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The map label for this gene is gyrA [H]

Identifier: 220930857

GI number: 220930857

Start: 7134

End: 9584

Strand: Direct

Name: gyrA [H]

Synonym: Hore_00070

Alternate gene names: 220930857

Gene position: 7134-9584 (Clockwise)

Preceding gene: 220930856

Following gene: 220930860

Centisome position: 0.28

GC content: 43.98

Gene sequence:

>2451_bases
ATGGTAATGGATATAAACAATGGTAAGGTCCTTGAGGTTGATATTGAGAATGAAATGAAGGGTGCCTACCTGGACTATGC
CATGAGTGTTATTGTAAGCCGGGCTCTACCTGATGTCAGGGATGGATTGAAACCGGTACAGCGGAGGATACTCTATGCCC
TGCATGATCTGGGGATTACCCCCAATAAACCCCATAAAAAATCAGCCAGGGTTGTCGGTGAAGTCCTGGGTAAATACCAT
CCCCATGGCGATACTGCTGTCTATGATACCATGGTCAGGATGGCCCAGGAATTTTCCTTTCGTTATCCCCTGGTTGATGG
CCACGGTAATTTTGGTTCTATTGACGGCGACTCAGCTGCGGCAATGAGGTATACCGAGGTCAGAATGGCCAGGTTAACCA
CCGAACTCTTGAGGGATATTGATAAAAACACGGTGGATTTTGCTCCCAACTTTGATGAATCCCTTGAAGAACCAGAGGTA
TTGCCGGCCAGATTACCAAATCTTTTGATGAATGGAGTCTCCGGGATTGCTGTCGGGATGTCTACCAATATTCCACCCCA
CAACCTCGGTGAGGTTATCGACGGTGTTGTTGCTTTAATAGATAACCCTGACCTTGAGGTTAAAGATTTAATGAAAATAA
TAAAAGGGCCTGATTTCCCTACTGGTGGTATAATTATGGGTAAAGATAAAATTTACCAGGCCTATAAGACCGGGCGGGGA
CGGTTAAAAGTCAGGGGAAAGGCCCGGATAGAAGAGGATAAGAACGGTAAGTCGAAAATAATAATTACGGAAATTCCCTA
TCAGGTTAATAAAGCCCGCCTGGTGGAAAAGATAGCAAATCTCGTCCGGGATGAAAAGATAACCGGAATAAGTGATTTAA
GGGATGAATCGGACAGGCGCGGACTCCGGATTGTGATAGAACTTAAAAAAGGGACTGTCCCTAAAGTTATTTTAAACCGT
CTGTATAAATATACCCAGCTCCAGGTAACCTATGGGGTTATTATGCTGGCCCTGGTTGATGGTATGCCCAGGGTTTTAAC
CTTAAAGGAGCTATTAAACCATTACCTGGAACATCAAAAAGAAGTAGTTACCAGACGGACAAAATACCAGCTGGATAAAG
CTGAAGCCAGAGCCCATATCCTGGAGGGACTCAGGATAGCCCTGGCCAATATTGATGATATAGTCCAGTTAATTAGAGAA
GCACCTGATGTTGATACTGCCCGCAGGGGTTTAATTGAAAACTTTAACCTTACTGAAAAACAGGCTGAAGCCATCCTGAG
AATGAGGCTGCAGAGGCTTACCGGTCTGGAGAGGGATAAAATTGAGGCTGAATATAAGGAGCTTAAAGAAAAGATTGCCT
ATTACAGATCTATCCTGGCAGATGAAGGCAAGTTACTGGGTATTATCAAGGATGAGCTTCTTGAATTAAAGGAAAAATTC
CAGGATGAAAGAAGGACTGAAATATCTATTCAGGCTGTTGACCTCGATGTAGAGGATCTGATACCTGAAGAACAGGTGGT
AATCACCTTAACCCACCATGGTTATATAAAGAGAATGCCTATTGATATTTACCGCAGTCAGCGTCGTGGCGGTAAAGGTA
TAATAGGTATTAATACCAAAGAGGAAGACTTTGTTGAACACGTCTTTACAACTTCAACCCATCATTACTTTCTGTTCTTT
ACAAATAAGGGTAAGGTATACCGACTCCGGGTTTTTGAGATTCCACAGGCCAGCCGCCAGGCCCGGGGTACTGCCATTGT
AAACCTGCTGGAACTGGAAGAAGAAGAGAGGATAACTACTGTTATCCCCATCAGGGAATTTGATGAGGAGAGGTACCTGG
TTATGGTAACCAGAAATGGTATGATAAAAAAGACACCCCTGGCCGAATATGAGTCCCGGTATACCGGTTTAATCGGTTTA
ACTTTAAGGGATGAAGATGAACTAATTGATGTTAAATATACTGATGGAAACCAGAGTGTAATTATTGTTACCCACAGGGG
TAAAGCCATTCACTTTAAAGAAAATGAAGTCAGGTCTATGGGAAGAACGGCCATGGGAGTTAAAGCTATAACTTTAGAGG
ATGGAGACTATGTTGTCGGGATGGGGGTTGATAGTGAAGGAGATGACCTCCTGGTTATTACCGAAAAGGGTTATGGTAAG
AGAACCCCACTTGAGGAATACCGACTGCAGAGCCGTGGTGGTAAAGGACTTATTACGGCAAATATAACAGAGAAAAATGG
TAACCTGGCCGGGGTTAAAGTTGTTAGAGAAGACCATGACCTGATTCTTATCACCAGTGAAGGTATCATTATCAGGACCA
GGGTTGAAGGGATATCTCGCCTGGGTCGAAATACCCTGGGTGTTAAGGTTATCAGGCTTGAAGAGGGTGACCGGGTGGTT
TCCCTGGCACGGATTTCCCCTGAAGAAAAGGATATTGAGGAGATGGATTAA

Upstream 100 bases:

>100_bases
ATTTCCTTGTTAATTTCCTAAATATCCTTAACTAATTTATTTCCTTTTTATCTCTAACTTTACCAGCTTTATATAAATTA
AATCGGCAGGTGAATTATTA

Downstream 100 bases:

>100_bases
TTGTTGAATGGTTAAAGACAGGATTACTTATGTTTAAATTGTGTTTAAATGGAGAACTTAATATTAAACCTGTAGAGATA
CCCAGCCCTTAAAAGGGCTG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MVMDINNGKVLEVDIENEMKGAYLDYAMSVIVSRALPDVRDGLKPVQRRILYALHDLGITPNKPHKKSARVVGEVLGKYH
PHGDTAVYDTMVRMAQEFSFRYPLVDGHGNFGSIDGDSAAAMRYTEVRMARLTTELLRDIDKNTVDFAPNFDESLEEPEV
LPARLPNLLMNGVSGIAVGMSTNIPPHNLGEVIDGVVALIDNPDLEVKDLMKIIKGPDFPTGGIIMGKDKIYQAYKTGRG
RLKVRGKARIEEDKNGKSKIIITEIPYQVNKARLVEKIANLVRDEKITGISDLRDESDRRGLRIVIELKKGTVPKVILNR
LYKYTQLQVTYGVIMLALVDGMPRVLTLKELLNHYLEHQKEVVTRRTKYQLDKAEARAHILEGLRIALANIDDIVQLIRE
APDVDTARRGLIENFNLTEKQAEAILRMRLQRLTGLERDKIEAEYKELKEKIAYYRSILADEGKLLGIIKDELLELKEKF
QDERRTEISIQAVDLDVEDLIPEEQVVITLTHHGYIKRMPIDIYRSQRRGGKGIIGINTKEEDFVEHVFTTSTHHYFLFF
TNKGKVYRLRVFEIPQASRQARGTAIVNLLELEEEERITTVIPIREFDEERYLVMVTRNGMIKKTPLAEYESRYTGLIGL
TLRDEDELIDVKYTDGNQSVIIVTHRGKAIHFKENEVRSMGRTAMGVKAITLEDGDYVVGMGVDSEGDDLLVITEKGYGK
RTPLEEYRLQSRGGKGLITANITEKNGNLAGVKVVREDHDLILITSEGIIIRTRVEGISRLGRNTLGVKVIRLEEGDRVV
SLARISPEEKDIEEMD

Sequences:

>Translated_816_residues
MVMDINNGKVLEVDIENEMKGAYLDYAMSVIVSRALPDVRDGLKPVQRRILYALHDLGITPNKPHKKSARVVGEVLGKYH
PHGDTAVYDTMVRMAQEFSFRYPLVDGHGNFGSIDGDSAAAMRYTEVRMARLTTELLRDIDKNTVDFAPNFDESLEEPEV
LPARLPNLLMNGVSGIAVGMSTNIPPHNLGEVIDGVVALIDNPDLEVKDLMKIIKGPDFPTGGIIMGKDKIYQAYKTGRG
RLKVRGKARIEEDKNGKSKIIITEIPYQVNKARLVEKIANLVRDEKITGISDLRDESDRRGLRIVIELKKGTVPKVILNR
LYKYTQLQVTYGVIMLALVDGMPRVLTLKELLNHYLEHQKEVVTRRTKYQLDKAEARAHILEGLRIALANIDDIVQLIRE
APDVDTARRGLIENFNLTEKQAEAILRMRLQRLTGLERDKIEAEYKELKEKIAYYRSILADEGKLLGIIKDELLELKEKF
QDERRTEISIQAVDLDVEDLIPEEQVVITLTHHGYIKRMPIDIYRSQRRGGKGIIGINTKEEDFVEHVFTTSTHHYFLFF
TNKGKVYRLRVFEIPQASRQARGTAIVNLLELEEEERITTVIPIREFDEERYLVMVTRNGMIKKTPLAEYESRYTGLIGL
TLRDEDELIDVKYTDGNQSVIIVTHRGKAIHFKENEVRSMGRTAMGVKAITLEDGDYVVGMGVDSEGDDLLVITEKGYGK
RTPLEEYRLQSRGGKGLITANITEKNGNLAGVKVVREDHDLILITSEGIIIRTRVEGISRLGRNTLGVKVIRLEEGDRVV
SLARISPEEKDIEEMD
>Mature_816_residues
MVMDINNGKVLEVDIENEMKGAYLDYAMSVIVSRALPDVRDGLKPVQRRILYALHDLGITPNKPHKKSARVVGEVLGKYH
PHGDTAVYDTMVRMAQEFSFRYPLVDGHGNFGSIDGDSAAAMRYTEVRMARLTTELLRDIDKNTVDFAPNFDESLEEPEV
LPARLPNLLMNGVSGIAVGMSTNIPPHNLGEVIDGVVALIDNPDLEVKDLMKIIKGPDFPTGGIIMGKDKIYQAYKTGRG
RLKVRGKARIEEDKNGKSKIIITEIPYQVNKARLVEKIANLVRDEKITGISDLRDESDRRGLRIVIELKKGTVPKVILNR
LYKYTQLQVTYGVIMLALVDGMPRVLTLKELLNHYLEHQKEVVTRRTKYQLDKAEARAHILEGLRIALANIDDIVQLIRE
APDVDTARRGLIENFNLTEKQAEAILRMRLQRLTGLERDKIEAEYKELKEKIAYYRSILADEGKLLGIIKDELLELKEKF
QDERRTEISIQAVDLDVEDLIPEEQVVITLTHHGYIKRMPIDIYRSQRRGGKGIIGINTKEEDFVEHVFTTSTHHYFLFF
TNKGKVYRLRVFEIPQASRQARGTAIVNLLELEEEERITTVIPIREFDEERYLVMVTRNGMIKKTPLAEYESRYTGLIGL
TLRDEDELIDVKYTDGNQSVIIVTHRGKAIHFKENEVRSMGRTAMGVKAITLEDGDYVVGMGVDSEGDDLLVITEKGYGK
RTPLEEYRLQSRGGKGLITANITEKNGNLAGVKVVREDHDLILITSEGIIIRTRVEGISRLGRNTLGVKVIRLEEGDRVV
SLARISPEEKDIEEMD

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=442, Percent_Identity=24.4343891402715, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=174, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1788562, Length=846, Percent_Identity=50.354609929078, Blast_Score=838, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=568, Percent_Identity=41.1971830985916, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI212645845, Length=393, Percent_Identity=26.7175572519084, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17535065, Length=379, Percent_Identity=26.1213720316623, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=378, Percent_Identity=25.9259259259259, Blast_Score=87, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324241, Length=177, Percent_Identity=33.8983050847458, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136538, Length=365, Percent_Identity=25.4794520547945, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR010235
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; PF08780 NTase_sub_bind [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92498; Mature: 92498

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMDINNGKVLEVDIENEMKGAYLDYAMSVIVSRALPDVRDGLKPVQRRILYALHDLGIT
CEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
PNKPHKKSARVVGEVLGKYHPHGDTAVYDTMVRMAQEFSFRYPLVDGHGNFGSIDGDSAA
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHH
AMRYTEVRMARLTTELLRDIDKNTVDFAPNFDESLEEPEVLPARLPNLLMNGVSGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHCCCCCCCHHHHHHHHHCCCCCEEEEC
STNIPPHNLGEVIDGVVALIDNPDLEVKDLMKIIKGPDFPTGGIIMGKDKIYQAYKTGRG
CCCCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCC
RLKVRGKARIEEDKNGKSKIIITEIPYQVNKARLVEKIANLVRDEKITGISDLRDESDRR
EEEEEECEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GLRIVIELKKGTVPKVILNRLYKYTQLQVTYGVIMLALVDGMPRVLTLKELLNHYLEHQK
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EVVTRRTKYQLDKAEARAHILEGLRIALANIDDIVQLIREAPDVDTARRGLIENFNLTEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
QAEAILRMRLQRLTGLERDKIEAEYKELKEKIAYYRSILADEGKLLGIIKDELLELKEKF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
QDERRTEISIQAVDLDVEDLIPEEQVVITLTHHGYIKRMPIDIYRSQRRGGKGIIGINTK
HHHCCCEEEEEEEECCHHHCCCCCEEEEEEECCCEEEECCHHHHHHHCCCCCEEEECCCC
EEDFVEHVFTTSTHHYFLFFTNKGKVYRLRVFEIPQASRQARGTAIVNLLELEEEERITT
HHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCHHHHCCCHHEEHEECCCCCCCEEE
VIPIREFDEERYLVMVTRNGMIKKTPLAEYESRYTGLIGLTLRDEDELIDVKYTDGNQSV
EEEHHHCCCCCEEEEEECCCCEECCCCHHHHCCCCEEEEEEEECCCCEEEEEEECCCCEE
IIVTHRGKAIHFKENEVRSMGRTAMGVKAITLEDGDYVVGMGVDSEGDDLLVITEKGYGK
EEEEECCCEEEECHHHHHHCCCHHHCEEEEEEECCCEEEEECCCCCCCCEEEEECCCCCC
RTPLEEYRLQSRGGKGLITANITEKNGNLAGVKVVREDHDLILITSEGIIIRTRVEGISR
CCCHHHHHHHCCCCCEEEEEEEEECCCCEEEEEEEECCCCEEEEECCCEEEEEEHHHHHH
LGRNTLGVKVIRLEEGDRVVSLARISPEEKDIEEMD
HCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHCC
>Mature Secondary Structure
MVMDINNGKVLEVDIENEMKGAYLDYAMSVIVSRALPDVRDGLKPVQRRILYALHDLGIT
CEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
PNKPHKKSARVVGEVLGKYHPHGDTAVYDTMVRMAQEFSFRYPLVDGHGNFGSIDGDSAA
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHH
AMRYTEVRMARLTTELLRDIDKNTVDFAPNFDESLEEPEVLPARLPNLLMNGVSGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHCCCCCCCHHHHHHHHHCCCCCEEEEC
STNIPPHNLGEVIDGVVALIDNPDLEVKDLMKIIKGPDFPTGGIIMGKDKIYQAYKTGRG
CCCCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCEEECHHHHHHHHHCCCC
RLKVRGKARIEEDKNGKSKIIITEIPYQVNKARLVEKIANLVRDEKITGISDLRDESDRR
EEEEEECEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GLRIVIELKKGTVPKVILNRLYKYTQLQVTYGVIMLALVDGMPRVLTLKELLNHYLEHQK
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
EVVTRRTKYQLDKAEARAHILEGLRIALANIDDIVQLIREAPDVDTARRGLIENFNLTEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHH
QAEAILRMRLQRLTGLERDKIEAEYKELKEKIAYYRSILADEGKLLGIIKDELLELKEKF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
QDERRTEISIQAVDLDVEDLIPEEQVVITLTHHGYIKRMPIDIYRSQRRGGKGIIGINTK
HHHCCCEEEEEEEECCHHHCCCCCEEEEEEECCCEEEECCHHHHHHHCCCCCEEEECCCC
EEDFVEHVFTTSTHHYFLFFTNKGKVYRLRVFEIPQASRQARGTAIVNLLELEEEERITT
HHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEECCCHHHHCCCHHEEHEECCCCCCCEEE
VIPIREFDEERYLVMVTRNGMIKKTPLAEYESRYTGLIGLTLRDEDELIDVKYTDGNQSV
EEEHHHCCCCCEEEEEECCCCEECCCCHHHHCCCCEEEEEEEECCCCEEEEEEECCCCEE
IIVTHRGKAIHFKENEVRSMGRTAMGVKAITLEDGDYVVGMGVDSEGDDLLVITEKGYGK
EEEEECCCEEEECHHHHHHCCCHHHCEEEEEEECCCEEEEECCCCCCCCEEEEECCCCCC
RTPLEEYRLQSRGGKGLITANITEKNGNLAGVKVVREDHDLILITSEGIIIRTRVEGISR
CCCHHHHHHHCCCCCEEEEEEEEECCCCEEEEEEEECCCCEEEEECCCEEEEEEHHHHHH
LGRNTLGVKVIRLEEGDRVVSLARISPEEKDIEEMD
HCCCCCCEEEEEEECCCCEEEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10427704; 11058132 [H]