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The map label for this gene is lepB [H]

Identifier: 220919390

GI number: 220919390

Start: 4803513

End: 4804184

Strand: Direct

Name: lepB [H]

Synonym: A2cp1_4311

Alternate gene names: 220919390

Gene position: 4803513-4804184 (Clockwise)

Preceding gene: 220919389

Following gene: 220919408

Centisome position: 95.51

GC content: 72.02

Gene sequence:

>672_bases
ATGAGAGAGGTACGGGGCTGGACGCTCACCATCCTCGCGGTGCTCGCCTTCCGGACGTTCCTCTACGAGGCCGTCTACAT
CCCGTCGGGCTCGATGCTGCCGACGCTGGAGATCGGCGACTACGTCATCGTGGAGAAGTGGGCCTACGGCGCGCGGCTGC
CGTTCACCGCGACCGCGCAGGCCACGTGGGCCACCCCGAAGCGCGGCGACATCGTGGTGCTGCTCGCGCCCCCCGGGAAC
CCGCGCGACGACGACCTCATCAAGCGGGTGGTGGCGGTCGGCGGCGACACGGTCGAGATCCTCGACGGGCACCTGGTGCT
GAACGGCCAGCCCGTGCCCCGCGAGCGCATCGCCGGCTCGTGCAGCTACTGGGATCGCCCCGAGGGCTCCGGCTGGCGCG
AGGAGCCGTGCGTGGACGCCCTCGAGCAGCTCGGGCCGCACCGCTACCACACGTACTGCACCCCGTACCAGGAGTGCGGT
GACGTGCCGGCGCAGAAGGTGCCCGAGGGCACGGTGTGGCTCGCCGGCGACCACCGCGACCACTCCGCCGACAGCCGCGT
GTTCGGCCCCGTCCCCGTCGGCCGCATCAAGGGCCGCGCCTGGATCGCGCTCGCGTCCTGGGGGCCGGGCGGGCCGCGGT
GGAACCGGCTGTTCCACTTCGTGAATCATTAG

Upstream 100 bases:

>100_bases
TGTTCGGCATCTACCCGGCCGCCCGAGCCTCGAAGCTCGACCCGGTGGAGGCGATGCGGATCGAATAGGAGAGCGGCGGC
GCGTGGACAGAGCGAAGGTG

Downstream 100 bases:

>100_bases
CCACGGGGACTGCGTCCCCGCCCCGCCGGCGGAGCCGTCGGGGCCCCACCCCTGCTGCGCGGGGCCCGTGACCTCGCGCG
CCCGCCTGCGCGGGCGCGCG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MREVRGWTLTILAVLAFRTFLYEAVYIPSGSMLPTLEIGDYVIVEKWAYGARLPFTATAQATWATPKRGDIVVLLAPPGN
PRDDDLIKRVVAVGGDTVEILDGHLVLNGQPVPRERIAGSCSYWDRPEGSGWREEPCVDALEQLGPHRYHTYCTPYQECG
DVPAQKVPEGTVWLAGDHRDHSADSRVFGPVPVGRIKGRAWIALASWGPGGPRWNRLFHFVNH

Sequences:

>Translated_223_residues
MREVRGWTLTILAVLAFRTFLYEAVYIPSGSMLPTLEIGDYVIVEKWAYGARLPFTATAQATWATPKRGDIVVLLAPPGN
PRDDDLIKRVVAVGGDTVEILDGHLVLNGQPVPRERIAGSCSYWDRPEGSGWREEPCVDALEQLGPHRYHTYCTPYQECG
DVPAQKVPEGTVWLAGDHRDHSADSRVFGPVPVGRIKGRAWIALASWGPGGPRWNRLFHFVNH
>Mature_223_residues
MREVRGWTLTILAVLAFRTFLYEAVYIPSGSMLPTLEIGDYVIVEKWAYGARLPFTATAQATWATPKRGDIVVLLAPPGN
PRDDDLIKRVVAVGGDTVEILDGHLVLNGQPVPRERIAGSCSYWDRPEGSGWREEPCVDALEQLGPHRYHTYCTPYQECG
DVPAQKVPEGTVWLAGDHRDHSADSRVFGPVPVGRIKGRAWIALASWGPGGPRWNRLFHFVNH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=250, Percent_Identity=34.8, Blast_Score=97, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 24780; Mature: 24780

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVRGWTLTILAVLAFRTFLYEAVYIPSGSMLPTLEIGDYVIVEKWAYGARLPFTATAQ
CCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEECCC
ATWATPKRGDIVVLLAPPGNPRDDDLIKRVVAVGGDTVEILDGHLVLNGQPVPRERIAGS
EEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECEEEECCCCCCHHHHCCC
CSYWDRPEGSGWREEPCVDALEQLGPHRYHTYCTPYQECGDVPAQKVPEGTVWLAGDHRD
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCHHHCCCCEEEEEECCCC
HSADSRVFGPVPVGRIKGRAWIALASWGPGGPRWNRLFHFVNH
CCCCCEEECCCCCCEECCEEEEEEECCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MREVRGWTLTILAVLAFRTFLYEAVYIPSGSMLPTLEIGDYVIVEKWAYGARLPFTATAQ
CCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEEECCCEEEEEECCCCCCCCCEECCC
ATWATPKRGDIVVLLAPPGNPRDDDLIKRVVAVGGDTVEILDGHLVLNGQPVPRERIAGS
EEECCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECEEEECCCCCCHHHHCCC
CSYWDRPEGSGWREEPCVDALEQLGPHRYHTYCTPYQECGDVPAQKVPEGTVWLAGDHRD
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCHHHCCCCEEEEEECCCC
HSADSRVFGPVPVGRIKGRAWIALASWGPGGPRWNRLFHFVNH
CCCCCEEECCCCCCEECCEEEEEEECCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]