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The map label for this gene is fhs

Identifier: 220930908

GI number: 220930908

Start: 69708

End: 71372

Strand: Direct

Name: fhs

Synonym: Hore_00600

Alternate gene names: 220930908

Gene position: 69708-71372 (Clockwise)

Preceding gene: 220930907

Following gene: 220930909

Centisome position: 2.7

GC content: 44.5

Gene sequence:

>1665_bases
TTGAAAAGTGATATTGAGATTGCCCAGGATGCCAGGATGGAACCTATTGAGGAGATAGCAGAAAAGGCAGGATTACATAA
AGACCAGATTGAGTTATATGGGAAGTACAAAGCAAAGGTAAATACCGATATCATTGATGATGATAAAAAGGACGGCAAGC
TGGTTCTGGTAACGGCTATTACACCAACCCCGGCCGGTGAGGGAAAAACGACCACTACGGTGGGGCTGGGGCAGGCCCTT
AACCTGTTAGGAAAAAAGGCCATTATTGCTTTAAGGGAGCCGTCCTTAGGCCCGACGATGGGGATAAAAGGTGGAGCAGC
CGGTGGCGGTTATTCCCAGGTTTTACCGATGGAAGATATAAATTTACATTTCACTGGTGATATACATGCCATTGGGGCTG
CCCATAATTTACTTTCAGCTGTAATAGATAACCATATAAAACAGGGTAATGACCTGGGGATTGATCCTACTTCAGTGACC
TGGAAAAGGGTAGTCGACATGAATGACAGGGCCCTCAGGAATATCGTTGTTGGTCTGGGTGGTAAAGCCCATGGTGTTCC
CCGGGAAGATGGGTTTATGATTACAGTGGCCTCAGAGATTATGGCTATTCTATGCCTGGCCAACAATTTAGAAGACCTGA
AAAATAAGATAAGTAATATAGTAGTAGGTTATACTTATGATGGGGAAGCAATAACCGCAGGTGACTTAAAGGTATCTGGA
GCAATGACAGCCCTGTTAAAGGATGCTATTAAACCGAATCTGGTTCAAACCCTTGAAAATACTCCGGCCTTTATCCACGG
TGGTCCCTTTGCCAATATTGCCCATGGATGTAATAGTATTATGGCAACCAAAATGGCCCTTAAACTCGGTGAAATTACTG
TTACAGAGGCCGGGTTTGGAGCCGACCTCGGTGCTGAGAAATTTTTTAACATTAAGTGCAGGTATGCTGGACTTAATCCT
GATGCGGCCGTGGTTGTGGCCACTGTCAGGGCACTAAAGATGCACGGTGGGGTGGATAAAGATAGCCTGTCTGAGGAAAA
CCTAGACGCCCTTGCCAGGGGTTTTGAAAACCTGGAAAAACACCTCGAAAATGTTTCTAAATTTGGTGTGCCATCAGTTG
TGGCCATTAATCGATTCCCCGGGGATACAGAAGCAGAGTTGAACCTTGTAAGGGATAAATGTGAAGAGATGGGAGTGCCG
GTTGCTATTTCAGAAGTATGGGCCAGAGGTGGAGAGGGAGGACTGGATCTGGCCAGAAAGTTGGTTGATGTCCTAGAAAA
TACCCCCGGCCAGTTCAGTTATCTATATGATGTTAACTTTCCTATTACCGACAAGATTGAAAAAATTGCAAAAGAAATTT
ACGGGGCTGACGGGGTTAATTACACCAGTAAAGCATTAAAACAGATAGATAAATATACTGAACTGGGCTATGATAAACTA
CCGATCTGTATGGCCAAAACCCAGAGTTCAATATCTGATGATCCCTCTTTAAAGGGAAGGCCTAGAGGGTTTAGAATAAA
TGTAAGAGAGGTTAATTTATCAGCAGGGGCAGGGTTTATAATTCCCCTGACAGGACCTGTCCTGACGATGCCCGGTTTAC
CAAAAAAACCTGCTGCTGAAGGAATAGATATAGATGCTGACGGCAAAATAAGCGGTCTATTTTAG

Upstream 100 bases:

>100_bases
AATTAAATGCCCCTTTCTAAATAAAAATAATTAAAGAAGGATATTTATATAGTTACATGGAATTTAATGAACAAGATTAA
AAAAGAAAGGGGAGTTTGAG

Downstream 100 bases:

>100_bases
AAATCAAGGGTTGAGTTATTCAGGGTCTTTAATAATTAATTTTTCTGGCCGTAAAACCGGAGGCCAGATTAAAAAACCAA
TAATTATAAATTTATGAAAT

Product: Formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MKSDIEIAQDARMEPIEEIAEKAGLHKDQIELYGKYKAKVNTDIIDDDKKDGKLVLVTAITPTPAGEGKTTTTVGLGQAL
NLLGKKAIIALREPSLGPTMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAIGAAHNLLSAVIDNHIKQGNDLGIDPTSVT
WKRVVDMNDRALRNIVVGLGGKAHGVPREDGFMITVASEIMAILCLANNLEDLKNKISNIVVGYTYDGEAITAGDLKVSG
AMTALLKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIMATKMALKLGEITVTEAGFGADLGAEKFFNIKCRYAGLNP
DAAVVVATVRALKMHGGVDKDSLSEENLDALARGFENLEKHLENVSKFGVPSVVAINRFPGDTEAELNLVRDKCEEMGVP
VAISEVWARGGEGGLDLARKLVDVLENTPGQFSYLYDVNFPITDKIEKIAKEIYGADGVNYTSKALKQIDKYTELGYDKL
PICMAKTQSSISDDPSLKGRPRGFRINVREVNLSAGAGFIIPLTGPVLTMPGLPKKPAAEGIDIDADGKISGLF

Sequences:

>Translated_554_residues
MKSDIEIAQDARMEPIEEIAEKAGLHKDQIELYGKYKAKVNTDIIDDDKKDGKLVLVTAITPTPAGEGKTTTTVGLGQAL
NLLGKKAIIALREPSLGPTMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAIGAAHNLLSAVIDNHIKQGNDLGIDPTSVT
WKRVVDMNDRALRNIVVGLGGKAHGVPREDGFMITVASEIMAILCLANNLEDLKNKISNIVVGYTYDGEAITAGDLKVSG
AMTALLKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIMATKMALKLGEITVTEAGFGADLGAEKFFNIKCRYAGLNP
DAAVVVATVRALKMHGGVDKDSLSEENLDALARGFENLEKHLENVSKFGVPSVVAINRFPGDTEAELNLVRDKCEEMGVP
VAISEVWARGGEGGLDLARKLVDVLENTPGQFSYLYDVNFPITDKIEKIAKEIYGADGVNYTSKALKQIDKYTELGYDKL
PICMAKTQSSISDDPSLKGRPRGFRINVREVNLSAGAGFIIPLTGPVLTMPGLPKKPAAEGIDIDADGKISGLF
>Mature_554_residues
MKSDIEIAQDARMEPIEEIAEKAGLHKDQIELYGKYKAKVNTDIIDDDKKDGKLVLVTAITPTPAGEGKTTTTVGLGQAL
NLLGKKAIIALREPSLGPTMGIKGGAAGGGYSQVLPMEDINLHFTGDIHAIGAAHNLLSAVIDNHIKQGNDLGIDPTSVT
WKRVVDMNDRALRNIVVGLGGKAHGVPREDGFMITVASEIMAILCLANNLEDLKNKISNIVVGYTYDGEAITAGDLKVSG
AMTALLKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIMATKMALKLGEITVTEAGFGADLGAEKFFNIKCRYAGLNP
DAAVVVATVRALKMHGGVDKDSLSEENLDALARGFENLEKHLENVSKFGVPSVVAINRFPGDTEAELNLVRDKCEEMGVP
VAISEVWARGGEGGLDLARKLVDVLENTPGQFSYLYDVNFPITDKIEKIAKEIYGADGVNYTSKALKQIDKYTELGYDKL
PICMAKTQSSISDDPSLKGRPRGFRINVREVNLSAGAGFIIPLTGPVLTMPGLPKKPAAEGIDIDADGKISGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=46.6882067851373, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=47.172859450727, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=47.6744186046512, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=48.2315112540193, Blast_Score=513, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=48.2315112540193, Blast_Score=513, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=44.6909667194929, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=44.408945686901, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=44.0322580645161, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=44.0322580645161, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=44.0322580645161, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=44.0322580645161, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_HALOH (B8D067)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002507816.1
- ProteinModelPortal:   B8D067
- SMR:   B8D067
- GeneID:   7314278
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_00600
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59070; Mature: 59070

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIAQDARMEPIEEIAEKAGLHKDQIELYGKYKAKVNTDIIDDDKKDGKLVLVTAI
CCCCCCHHHHCCCCHHHHHHHHHCCCHHHHHEEEEEEEEECCCCCCCCCCCCCEEEEEEE
TPTPAGEGKTTTTVGLGQALNLLGKKAIIALREPSLGPTMGIKGGAAGGGYSQVLPMEDI
CCCCCCCCCCEEEEHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NLHFTGDIHAIGAAHNLLSAVIDNHIKQGNDLGIDPTSVTWKRVVDMNDRALRNIVVGLG
CEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCC
GKAHGVPREDGFMITVASEIMAILCLANNLEDLKNKISNIVVGYTYDGEAITAGDLKVSG
CCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCEEEECCEEEHH
AMTALLKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIMATKMALKLGEITVTEAGFG
HHHHHHHHHCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
ADLGAEKFFNIKCRYAGLNPDAAVVVATVRALKMHGGVDKDSLSEENLDALARGFENLEK
CCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHH
HLENVSKFGVPSVVAINRFPGDTEAELNLVRDKCEEMGVPVAISEVWARGGEGGLDLARK
HHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCHHHHHH
LVDVLENTPGQFSYLYDVNFPITDKIEKIAKEIYGADGVNYTSKALKQIDKYTELGYDKL
HHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
PICMAKTQSSISDDPSLKGRPRGFRINVREVNLSAGAGFIIPLTGPVLTMPGLPKKPAAE
CEEEHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEECCCCEEECCCCCCCCCCC
GIDIDADGKISGLF
CCCCCCCCCCCCCC
>Mature Secondary Structure
MKSDIEIAQDARMEPIEEIAEKAGLHKDQIELYGKYKAKVNTDIIDDDKKDGKLVLVTAI
CCCCCCHHHHCCCCHHHHHHHHHCCCHHHHHEEEEEEEEECCCCCCCCCCCCCEEEEEEE
TPTPAGEGKTTTTVGLGQALNLLGKKAIIALREPSLGPTMGIKGGAAGGGYSQVLPMEDI
CCCCCCCCCCEEEEHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NLHFTGDIHAIGAAHNLLSAVIDNHIKQGNDLGIDPTSVTWKRVVDMNDRALRNIVVGLG
CEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHCCC
GKAHGVPREDGFMITVASEIMAILCLANNLEDLKNKISNIVVGYTYDGEAITAGDLKVSG
CCCCCCCCCCCEEEEEHHHHHHHHHHHCCHHHHHHHHCCEEEEEEECCCEEEECCEEEHH
AMTALLKDAIKPNLVQTLENTPAFIHGGPFANIAHGCNSIMATKMALKLGEITVTEAGFG
HHHHHHHHHCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
ADLGAEKFFNIKCRYAGLNPDAAVVVATVRALKMHGGVDKDSLSEENLDALARGFENLEK
CCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHH
HLENVSKFGVPSVVAINRFPGDTEAELNLVRDKCEEMGVPVAISEVWARGGEGGLDLARK
HHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHCCCCCCHHHHHH
LVDVLENTPGQFSYLYDVNFPITDKIEKIAKEIYGADGVNYTSKALKQIDKYTELGYDKL
HHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
PICMAKTQSSISDDPSLKGRPRGFRINVREVNLSAGAGFIIPLTGPVLTMPGLPKKPAAE
CEEEHHHHCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEECCCCEEECCCCCCCCCCC
GIDIDADGKISGLF
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA