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The map label for this gene is argH [H]

Identifier: 220931140

GI number: 220931140

Start: 299412

End: 300806

Strand: Direct

Name: argH [H]

Synonym: Hore_02920

Alternate gene names: 220931140

Gene position: 299412-300806 (Clockwise)

Preceding gene: 220931139

Following gene: 220931141

Centisome position: 11.61

GC content: 40.07

Gene sequence:

>1395_bases
ATGATGAAATTATGGGGTGGCAGGTTCAGTAAACAGACCCATAAACTTATGGAAGAATTTAATTCATCTCTTTCTTTTGA
TAAAAGGCTTTACAGCTATGATATTAAAGGGAGTATCGCCCATGTTAAAATGCTGTCCAGGACTGGTGTTTTATCTAAAT
CTGAAGCAGAAACAATTATTAAGGGTTTACAGGAGATAAAAGAAGAGATAGATGAAGGTATAATTTCTCTGGAGGGTCGA
TATGAAGATATTCACAGTCTGGTAGAAAAAAATTTGATAGATAAGGTTGGGGCAGTAGGGGGAAAACTCCATACTGCCCG
TAGTAGAAATGACCAGGTGGCCCTGGATACCAGGCTTTATTTGCGTGATGAAATCTTTAATATTCAGGAACTGTTAATAA
TCTTTTTAAAAACCCTCCTTGAGCTGGGTGAAAAATATAAAAAGGTAGTTATGCCCGGATATACCCATCTTCAAAGAGCC
CAGCCGGTATCAATGGGCCATCATTTACTGGCTTATTATTTTAAGTTAAAAAGGGATTATGACAGGTTAAATGATAATAT
GAAGCGGGTTAATGTTTTACCCCTTGGATGTGGAGCCCTGGCAGGGACTACTTTCCCCATTGACAGAGAATGGGTTGCCA
GGGAGCTGGGGTTTGAAAAGATAGCCCTCAATTCTATAGATGGGGTTAGCGACCGGGATTATATTATAGAATTTATGGGT
ATTGCGGCTTCAATAATGGTTCACCTGAGCAGGTTTAGTGCTGAATTAATCTTGTGGTCTTCAAGTGAATTTAGTTTTAT
TGAACTGGATGACAGTTTTACCACCGGGAGTAGTATTATGCCCCAGAAGAAAAATCCCGATGTTGCTGAATTGGTCAGGG
GTAAAAGTGGCAGGATATTCGGGAATTTAGTTCAATTACTGTCCCTGCTTAAGGGGTTACCTCTGGCTTATAATAAAGAT
ATGCAGGAGGATAAAGAGGCCCTTTTTGATACAATTGATAACCTCAAGATTATTTTAGAAATATTCCCGCCGATGTTAAA
AACGATGAAGGTAAACAAGGACCGGTTATACCGGGCCGCCAACCGGGGATTTGTTAACGCAACTGATTTAGCTGATTATC
TGGCCAGGAAAGGGGTTCCCTTTCGTGAAGCACACGGGATGGTGGGAAAGGCTGTCTTATATGCCCTGGAAAAAGATAAA
GAATTAAACCAGATAACTATCGAGGAATGGAACCAGCTTTTTCCGGATTACGGTGATATATTTGATAAAGGTTTGTCAGA
AATTCTTGATGTAAATACGAGTTTGAATAATCGTAAGTCTTCGGGAGGACCAGCTCCTGAGGAAGTGGAGAGGGTAATCA
GTATAGAGAGGGAGTGGATTGAATCATTTACTTAA

Upstream 100 bases:

>100_bases
TTAAATTTTATCTTAAGAATGGTTACCGATGTGTCCGCATTGATAACAGTTACCCATATCGGCGGGGTCTCTGGGTGAAA
AGACTTAACGGAGTTGATCA

Downstream 100 bases:

>100_bases
AAATGGTATAATTAAGTATTAACAGGTAGTCAGAATAGAGATTACGTTTTCTGGTACAAAATGAGTTAATAATATACTTA
TTGTGGAATTGTTTATATAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MMKLWGGRFSKQTHKLMEEFNSSLSFDKRLYSYDIKGSIAHVKMLSRTGVLSKSEAETIIKGLQEIKEEIDEGIISLEGR
YEDIHSLVEKNLIDKVGAVGGKLHTARSRNDQVALDTRLYLRDEIFNIQELLIIFLKTLLELGEKYKKVVMPGYTHLQRA
QPVSMGHHLLAYYFKLKRDYDRLNDNMKRVNVLPLGCGALAGTTFPIDREWVARELGFEKIALNSIDGVSDRDYIIEFMG
IAASIMVHLSRFSAELILWSSSEFSFIELDDSFTTGSSIMPQKKNPDVAELVRGKSGRIFGNLVQLLSLLKGLPLAYNKD
MQEDKEALFDTIDNLKIILEIFPPMLKTMKVNKDRLYRAANRGFVNATDLADYLARKGVPFREAHGMVGKAVLYALEKDK
ELNQITIEEWNQLFPDYGDIFDKGLSEILDVNTSLNNRKSSGGPAPEEVERVISIEREWIESFT

Sequences:

>Translated_464_residues
MMKLWGGRFSKQTHKLMEEFNSSLSFDKRLYSYDIKGSIAHVKMLSRTGVLSKSEAETIIKGLQEIKEEIDEGIISLEGR
YEDIHSLVEKNLIDKVGAVGGKLHTARSRNDQVALDTRLYLRDEIFNIQELLIIFLKTLLELGEKYKKVVMPGYTHLQRA
QPVSMGHHLLAYYFKLKRDYDRLNDNMKRVNVLPLGCGALAGTTFPIDREWVARELGFEKIALNSIDGVSDRDYIIEFMG
IAASIMVHLSRFSAELILWSSSEFSFIELDDSFTTGSSIMPQKKNPDVAELVRGKSGRIFGNLVQLLSLLKGLPLAYNKD
MQEDKEALFDTIDNLKIILEIFPPMLKTMKVNKDRLYRAANRGFVNATDLADYLARKGVPFREAHGMVGKAVLYALEKDK
ELNQITIEEWNQLFPDYGDIFDKGLSEILDVNTSLNNRKSSGGPAPEEVERVISIEREWIESFT
>Mature_464_residues
MMKLWGGRFSKQTHKLMEEFNSSLSFDKRLYSYDIKGSIAHVKMLSRTGVLSKSEAETIIKGLQEIKEEIDEGIISLEGR
YEDIHSLVEKNLIDKVGAVGGKLHTARSRNDQVALDTRLYLRDEIFNIQELLIIFLKTLLELGEKYKKVVMPGYTHLQRA
QPVSMGHHLLAYYFKLKRDYDRLNDNMKRVNVLPLGCGALAGTTFPIDREWVARELGFEKIALNSIDGVSDRDYIIEFMG
IAASIMVHLSRFSAELILWSSSEFSFIELDDSFTTGSSIMPQKKNPDVAELVRGKSGRIFGNLVQLLSLLKGLPLAYNKD
MQEDKEALFDTIDNLKIILEIFPPMLKTMKVNKDRLYRAANRGFVNATDLADYLARKGVPFREAHGMVGKAVLYALEKDK
ELNQITIEEWNQLFPDYGDIFDKGLSEILDVNTSLNNRKSSGGPAPEEVERVISIEREWIESFT

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=448, Percent_Identity=43.5267857142857, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI68303542, Length=448, Percent_Identity=43.5267857142857, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI68303547, Length=448, Percent_Identity=40.8482142857143, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=40.5764966740577, Blast_Score=361, Evalue=1e-100,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=47.0459518599562, Blast_Score=421, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321806, Length=454, Percent_Identity=43.1718061674009, Blast_Score=358, Evalue=1e-99,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=38.7024608501119, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=38.7024608501119, Blast_Score=346, Evalue=2e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52806; Mature: 52806

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLWGGRFSKQTHKLMEEFNSSLSFDKRLYSYDIKGSIAHVKMLSRTGVLSKSEAETII
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHEECCCCCHHHHHHHHHCCCCCCHHHHHHH
KGLQEIKEEIDEGIISLEGRYEDIHSLVEKNLIDKVGAVGGKLHTARSRNDQVALDTRLY
HHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEHHHHH
LRDEIFNIQELLIIFLKTLLELGEKYKKVVMPGYTHLQRAQPVSMGHHLLAYYFKLKRDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
DRLNDNMKRVNVLPLGCGALAGTTFPIDREWVARELGFEKIALNSIDGVSDRDYIIEFMG
HHHCCCHHEEEEEEECCHHHCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHH
IAASIMVHLSRFSAELILWSSSEFSFIELDDSFTTGSSIMPQKKNPDVAELVRGKSGRIF
HHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLVQLLSLLKGLPLAYNKDMQEDKEALFDTIDNLKIILEIFPPMLKTMKVNKDRLYRAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
NRGFVNATDLADYLARKGVPFREAHGMVGKAVLYALEKDKELNQITIEEWNQLFPDYGDI
CCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCHHHH
FDKGLSEILDVNTSLNNRKSSGGPAPEEVERVISIEREWIESFT
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKLWGGRFSKQTHKLMEEFNSSLSFDKRLYSYDIKGSIAHVKMLSRTGVLSKSEAETII
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHEECCCCCHHHHHHHHHCCCCCCHHHHHHH
KGLQEIKEEIDEGIISLEGRYEDIHSLVEKNLIDKVGAVGGKLHTARSRNDQVALDTRLY
HHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEHHHHH
LRDEIFNIQELLIIFLKTLLELGEKYKKVVMPGYTHLQRAQPVSMGHHLLAYYFKLKRDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
DRLNDNMKRVNVLPLGCGALAGTTFPIDREWVARELGFEKIALNSIDGVSDRDYIIEFMG
HHHCCCHHEEEEEEECCHHHCCCCCCCCHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHH
IAASIMVHLSRFSAELILWSSSEFSFIELDDSFTTGSSIMPQKKNPDVAELVRGKSGRIF
HHHHHHHHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCHH
GNLVQLLSLLKGLPLAYNKDMQEDKEALFDTIDNLKIILEIFPPMLKTMKVNKDRLYRAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
NRGFVNATDLADYLARKGVPFREAHGMVGKAVLYALEKDKELNQITIEEWNQLFPDYGDI
CCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCHHHH
FDKGLSEILDVNTSLNNRKSSGGPAPEEVERVISIEREWIESFT
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA