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The map label for this gene is pyrP [H]

Identifier: 220931779

GI number: 220931779

Start: 1008987

End: 1010288

Strand: Direct

Name: pyrP [H]

Synonym: Hore_09360

Alternate gene names: 220931779

Gene position: 1008987-1010288 (Clockwise)

Preceding gene: 220931778

Following gene: 220931780

Centisome position: 39.14

GC content: 40.63

Gene sequence:

>1302_bases
ATGAAATTTATAAACCAGATGAAGAATAACATAACAAAATTAAGAGAAAATAATATTAACAGTTTTCAATGTTTAATGAT
GGCATTACAGCACATATTTGCCATGTTTGGGGCTACTGTATTGGTACCTGCCCTGACCGGATTAGACCCTTCGGTAGCAT
TGTTCACCTCCGGGCTGGGGACACTGGTATTCCATATAATTACAAAAGGAAAAGTTCCGGCCTATCTGGGTTCATCTTTT
GCCTTTATTGCGCCGATAATTGCGGCCAGGGCAAAGGCCGGTGTTGGTGGAGCTATGGTAGGAATTATAACAGCGGGAAT
AATTTATATCTTAATGGCAGCTTTAATAAAGTTAATCGGACCAAAATTTTTTAAAAAACTTTTACCCCCGGTTGTGGTAG
GACCGGTTATTATAACTATTGGACTTGGTCTGGCACCGGTAGCTAAAGACTATGCCTCTGAACACCTGTTAACTGCCCTT
GTAACTCTGGTTATTACCATAATCTTTAGTGTTTTTGCCAGGGGTATATTCAAAGTAATACCTGTCCTGATGGGGATCAT
CGGTGGATACATCTTTGCCAGTACTCAGGGTCTGGTTGATTTCACTCAGGTAAGGGATGCTGCCTTAATTTCTGTGCCTC
ACTTTACCTTTCCTGATTTTAGTGGCAGTCTACAGGCAATTTCTTTAATAGCACCCATTGCCCTGGTTACCATGGTTGAG
CATCTCGGTGATGTTCTGGCTCTCGGTTCTACAACAAAAGAAGATTATGTAACTGAACCCGGTTTGCACCGCACCCTTCT
TGGTGATGGGATTGCAACAGCCCTGGCTGGATTACTGGGTGGTCCTCCAAATACGACATATGGGGAAAATATCGGGGTTC
TGGCAATTACCAGGATATATAATCCACTGATAATTGAGTTAACAGCTATTATGGTTCTGGCCTTCAGCTTTATAGAAAAA
ATTGGAGCAGTAATCAGAACAATTCCCCAGGCGGTTATGGGTGGCATAGTTTTTCTCCTCTTTGGGATGATCGCTTCTAT
CGGACTCAGGACTTTAATTGAGAATAAGGTGAATTTTTCTGATAACCGTAACCTGGTTATTGTTTCAGTGATACTGGTTG
TTGGTATAAGTAATTTAACAATAACAATCGGGCGTTTTGAATTTGCTGGAATGGGACTGGCTGCTCTGGTTGGGATTATA
TTGAATTTGCTCCTTAATATCCTTCCTGAACTATTAAATCCTGAATACAAAAAACAGGTTATTAAAAATGAAATAAATGA
GCTGGGATATGAGACTAACTAA

Upstream 100 bases:

>100_bases
CAGTCTGTGGCTGGTAAGGAGTTTTTTTGTATATTATTAAGACTGTTAAACAGTCTGGTATTGAAACAAATGAACTGAAA
ACTTAACAGGAGGGATATTA

Downstream 100 bases:

>100_bases
TAATACAGGAACCCTGATGGTAATCCATCAGGGTTTTCTTTAAATGCTTTAACCTGAACCAGGCCACTTAACACGTTAAT
AAAAATGTATTATTAAGGAA

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKFINQMKNNITKLRENNINSFQCLMMALQHIFAMFGATVLVPALTGLDPSVALFTSGLGTLVFHIITKGKVPAYLGSSF
AFIAPIIAARAKAGVGGAMVGIITAGIIYILMAALIKLIGPKFFKKLLPPVVVGPVIITIGLGLAPVAKDYASEHLLTAL
VTLVITIIFSVFARGIFKVIPVLMGIIGGYIFASTQGLVDFTQVRDAALISVPHFTFPDFSGSLQAISLIAPIALVTMVE
HLGDVLALGSTTKEDYVTEPGLHRTLLGDGIATALAGLLGGPPNTTYGENIGVLAITRIYNPLIIELTAIMVLAFSFIEK
IGAVIRTIPQAVMGGIVFLLFGMIASIGLRTLIENKVNFSDNRNLVIVSVILVVGISNLTITIGRFEFAGMGLAALVGII
LNLLLNILPELLNPEYKKQVIKNEINELGYETN

Sequences:

>Translated_433_residues
MKFINQMKNNITKLRENNINSFQCLMMALQHIFAMFGATVLVPALTGLDPSVALFTSGLGTLVFHIITKGKVPAYLGSSF
AFIAPIIAARAKAGVGGAMVGIITAGIIYILMAALIKLIGPKFFKKLLPPVVVGPVIITIGLGLAPVAKDYASEHLLTAL
VTLVITIIFSVFARGIFKVIPVLMGIIGGYIFASTQGLVDFTQVRDAALISVPHFTFPDFSGSLQAISLIAPIALVTMVE
HLGDVLALGSTTKEDYVTEPGLHRTLLGDGIATALAGLLGGPPNTTYGENIGVLAITRIYNPLIIELTAIMVLAFSFIEK
IGAVIRTIPQAVMGGIVFLLFGMIASIGLRTLIENKVNFSDNRNLVIVSVILVVGISNLTITIGRFEFAGMGLAALVGII
LNLLLNILPELLNPEYKKQVIKNEINELGYETN
>Mature_433_residues
MKFINQMKNNITKLRENNINSFQCLMMALQHIFAMFGATVLVPALTGLDPSVALFTSGLGTLVFHIITKGKVPAYLGSSF
AFIAPIIAARAKAGVGGAMVGIITAGIIYILMAALIKLIGPKFFKKLLPPVVVGPVIITIGLGLAPVAKDYASEHLLTAL
VTLVITIIFSVFARGIFKVIPVLMGIIGGYIFASTQGLVDFTQVRDAALISVPHFTFPDFSGSLQAISLIAPIALVTMVE
HLGDVLALGSTTKEDYVTEPGLHRTLLGDGIATALAGLLGGPPNTTYGENIGVLAITRIYNPLIIELTAIMVLAFSFIEK
IGAVIRTIPQAVMGGIVFLLFGMIASIGLRTLIENKVNFSDNRNLVIVSVILVVGISNLTITIGRFEFAGMGLAALVGII
LNLLLNILPELLNPEYKKQVIKNEINELGYETN

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=453, Percent_Identity=23.841059602649, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI40316845, Length=453, Percent_Identity=23.841059602649, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI44680145, Length=438, Percent_Identity=22.6027397260274, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI44680143, Length=442, Percent_Identity=22.3981900452489, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788843, Length=405, Percent_Identity=40.4938271604938, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI87081818, Length=414, Percent_Identity=40.5797101449275, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082181, Length=447, Percent_Identity=25.9507829977629, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082178, Length=382, Percent_Identity=25.9162303664921, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790087, Length=396, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17558856, Length=288, Percent_Identity=23.2638888888889, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=226, Percent_Identity=25.6637168141593, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356175, Length=429, Percent_Identity=26.8065268065268, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46083; Mature: 46083

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCCC
>Mature Secondary Structure
MKFINQMKNNITKLRENNINSFQCLMMALQHIFAMFGATVLVPALTGLDPSVALFTSGLG
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TLVFHIITKGKVPAYLGSSFAFIAPIIAARAKAGVGGAMVGIITAGIIYILMAALIKLIG
HHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
PKFFKKLLPPVVVGPVIITIGLGLAPVAKDYASEHLLTALVTLVITIIFSVFARGIFKVI
HHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVLMGIIGGYIFASTQGLVDFTQVRDAALISVPHFTFPDFSGSLQAISLIAPIALVTMVE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
HLGDVLALGSTTKEDYVTEPGLHRTLLGDGIATALAGLLGGPPNTTYGENIGVLAITRIY
HHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEHHHHH
NPLIIELTAIMVLAFSFIEKIGAVIRTIPQAVMGGIVFLLFGMIASIGLRTLIENKVNFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DNRNLVIVSVILVVGISNLTITIGRFEFAGMGLAALVGIILNLLLNILPELLNPEYKKQV
CCCCCHHHHHHHHHCCCCCEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
IKNEINELGYETN
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1709162; 8206849; 9384377 [H]