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The map label for this gene is panF [H]

Identifier: 220930907

GI number: 220930907

Start: 68192

End: 69574

Strand: Direct

Name: panF [H]

Synonym: Hore_00590

Alternate gene names: 220930907

Gene position: 68192-69574 (Clockwise)

Preceding gene: 220930906

Following gene: 220930908

Centisome position: 2.65

GC content: 44.03

Gene sequence:

>1383_bases
ATGGTTTTAACAACAGTTATAGTCTATATGCTATTATTACTGGCAATCGGGTACTGGGCCAACAGAAAAATTAAGGGTTT
AACCGATTATCTACTGGCCGGAAGAAGGCTCGGTTTATGGCTGACGGCCGGAGCTCTGGCTGCTACCCATTTTGGTGGAG
GTATGGTAGTAGGTGGTGGTGAGTACGGATTTATTCATGGGTTTTCTGGAGCCTGGTATGGGATAAGCTGTGGAATTGGA
CTATTATTTTTATCATTTCTAACTGCAGGTAAATTCAGGGATTTATCCCTTTATACTGTTCCCGATTATCTAGCACATAG
ATATGGTGGAAAAACGGTAAGAGTCCTCGGCGCCATACTATCAGTGGTTGCAATAATAGGAATCATTGCTGCCCAGGTAC
TGGCAGCTAAAAGTGCCCTGGCTATACTCGGTATCAAAGGTAATGCCGGGGCTATTATAGCAACCCTTATATTTATAATT
TATACTGTCCTGGGAGGACTGTGGGCTGCCACCATAACTGATTTTATTCAGGTAATTATTGCCGGGGTGGGGACGGTTAT
TGCGGCCTCAATGGTATTATCTAATACTGGAGGGTTATCCGGGTTAAAGGAATCCCTATCTACTGTGAGTCCAGGTGTTG
ATTATTTTAACCTTTTTGGGTTTGGATGGACGACCATTTTATGGATATTATTACCTACTGTAATGTATACCCTTATCGGA
CAGGATTTTTACCAGAGGTTATTTGCCAGTAAGGATGGGATAACGGCCCGAAAGGCTTCTTTTATCGGAGGTATTTTCTT
AATTATTATCAGTTTCTTTCCTGTAATTACAGGAATGGGAGCCAGAATGTATTTTCCGGAAATGACAGATGCCAGTATGG
CTTTACCCCGTCTTGTTCAGGAATTGTTCCCCCTGGGTCTGGGGGCAGTCTTTCTGGCAGCCCTTCTTGCAGCAATTATG
TCTACGGCTGATTCCCTACTGACGGCAGGTACCTCCCACCTTATCAAGGATTTCTGGTTTGAGGTGTTTAACCGCGGTCA
GGACAGGGATAAGGGTCAGATTTTAACAATTTCAAGAGTTACGACCGGTGTTCTCGGTCTTTTAGCCCTGATTATTGCCC
TACTGGTTCCAACTGTGATTGATGCCTTGATTTATTCATATACAATGTATACCGCCGGTGTTTTTATTCCCCTGATCGGA
GGGGTACTGTGGCGCGGGGCAACCCGTAAGGGGGCCATTTCAGCTATTTTTGCCGGCAGTCTGGTTGCCATAACCGGTAT
TTTAACCGGATTTGAGGCCTGGGGAATACCAGTTGAAGTATATTCAGCGGTAATATCCCTGGTATTCTTTGTTGTAATTT
CTCTGGCAGATAAAAAAGATTAA

Upstream 100 bases:

>100_bases
TTTTTAATTATTATAACCAATTACTGATTTATTTTTTTCTTGACTTTAATATAATAAAGTGATAAAGTATTAAAGAGATT
AAAAAAACGGAGGGATATAG

Downstream 100 bases:

>100_bases
TTTTTTCAGGGCATTGAAATGCCCTGTTTTTTTAATTAAATGCCCCTTTCTAAATAAAAATAATTAAAGAAGGATATTTA
TATAGTTACATGGAATTTAA

Product: Sodium:solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MVLTTVIVYMLLLLAIGYWANRKIKGLTDYLLAGRRLGLWLTAGALAATHFGGGMVVGGGEYGFIHGFSGAWYGISCGIG
LLFLSFLTAGKFRDLSLYTVPDYLAHRYGGKTVRVLGAILSVVAIIGIIAAQVLAAKSALAILGIKGNAGAIIATLIFII
YTVLGGLWAATITDFIQVIIAGVGTVIAASMVLSNTGGLSGLKESLSTVSPGVDYFNLFGFGWTTILWILLPTVMYTLIG
QDFYQRLFASKDGITARKASFIGGIFLIIISFFPVITGMGARMYFPEMTDASMALPRLVQELFPLGLGAVFLAALLAAIM
STADSLLTAGTSHLIKDFWFEVFNRGQDRDKGQILTISRVTTGVLGLLALIIALLVPTVIDALIYSYTMYTAGVFIPLIG
GVLWRGATRKGAISAIFAGSLVAITGILTGFEAWGIPVEVYSAVISLVFFVVISLADKKD

Sequences:

>Translated_460_residues
MVLTTVIVYMLLLLAIGYWANRKIKGLTDYLLAGRRLGLWLTAGALAATHFGGGMVVGGGEYGFIHGFSGAWYGISCGIG
LLFLSFLTAGKFRDLSLYTVPDYLAHRYGGKTVRVLGAILSVVAIIGIIAAQVLAAKSALAILGIKGNAGAIIATLIFII
YTVLGGLWAATITDFIQVIIAGVGTVIAASMVLSNTGGLSGLKESLSTVSPGVDYFNLFGFGWTTILWILLPTVMYTLIG
QDFYQRLFASKDGITARKASFIGGIFLIIISFFPVITGMGARMYFPEMTDASMALPRLVQELFPLGLGAVFLAALLAAIM
STADSLLTAGTSHLIKDFWFEVFNRGQDRDKGQILTISRVTTGVLGLLALIIALLVPTVIDALIYSYTMYTAGVFIPLIG
GVLWRGATRKGAISAIFAGSLVAITGILTGFEAWGIPVEVYSAVISLVFFVVISLADKKD
>Mature_460_residues
MVLTTVIVYMLLLLAIGYWANRKIKGLTDYLLAGRRLGLWLTAGALAATHFGGGMVVGGGEYGFIHGFSGAWYGISCGIG
LLFLSFLTAGKFRDLSLYTVPDYLAHRYGGKTVRVLGAILSVVAIIGIIAAQVLAAKSALAILGIKGNAGAIIATLIFII
YTVLGGLWAATITDFIQVIIAGVGTVIAASMVLSNTGGLSGLKESLSTVSPGVDYFNLFGFGWTTILWILLPTVMYTLIG
QDFYQRLFASKDGITARKASFIGGIFLIIISFFPVITGMGARMYFPEMTDASMALPRLVQELFPLGLGAVFLAALLAAIM
STADSLLTAGTSHLIKDFWFEVFNRGQDRDKGQILTISRVTTGVLGLLALIIALLVPTVIDALIYSYTMYTAGVFIPLIG
GVLWRGATRKGAISAIFAGSLVAITGILTGFEAWGIPVEVYSAVISLVFFVVISLADKKD

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=485, Percent_Identity=27.2164948453608, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI17941285, Length=461, Percent_Identity=24.7288503253796, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI14140236, Length=479, Percent_Identity=22.964509394572, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI11141885, Length=461, Percent_Identity=26.6811279826464, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI109659836, Length=473, Percent_Identity=24.9471458773784, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4507033, Length=395, Percent_Identity=26.3291139240506, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI109659839, Length=489, Percent_Identity=24.1308793456033, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4507031, Length=401, Percent_Identity=24.1895261845387, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI110835708, Length=474, Percent_Identity=24.2616033755274, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI206597483, Length=388, Percent_Identity=24.4845360824742, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI206597487, Length=420, Percent_Identity=23.8095238095238, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI87082237, Length=436, Percent_Identity=27.2935779816514, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790503, Length=451, Percent_Identity=24.390243902439, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1790113, Length=423, Percent_Identity=26.0047281323877, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1787251, Length=448, Percent_Identity=24.5535714285714, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539284, Length=413, Percent_Identity=26.8765133171913, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24648033, Length=402, Percent_Identity=26.865671641791, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356865, Length=402, Percent_Identity=26.865671641791, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 48825; Mature: 48825

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLTTVIVYMLLLLAIGYWANRKIKGLTDYLLAGRRLGLWLTAGALAATHFGGGMVVGGG
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCC
EYGFIHGFSGAWYGISCGIGLLFLSFLTAGKFRDLSLYTVPDYLAHRYGGKTVRVLGAIL
CCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCHHHHHHHHHH
SVVAIIGIIAAQVLAAKSALAILGIKGNAGAIIATLIFIIYTVLGGLWAATITDFIQVII
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVGTVIAASMVLSNTGGLSGLKESLSTVSPGVDYFNLFGFGWTTILWILLPTVMYTLIG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFYQRLFASKDGITARKASFIGGIFLIIISFFPVITGMGARMYFPEMTDASMALPRLVQ
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
ELFPLGLGAVFLAALLAAIMSTADSLLTAGTSHLIKDFWFEVFNRGQDRDKGQILTISRV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHH
TTGVLGLLALIIALLVPTVIDALIYSYTMYTAGVFIPLIGGVLWRGATRKGAISAIFAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LVAITGILTGFEAWGIPVEVYSAVISLVFFVVISLADKKD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLTTVIVYMLLLLAIGYWANRKIKGLTDYLLAGRRLGLWLTAGALAATHFGGGMVVGGG
CHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCC
EYGFIHGFSGAWYGISCGIGLLFLSFLTAGKFRDLSLYTVPDYLAHRYGGKTVRVLGAIL
CCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHCCCHHHHHHHHHH
SVVAIIGIIAAQVLAAKSALAILGIKGNAGAIIATLIFIIYTVLGGLWAATITDFIQVII
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVGTVIAASMVLSNTGGLSGLKESLSTVSPGVDYFNLFGFGWTTILWILLPTVMYTLIG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFYQRLFASKDGITARKASFIGGIFLIIISFFPVITGMGARMYFPEMTDASMALPRLVQ
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHH
ELFPLGLGAVFLAALLAAIMSTADSLLTAGTSHLIKDFWFEVFNRGQDRDKGQILTISRV
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHH
TTGVLGLLALIIALLVPTVIDALIYSYTMYTAGVFIPLIGGVLWRGATRKGAISAIFAGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LVAITGILTGFEAWGIPVEVYSAVISLVFFVVISLADKKD
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]