Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 220931034

GI number: 220931034

Start: 191584

End: 192645

Strand: Direct

Name: hisC [H]

Synonym: Hore_01850

Alternate gene names: 220931034

Gene position: 191584-192645 (Clockwise)

Preceding gene: 220931033

Following gene: 220931035

Centisome position: 7.43

GC content: 37.29

Gene sequence:

>1062_bases
ATGAGTAAGTACTGGAGTAATACAATTAAGGATATTGAACCCTATGTACCCGGGGAACAGCCAAAGGATAAAACATATAT
AAAACTTAATACCAACGAAAACCCCTACCCTCCTTCCCCGCGGGTAATCAAGGCTATAAAGGAGAATACAAATAATAACT
TAAGGCTTTATCCCGACCCCGGTTGTGATAACTTGAAGGAGGCAATTGCCAGTTATTATAATCTGGACAGGGATCAGGTG
TTTGTAGGTAATGGTTCTGATGAAGTACTGGCCTTTTCGTTTATGGCTTTTTTTGACCGGGAAAGGCCCCTCCTGTTCCC
GACTATTACCTACAGTTTTTACCCTGTTTACTGCAGGTTATTAAATATCGAGTACCGGCAGGTTCCATTACAGGATGATT
TTACCCTCAATGTAGAGGAATTCTACCGTGAGAATCATGGTATTATTTTTCCCAATCCCAATGCTCCGACCGGTATCTAT
TTACCCTTATCGAAAGTTGAAAAAATAGTAGCATATAATATAGATAAAGTTGTTATTATTGATGAGGCCTATATAGATTT
TGGAGGAAAATCAGCTGTTTCTTTAATTGATAAATACCCCAATCTGCTTATTGTTCAGACATTTTCTAAATCCAGGTCCC
TGGCAGGGTTGAGAATAGGTTTTGCGATGGGAAATAAGAAGTTAATTGAAGGTTTAAACAGGGTTAAAAATTCTATTAAC
TCTTATACCCTTGATACCCTGGCCATGATTGCAGCCCGTGAAGCTATTAAAGATGATAAATATTTTGAGGAAACAAGATT
AAAGATCATAAAAACCCGTGACAGGGTGGCAAAAAATTTAAGAAAAATAGGATTTAAGGTTCTTGACTCCAGGGCCAATT
TTATTTTTATCAGTCACCAAAGTTACCCGGCCTGTGATCTATTTAATGAACTTAAGGATAAAGGAATTCTTGTTCGTTAT
TTTAATCAACCGGGGATCAGTAATTACTTGAGGGTCAGTGTGGGGACAGAAAGAGAAATGGATGTTTTTATAAAAACTAT
TGAAGAGATTATTTCAGGGTAA

Upstream 100 bases:

>100_bases
ACTGGTGTGTTACTGAACGGAATAATCTACACTCATATTTAAATAACTGTTAAACCCTGAATGAATTTATTATAAAAATT
ATTAAGAAAGGAGTTTCAAG

Downstream 100 bases:

>100_bases
TATCCCTTTTATGATGGCTAAAAACCTCTGTTTGGCGAATTATTATGTAGTTGATTCAAACATATATCTGGTTTACTTAG
AAATATGTTAAATAATGAAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSKYWSNTIKDIEPYVPGEQPKDKTYIKLNTNENPYPPSPRVIKAIKENTNNNLRLYPDPGCDNLKEAIASYYNLDRDQV
FVGNGSDEVLAFSFMAFFDRERPLLFPTITYSFYPVYCRLLNIEYRQVPLQDDFTLNVEEFYRENHGIIFPNPNAPTGIY
LPLSKVEKIVAYNIDKVVIIDEAYIDFGGKSAVSLIDKYPNLLIVQTFSKSRSLAGLRIGFAMGNKKLIEGLNRVKNSIN
SYTLDTLAMIAAREAIKDDKYFEETRLKIIKTRDRVAKNLRKIGFKVLDSRANFIFISHQSYPACDLFNELKDKGILVRY
FNQPGISNYLRVSVGTEREMDVFIKTIEEIISG

Sequences:

>Translated_353_residues
MSKYWSNTIKDIEPYVPGEQPKDKTYIKLNTNENPYPPSPRVIKAIKENTNNNLRLYPDPGCDNLKEAIASYYNLDRDQV
FVGNGSDEVLAFSFMAFFDRERPLLFPTITYSFYPVYCRLLNIEYRQVPLQDDFTLNVEEFYRENHGIIFPNPNAPTGIY
LPLSKVEKIVAYNIDKVVIIDEAYIDFGGKSAVSLIDKYPNLLIVQTFSKSRSLAGLRIGFAMGNKKLIEGLNRVKNSIN
SYTLDTLAMIAAREAIKDDKYFEETRLKIIKTRDRVAKNLRKIGFKVLDSRANFIFISHQSYPACDLFNELKDKGILVRY
FNQPGISNYLRVSVGTEREMDVFIKTIEEIISG
>Mature_352_residues
SKYWSNTIKDIEPYVPGEQPKDKTYIKLNTNENPYPPSPRVIKAIKENTNNNLRLYPDPGCDNLKEAIASYYNLDRDQVF
VGNGSDEVLAFSFMAFFDRERPLLFPTITYSFYPVYCRLLNIEYRQVPLQDDFTLNVEEFYRENHGIIFPNPNAPTGIYL
PLSKVEKIVAYNIDKVVIIDEAYIDFGGKSAVSLIDKYPNLLIVQTFSKSRSLAGLRIGFAMGNKKLIEGLNRVKNSINS
YTLDTLAMIAAREAIKDDKYFEETRLKIIKTRDRVAKNLRKIGFKVLDSRANFIFISHQSYPACDLFNELKDKGILVRYF
NQPGISNYLRVSVGTEREMDVFIKTIEEIISG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=351, Percent_Identity=28.7749287749288, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788722, Length=258, Percent_Identity=30.2325581395349, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=360, Percent_Identity=31.9444444444444, Blast_Score=132, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40610; Mature: 40479

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKYWSNTIKDIEPYVPGEQPKDKTYIKLNTNENPYPPSPRVIKAIKENTNNNLRLYPDP
CCCHHCCHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCC
GCDNLKEAIASYYNLDRDQVFVGNGSDEVLAFSFMAFFDRERPLLFPTITYSFYPVYCRL
CCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHEEHHHE
LNIEYRQVPLQDDFTLNVEEFYRENHGIIFPNPNAPTGIYLPLSKVEKIVAYNIDKVVII
ECCHHEECCCCCCCEECHHHHHHCCCCEEECCCCCCCEEEEEHHHHHHHHHCCCCEEEEE
DEAYIDFGGKSAVSLIDKYPNLLIVQTFSKSRSLAGLRIGFAMGNKKLIEGLNRVKNSIN
EEHEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
SYTLDTLAMIAAREAIKDDKYFEETRLKIIKTRDRVAKNLRKIGFKVLDSRANFIFISHQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SYPACDLFNELKDKGILVRYFNQPGISNYLRVSVGTEREMDVFIKTIEEIISG
CCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKYWSNTIKDIEPYVPGEQPKDKTYIKLNTNENPYPPSPRVIKAIKENTNNNLRLYPDP
CCHHCCHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECCC
GCDNLKEAIASYYNLDRDQVFVGNGSDEVLAFSFMAFFDRERPLLFPTITYSFYPVYCRL
CCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHEEHHHE
LNIEYRQVPLQDDFTLNVEEFYRENHGIIFPNPNAPTGIYLPLSKVEKIVAYNIDKVVII
ECCHHEECCCCCCCEECHHHHHHCCCCEEECCCCCCCEEEEEHHHHHHHHHCCCCEEEEE
DEAYIDFGGKSAVSLIDKYPNLLIVQTFSKSRSLAGLRIGFAMGNKKLIEGLNRVKNSIN
EEHEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
SYTLDTLAMIAAREAIKDDKYFEETRLKIIKTRDRVAKNLRKIGFKVLDSRANFIFISHQ
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
SYPACDLFNELKDKGILVRYFNQPGISNYLRVSVGTEREMDVFIKTIEEIISG
CCCHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]