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The map label for this gene is penA [H]

Identifier: 220918990

GI number: 220918990

Start: 4342386

End: 4344413

Strand: Direct

Name: penA [H]

Synonym: A2cp1_3905

Alternate gene names: 220918990

Gene position: 4342386-4344413 (Clockwise)

Preceding gene: 220918989

Following gene: 220918991

Centisome position: 86.34

GC content: 78.01

Gene sequence:

>2028_bases
GTGCGCGCCGGGCCGGACCCCCGCGCCGCGCGCTGGATCGCCATCCGCATCACCGTCTTCGCCGTCCTCCTCGCCGCCGG
CCTCGCCGCGGTCGCGGGGCGGGTGTTCTGGCTGCAGGTGCTGCAGCGCGACGCGCTCGCCGGGGAGGCGGTGGACCAGT
ACCTGCGCGAGCTGGTGCTCCGCCCGCGGCGCGGCGTCATCACCGACCGCAGCGGCGTGCTGCTCGCCGGCAGCGCCGAC
GCCCAGTCCGCCTACGCCGACCCCAAGCTGCTCGCCGAGCACGACCGCTCCGGCGCCGCGGTCCGCCGCATCGCGCGGAT
CCTGAAGCAGGACCCGCGGGCGCTGCAGCGGAAGCTCGCGAAGGGCGGGCGCTTCGTGTGGCTGGAGCGGCGCATCCCGC
CCGCCGAGGCGGCCGCGCTGCGCAAATGGATCGACGAGGAGCGGGTGCGCGCGGTGCGCCTCGTGCCCGAGACGCGGCGC
TACTACCCGAAGCTCGAGCTGGCCGCGCAGGTCCTGGGCGTGGTGGACGACGACGGCGCGGGCCGCGAGGGCGTGGAGCT
CGCCGAGGACGAGCTGCTCCGCGGCGAGCCGGCGCGGGTGCCGTCGCTGCGCGACGGGCGCGGGCGGGTGGTGCTCGCCG
ACGCGCCCTCGCCCGGCCGCGAGCGCGAGGGCGCGCGGGTGGAGCTGACGCTCGACCAGGGCCTGCAGGTGGTGACGGAG
CGGGCGCTGGCGCGGGCGGTGACCGGCTCGCGCGCGCTGTCCGGCACCGCCGTCGCGATGGACCCGCGCACCGGCGAGGT
GCTGGCGCTCGCCAGCTACCCGGTCGCGAACGCGAACGCGCCGCGCAGCGCGGACGCCATCCGCAACCGCCCGGTGACCG
ACGCGTTCGAGCCGGGCTCGACCATCAAGACGTTCGTGATCGCGGCGGCGCTCGACCGCGGCGCGGTCGGCCCGAAGGAC
CCGTTCGACTGCGGCGCCGGGCGCTGGCCGGTGGGCAGCCACGTGATCCACGACACGCACCCGGTGGGCTGGGCGGGCCC
GTCGCGCATCCTGGTGGAGAGCTCGAACATCGGGGCGGCGCACGTCGGCGCCCGGCTCGGGCGCGAGGGCGTGCGCGAGG
CGCTGCTCGCGTTCGGCTTCGGCGAGCGCCCCGGGATCGGGCTGCCCGGCGAGATCCGCGGGCAGGTGCTGCTGGCCCGG
TCCGACATCGCGCTCGCCACCCAGAGCTTCGGCCAGGGCCCCATCACCGCCAGCCCGCTCCAGGTCACGACGGCGATGGC
CGCGATCGCGAACGGCGGCGCGCTGGTGCGCCCGCGCCTGGTGAAGCGCGTGCTCGACCCCGCCACCGGGCAGGTGCTGG
AGGCGCCCGCCGCCGAGGTGGTCCGGCAGGCGGTGCGCCCGGAGGTCGCCGCGATGGTGGCGCGGTGGCTGGTGGGCGTG
GTGGAGGAGCCGAAGGGAACGGGGAAGCGCGCGCGGCTCGACGGCTGGCGCGCCGCCGGCAAGACCGGCACCGCCCAGAA
GCCGGACCGGATCTCCGGCGGCTACTCCTCCGACCGGCACTACAGCTCGTTCGTGGGCTTCGCGCCGGCCGAGCAGGCGC
GCATCGCCATCGGCGTGTTCATCGACGAGCCGCGGGGCGAGATCTACGGCGGCGAGGTGGCGGCGCCCGCGTTCCGGGAG
ATCGCCGAGTACGCGCTGCGGATGATGGGCGTGCCGCCGGATCCATCGGCGGTGCGCACGCCCCCGCCCGCCGCGGTCGA
GGTGGCGCAGGCGCCGCCCGCGGACGAGCCGCCCGAGCCGCCGGCGGTGGAGTGGGCCGACCGGCGCCAGGCGGCGATGC
CCGCAGGCAGCGTGGCGGTCCCGGCGCTCGCCGGGCTCCCCATGCGCGCCGCCATCCGCCGCCTGGAGGAGCTCGACCTC
GCCCCCGAGCCGAGCGGCTCTGGCCGGGTGGTCGGCCAGACGCCCGCCGCGGGCAAGGTGGTCGGGCGCGGCTCGCGCGT
CCGGGTGACGCTCGCTCCGGCGGGATGA

Upstream 100 bases:

>100_bases
GCGGGCGGCGGCGGCGGGGCCTGTGGCGGCTCCCGGGGCGGCGTACGCGCTCCGGGGCCCGCTGCGGGCGGGTCGCGCGC
CGCCGGGGGAGCCGTAGGCC

Downstream 100 bases:

>100_bases
TAGAAGGAGGCGCGCCGCCCGTGTCCCGCCGGACACGCCCGCGCGCAAGCGGCCGGACCCGCGGAGGAAAACGAGGCGGA
CGGCCGTTTGCATGGTATCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MRAGPDPRAARWIAIRITVFAVLLAAGLAAVAGRVFWLQVLQRDALAGEAVDQYLRELVLRPRRGVITDRSGVLLAGSAD
AQSAYADPKLLAEHDRSGAAVRRIARILKQDPRALQRKLAKGGRFVWLERRIPPAEAAALRKWIDEERVRAVRLVPETRR
YYPKLELAAQVLGVVDDDGAGREGVELAEDELLRGEPARVPSLRDGRGRVVLADAPSPGREREGARVELTLDQGLQVVTE
RALARAVTGSRALSGTAVAMDPRTGEVLALASYPVANANAPRSADAIRNRPVTDAFEPGSTIKTFVIAAALDRGAVGPKD
PFDCGAGRWPVGSHVIHDTHPVGWAGPSRILVESSNIGAAHVGARLGREGVREALLAFGFGERPGIGLPGEIRGQVLLAR
SDIALATQSFGQGPITASPLQVTTAMAAIANGGALVRPRLVKRVLDPATGQVLEAPAAEVVRQAVRPEVAAMVARWLVGV
VEEPKGTGKRARLDGWRAAGKTGTAQKPDRISGGYSSDRHYSSFVGFAPAEQARIAIGVFIDEPRGEIYGGEVAAPAFRE
IAEYALRMMGVPPDPSAVRTPPPAAVEVAQAPPADEPPEPPAVEWADRRQAAMPAGSVAVPALAGLPMRAAIRRLEELDL
APEPSGSGRVVGQTPAAGKVVGRGSRVRVTLAPAG

Sequences:

>Translated_675_residues
MRAGPDPRAARWIAIRITVFAVLLAAGLAAVAGRVFWLQVLQRDALAGEAVDQYLRELVLRPRRGVITDRSGVLLAGSAD
AQSAYADPKLLAEHDRSGAAVRRIARILKQDPRALQRKLAKGGRFVWLERRIPPAEAAALRKWIDEERVRAVRLVPETRR
YYPKLELAAQVLGVVDDDGAGREGVELAEDELLRGEPARVPSLRDGRGRVVLADAPSPGREREGARVELTLDQGLQVVTE
RALARAVTGSRALSGTAVAMDPRTGEVLALASYPVANANAPRSADAIRNRPVTDAFEPGSTIKTFVIAAALDRGAVGPKD
PFDCGAGRWPVGSHVIHDTHPVGWAGPSRILVESSNIGAAHVGARLGREGVREALLAFGFGERPGIGLPGEIRGQVLLAR
SDIALATQSFGQGPITASPLQVTTAMAAIANGGALVRPRLVKRVLDPATGQVLEAPAAEVVRQAVRPEVAAMVARWLVGV
VEEPKGTGKRARLDGWRAAGKTGTAQKPDRISGGYSSDRHYSSFVGFAPAEQARIAIGVFIDEPRGEIYGGEVAAPAFRE
IAEYALRMMGVPPDPSAVRTPPPAAVEVAQAPPADEPPEPPAVEWADRRQAAMPAGSVAVPALAGLPMRAAIRRLEELDL
APEPSGSGRVVGQTPAAGKVVGRGSRVRVTLAPAG
>Mature_675_residues
MRAGPDPRAARWIAIRITVFAVLLAAGLAAVAGRVFWLQVLQRDALAGEAVDQYLRELVLRPRRGVITDRSGVLLAGSAD
AQSAYADPKLLAEHDRSGAAVRRIARILKQDPRALQRKLAKGGRFVWLERRIPPAEAAALRKWIDEERVRAVRLVPETRR
YYPKLELAAQVLGVVDDDGAGREGVELAEDELLRGEPARVPSLRDGRGRVVLADAPSPGREREGARVELTLDQGLQVVTE
RALARAVTGSRALSGTAVAMDPRTGEVLALASYPVANANAPRSADAIRNRPVTDAFEPGSTIKTFVIAAALDRGAVGPKD
PFDCGAGRWPVGSHVIHDTHPVGWAGPSRILVESSNIGAAHVGARLGREGVREALLAFGFGERPGIGLPGEIRGQVLLAR
SDIALATQSFGQGPITASPLQVTTAMAAIANGGALVRPRLVKRVLDPATGQVLEAPAAEVVRQAVRPEVAAMVARWLVGV
VEEPKGTGKRARLDGWRAAGKTGTAQKPDRISGGYSSDRHYSSFVGFAPAEQARIAIGVFIDEPRGEIYGGEVAAPAFRE
IAEYALRMMGVPPDPSAVRTPPPAAVEVAQAPPADEPPEPPAVEWADRRQAAMPAGSVAVPALAGLPMRAAIRRLEELDL
APEPSGSGRVVGQTPAAGKVVGRGSRVRVTLAPAG

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=578, Percent_Identity=33.9100346020761, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1786854, Length=589, Percent_Identity=23.5993208828523, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI87082258, Length=204, Percent_Identity=27.4509803921569, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71307; Mature: 71307

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAGPDPRAARWIAIRITVFAVLLAAGLAAVAGRVFWLQVLQRDALAGEAVDQYLRELVL
CCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPRRGVITDRSGVLLAGSADAQSAYADPKLLAEHDRSGAAVRRIARILKQDPRALQRKLA
CCCCCCEECCCCEEEECCCCCCHHCCCCHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHH
KGGRFVWLERRIPPAEAAALRKWIDEERVRAVRLVPETRRYYPKLELAAQVLGVVDDDGA
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHCCHHHHHHHHHHCCCCCCC
GREGVELAEDELLRGEPARVPSLRDGRGRVVLADAPSPGREREGARVELTLDQGLQVVTE
CCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHH
RALARAVTGSRALSGTAVAMDPRTGEVLALASYPVANANAPRSADAIRNRPVTDAFEPGS
HHHHHHHHCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCC
TIKTFVIAAALDRGAVGPKDPFDCGAGRWPVGSHVIHDTHPVGWAGPSRILVESSNIGAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHH
HVGARLGREGVREALLAFGFGERPGIGLPGEIRGQVLLARSDIALATQSFGQGPITASPL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCCCH
QVTTAMAAIANGGALVRPRLVKRVLDPATGQVLEAPAAEVVRQAVRPEVAAMVARWLVGV
HHHHHHHHHHCCCCEECHHHHHHHHCCCCCHHHCCCHHHHHHHHHCHHHHHHHHHHHHHH
VEEPKGTGKRARLDGWRAAGKTGTAQKPDRISGGYSSDRHYSSFVGFAPAEQARIAIGVF
HCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEE
IDEPRGEIYGGEVAAPAFREIAEYALRMMGVPPDPSAVRTPPPAAVEVAQAPPADEPPEP
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
PAVEWADRRQAAMPAGSVAVPALAGLPMRAAIRRLEELDLAPEPSGSGRVVGQTPAAGKV
CCCCHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCE
VGRGSRVRVTLAPAG
ECCCCEEEEEEECCC
>Mature Secondary Structure
MRAGPDPRAARWIAIRITVFAVLLAAGLAAVAGRVFWLQVLQRDALAGEAVDQYLRELVL
CCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RPRRGVITDRSGVLLAGSADAQSAYADPKLLAEHDRSGAAVRRIARILKQDPRALQRKLA
CCCCCCEECCCCEEEECCCCCCHHCCCCHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHH
KGGRFVWLERRIPPAEAAALRKWIDEERVRAVRLVPETRRYYPKLELAAQVLGVVDDDGA
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCHHHHHCCHHHHHHHHHHCCCCCCC
GREGVELAEDELLRGEPARVPSLRDGRGRVVLADAPSPGREREGARVELTLDQGLQVVTE
CCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHHH
RALARAVTGSRALSGTAVAMDPRTGEVLALASYPVANANAPRSADAIRNRPVTDAFEPGS
HHHHHHHHCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCC
TIKTFVIAAALDRGAVGPKDPFDCGAGRWPVGSHVIHDTHPVGWAGPSRILVESSNIGAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCEEEEECCCCCHH
HVGARLGREGVREALLAFGFGERPGIGLPGEIRGQVLLARSDIALATQSFGQGPITASPL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCCCCH
QVTTAMAAIANGGALVRPRLVKRVLDPATGQVLEAPAAEVVRQAVRPEVAAMVARWLVGV
HHHHHHHHHHCCCCEECHHHHHHHHCCCCCHHHCCCHHHHHHHHHCHHHHHHHHHHHHHH
VEEPKGTGKRARLDGWRAAGKTGTAQKPDRISGGYSSDRHYSSFVGFAPAEQARIAIGVF
HCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEE
IDEPRGEIYGGEVAAPAFREIAEYALRMMGVPPDPSAVRTPPPAAVEVAQAPPADEPPEP
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
PAVEWADRRQAAMPAGSVAVPALAGLPMRAAIRRLEELDLAPEPSGSGRVVGQTPAAGKV
CCCCHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCE
VGRGSRVRVTLAPAG
ECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]