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The map label for this gene is argD [H]

Identifier: 220931133

GI number: 220931133

Start: 288086

End: 289285

Strand: Direct

Name: argD [H]

Synonym: Hore_02850

Alternate gene names: 220931133

Gene position: 288086-289285 (Clockwise)

Preceding gene: 220931132

Following gene: 220931134

Centisome position: 11.17

GC content: 41.0

Gene sequence:

>1200_bases
TTGCTCAGAGATGAAATCATTACCTGTGATAAAAATTATTTTATGAATGTTTTTAAGGGCAGGTTTCCCCTGGTTGTTGA
CCATGGGGAAGGGGTTAAAGTATATGATAAAAACGGTAAGGTTTATTGTGATTTCCTGTCAGGTATAGGGGTTAATGCCC
TCGGTTATTCCTGTCCGGAACTGGTAGAGGCCCTTAGAGAGCAGGTAGAGAAAATAATCCATTGTTCCAATTTATATTAT
ATTGAACCCCAGGCTGAACTGGAGAAATGGCTGGTTAACCACTCGGTGGCTGACCGGGTGTTTTTTTCAAATAGTGGCGC
AGAAGCCAATGAAGGGGCAATAAAACTGGCCCGGAAGTATTTTGAAGTAAGGAATGAGAATAAATATGAAATTATAACCG
CTCAAAATTCGTTCCACGGGAGAACGCTTATGACCCTGGCAGCAACAGGTCAGGAAAAATACCATCGTTTTTTTCAACCC
CTGCCGCAAGGTTTTAAATACGTTCCCTTTAACGACCTGGAGGCTGTTTACCGGTCGGTGGGTCCCAATACTGCAGCCAT
AATGGTAGAGCCAATTCAGGGTGAAGGGGGGGTTTATCCGGCTACCCGTGAATACCTTGAAGGACTCAGGAAACTATGTG
ATGAGGAGAATATATTATTAATATTTGATGAAATTCAATGTGGAATAGGGAAAACAGGTACCCTTTTTGCCTATGAATAT
TATGGAGTAGAACCAGATATTTTTACCCTGGCTAAAGCCCTGGGAGGTGGAGTTCCCATCGGGGCTTTTCTGGCCAGAGA
AGAGGTGGCTAACGCCTTCAAACCAGGAGACCACGGTTCCACATTCGGGGGTAATCCCCTGGCAACCAGGGCTGCCATTA
CTACCCTCAAAGTTATTAAAGAACGGGGATTACTTAATAAGGTTAAAAAAACCGGGCAATATTTCAAAAACCTTCTAGAG
GAATTGAAGGAAGAAATTGATATTGTTAATGAGGTTAGAGGGGTAGGGTTGATGCTGGCTATAGAACTTAATAGAAATAA
AGCCCGGGATATTGTAAACTACATGTTTGAAAAGGGGTTTTTGCTTAATGCTGTTAAGGATAATATAATCAGGTTTTTAC
CACCTCTTATTATTGAAAAGACTGATATAAAAAATATGGTGGGAGAGTTAAAAACAGTTTTGGAAAAAAATAATTTATGA

Upstream 100 bases:

>100_bases
GCACCCATATTTTAAATGGTCTAATTCCCCATGCCCTGTTACTGGAGATTTTTACAGACCGGGGTATTGGAACCATGATT
TTAAAGGAGAGGTGAAAGAG

Downstream 100 bases:

>100_bases
TTTTTTCTGGACATTGGGTCTAAAAATTGGTAAAATAGAATACTAAGTACACCTTATAAGGTGCAAATAAGTGAAAAAGG
AGGATTATAGTAGATGAGAA

Product: acetylornithine and succinylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLRDEIITCDKNYFMNVFKGRFPLVVDHGEGVKVYDKNGKVYCDFLSGIGVNALGYSCPELVEALREQVEKIIHCSNLYY
IEPQAELEKWLVNHSVADRVFFSNSGAEANEGAIKLARKYFEVRNENKYEIITAQNSFHGRTLMTLAATGQEKYHRFFQP
LPQGFKYVPFNDLEAVYRSVGPNTAAIMVEPIQGEGGVYPATREYLEGLRKLCDEENILLIFDEIQCGIGKTGTLFAYEY
YGVEPDIFTLAKALGGGVPIGAFLAREEVANAFKPGDHGSTFGGNPLATRAAITTLKVIKERGLLNKVKKTGQYFKNLLE
ELKEEIDIVNEVRGVGLMLAIELNRNKARDIVNYMFEKGFLLNAVKDNIIRFLPPLIIEKTDIKNMVGELKTVLEKNNL

Sequences:

>Translated_399_residues
MLRDEIITCDKNYFMNVFKGRFPLVVDHGEGVKVYDKNGKVYCDFLSGIGVNALGYSCPELVEALREQVEKIIHCSNLYY
IEPQAELEKWLVNHSVADRVFFSNSGAEANEGAIKLARKYFEVRNENKYEIITAQNSFHGRTLMTLAATGQEKYHRFFQP
LPQGFKYVPFNDLEAVYRSVGPNTAAIMVEPIQGEGGVYPATREYLEGLRKLCDEENILLIFDEIQCGIGKTGTLFAYEY
YGVEPDIFTLAKALGGGVPIGAFLAREEVANAFKPGDHGSTFGGNPLATRAAITTLKVIKERGLLNKVKKTGQYFKNLLE
ELKEEIDIVNEVRGVGLMLAIELNRNKARDIVNYMFEKGFLLNAVKDNIIRFLPPLIIEKTDIKNMVGELKTVLEKNNL
>Mature_399_residues
MLRDEIITCDKNYFMNVFKGRFPLVVDHGEGVKVYDKNGKVYCDFLSGIGVNALGYSCPELVEALREQVEKIIHCSNLYY
IEPQAELEKWLVNHSVADRVFFSNSGAEANEGAIKLARKYFEVRNENKYEIITAQNSFHGRTLMTLAATGQEKYHRFFQP
LPQGFKYVPFNDLEAVYRSVGPNTAAIMVEPIQGEGGVYPATREYLEGLRKLCDEENILLIFDEIQCGIGKTGTLFAYEY
YGVEPDIFTLAKALGGGVPIGAFLAREEVANAFKPGDHGSTFGGNPLATRAAITTLKVIKERGLLNKVKKTGQYFKNLLE
ELKEEIDIVNEVRGVGLMLAIELNRNKARDIVNYMFEKGFLLNAVKDNIIRFLPPLIIEKTDIKNMVGELKTVLEKNNL

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=383, Percent_Identity=38.1201044386423, Blast_Score=251, Evalue=7e-67,
Organism=Homo sapiens, GI284507298, Length=292, Percent_Identity=41.0958904109589, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI13994255, Length=450, Percent_Identity=26.8888888888889, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=25.7142857142857, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=25.2380952380952, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI226442709, Length=383, Percent_Identity=26.1096605744125, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI24119277, Length=415, Percent_Identity=24.8192771084337, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI188536080, Length=408, Percent_Identity=24.5098039215686, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI38679950, Length=408, Percent_Identity=24.5098039215686, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI38679946, Length=408, Percent_Identity=24.5098039215686, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789759, Length=359, Percent_Identity=46.7966573816156, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1788044, Length=377, Percent_Identity=44.2970822281167, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI145693181, Length=362, Percent_Identity=39.2265193370166, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789016, Length=404, Percent_Identity=35.1485148514851, Blast_Score=221, Evalue=5e-59,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=34.1708542713568, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=27.9236276849642, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=32.7380952380952, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25144271, Length=370, Percent_Identity=37.8378378378378, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI25144274, Length=279, Percent_Identity=38.7096774193548, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=419, Percent_Identity=30.5489260143198, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=434, Percent_Identity=27.4193548387097, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=418, Percent_Identity=25.1196172248804, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=155, Percent_Identity=32.258064516129, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324432, Length=371, Percent_Identity=39.3530997304582, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6323470, Length=389, Percent_Identity=36.7609254498715, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6321456, Length=376, Percent_Identity=25.531914893617, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=443, Percent_Identity=23.7020316027088, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357415, Length=400, Percent_Identity=37.25, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI28574759, Length=440, Percent_Identity=29.7727272727273, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=29.3181818181818, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21356575, Length=402, Percent_Identity=27.1144278606965, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281366494, Length=423, Percent_Identity=27.6595744680851, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667139, Length=423, Percent_Identity=27.6595744680851, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24667143, Length=423, Percent_Identity=27.6595744680851, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 44878; Mature: 44878

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRDEIITCDKNYFMNVFKGRFPLVVDHGEGVKVYDKNGKVYCDFLSGIGVNALGYSCPE
CCCCCEEECCHHHHHHHHCCCCCEEEECCCCEEEEECCCCEEEEECCCCCCCHHCCCCHH
LVEALREQVEKIIHCSNLYYIEPQAELEKWLVNHSVADRVFFSNSGAEANEGAIKLARKY
HHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
FEVRNENKYEIITAQNSFHGRTLMTLAATGQEKYHRFFQPLPQGFKYVPFNDLEAVYRSV
HHHCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHC
GPNTAAIMVEPIQGEGGVYPATREYLEGLRKLCDEENILLIFDEIQCGIGKTGTLFAYEY
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEE
YGVEPDIFTLAKALGGGVPIGAFLAREEVANAFKPGDHGSTFGGNPLATRAAITTLKVIK
ECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ERGLLNKVKKTGQYFKNLLEELKEEIDIVNEVRGVGLMLAIELNRNKARDIVNYMFEKGF
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCCH
LLNAVKDNIIRFLPPLIIEKTDIKNMVGELKTVLEKNNL
HHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRDEIITCDKNYFMNVFKGRFPLVVDHGEGVKVYDKNGKVYCDFLSGIGVNALGYSCPE
CCCCCEEECCHHHHHHHHCCCCCEEEECCCCEEEEECCCCEEEEECCCCCCCHHCCCCHH
LVEALREQVEKIIHCSNLYYIEPQAELEKWLVNHSVADRVFFSNSGAEANEGAIKLARKY
HHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHH
FEVRNENKYEIITAQNSFHGRTLMTLAATGQEKYHRFFQPLPQGFKYVPFNDLEAVYRSV
HHHCCCCCEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHC
GPNTAAIMVEPIQGEGGVYPATREYLEGLRKLCDEENILLIFDEIQCGIGKTGTLFAYEY
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEE
YGVEPDIFTLAKALGGGVPIGAFLAREEVANAFKPGDHGSTFGGNPLATRAAITTLKVIK
ECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ERGLLNKVKKTGQYFKNLLEELKEEIDIVNEVRGVGLMLAIELNRNKARDIVNYMFEKGF
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCCH
LLNAVKDNIIRFLPPLIIEKTDIKNMVGELKTVLEKNNL
HHHHHHHHHHHHCCHHHEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]