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The map label for this gene is pbpA [H]

Identifier: 220931413

GI number: 220931413

Start: 621137

End: 623557

Strand: Reverse

Name: pbpA [H]

Synonym: Hore_05690

Alternate gene names: 220931413

Gene position: 623557-621137 (Counterclockwise)

Preceding gene: 220931433

Following gene: 220931398

Centisome position: 24.19

GC content: 40.85

Gene sequence:

>2421_bases
ATGGCCAAACAGAGAAAGAACTATATTTTTGCTACCATTATTTTGATTTTTGCTCTTATTTTTGGTCTTGTCATTGGATC
TATAACCTGGATTATTAAAAATACTCCGGATATTACAAATTATAAAGGCCCCAATGAGGCCACTTTAATATATAGTGCTG
ATGGACAACTTTTAACCAAGCTTTACCGGGAAAACAGGGTCTACGTTCCCCTGGAAAGAATACCTGTTGACCTTCAAAAT
GCTATTGTTGCTATTGAGGATACTAAATTTTATGCCCATCATGGTATTGATTTCTGGGGAATTCCCCGGGCTTTAATAAC
CAATATCAAAGAAGGAAGAATAGCCCAGGGTTTTAGTACCATTACTATGCAGCTTGCTGAAAATGCCCTCTTCCATAGGC
AACAGAGAACCTTTTACCGTAAAATTCAGGAAATTTATCTGGCCTTACAATTTGAAAGACTCTATACAAAACCTGAAATC
CTTGAAATGTATTTAAATGAAATCTTTTTAGGACATAGTGCCTATGGTGTTGAGACTGCGGCCCAGCAATATTTTGGAAA
ACATGTCTGGGAGCTTGACTTAAGTGAGTGTGCTTTAGTCGCTGGACTCCCTAAAGCACCTAACTATTACTCTCCCTTTA
ATAACATTGATGCTGCCAAAACAAGGCGCAATGTAGTTTTAAACCGGATGTTAGAACTGGGTTATATTACCAGAGAAGAA
TATGAAAGTGCTCGAAAACAGGATATAATAATAAAGCCATCAGAACCGAAAAAAGAGAATACGGCCCCCTATTTTATCAG
ATATGTCAGGGACAGGTTAATAGACCGTTTCGGGGCCCAGATGGTTTATGGTGGTGGGTTAAAGGTATATACAACCCTTG
ACCTCGAAATGCAAAAAACAGCTGAATCTACCATTAAAAAAGCCATTGAAAATAAATACTTACCTACTGTTGAAAGGGAT
AATACCCCGGATAAATTACAACCCCAGCTGGCCCTGATTACTATTGAACCTCAGACCGGTGCCATCAGGGCTATGGTTGG
AGGAAGAGGAAATGATCAATTTAACAGAGCAACCCAGGCCGTAAGACAGCCAGGCTCTGCTTTCAAACCCTTTGTTTATA
CAACTGCTATTAAACAGGGCTGGTCACCGGGGTCAGTTATCAATGATATGCCCATGTTGGCCCATAAAGAGCAGGGAGAA
CCCCTCTCCATCTGGCCCAGTAATTTTGAAGACAAATACCGCGGTTATGTTTCATTACGTACCGCCCTGAGATATTCTAT
AAATGTGGCTGCAGTTAAATTGATCAAACAGGTTGGGGTCAACAATACTATTAAAACTGCAGAAGAAATGGGGATATCCA
CCTTTCAGCCAGCCGACAATAAAGAATCACATCTATCACTGGCCCTCGGGGGGTTGAATAAAGGGGTCACCCCCATGGAA
ATGGCCTCTGCCTATGGTGTCTTTGCCAACAGAGGTATCTGGGTAGAACCCTATGTTATTACCAGAGTTATGGACCGGAG
AAATAATGTAATCTATGAAGCCCATCCTGATAAAAAAATAGTGTTATCTGAGGATGTAGCTTATCTCATGACCAATATGC
TGGAATCTGTTATTAGCGGTGGAACCGGATGGAGAGCCAGACTGGGAAGACCAGTAGCCGGTAAAACAGGAACAACCAAT
AATTATACAGATGCCTGGTTTGTTGGTTTCACACCAGATCTTGTCACCAGTGTCTGGATAGGGGAAGATAACCTCCATCC
CATGGAATATGACCAAAAGGACGAGAACGGTAATTATCTATTTACTGAAAATGGCCGCCCCAAAATAATATCCAGTGCTG
AAGCCGCCCAGCTATGGGGGAATTATATGCGCCAGGTAGTTAAAAATAGAGAGGTAAAATACTTTAATGTTCCTGATAAT
ATCGTTAAGGCAGAGATTGACCCGGTAACCGGGTTGTTACCCAATAAATATACCCCCAGGGTTGTAAAAGAAATATTCCG
TAAACACAATGTCCCTACCGAAGTTGAAAATCTACATGAACCCATAGTCACTGAAAAAATAGATAAAGAAAGTGGCCTTC
TCGCCACACCTAACTGCCCACGGGAAAATGTTGTTGAATACAGTTACTTTGCCAGCAGTGGAATCAGGGTTGGACCTGCT
ACCATTGAATTCGGGGGAATTAAAAAGGAAAAAGATGAAGATGAAAATGAAGAAGAACAAATTCAGGAAGTAATTGAAGG
AACCTATATTGTTGATAAAGGAGAGCCAGTACAAAAAATAAACCCGGAAACCGGGGTTCCCATAACAAATAACGGGCAGG
TAATCTATGAAAGAATACCTACCCGTAAGTGTGACCTCCACGGTAATGGACAGCAGAATTTCTTTGATAACCTCTGGGAT
ATGTTTAAATTTAATAATTAG

Upstream 100 bases:

>100_bases
ATATTTTCTTTATTATAACAGAACATGGGGGCCTCTAACAAGGGGTATTAAACTAAAGGTTTTTATGTTATAATATGTGA
TAGTGAGGGGAGGAAAGTTA

Downstream 100 bases:

>100_bases
GATTTGAGGTCAGCAATTGTCACCCCACTCCCACCTTCTTCCTGCCTTCCCAGGCGGTAAGAGGTGATGTGGGGGTTTTT
TTCTAATACAGTATGAACAG

Product: penicillin-binding protein, 1A family

Products: NA

Alternate protein names: PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MAKQRKNYIFATIILIFALIFGLVIGSITWIIKNTPDITNYKGPNEATLIYSADGQLLTKLYRENRVYVPLERIPVDLQN
AIVAIEDTKFYAHHGIDFWGIPRALITNIKEGRIAQGFSTITMQLAENALFHRQQRTFYRKIQEIYLALQFERLYTKPEI
LEMYLNEIFLGHSAYGVETAAQQYFGKHVWELDLSECALVAGLPKAPNYYSPFNNIDAAKTRRNVVLNRMLELGYITREE
YESARKQDIIIKPSEPKKENTAPYFIRYVRDRLIDRFGAQMVYGGGLKVYTTLDLEMQKTAESTIKKAIENKYLPTVERD
NTPDKLQPQLALITIEPQTGAIRAMVGGRGNDQFNRATQAVRQPGSAFKPFVYTTAIKQGWSPGSVINDMPMLAHKEQGE
PLSIWPSNFEDKYRGYVSLRTALRYSINVAAVKLIKQVGVNNTIKTAEEMGISTFQPADNKESHLSLALGGLNKGVTPME
MASAYGVFANRGIWVEPYVITRVMDRRNNVIYEAHPDKKIVLSEDVAYLMTNMLESVISGGTGWRARLGRPVAGKTGTTN
NYTDAWFVGFTPDLVTSVWIGEDNLHPMEYDQKDENGNYLFTENGRPKIISSAEAAQLWGNYMRQVVKNREVKYFNVPDN
IVKAEIDPVTGLLPNKYTPRVVKEIFRKHNVPTEVENLHEPIVTEKIDKESGLLATPNCPRENVVEYSYFASSGIRVGPA
TIEFGGIKKEKDEDENEEEQIQEVIEGTYIVDKGEPVQKINPETGVPITNNGQVIYERIPTRKCDLHGNGQQNFFDNLWD
MFKFNN

Sequences:

>Translated_806_residues
MAKQRKNYIFATIILIFALIFGLVIGSITWIIKNTPDITNYKGPNEATLIYSADGQLLTKLYRENRVYVPLERIPVDLQN
AIVAIEDTKFYAHHGIDFWGIPRALITNIKEGRIAQGFSTITMQLAENALFHRQQRTFYRKIQEIYLALQFERLYTKPEI
LEMYLNEIFLGHSAYGVETAAQQYFGKHVWELDLSECALVAGLPKAPNYYSPFNNIDAAKTRRNVVLNRMLELGYITREE
YESARKQDIIIKPSEPKKENTAPYFIRYVRDRLIDRFGAQMVYGGGLKVYTTLDLEMQKTAESTIKKAIENKYLPTVERD
NTPDKLQPQLALITIEPQTGAIRAMVGGRGNDQFNRATQAVRQPGSAFKPFVYTTAIKQGWSPGSVINDMPMLAHKEQGE
PLSIWPSNFEDKYRGYVSLRTALRYSINVAAVKLIKQVGVNNTIKTAEEMGISTFQPADNKESHLSLALGGLNKGVTPME
MASAYGVFANRGIWVEPYVITRVMDRRNNVIYEAHPDKKIVLSEDVAYLMTNMLESVISGGTGWRARLGRPVAGKTGTTN
NYTDAWFVGFTPDLVTSVWIGEDNLHPMEYDQKDENGNYLFTENGRPKIISSAEAAQLWGNYMRQVVKNREVKYFNVPDN
IVKAEIDPVTGLLPNKYTPRVVKEIFRKHNVPTEVENLHEPIVTEKIDKESGLLATPNCPRENVVEYSYFASSGIRVGPA
TIEFGGIKKEKDEDENEEEQIQEVIEGTYIVDKGEPVQKINPETGVPITNNGQVIYERIPTRKCDLHGNGQQNFFDNLWD
MFKFNN
>Mature_805_residues
AKQRKNYIFATIILIFALIFGLVIGSITWIIKNTPDITNYKGPNEATLIYSADGQLLTKLYRENRVYVPLERIPVDLQNA
IVAIEDTKFYAHHGIDFWGIPRALITNIKEGRIAQGFSTITMQLAENALFHRQQRTFYRKIQEIYLALQFERLYTKPEIL
EMYLNEIFLGHSAYGVETAAQQYFGKHVWELDLSECALVAGLPKAPNYYSPFNNIDAAKTRRNVVLNRMLELGYITREEY
ESARKQDIIIKPSEPKKENTAPYFIRYVRDRLIDRFGAQMVYGGGLKVYTTLDLEMQKTAESTIKKAIENKYLPTVERDN
TPDKLQPQLALITIEPQTGAIRAMVGGRGNDQFNRATQAVRQPGSAFKPFVYTTAIKQGWSPGSVINDMPMLAHKEQGEP
LSIWPSNFEDKYRGYVSLRTALRYSINVAAVKLIKQVGVNNTIKTAEEMGISTFQPADNKESHLSLALGGLNKGVTPMEM
ASAYGVFANRGIWVEPYVITRVMDRRNNVIYEAHPDKKIVLSEDVAYLMTNMLESVISGGTGWRARLGRPVAGKTGTTNN
YTDAWFVGFTPDLVTSVWIGEDNLHPMEYDQKDENGNYLFTENGRPKIISSAEAAQLWGNYMRQVVKNREVKYFNVPDNI
VKAEIDPVTGLLPNKYTPRVVKEIFRKHNVPTEVENLHEPIVTEKIDKESGLLATPNCPRENVVEYSYFASSGIRVGPAT
IEFGGIKKEKDEDENEEEQIQEVIEGTYIVDKGEPVQKINPETGVPITNNGQVIYERIPTRKCDLHGNGQQNFFDNLWDM
FKFNN

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=559, Percent_Identity=33.6314847942755, Blast_Score=257, Evalue=2e-69,
Organism=Escherichia coli, GI87082258, Length=307, Percent_Identity=40.7166123778502, Blast_Score=232, Evalue=8e-62,
Organism=Escherichia coli, GI1788867, Length=561, Percent_Identity=27.4509803921569, Blast_Score=188, Evalue=1e-48,
Organism=Escherichia coli, GI1789601, Length=167, Percent_Identity=35.3293413173653, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.1.129; 3.4.-.- [C]

Molecular weight: Translated: 91522; Mature: 91390

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQRKNYIFATIILIFALIFGLVIGSITWIIKNTPDITNYKGPNEATLIYSADGQLLTK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEECCHHHHHH
LYRENRVYVPLERIPVDLQNAIVAIEDTKFYAHHGIDFWGIPRALITNIKEGRIAQGFST
HHHCCCEEEEHHHCCCCCCCCEEEEECCEEEHHCCCCCCCCCHHHHCCCCCCCCCCCHHH
ITMQLAENALFHRQQRTFYRKIQEIYLALQFERLYTKPEILEMYLNEIFLGHSAYGVETA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
AQQYFGKHVWELDLSECALVAGLPKAPNYYSPFNNIDAAKTRRNVVLNRMLELGYITREE
HHHHHCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
YESARKQDIIIKPSEPKKENTAPYFIRYVRDRLIDRFGAQMVYGGGLKVYTTLDLEMQKT
HHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCHHHHH
AESTIKKAIENKYLPTVERDNTPDKLQPQLALITIEPQTGAIRAMVGGRGNDQFNRATQA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHH
VRQPGSAFKPFVYTTAIKQGWSPGSVINDMPMLAHKEQGEPLSIWPSNFEDKYRGYVSLR
HHCCCCCCCCCEEEHHHHCCCCCCCHHCCCCHHHCCCCCCCEEECCCCCCHHHHHHHHHH
TALRYSINVAAVKLIKQVGVNNTIKTAEEMGISTFQPADNKESHLSLALGGLNKGVTPME
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
MASAYGVFANRGIWVEPYVITRVMDRRNNVIYEAHPDKKIVLSEDVAYLMTNMLESVISG
HHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHCC
GTGWRARLGRPVAGKTGTTNNYTDAWFVGFTPDLVTSVWIGEDNLHPMEYDQKDENGNYL
CCCCHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHEEEECCCCCCCCCCCCCCCCCCEE
FTENGRPKIISSAEAAQLWGNYMRQVVKNREVKYFNVPDNIVKAEIDPVTGLLPNKYTPR
EECCCCCCEECCHHHHHHHHHHHHHHHHCCCEEEEECCCHHEEEECCCCCCCCCCCCCHH
VVKEIFRKHNVPTEVENLHEPIVTEKIDKESGLLATPNCPRENVVEYSYFASSGIRVGPA
HHHHHHHHCCCCHHHHHHHCCHHHHHCCCCCCEEECCCCCHHCCEEEEEHHCCCCEECCC
TIEFGGIKKEKDEDENEEEQIQEVIEGTYIVDKGEPVQKINPETGVPITNNGQVIYERIP
EEEECCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHCCCCCCCEECCCCCEEEEECC
TRKCDLHGNGQQNFFDNLWDMFKFNN
CCEECCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKQRKNYIFATIILIFALIFGLVIGSITWIIKNTPDITNYKGPNEATLIYSADGQLLTK
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEEECCHHHHHH
LYRENRVYVPLERIPVDLQNAIVAIEDTKFYAHHGIDFWGIPRALITNIKEGRIAQGFST
HHHCCCEEEEHHHCCCCCCCCEEEEECCEEEHHCCCCCCCCCHHHHCCCCCCCCCCCHHH
ITMQLAENALFHRQQRTFYRKIQEIYLALQFERLYTKPEILEMYLNEIFLGHSAYGVETA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
AQQYFGKHVWELDLSECALVAGLPKAPNYYSPFNNIDAAKTRRNVVLNRMLELGYITREE
HHHHHCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
YESARKQDIIIKPSEPKKENTAPYFIRYVRDRLIDRFGAQMVYGGGLKVYTTLDLEMQKT
HHHHHHCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCEEEEEEECCHHHHH
AESTIKKAIENKYLPTVERDNTPDKLQPQLALITIEPQTGAIRAMVGGRGNDQFNRATQA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHH
VRQPGSAFKPFVYTTAIKQGWSPGSVINDMPMLAHKEQGEPLSIWPSNFEDKYRGYVSLR
HHCCCCCCCCCEEEHHHHCCCCCCCHHCCCCHHHCCCCCCCEEECCCCCCHHHHHHHHHH
TALRYSINVAAVKLIKQVGVNNTIKTAEEMGISTFQPADNKESHLSLALGGLNKGVTPME
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
MASAYGVFANRGIWVEPYVITRVMDRRNNVIYEAHPDKKIVLSEDVAYLMTNMLESVISG
HHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHCC
GTGWRARLGRPVAGKTGTTNNYTDAWFVGFTPDLVTSVWIGEDNLHPMEYDQKDENGNYL
CCCCHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHEEEECCCCCCCCCCCCCCCCCCEE
FTENGRPKIISSAEAAQLWGNYMRQVVKNREVKYFNVPDNIVKAEIDPVTGLLPNKYTPR
EECCCCCCEECCHHHHHHHHHHHHHHHHCCCEEEEECCCHHEEEECCCCCCCCCCCCCHH
VVKEIFRKHNVPTEVENLHEPIVTEKIDKESGLLATPNCPRENVVEYSYFASSGIRVGPA
HHHHHHHHCCCCHHHHHHHCCHHHHHCCCCCCEEECCCCCHHCCEEEEEHHCCCCEECCC
TIEFGGIKKEKDEDENEEEQIQEVIEGTYIVDKGEPVQKINPETGVPITNNGQVIYERIP
EEEECCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCHHHCCCCCCCEECCCCCEEEEECC
TRKCDLHGNGQQNFFDNLWDMFKFNN
CCEECCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA