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The map label for this gene is rnhA [H]

Identifier: 220931738

GI number: 220931738

Start: 966757

End: 967566

Strand: Direct

Name: rnhA [H]

Synonym: Hore_08950

Alternate gene names: 220931738

Gene position: 966757-967566 (Clockwise)

Preceding gene: 220931737

Following gene: 220931740

Centisome position: 37.5

GC content: 32.72

Gene sequence:

>810_bases
ATGAAGATGTTTAAAATTAAAGCTGTCGCTTATGTAAAAACCCCGATTAAAAATAAAATAAACCAAAAACAAATATCCAA
TTCCAGTAATTATTATATTAAGCTTAAGGAAGAATTGAAAAATAAAATAAACATTTATAAAAATAATAAACAATTATATA
TTATTTATTATGATTGTGATACCGTTAACAGTTTAAATAATCTGGCTATAGATCTTGTTAAAGTAAAGGATTTAAAAAAC
AGTAAGTTGATTATAGATCCAGTCGATATCAGGGATGAGACCCCAGTTCTTGATATTATACCCTGTTGTGATAATAATGG
AGTTAATTTTAAAGAGAGGGATATTTCAATAACAAGGGAGATGACAAAGATGGAACCAATTAAAGTATATACAGATGGTG
CCTGTTCCGGGAACCCGGGACCAGGTGGTTATGCTGCTGTTATATTGAATCAGGGGCAGGAAAGAGTAGTAGCCGGGTAT
GAAGATGAAACCACCAATAACAGGATGGAACTGAGGGCTGTAATAGAAGCTTTAAAAGAGATAAAAGAGGGTAGAGAGGT
CCATGTTTATTCTGATTCAAGTTACATAATAAACGGTATGAAGAGCTGGATTGATGACTGGAAAAAACGGGGGTGGAAAA
CAAGTAGTAATAAACCTGTTTCCAATAAGGATCTGTGGTTAAAGCTTGATAATCTATCCAGTAAATTTAACATTAAGTTT
AAAAAAGTAAAAGGACATTCAGGTGATGAATATAACGAAAAGGCTGATTCTCTGGCCAGGAAACAGATAGAAGAGAATAG
TCCTGAATAA

Upstream 100 bases:

>100_bases
ATAAATTTTGCATATCCAACCCAGCGTCTGTATTTAAAAGAGTTATCTAAATATAATGTAATGGGAAACCGGTCTAACGG
AGAAGGGATTAAAGGTGGAG

Downstream 100 bases:

>100_bases
AAAAGAATCATAAACTTTTTAGTTATAAAATTTGTTTAATATAATAAAACAGGTAAATACCTTTTAATTTATGGTATTTA
CCCTGTGTTAAACTTTAATT

Product: Ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKMFKIKAVAYVKTPIKNKINQKQISNSSNYYIKLKEELKNKINIYKNNKQLYIIYYDCDTVNSLNNLAIDLVKVKDLKN
SKLIIDPVDIRDETPVLDIIPCCDNNGVNFKERDISITREMTKMEPIKVYTDGACSGNPGPGGYAAVILNQGQERVVAGY
EDETTNNRMELRAVIEALKEIKEGREVHVYSDSSYIINGMKSWIDDWKKRGWKTSSNKPVSNKDLWLKLDNLSSKFNIKF
KKVKGHSGDEYNEKADSLARKQIEENSPE

Sequences:

>Translated_269_residues
MKMFKIKAVAYVKTPIKNKINQKQISNSSNYYIKLKEELKNKINIYKNNKQLYIIYYDCDTVNSLNNLAIDLVKVKDLKN
SKLIIDPVDIRDETPVLDIIPCCDNNGVNFKERDISITREMTKMEPIKVYTDGACSGNPGPGGYAAVILNQGQERVVAGY
EDETTNNRMELRAVIEALKEIKEGREVHVYSDSSYIINGMKSWIDDWKKRGWKTSSNKPVSNKDLWLKLDNLSSKFNIKF
KKVKGHSGDEYNEKADSLARKQIEENSPE
>Mature_269_residues
MKMFKIKAVAYVKTPIKNKINQKQISNSSNYYIKLKEELKNKINIYKNNKQLYIIYYDCDTVNSLNNLAIDLVKVKDLKN
SKLIIDPVDIRDETPVLDIIPCCDNNGVNFKERDISITREMTKMEPIKVYTDGACSGNPGPGGYAAVILNQGQERVVAGY
EDETTNNRMELRAVIEALKEIKEGREVHVYSDSSYIINGMKSWIDDWKKRGWKTSSNKPVSNKDLWLKLDNLSSKFNIKF
KKVKGHSGDEYNEKADSLARKQIEENSPE

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=145, Percent_Identity=36.551724137931, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=48.9051094890511, Blast_Score=148, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI115532542, Length=227, Percent_Identity=31.2775330396476, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17505482, Length=137, Percent_Identity=32.8467153284672, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137476, Length=140, Percent_Identity=37.8571428571429, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45552509, Length=140, Percent_Identity=37.8571428571429, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 30856; Mature: 30856

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMFKIKAVAYVKTPIKNKINQKQISNSSNYYIKLKEELKNKINIYKNNKQLYIIYYDCD
CCEEEEEEEEEEECCHHHCCCHHHHCCCCCEEEEEHHHHCCCEEEEECCCEEEEEEEECC
TVNSLNNLAIDLVKVKDLKNSKLIIDPVDIRDETPVLDIIPCCDNNGVNFKERDISITRE
CCCCCCHHEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCHHHHHH
MTKMEPIKVYTDGACSGNPGPGGYAAVILNQGQERVVAGYEDETTNNRMELRAVIEALKE
HHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHH
IKEGREVHVYSDSSYIINGMKSWIDDWKKRGWKTSSNKPVSNKDLWLKLDNLSSKFNIKF
HHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
KKVKGHSGDEYNEKADSLARKQIEENSPE
EEECCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKMFKIKAVAYVKTPIKNKINQKQISNSSNYYIKLKEELKNKINIYKNNKQLYIIYYDCD
CCEEEEEEEEEEECCHHHCCCHHHHCCCCCEEEEEHHHHCCCEEEEECCCEEEEEEEECC
TVNSLNNLAIDLVKVKDLKNSKLIIDPVDIRDETPVLDIIPCCDNNGVNFKERDISITRE
CCCCCCHHEEEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEECCCHHHHHH
MTKMEPIKVYTDGACSGNPGPGGYAAVILNQGQERVVAGYEDETTNNRMELRAVIEALKE
HHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHH
IKEGREVHVYSDSSYIINGMKSWIDDWKKRGWKTSSNKPVSNKDLWLKLDNLSSKFNIKF
HHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCEEEEEE
KKVKGHSGDEYNEKADSLARKQIEENSPE
EEECCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA