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The map label for this gene is pyrH [H]

Identifier: 220931611

GI number: 220931611

Start: 824258

End: 824977

Strand: Direct

Name: pyrH [H]

Synonym: Hore_07670

Alternate gene names: 220931611

Gene position: 824258-824977 (Clockwise)

Preceding gene: 220931610

Following gene: 220931612

Centisome position: 31.97

GC content: 42.5

Gene sequence:

>720_bases
ATGGGGGAAAAAGCAGCATATTCACGTGTCCTTTTGAAAATAAGTGGAGAGGCTCTGGCTGGAGAAGAAGGTTTTGGAAT
AGATCCTGTTATTATTAAGGGGATTGCCAGGCAAATATTTGAAGTGGTTACAGATACTGGCGTAGAAATGGCTATAGTTG
TCGGAGGCGGAAACATATTCAGGGGTGTGGCCGGTAGTGCTAAAGGTATGGACCGGGGAACTGCTGATTATATGGGAATG
CTGGCTACAGTAATAAATGCGCTTGCCCTCCAGGATGCCATTGAAAAACTGGGTCTTGAAACCAGGGTTCAATCGGCCAT
TGAAATGAGACAGGTGGCTGAGCCATATATCAGAAGAAGGGCTATTAGACATCTGGAAAAGGGAAGGGTTGTTATTTTTG
CTGCTGGAACCGGTAATCCGTTCTTTTCCACTGATACCACAGCAGCCTTGAGGGCTGCTGAAATTTCAGCTGATGCTATA
TTGATGGCAAAAAATGTTGATGGAGTTTATGATTCTGATCCTGCTGATAATCCAGATGCTGTTAAATATAAAGAACTGGC
ATATATAGATGTGTTGAGCCGGTCTTTAAGGGTAATGGATTCTACAGCTGTATCCCTGTGTATGGATAACAATATTCCCC
TGATAGTATTTGGTGTGAAAGAAGAGGGTAATATTAAAAAGGCAATCCTTGGAGAAGAAATCGGGACTTTTGTAAGATAA

Upstream 100 bases:

>100_bases
TATTTTTTAATATTAAAATTAATAAATTTGATTAAAGTTTTGTCTTAAAGAAAAGGAAAAAATAATTCTTTATCGAATAA
ATAATATTGGAGGTTAAGCA

Downstream 100 bases:

>100_bases
AGAAGTAATTTATAAAATAAAAACAATTAGTAAATAAATTATCCTTAAAAAGCTATTTTATATAACTGTGTTATAACTAA
GCTATATAATTTATTTAGGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MGEKAAYSRVLLKISGEALAGEEGFGIDPVIIKGIARQIFEVVTDTGVEMAIVVGGGNIFRGVAGSAKGMDRGTADYMGM
LATVINALALQDAIEKLGLETRVQSAIEMRQVAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEISADAI
LMAKNVDGVYDSDPADNPDAVKYKELAYIDVLSRSLRVMDSTAVSLCMDNNIPLIVFGVKEEGNIKKAILGEEIGTFVR

Sequences:

>Translated_239_residues
MGEKAAYSRVLLKISGEALAGEEGFGIDPVIIKGIARQIFEVVTDTGVEMAIVVGGGNIFRGVAGSAKGMDRGTADYMGM
LATVINALALQDAIEKLGLETRVQSAIEMRQVAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEISADAI
LMAKNVDGVYDSDPADNPDAVKYKELAYIDVLSRSLRVMDSTAVSLCMDNNIPLIVFGVKEEGNIKKAILGEEIGTFVR
>Mature_238_residues
GEKAAYSRVLLKISGEALAGEEGFGIDPVIIKGIARQIFEVVTDTGVEMAIVVGGGNIFRGVAGSAKGMDRGTADYMGML
ATVINALALQDAIEKLGLETRVQSAIEMRQVAEPYIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEISADAIL
MAKNVDGVYDSDPADNPDAVKYKELAYIDVLSRSLRVMDSTAVSLCMDNNIPLIVFGVKEEGNIKKAILGEEIGTFVR

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=46.3829787234043, Blast_Score=224, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25572; Mature: 25441

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEKAAYSRVLLKISGEALAGEEGFGIDPVIIKGIARQIFEVVTDTGVEMAIVVGGGNIF
CCCHHHHHEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHH
RGVAGSAKGMDRGTADYMGMLATVINALALQDAIEKLGLETRVQSAIEMRQVAEPYIRRR
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEISADAILMAKNVDGVYDSDPADNPDA
HHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
VKYKELAYIDVLSRSLRVMDSTAVSLCMDNNIPLIVFGVKEEGNIKKAILGEEIGTFVR
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GEKAAYSRVLLKISGEALAGEEGFGIDPVIIKGIARQIFEVVTDTGVEMAIVVGGGNIF
CCHHHHHEEEEEECCCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHH
RGVAGSAKGMDRGTADYMGMLATVINALALQDAIEKLGLETRVQSAIEMRQVAEPYIRRR
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AIRHLEKGRVVIFAAGTGNPFFSTDTTAALRAAEISADAILMAKNVDGVYDSDPADNPDA
HHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCC
VKYKELAYIDVLSRSLRVMDSTAVSLCMDNNIPLIVFGVKEEGNIKKAILGEEIGTFVR
CHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA