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The map label for this gene is 220931362

Identifier: 220931362

GI number: 220931362

Start: 563664

End: 565625

Strand: Direct

Name: 220931362

Synonym: Hore_05170

Alternate gene names: NA

Gene position: 563664-565625 (Clockwise)

Preceding gene: 220931358

Following gene: 220931363

Centisome position: 21.86

GC content: 38.18

Gene sequence:

>1962_bases
ATGGATTCAAAAAAATATAAAGTACTATTAACAGCATTTATTGTAATCGGGATATTATTATTTTTACCTGCCTGCTCACC
GGAGCCGGATACGGGGTATAAGTATTATGATATTTACGGATGGGTTACTGAATACAATAGTGGTGATCCAATTAAAGATG
CTTTTGTTTACATAGCAGGGCAGACAGCCTATACAGACGAAACAGGATATTATCATATATCTAATATACCTGAAGGAGTT
CATACCTGGAGAGTAAGTGCTGATGGTTATCAGGGATATTCAGAAACAATTGAGGTTAGTAGTGATTTGAAGGTTAGTAT
TAAATTGTTCCCCATTGGTGATGGTAATGTTTCAGGAAAGGTTACTGTTAATAACAATACCGGATATCAGAGGGTAGATG
TTAGTACAGCTTCTACCAGTAATAATGGTTCTGCCGTTATATTTAATAAGTCCAGTGATGGAATACAATATAAAGAAAAC
GAAATTCTGGTGAAATATAAAAATGAAGTATCTACCCTTTCTACAAATAGCCTGGAAAACAATAATGGAGTTCAAATCAT
GGGAACAAGAGAGCTTCCAGATGGGAAGGTTAAGCATTACAGGATACCTGAAGATAAGACAGTTAGTGAAATGGTAGATT
ATTATAACAATCTCCCTGAAGTTGAATGGGCCCAGCCCAATTATATCTATCATATCAGTGCCATTCCTGATGATGAATAC
TATATTTATGAACAGCGGGGGCATATAATAACCAACCTGGAGGCAGCCTGGGATGTGGAAAAAGGTGATAACAGTGTAAC
AGTGGCTGTAGTCGATTCAGGGATTATTCCCGATCACCCTGACCTTGCAGGCAATTTAGTGCCAGGTCATGATTTTGTCG
ATGATGATAATGATCCAACTGATAAAACCCCTGAATCTAATTCTGGTAGCCACGGTACCCATGTAGCCGGTATTATTGGA
GCCGTTACTAACAATGGTACCGGGGTAGCCGGGGTAAACTGGGATGTTAACATTTTGCCGGTCAGGGTTATGGGAACAGA
TGGCTCAGGGTTTACAGATGTTATTGCAGATGGAATAAGGTATGCTGTGAATAATAATGTTGATATAATTAATCTAAGTT
TGGGTGTAGATCCGTCAAGACTTGAAAACGGAAGTGACCCATATATGGATGATGCAATTAATTATGCAGTAAATAACGGG
GTTATTGTAATAGCAGCAGCCGGCAATGGGGGAAGTGATAGCATTGGAGATAGTTATGTGGATTACCCGGCAAACATGGA
TAGTACAATTGCTGTAGGGGCTGTAGATTTTAATAAAGATATTGCTAGTTTTTCGAACTATGGACAGAATCTGGACCTGG
TTGCTCCTGGTGTTGGTATATACAGTACCTGGGGATACTATGATGGGTATAATTATGAGACTATATCTGATTATTATAAT
ATGAGTGGAACATCAATGGCAACCCCCTATGTTAGTGGAATAGCAGCTCTTTTACTCGCCAATGGTGTTCCTTCATATGA
AGTAAGGAATCGTTTAACCTCTACAGCTGTTGACCTTGGGGGTACGGGATGGGATCAGTATTATGGATATGGGTTGGTTG
ACGCCTATGGTGCCCTGCTTGGTAAAAAGTTATCAAAGCCATATGTAATGGCCGCAGAATTTGATGAAACTACAAATACA
GTTTACCCCAGGAGTGAGATTGTTCAGGTAAATGATGATGGAACCTATTCTTTACAGAATGTAACACCGGGGGAATGGTA
TATAATTGCCTACCGGGATGTTGATGATAATGGTTATATAGATGCTGGAGATTACTATGGTGAAACCAGTAATACTTATT
CTATTAATACAGATACAAGTTTAAAAGATATAAATGTTAATATGTATTATGTGACTGGATACAATACTTCAACAAGTTTA
AAAATTAACGGGATTGCAGAAATTGAAGAGGTAAATAATTAA

Upstream 100 bases:

>100_bases
AGAACTTACATAATACTTATGACAGTTTTTTTATATTTACTGTCGTATAAAGTCAATTTACTGGTCGATAAATGTATTTT
CAAGGAGAGGAGATATTTAT

Downstream 100 bases:

>100_bases
TAATAAATCCAGGGTAATTAATAAGACATAAATCATTAAAACCATTAAGAAAGGAAGGGTATTATGAAAAAAAGGTTTAT
CAATATATTGGTATTATCAC

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MDSKKYKVLLTAFIVIGILLFLPACSPEPDTGYKYYDIYGWVTEYNSGDPIKDAFVYIAGQTAYTDETGYYHISNIPEGV
HTWRVSADGYQGYSETIEVSSDLKVSIKLFPIGDGNVSGKVTVNNNTGYQRVDVSTASTSNNGSAVIFNKSSDGIQYKEN
EILVKYKNEVSTLSTNSLENNNGVQIMGTRELPDGKVKHYRIPEDKTVSEMVDYYNNLPEVEWAQPNYIYHISAIPDDEY
YIYEQRGHIITNLEAAWDVEKGDNSVTVAVVDSGIIPDHPDLAGNLVPGHDFVDDDNDPTDKTPESNSGSHGTHVAGIIG
AVTNNGTGVAGVNWDVNILPVRVMGTDGSGFTDVIADGIRYAVNNNVDIINLSLGVDPSRLENGSDPYMDDAINYAVNNG
VIVIAAAGNGGSDSIGDSYVDYPANMDSTIAVGAVDFNKDIASFSNYGQNLDLVAPGVGIYSTWGYYDGYNYETISDYYN
MSGTSMATPYVSGIAALLLANGVPSYEVRNRLTSTAVDLGGTGWDQYYGYGLVDAYGALLGKKLSKPYVMAAEFDETTNT
VYPRSEIVQVNDDGTYSLQNVTPGEWYIIAYRDVDDNGYIDAGDYYGETSNTYSINTDTSLKDINVNMYYVTGYNTSTSL
KINGIAEIEEVNN

Sequences:

>Translated_653_residues
MDSKKYKVLLTAFIVIGILLFLPACSPEPDTGYKYYDIYGWVTEYNSGDPIKDAFVYIAGQTAYTDETGYYHISNIPEGV
HTWRVSADGYQGYSETIEVSSDLKVSIKLFPIGDGNVSGKVTVNNNTGYQRVDVSTASTSNNGSAVIFNKSSDGIQYKEN
EILVKYKNEVSTLSTNSLENNNGVQIMGTRELPDGKVKHYRIPEDKTVSEMVDYYNNLPEVEWAQPNYIYHISAIPDDEY
YIYEQRGHIITNLEAAWDVEKGDNSVTVAVVDSGIIPDHPDLAGNLVPGHDFVDDDNDPTDKTPESNSGSHGTHVAGIIG
AVTNNGTGVAGVNWDVNILPVRVMGTDGSGFTDVIADGIRYAVNNNVDIINLSLGVDPSRLENGSDPYMDDAINYAVNNG
VIVIAAAGNGGSDSIGDSYVDYPANMDSTIAVGAVDFNKDIASFSNYGQNLDLVAPGVGIYSTWGYYDGYNYETISDYYN
MSGTSMATPYVSGIAALLLANGVPSYEVRNRLTSTAVDLGGTGWDQYYGYGLVDAYGALLGKKLSKPYVMAAEFDETTNT
VYPRSEIVQVNDDGTYSLQNVTPGEWYIIAYRDVDDNGYIDAGDYYGETSNTYSINTDTSLKDINVNMYYVTGYNTSTSL
KINGIAEIEEVNN
>Mature_653_residues
MDSKKYKVLLTAFIVIGILLFLPACSPEPDTGYKYYDIYGWVTEYNSGDPIKDAFVYIAGQTAYTDETGYYHISNIPEGV
HTWRVSADGYQGYSETIEVSSDLKVSIKLFPIGDGNVSGKVTVNNNTGYQRVDVSTASTSNNGSAVIFNKSSDGIQYKEN
EILVKYKNEVSTLSTNSLENNNGVQIMGTRELPDGKVKHYRIPEDKTVSEMVDYYNNLPEVEWAQPNYIYHISAIPDDEY
YIYEQRGHIITNLEAAWDVEKGDNSVTVAVVDSGIIPDHPDLAGNLVPGHDFVDDDNDPTDKTPESNSGSHGTHVAGIIG
AVTNNGTGVAGVNWDVNILPVRVMGTDGSGFTDVIADGIRYAVNNNVDIINLSLGVDPSRLENGSDPYMDDAINYAVNNG
VIVIAAAGNGGSDSIGDSYVDYPANMDSTIAVGAVDFNKDIASFSNYGQNLDLVAPGVGIYSTWGYYDGYNYETISDYYN
MSGTSMATPYVSGIAALLLANGVPSYEVRNRLTSTAVDLGGTGWDQYYGYGLVDAYGALLGKKLSKPYVMAAEFDETTNT
VYPRSEIVQVNDDGTYSLQNVTPGEWYIIAYRDVDDNGYIDAGDYYGETSNTYSINTDTSLKDINVNMYYVTGYNTSTSL
KINGIAEIEEVNN

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4505577, Length=372, Percent_Identity=27.4193548387097, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI20336190, Length=372, Percent_Identity=27.4193548387097, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI27894285, Length=372, Percent_Identity=27.4193548387097, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI20336180, Length=372, Percent_Identity=27.4193548387097, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI20336188, Length=372, Percent_Identity=27.4193548387097, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI20336182, Length=372, Percent_Identity=27.4193548387097, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI20336184, Length=372, Percent_Identity=27.4193548387097, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI4505579, Length=323, Percent_Identity=30.3405572755418, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI76443679, Length=382, Percent_Identity=26.4397905759162, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI4506775, Length=303, Percent_Identity=27.3927392739274, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI20336186, Length=315, Percent_Identity=27.3015873015873, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI20336246, Length=355, Percent_Identity=24.5070422535211, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI299523015, Length=355, Percent_Identity=24.5070422535211, Blast_Score=70, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71983555, Length=455, Percent_Identity=24.8351648351648, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25141268, Length=455, Percent_Identity=24.8351648351648, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988308, Length=363, Percent_Identity=25.8953168044077, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988312, Length=359, Percent_Identity=25.9052924791086, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988315, Length=354, Percent_Identity=26.271186440678, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=354, Percent_Identity=26.271186440678, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=204, Percent_Identity=30.8823529411765, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=354, Percent_Identity=26.271186440678, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319893, Length=248, Percent_Identity=33.8709677419355, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324576, Length=252, Percent_Identity=34.1269841269841, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320775, Length=247, Percent_Identity=31.9838056680162, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45550681, Length=322, Percent_Identity=26.3975155279503, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 71147; Mature: 71147

Theoretical pI: Translated: 3.96; Mature: 3.96

Prosite motif: PS00018 EF_HAND_1 ; PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSKKYKVLLTAFIVIGILLFLPACSPEPDTGYKYYDIYGWVTEYNSGDPIKDAFVYIAG
CCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCEEEEEEEC
QTAYTDETGYYHISNIPEGVHTWRVSADGYQGYSETIEVSSDLKVSIKLFPIGDGNVSGK
CEEECCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEEEECCCCCCEEE
VTVNNNTGYQRVDVSTASTSNNGSAVIFNKSSDGIQYKENEILVKYKNEVSTLSTNSLEN
EEECCCCCEEEEEEEECCCCCCCCEEEEECCCCCCEEECCEEEEEECCCCCEEECCCCCC
NNGVQIMGTRELPDGKVKHYRIPEDKTVSEMVDYYNNLPEVEWAQPNYIYHISAIPDDEY
CCCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEECCCCEEEEEEECCCCCE
YIYEQRGHIITNLEAAWDVEKGDNSVTVAVVDSGIIPDHPDLAGNLVPGHDFVDDDNDPT
EEEECCCCEEEECHHEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
DKTPESNSGSHGTHVAGIIGAVTNNGTGVAGVNWDVNILPVRVMGTDGSGFTDVIADGIR
CCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCCEEEEEEEEEECCCCCHHHHHHCCEE
YAVNNNVDIINLSLGVDPSRLENGSDPYMDDAINYAVNNGVIVIAAAGNGGSDSIGDSYV
EEECCCEEEEEEEECCCHHHCCCCCCCCHHHHHHEEECCCEEEEEECCCCCCCCCCCCCC
DYPANMDSTIAVGAVDFNKDIASFSNYGQNLDLVAPGVGIYSTWGYYDGYNYETISDYYN
CCCCCCCCEEEEEEEECCHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCHHHHHC
MSGTSMATPYVSGIAALLLANGVPSYEVRNRLTSTAVDLGGTGWDQYYGYGLVDAYGALL
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCHHHHCCCCHHHHHHHHH
GKKLSKPYVMAAEFDETTNTVYPRSEIVQVNDDGTYSLQNVTPGEWYIIAYRDVDDNGYI
HHHCCCCEEEEEECCCCCCEECCCCEEEEECCCCCEEECCCCCCCEEEEEEEECCCCCCE
DAGDYYGETSNTYSINTDTSLKDINVNMYYVTGYNTSTSLKINGIAEIEEVNN
ECCCCCCCCCCEEEECCCCCEEEEEEEEEEEEECCCCCEEEECCEEEEHCCCC
>Mature Secondary Structure
MDSKKYKVLLTAFIVIGILLFLPACSPEPDTGYKYYDIYGWVTEYNSGDPIKDAFVYIAG
CCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCEEEEEEEC
QTAYTDETGYYHISNIPEGVHTWRVSADGYQGYSETIEVSSDLKVSIKLFPIGDGNVSGK
CEEECCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEEEECCCCCCEEE
VTVNNNTGYQRVDVSTASTSNNGSAVIFNKSSDGIQYKENEILVKYKNEVSTLSTNSLEN
EEECCCCCEEEEEEEECCCCCCCCEEEEECCCCCCEEECCEEEEEECCCCCEEECCCCCC
NNGVQIMGTRELPDGKVKHYRIPEDKTVSEMVDYYNNLPEVEWAQPNYIYHISAIPDDEY
CCCEEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEECCCCEEEEEEECCCCCE
YIYEQRGHIITNLEAAWDVEKGDNSVTVAVVDSGIIPDHPDLAGNLVPGHDFVDDDNDPT
EEEECCCCEEEECHHEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
DKTPESNSGSHGTHVAGIIGAVTNNGTGVAGVNWDVNILPVRVMGTDGSGFTDVIADGIR
CCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCCEEEEEEEEEECCCCCHHHHHHCCEE
YAVNNNVDIINLSLGVDPSRLENGSDPYMDDAINYAVNNGVIVIAAAGNGGSDSIGDSYV
EEECCCEEEEEEEECCCHHHCCCCCCCCHHHHHHEEECCCEEEEEECCCCCCCCCCCCCC
DYPANMDSTIAVGAVDFNKDIASFSNYGQNLDLVAPGVGIYSTWGYYDGYNYETISDYYN
CCCCCCCCEEEEEEEECCHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCHHHHHC
MSGTSMATPYVSGIAALLLANGVPSYEVRNRLTSTAVDLGGTGWDQYYGYGLVDAYGALL
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCHHHHCCCCHHHHHHHHH
GKKLSKPYVMAAEFDETTNTVYPRSEIVQVNDDGTYSLQNVTPGEWYIIAYRDVDDNGYI
HHHCCCCEEEEEECCCCCCEECCCCEEEEECCCCCEEECCCCCCCEEEEEEEECCCCCCE
DAGDYYGETSNTYSINTDTSLKDINVNMYYVTGYNTSTSLKINGIAEIEEVNN
ECCCCCCCCCCEEEECCCCCEEEEEEEEEEEEECCCCCEEEECCEEEEHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]