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The map label for this gene is pepP [H]

Identifier: 220918499

GI number: 220918499

Start: 3794456

End: 3795775

Strand: Reverse

Name: pepP [H]

Synonym: A2cp1_3406

Alternate gene names: 220918499

Gene position: 3795775-3794456 (Counterclockwise)

Preceding gene: 220918500

Following gene: 220918497

Centisome position: 75.47

GC content: 72.2

Gene sequence:

>1320_bases
ATGGCCCACGACCCCAGCATCCACGCCGCCCGCCGCGCCCGCGTCTTCGAGGAGATGGAGAAGCGAGGCGGCGGCGTGAT
GGTGCTCCCCGCCGCCGACGAGAAGGTCCGCAACCACGACTCCGAGTACCTGTTCCGCCAGGACTCCGACTACGCGTGGG
CGATCGGCCTCGACGAGCCCACCGGCTGCGCCGTGCTGCTCGCGCGCGGCGGCGAGCGGAAGCTCGTGCTGTTCGTGCGG
CCGCGGGATCGCGAGAAGGAGATCTGGACCGGGCGCCGCGCCGGGGTGGAGGGCGCGAAGGAGCTGTACGGCGCCGACGA
GGCGTACGTCGTCGCCGAGCTGGACGAGAAGCTGCCCCGGCTCGTCGAGGGGGCGCGGACGCTCTGGTACCGCATCGGCT
TCGACGCCGCCTGGGACGCGCGGCTCTCGCGCATCCTCACCGAGCTGCGCGGCGCCGCCCGGCTCGGCAAGCTGCCCCCC
GAGGCGGTCGTCGATCCCGGCCGCATCGTCCACGAGCTGCGGCTCGTGAAGACGCCCGACGAGATCGTGAAGCTCCGCCG
CGCAGCCGAGATCAGCGCCGAGGCGCACATGGCCGCCATGCGCGACGGCCTGCCCGGCCGCCGCGAGTACCAGGTGCAGT
CGGAGATCGAGTACGCGTTCCGCCGCCGCGGCGGGAGCGGGCCCGGCTACGGGACCATCGTGGCCGCCGGCGTGAACTCG
ACGATCCTCCACTACCGCGCCGGCGACGCCGTGCTGAAGGACGGCGACGTGTGCCTGGTGGACGCCGGCGGCGAGTACCA
GTGGTACACCGCCGACGTGACCCGCACGTTCCCCGTGTCCGGCGAGTTCTCCCCCGCGCAGGCCGAGCTGTACTCGCTCT
GCCTCGAGGTGCAGAAGCGCGCCGTCGCCTCGGTGCGCCCCGGGACCACGCTCGACGCCATCCACGACCAGACCGTCCGC
GAGCTGACCGACGGCCTCATCGGCCTTGGCCTGCTGAAGGGGAGCGTGGACGAGCGCATCGCCGACAAGTCGTTCCGCCG
GTACTACATGCACCGCACCAGCCACTGGCTCGGCATGGACGTGCACGACGTCGGCGACTACTACGTGGACGGCAAGTCGC
GGCCGCTCGTGCCCGGCATGGTGCTGACCATCGAGCCCGGCCTGTACGTCGCCGAGGACGACCCGGACGCCCCCGAAGCG
CTTCGCGGCGTCGGCATCCGCATCGAGGACGACGTGCTCGTCACCGACGACGGTCACGCGAACCTCACCGAGGCCGTGCC
CAAGGAGATCGCCGAGATGGAGGCGGTCTGCGTGAGGTAG

Upstream 100 bases:

>100_bases
GCCATCATGACGCCGCGCGCCGGGGGCGCCGTGCCCCGGCCGGCCGTGCCCTGATCACGGCCCGAGCCTGCCTGCGGGGG
CTGGGTTATAAGGGTCCGCC

Downstream 100 bases:

>100_bases
GCCGTCGTCCGCTTACCCTGAGCTCCGTCGAAGGGTGAGCGGAGCCGTGCAGCCCGCCCCCGCCCCTCACCCTGAGCCTG
TCGAAGGATGAGCTGACGCG

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MAHDPSIHAARRARVFEEMEKRGGGVMVLPAADEKVRNHDSEYLFRQDSDYAWAIGLDEPTGCAVLLARGGERKLVLFVR
PRDREKEIWTGRRAGVEGAKELYGADEAYVVAELDEKLPRLVEGARTLWYRIGFDAAWDARLSRILTELRGAARLGKLPP
EAVVDPGRIVHELRLVKTPDEIVKLRRAAEISAEAHMAAMRDGLPGRREYQVQSEIEYAFRRRGGSGPGYGTIVAAGVNS
TILHYRAGDAVLKDGDVCLVDAGGEYQWYTADVTRTFPVSGEFSPAQAELYSLCLEVQKRAVASVRPGTTLDAIHDQTVR
ELTDGLIGLGLLKGSVDERIADKSFRRYYMHRTSHWLGMDVHDVGDYYVDGKSRPLVPGMVLTIEPGLYVAEDDPDAPEA
LRGVGIRIEDDVLVTDDGHANLTEAVPKEIAEMEAVCVR

Sequences:

>Translated_439_residues
MAHDPSIHAARRARVFEEMEKRGGGVMVLPAADEKVRNHDSEYLFRQDSDYAWAIGLDEPTGCAVLLARGGERKLVLFVR
PRDREKEIWTGRRAGVEGAKELYGADEAYVVAELDEKLPRLVEGARTLWYRIGFDAAWDARLSRILTELRGAARLGKLPP
EAVVDPGRIVHELRLVKTPDEIVKLRRAAEISAEAHMAAMRDGLPGRREYQVQSEIEYAFRRRGGSGPGYGTIVAAGVNS
TILHYRAGDAVLKDGDVCLVDAGGEYQWYTADVTRTFPVSGEFSPAQAELYSLCLEVQKRAVASVRPGTTLDAIHDQTVR
ELTDGLIGLGLLKGSVDERIADKSFRRYYMHRTSHWLGMDVHDVGDYYVDGKSRPLVPGMVLTIEPGLYVAEDDPDAPEA
LRGVGIRIEDDVLVTDDGHANLTEAVPKEIAEMEAVCVR
>Mature_438_residues
AHDPSIHAARRARVFEEMEKRGGGVMVLPAADEKVRNHDSEYLFRQDSDYAWAIGLDEPTGCAVLLARGGERKLVLFVRP
RDREKEIWTGRRAGVEGAKELYGADEAYVVAELDEKLPRLVEGARTLWYRIGFDAAWDARLSRILTELRGAARLGKLPPE
AVVDPGRIVHELRLVKTPDEIVKLRRAAEISAEAHMAAMRDGLPGRREYQVQSEIEYAFRRRGGSGPGYGTIVAAGVNST
ILHYRAGDAVLKDGDVCLVDAGGEYQWYTADVTRTFPVSGEFSPAQAELYSLCLEVQKRAVASVRPGTTLDAIHDQTVRE
LTDGLIGLGLLKGSVDERIADKSFRRYYMHRTSHWLGMDVHDVGDYYVDGKSRPLVPGMVLTIEPGLYVAEDDPDAPEAL
RGVGIRIEDDVLVTDDGHANLTEAVPKEIAEMEAVCVR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=443, Percent_Identity=35.8916478555305, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI149589008, Length=469, Percent_Identity=31.7697228144989, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI260593665, Length=298, Percent_Identity=35.9060402684564, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI260593663, Length=468, Percent_Identity=29.0598290598291, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1789275, Length=429, Percent_Identity=44.2890442890443, Blast_Score=356, Evalue=2e-99,
Organism=Escherichia coli, GI1788728, Length=262, Percent_Identity=30.9160305343511, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=28, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17508215, Length=468, Percent_Identity=30.3418803418803, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71989583, Length=371, Percent_Identity=27.2237196765499, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6320922, Length=436, Percent_Identity=30.045871559633, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6321118, Length=431, Percent_Identity=32.4825986078886, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI19920384, Length=422, Percent_Identity=36.4928909952607, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI21357079, Length=461, Percent_Identity=32.1041214750542, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48593; Mature: 48461

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDPSIHAARRARVFEEMEKRGGGVMVLPAADEKVRNHDSEYLFRQDSDYAWAIGLDEP
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCEEEECCCCEEEEEECCCC
TGCAVLLARGGERKLVLFVRPRDREKEIWTGRRAGVEGAKELYGADEAYVVAELDEKLPR
CCEEEEEECCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHHCCCCEEEEEHHHHHHHH
LVEGARTLWYRIGFDAAWDARLSRILTELRGAARLGKLPPEAVVDPGRIVHELRLVKTPD
HHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHEECCHH
EIVKLRRAAEISAEAHMAAMRDGLPGRREYQVQSEIEYAFRRRGGSGPGYGTIVAAGVNS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
TILHYRAGDAVLKDGDVCLVDAGGEYQWYTADVTRTFPVSGEFSPAQAELYSLCLEVQKR
EEEEEECCCCEEECCCEEEEECCCCEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHH
AVASVRPGTTLDAIHDQTVRELTDGLIGLGLLKGSVDERIADKSFRRYYMHRTSHWLGMD
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
VHDVGDYYVDGKSRPLVPGMVLTIEPGLYVAEDDPDAPEALRGVGIRIEDDVLVTDDGHA
HHHCCCEEECCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHCCCCEEECCEEEECCCCC
NLTEAVPKEIAEMEAVCVR
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AHDPSIHAARRARVFEEMEKRGGGVMVLPAADEKVRNHDSEYLFRQDSDYAWAIGLDEP
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCEEEECCCCEEEEEECCCC
TGCAVLLARGGERKLVLFVRPRDREKEIWTGRRAGVEGAKELYGADEAYVVAELDEKLPR
CCEEEEEECCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHHCCCCEEEEEHHHHHHHH
LVEGARTLWYRIGFDAAWDARLSRILTELRGAARLGKLPPEAVVDPGRIVHELRLVKTPD
HHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHEECCHH
EIVKLRRAAEISAEAHMAAMRDGLPGRREYQVQSEIEYAFRRRGGSGPGYGTIVAAGVNS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
TILHYRAGDAVLKDGDVCLVDAGGEYQWYTADVTRTFPVSGEFSPAQAELYSLCLEVQKR
EEEEEECCCCEEECCCEEEEECCCCEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHH
AVASVRPGTTLDAIHDQTVRELTDGLIGLGLLKGSVDERIADKSFRRYYMHRTSHWLGMD
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCC
VHDVGDYYVDGKSRPLVPGMVLTIEPGLYVAEDDPDAPEALRGVGIRIEDDVLVTDDGHA
HHHCCCEEECCCCCCCCCCEEEEECCCEEEECCCCCCHHHHHCCCCEEECCEEEECCCCC
NLTEAVPKEIAEMEAVCVR
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]