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The map label for this gene is pepA [H]

Identifier: 220919326

GI number: 220919326

Start: 4729576

End: 4731132

Strand: Direct

Name: pepA [H]

Synonym: A2cp1_4247

Alternate gene names: 220919326

Gene position: 4729576-4731132 (Clockwise)

Preceding gene: 220919325

Following gene: 220919328

Centisome position: 94.04

GC content: 76.49

Gene sequence:

>1557_bases
ATGTCCCGAGGCATCGAGCGGATCGCGGTGAAGGCGGCAGGGGCGGCGCCGGCGGAGGCGGAGGCCGACGCGCTGGCGCT
GCCGGTGTTCGAGGACGAGGTCCGCGGCGCCGGGGCCGGCGCGGTGAAGGACCTCGACCGCCTGCTGGACGGCGCCCTCC
TCGCCGCCGCCCGCGCCGAGCGGTTCGCCGGCAAGGCCGGCCAGGAGCTGTCGCTCGCGACGCTCGGACGCGCCCGGGCA
GGCCGCGTGGTGCTCATGGGGATGGGGCCGCGCGCGAAGGCGCTCGAGGCCTGGGCGCGAGACGGGTACGAGGCGCTGCG
GGCCGCCGCGGGCAAGGCGGCGCGCGGCGCGGGGAAGGCCGGCGCGCGCAGGCTCGCGCTCGCCGCGCCGGCGCTGGACG
GGGACGCGCTCCCCGGCGCCGCCCGCGCGCTCGCCGAGGGCGCGCTCCTCGGCTCCTACCAGTTCACCCGCTACAAGAAG
GACGATCCGGCGCGGCCGTCCGGCGTCGCCGAGGTGGCGGTGCTGGTGCCGCCGTCGCTGGAGCGCGCCCGCGCGGTGAA
GGACGCGCTCGACGTCGCCCGCCGGATCGCGGGCGCGGTGGCCTGGGCGCGCGACCTCGTGAACCTGGGCCCGGCGGACT
GCACGCCGGAGCTGCTCGCGCGCGCGGCCGCCGAGGTGGCGCGGCGCGCCGGCCTCGCGGTGGAGGTGCGCGGGCCGAAG
GAGATCCAGGCGCTGAAGATGGGGATGTTCCTCGGCGTCACCCGCGGCTCCGCGGAGCCGCCGCGCCTCGTGAAGGTGAG
CTGGATCCCGCGCGGCGCCGCCGGACGGAAGGCGCCGGTGGTGCTGGTGGGCAAGGCCATCACCTTCGACTCGGGCGGGC
TCTCGCTGAAGCCCACCGAGAGCATGGTCACCATGAACACCGACATGGCGGGCAGCGCCGCGGTGCTCGGCGCGATGCAG
GTGATCGCCGCGCTGAAGCCGCCGTTCCCGGTGCACGCGGTGCTGGGCGCCTGCGAGAACATGCCGGGCGGGCGCGCCTA
CAAGCCGTCGGACGTGCTGGTGGCGCACGACGGGCAGACCGTCGAGATCACCAACACCGACGCGGAGGGGCGGCTGGTGC
TCGGGGACGTCCTCTCCTGGGCGGCGGACACCCTGAAGCCCGCGGCGATGATCGACGTCGCCACGCTCACCGGCGCGTGC
ATGGTGGCGCTCGGCAACGGCACCGCCGGCCTGTTCGGCCCGGAGGGCCCGGTCGCCGACGGCGTGCTCGCGGCCGCGCG
CGCGGCCGGCGAGGACGTCTGGCGCCTGCCCATGACCGAGGCGCTGAAGGAGCAGCTCAAGAGCGACCGCGCCGACCTGA
AGAACACCGGCGATCGCTGGGGCGGCGCCATCACCGCCGCGCACTTCCTCCACGCGTTCGCGAAGGAGACGCCCTGGGCG
CACCTCGACATCGCCGGGCCTTCCCACACCGGGAAGGAGCAGGGCTACGTCGCGAAGGGCGCGACCGGGTTCGCGGTCCG
CACGCTGGTCGAGTTCGTGCGCGCCTGGAAGGCGTGA

Upstream 100 bases:

>100_bases
CGGCGCGCCGGAGGCGGCCGAGGCCGTCCGCCGCATCGAGGCGGCGCAGTAGCCCTCGCCGTGCTAAACGACGCCTCCAC
ACACCCGTGGAGGAGCACGC

Downstream 100 bases:

>100_bases
GCGGCAGCATTCACGGTTCGTGATCGCGGCCGCCCGGGCCCGGCCCGGCGCGCCGCGATCACTCCGCGAGCGGCGCGTCC
TCGGTGCCGGCCGCGTCCGG

Product: Leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSRGIERIAVKAAGAAPAEAEADALALPVFEDEVRGAGAGAVKDLDRLLDGALLAAARAERFAGKAGQELSLATLGRARA
GRVVLMGMGPRAKALEAWARDGYEALRAAAGKAARGAGKAGARRLALAAPALDGDALPGAARALAEGALLGSYQFTRYKK
DDPARPSGVAEVAVLVPPSLERARAVKDALDVARRIAGAVAWARDLVNLGPADCTPELLARAAAEVARRAGLAVEVRGPK
EIQALKMGMFLGVTRGSAEPPRLVKVSWIPRGAAGRKAPVVLVGKAITFDSGGLSLKPTESMVTMNTDMAGSAAVLGAMQ
VIAALKPPFPVHAVLGACENMPGGRAYKPSDVLVAHDGQTVEITNTDAEGRLVLGDVLSWAADTLKPAAMIDVATLTGAC
MVALGNGTAGLFGPEGPVADGVLAAARAAGEDVWRLPMTEALKEQLKSDRADLKNTGDRWGGAITAAHFLHAFAKETPWA
HLDIAGPSHTGKEQGYVAKGATGFAVRTLVEFVRAWKA

Sequences:

>Translated_518_residues
MSRGIERIAVKAAGAAPAEAEADALALPVFEDEVRGAGAGAVKDLDRLLDGALLAAARAERFAGKAGQELSLATLGRARA
GRVVLMGMGPRAKALEAWARDGYEALRAAAGKAARGAGKAGARRLALAAPALDGDALPGAARALAEGALLGSYQFTRYKK
DDPARPSGVAEVAVLVPPSLERARAVKDALDVARRIAGAVAWARDLVNLGPADCTPELLARAAAEVARRAGLAVEVRGPK
EIQALKMGMFLGVTRGSAEPPRLVKVSWIPRGAAGRKAPVVLVGKAITFDSGGLSLKPTESMVTMNTDMAGSAAVLGAMQ
VIAALKPPFPVHAVLGACENMPGGRAYKPSDVLVAHDGQTVEITNTDAEGRLVLGDVLSWAADTLKPAAMIDVATLTGAC
MVALGNGTAGLFGPEGPVADGVLAAARAAGEDVWRLPMTEALKEQLKSDRADLKNTGDRWGGAITAAHFLHAFAKETPWA
HLDIAGPSHTGKEQGYVAKGATGFAVRTLVEFVRAWKA
>Mature_517_residues
SRGIERIAVKAAGAAPAEAEADALALPVFEDEVRGAGAGAVKDLDRLLDGALLAAARAERFAGKAGQELSLATLGRARAG
RVVLMGMGPRAKALEAWARDGYEALRAAAGKAARGAGKAGARRLALAAPALDGDALPGAARALAEGALLGSYQFTRYKKD
DPARPSGVAEVAVLVPPSLERARAVKDALDVARRIAGAVAWARDLVNLGPADCTPELLARAAAEVARRAGLAVEVRGPKE
IQALKMGMFLGVTRGSAEPPRLVKVSWIPRGAAGRKAPVVLVGKAITFDSGGLSLKPTESMVTMNTDMAGSAAVLGAMQV
IAALKPPFPVHAVLGACENMPGGRAYKPSDVLVAHDGQTVEITNTDAEGRLVLGDVLSWAADTLKPAAMIDVATLTGACM
VALGNGTAGLFGPEGPVADGVLAAARAAGEDVWRLPMTEALKEQLKSDRADLKNTGDRWGGAITAAHFLHAFAKETPWAH
LDIAGPSHTGKEQGYVAKGATGFAVRTLVEFVRAWKA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=493, Percent_Identity=35.9026369168357, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI47155554, Length=296, Percent_Identity=36.1486486486487, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1790710, Length=482, Percent_Identity=39.2116182572614, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87082123, Length=360, Percent_Identity=37.7777777777778, Blast_Score=176, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=299, Percent_Identity=32.4414715719064, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17565172, Length=336, Percent_Identity=26.4880952380952, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129969, Length=481, Percent_Identity=31.1850311850312, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24662227, Length=421, Percent_Identity=30.166270783848, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24661038, Length=444, Percent_Identity=29.954954954955, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161077148, Length=474, Percent_Identity=31.2236286919831, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20130057, Length=474, Percent_Identity=31.2236286919831, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355645, Length=422, Percent_Identity=30.8056872037915, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24662223, Length=422, Percent_Identity=30.8056872037915, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21355725, Length=443, Percent_Identity=29.7968397291196, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129963, Length=421, Percent_Identity=30.6413301662708, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI19922386, Length=419, Percent_Identity=29.3556085918854, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21357381, Length=342, Percent_Identity=32.1637426900585, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221379063, Length=342, Percent_Identity=32.1637426900585, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221379062, Length=342, Percent_Identity=32.1637426900585, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646701, Length=155, Percent_Identity=34.8387096774194, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646703, Length=155, Percent_Identity=34.8387096774194, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358201, Length=155, Percent_Identity=34.8387096774194, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53279; Mature: 53148

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGIERIAVKAAGAAPAEAEADALALPVFEDEVRGAGAGAVKDLDRLLDGALLAAARAE
CCCCHHHHEEEECCCCCCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
RFAGKAGQELSLATLGRARAGRVVLMGMGPRAKALEAWARDGYEALRAAAGKAARGAGKA
HHHCCCCCCEEHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCH
GARRLALAAPALDGDALPGAARALAEGALLGSYQFTRYKKDDPARPSGVAEVAVLVPPSL
HHHEEEEECCCCCCCCCCHHHHHHHHCHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCH
ERARAVKDALDVARRIAGAVAWARDLVNLGPADCTPELLARAAAEVARRAGLAVEVRGPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCH
EIQALKMGMFLGVTRGSAEPPRLVKVSWIPRGAAGRKAPVVLVGKAITFDSGGLSLKPTE
HHHHHHHHHHEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEECCCC
SMVTMNTDMAGSAAVLGAMQVIAALKPPFPVHAVLGACENMPGGRAYKPSDVLVAHDGQT
CEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCE
VEITNTDAEGRLVLGDVLSWAADTLKPAAMIDVATLTGACMVALGNGTAGLFGPEGPVAD
EEEECCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHH
GVLAAARAAGEDVWRLPMTEALKEQLKSDRADLKNTGDRWGGAITAAHFLHAFAKETPWA
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHCCCCE
HLDIAGPSHTGKEQGYVAKGATGFAVRTLVEFVRAWKA
EEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRGIERIAVKAAGAAPAEAEADALALPVFEDEVRGAGAGAVKDLDRLLDGALLAAARAE
CCCHHHHEEEECCCCCCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
RFAGKAGQELSLATLGRARAGRVVLMGMGPRAKALEAWARDGYEALRAAAGKAARGAGKA
HHHCCCCCCEEHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCH
GARRLALAAPALDGDALPGAARALAEGALLGSYQFTRYKKDDPARPSGVAEVAVLVPPSL
HHHEEEEECCCCCCCCCCHHHHHHHHCHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCH
ERARAVKDALDVARRIAGAVAWARDLVNLGPADCTPELLARAAAEVARRAGLAVEVRGPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCH
EIQALKMGMFLGVTRGSAEPPRLVKVSWIPRGAAGRKAPVVLVGKAITFDSGGLSLKPTE
HHHHHHHHHHEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEECCCCCEECCCC
SMVTMNTDMAGSAAVLGAMQVIAALKPPFPVHAVLGACENMPGGRAYKPSDVLVAHDGQT
CEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCE
VEITNTDAEGRLVLGDVLSWAADTLKPAAMIDVATLTGACMVALGNGTAGLFGPEGPVAD
EEEECCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHH
GVLAAARAAGEDVWRLPMTEALKEQLKSDRADLKNTGDRWGGAITAAHFLHAFAKETPWA
HHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHCCCCE
HLDIAGPSHTGKEQGYVAKGATGFAVRTLVEFVRAWKA
EEEECCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA