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The map label for this gene is clpP

Identifier: 220918591

GI number: 220918591

Start: 3913706

End: 3914317

Strand: Reverse

Name: clpP

Synonym: A2cp1_3499

Alternate gene names: 220918591

Gene position: 3914317-3913706 (Counterclockwise)

Preceding gene: 220918592

Following gene: 220918590

Centisome position: 77.83

GC content: 65.52

Gene sequence:

>612_bases
ATGCCCTACATCCCCATGCCGTACGTGGTCGAGCAGACCCACCGCGGCGAGCGCAGCTACGACATCTACTCGCGGCTCCT
GAAGGACCGGATCATCTTCCTGGGGACGCCGGTCGACGACGACGTCGCGAACGTCATCATCGCCCAGCTCCTCTTCCTCG
AGTCGGAGGACCCGGACAAGGACATCAACCTCTACATCAACAGCCCGGGCGGCTCCGTGACCTCGGGCCTCGCCATCTAC
GACACCATGCAGTACGTGAAGCCCCAGGTGTCCACCATCTGCCTCGGGCAGGCCGCCAGCATGGGCGCGTTCCTGCTCGC
GGGCGGCGCGGCCGGCAAGCGCTTCGCGGTGCCGAACGCGCGCATCATGATCCACCAGCTCTCCGGCGGCTTCCAGGGGC
AGGCCACCGACATCGAGATCCAGGCCAAGGAGGCGCTCCGTCTCAAGGCCAAGCTGAACGAGATCATGGCCCGGCACACC
CGCCAGCCGATCGAGCGGATCGAGCGGGACACCGAGCGGGACTACTTCATGAGCGCCGGAGAGGCGAAGGAATACGGGCT
GATCGACGACGTCTTCCTGCACAAGAAGGCGGCGGACAAGAAGCCACAGTAA

Upstream 100 bases:

>100_bases
GCGCGCGAGGCGCTAAAGAACAGGATCAGGGAGGAGAAGGCGCTCTCGCTGCTCTCCTCCGCTGCAACCATCCAGCAGTA
GCGAACGCCGGAGACCCGCG

Downstream 100 bases:

>100_bases
GATGAGGGAAGAGGCGAGGCGCCGGAGGGCATCCTCACCAGGGGAAGCAGCCGAGGAAGCGGGCTCGCGAACCGGAGGTG
GCACGTGGAGAAGCGCGAGA

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MPYIPMPYVVEQTHRGERSYDIYSRLLKDRIIFLGTPVDDDVANVIIAQLLFLESEDPDKDINLYINSPGGSVTSGLAIY
DTMQYVKPQVSTICLGQAASMGAFLLAGGAAGKRFAVPNARIMIHQLSGGFQGQATDIEIQAKEALRLKAKLNEIMARHT
RQPIERIERDTERDYFMSAGEAKEYGLIDDVFLHKKAADKKPQ

Sequences:

>Translated_203_residues
MPYIPMPYVVEQTHRGERSYDIYSRLLKDRIIFLGTPVDDDVANVIIAQLLFLESEDPDKDINLYINSPGGSVTSGLAIY
DTMQYVKPQVSTICLGQAASMGAFLLAGGAAGKRFAVPNARIMIHQLSGGFQGQATDIEIQAKEALRLKAKLNEIMARHT
RQPIERIERDTERDYFMSAGEAKEYGLIDDVFLHKKAADKKPQ
>Mature_202_residues
PYIPMPYVVEQTHRGERSYDIYSRLLKDRIIFLGTPVDDDVANVIIAQLLFLESEDPDKDINLYINSPGGSVTSGLAIYD
TMQYVKPQVSTICLGQAASMGAFLLAGGAAGKRFAVPNARIMIHQLSGGFQGQATDIEIQAKEALRLKAKLNEIMARHTR
QPIERIERDTERDYFMSAGEAKEYGLIDDVFLHKKAADKKPQ

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=194, Percent_Identity=59.2783505154639, Blast_Score=241, Evalue=2e-64,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=66.4921465968586, Blast_Score=283, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=55.7291666666667, Blast_Score=224, Evalue=3e-59,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=59.2592592592593, Blast_Score=237, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_ANAD2 (B8J5G7)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493895.1
- ProteinModelPortal:   B8J5G7
- SMR:   B8J5G7
- GeneID:   7296760
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_3499
- HOGENOM:   HBG558421
- ProtClustDB:   CLSK946628
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22635; Mature: 22504

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 100-100 ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYIPMPYVVEQTHRGERSYDIYSRLLKDRIIFLGTPVDDDVANVIIAQLLFLESEDPDK
CCCCCCCHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
DINLYINSPGGSVTSGLAIYDTMQYVKPQVSTICLGQAASMGAFLLAGGAAGKRFAVPNA
CEEEEEECCCCCHHCCHHHHHHHHHHCHHHHHHHHCCHHCCCEEEEECCCCCCEEECCCC
RIMIHQLSGGFQGQATDIEIQAKEALRLKAKLNEIMARHTRQPIERIERDTERDYFMSAG
EEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
EAKEYGLIDDVFLHKKAADKKPQ
CCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PYIPMPYVVEQTHRGERSYDIYSRLLKDRIIFLGTPVDDDVANVIIAQLLFLESEDPDK
CCCCCCHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
DINLYINSPGGSVTSGLAIYDTMQYVKPQVSTICLGQAASMGAFLLAGGAAGKRFAVPNA
CEEEEEECCCCCHHCCHHHHHHHHHHCHHHHHHHHCCHHCCCEEEEECCCCCCEEECCCC
RIMIHQLSGGFQGQATDIEIQAKEALRLKAKLNEIMARHTRQPIERIERDTERDYFMSAG
EEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
EAKEYGLIDDVFLHKKAADKKPQ
CCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA