENDKKMEAGEVITASQEDGIIVKTGDDAVKIIELQLAGRKKITA
CEEEEEEECCEEEEEECCCCCCCCCCEEEECCCCCEEEEECCCEEEEEEEEECCCCCCCC
DKFVLGYNIKEGDKLG
CEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA