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The map label for this gene is gmd [H]

Identifier: 220919527

GI number: 220919527

Start: 4951554

End: 4952576

Strand: Direct

Name: gmd [H]

Synonym: A2cp1_4448

Alternate gene names: 220919527

Gene position: 4951554-4952576 (Clockwise)

Preceding gene: 220919526

Following gene: 220919531

Centisome position: 98.45

GC content: 69.4

Gene sequence:

>1023_bases
GTGAAGAAGGCGTTCATCACCGGCATCACCGGCCAGGACGGCAGCTACCTCGCGGAGCTGCTGCTCGAGAAGGGCTACGA
GGTCCACGGCATGGTCCGCCGCTCCTCGTCCTTCAACACGCAGCGGATCGACCACATCTACCAGGACCCGCACACCCCGG
GCTGCCGGCTGTTCCTGCACTACGGCGACCTCAACGACAGCTCGTCGCTCAACCTCTTGCTGAAGAAGCTCCGCCCGGAC
GAGATCTACAACCTGGGCGCGCAGAGCCACGTGCGCGTGTCGTTCGACGTGCCGGAGTACACCGGCGAGGTCACGGGCCT
GGGCGCGACGCGCCTGCTCGAGGCGGTGCGCGAGCTGAACCTCGCCGACACCCGCATCTACCAGGCGTCCTCCTCCGAGA
TGTTCGGCGCCTCGCCGCCGCCGCAGAACGAGGCGACGCCGTTCTACCCGCGCAGCCCCTACGGCTGCGCCAAGGTCTAC
GCCTACTGGATCGGCGTGAACTACCGCGAGGCGTACGGGCTCCACGTCTCGAACGGCATCCTCTTCAACCACGAGTCGCC
GCGTCGCGGCGAGACCTTCGTCACGCGCAAGGTCACCCGCGCCGCCTCGCGCATCAAGGTGGGCCTCCAGCAGAAGCTCT
ACCTCGGCAACCTCGACGCGAAGCGCGACTGGGGCTACGCGAAGGACTACGTCGAGGCGATGTGGCTGATGCTCCAGCAG
CCGAGGGGCGACGACTACGTGGTCGCCACCGGCGAGGCGCACTCGGTCCGCGAGCTGTGCGAGGCGGCCTTCGGGCACGT
GGGGCTCGACTACCGCCAGCACGTCGAGATCGACCCGCGGTACTACCGCCCGACCGAGGTGGACCACCTCCTCGGCGACG
CCTCCAAGGCGACGCGCCAGCTCGGCTGGAAGCCGCGGACGAGCTTCGCCGAGCTGATCCGGCTGATGATGGAGTCGGAC
GTGGCGCTGGCCGAGCGCGAGCTGCGCGCCGGCGCGGGGCCGGCGGTGTCGCGGCACGGGTAG

Upstream 100 bases:

>100_bases
CGAAGGCCCTGCGCGAGTTCGGCTGGAAGGCGCGCATCGGGTTCGAGGACGGGCTGCGCGAGACGGTGGAGTGGTTCGAG
GCCAACCGAGGGAGCATCCC

Downstream 100 bases:

>100_bases
CGCGGAGCTGGACGAGCGGAGGCGGTCGAACCCGGCGCCTTGCGCTGCGGATCAGGGCAGCGCGTCATGATGACGGGCGC
GACGGCGCTCGAGGTACCGT

Product: GDP-mannose 4,6-dehydratase

Products: NA

Alternate protein names: GDP-D-mannose dehydratase [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MKKAFITGITGQDGSYLAELLLEKGYEVHGMVRRSSSFNTQRIDHIYQDPHTPGCRLFLHYGDLNDSSSLNLLLKKLRPD
EIYNLGAQSHVRVSFDVPEYTGEVTGLGATRLLEAVRELNLADTRIYQASSSEMFGASPPPQNEATPFYPRSPYGCAKVY
AYWIGVNYREAYGLHVSNGILFNHESPRRGETFVTRKVTRAASRIKVGLQQKLYLGNLDAKRDWGYAKDYVEAMWLMLQQ
PRGDDYVVATGEAHSVRELCEAAFGHVGLDYRQHVEIDPRYYRPTEVDHLLGDASKATRQLGWKPRTSFAELIRLMMESD
VALAERELRAGAGPAVSRHG

Sequences:

>Translated_340_residues
MKKAFITGITGQDGSYLAELLLEKGYEVHGMVRRSSSFNTQRIDHIYQDPHTPGCRLFLHYGDLNDSSSLNLLLKKLRPD
EIYNLGAQSHVRVSFDVPEYTGEVTGLGATRLLEAVRELNLADTRIYQASSSEMFGASPPPQNEATPFYPRSPYGCAKVY
AYWIGVNYREAYGLHVSNGILFNHESPRRGETFVTRKVTRAASRIKVGLQQKLYLGNLDAKRDWGYAKDYVEAMWLMLQQ
PRGDDYVVATGEAHSVRELCEAAFGHVGLDYRQHVEIDPRYYRPTEVDHLLGDASKATRQLGWKPRTSFAELIRLMMESD
VALAERELRAGAGPAVSRHG
>Mature_340_residues
MKKAFITGITGQDGSYLAELLLEKGYEVHGMVRRSSSFNTQRIDHIYQDPHTPGCRLFLHYGDLNDSSSLNLLLKKLRPD
EIYNLGAQSHVRVSFDVPEYTGEVTGLGATRLLEAVRELNLADTRIYQASSSEMFGASPPPQNEATPFYPRSPYGCAKVY
AYWIGVNYREAYGLHVSNGILFNHESPRRGETFVTRKVTRAASRIKVGLQQKLYLGNLDAKRDWGYAKDYVEAMWLMLQQ
PRGDDYVVATGEAHSVRELCEAAFGHVGLDYRQHVEIDPRYYRPTEVDHLLGDASKATRQLGWKPRTSFAELIRLMMESD
VALAERELRAGAGPAVSRHG

Specific function: Biosynthesis of the slime polysaccharide colanic acid. First of the three steps in the biosynthesis of GDP-fucose from GDP-mannose. [C]

COG id: COG1089

COG function: function code M; GDP-D-mannose dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GDP-mannose 4,6-dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI4504031, Length=341, Percent_Identity=58.6510263929619, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1788366, Length=354, Percent_Identity=55.3672316384181, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1788353, Length=286, Percent_Identity=24.4755244755245, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI48994969, Length=340, Percent_Identity=24.7058823529412, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=344, Percent_Identity=56.1046511627907, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17539424, Length=342, Percent_Identity=54.9707602339181, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17539422, Length=342, Percent_Identity=54.9707602339181, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133901788, Length=342, Percent_Identity=54.9707602339181, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133901786, Length=342, Percent_Identity=54.9707602339181, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI133901790, Length=342, Percent_Identity=54.9707602339181, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24158427, Length=345, Percent_Identity=56.8115942028986, Blast_Score=409, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR006368
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.47 [H]

Molecular weight: Translated: 38321; Mature: 38321

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAFITGITGQDGSYLAELLLEKGYEVHGMVRRSSSFNTQRIDHIYQDPHTPGCRLFLH
CCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEE
YGDLNDSSSLNLLLKKLRPDEIYNLGAQSHVRVSFDVPEYTGEVTGLGATRLLEAVRELN
ECCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
LADTRIYQASSSEMFGASPPPQNEATPFYPRSPYGCAKVYAYWIGVNYREAYGLHVSNGI
CHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCEEECCCE
LFNHESPRRGETFVTRKVTRAASRIKVGLQQKLYLGNLDAKRDWGYAKDYVEAMWLMLQQ
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHC
PRGDDYVVATGEAHSVRELCEAAFGHVGLDYRQHVEIDPRYYRPTEVDHLLGDASKATRQ
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHCCHHHHHHH
LGWKPRTSFAELIRLMMESDVALAERELRAGAGPAVSRHG
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKKAFITGITGQDGSYLAELLLEKGYEVHGMVRRSSSFNTQRIDHIYQDPHTPGCRLFLH
CCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCEEEEEE
YGDLNDSSSLNLLLKKLRPDEIYNLGAQSHVRVSFDVPEYTGEVTGLGATRLLEAVRELN
ECCCCCCCHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
LADTRIYQASSSEMFGASPPPQNEATPFYPRSPYGCAKVYAYWIGVNYREAYGLHVSNGI
CHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCEEECCCE
LFNHESPRRGETFVTRKVTRAASRIKVGLQQKLYLGNLDAKRDWGYAKDYVEAMWLMLQQ
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHC
PRGDDYVVATGEAHSVRELCEAAFGHVGLDYRQHVEIDPRYYRPTEVDHLLGDASKATRQ
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHCCHHHHHHH
LGWKPRTSFAELIRLMMESDVALAERELRAGAGPAVSRHG
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]