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The map label for this gene is atoS [H]

Identifier: 220918399

GI number: 220918399

Start: 3677950

End: 3679299

Strand: Reverse

Name: atoS [H]

Synonym: A2cp1_3303

Alternate gene names: 220918399

Gene position: 3679299-3677950 (Counterclockwise)

Preceding gene: 220918400

Following gene: 220918397

Centisome position: 73.16

GC content: 75.7

Gene sequence:

>1350_bases
ATGCGCGCGGCGGCGACCCTGGCGCGGCGGCGGGTGGGCTCCGGCCCGCCGCTGCCGGAGCGCATCCAGCGGGAGGAGTT
CTCCAGGCTGTTCGGGCGGCTGCTCACCTTCCGGCTGTGGGTGCTGCTGCCGGTGCTGTTGCTGGTGGGATGGGTGGTCT
GGATCGATCCGTCCCCCTGGCGGCGCGCGGTGCTGCTCGCGGCGCTGGTGGCGGTGTCGATCTTCTTCGTCCGGGAGCTG
CTCGCGTTCCGGGCGGGCGGGGCGGGTCAGCGGTCGGTGAACCGCAACGTGCTGCTCGCGACGTTCGGGCAGGTGGTGGT
CTCGTTCGCGACCGGCGGCATCGACAGCCCGTTCCTTCCGGCCGCGCTGGTGCTGGCGGTGATCCCGGCGATGCTGGTGG
AAGGGCCGGTGCGCTGGCTCATCCCTGCCATGCAGATCTCGGGGGTGCTGACGCTGGCGGCCCTGGGGGCGAGCGGCGCC
ATCCCGGATCTCAACCTGGCGGCGTTCGGCGGCGGCGCGCGCGTGGGCGCCGGCACCGCGTACCTGTGGGCCGACGCGGC
GCTGCTCTGCCTCATGCTGGCCGGCGTGCACGCGCTCGGGAACGGGCTGCGCCACGCGTACCAGGCCGTCCTCCGGCGCC
AGCTCGCCGCCCAGGAGGACGCGCTGCGCGCGCACCAGGAGCGCGCCGCCGAGCTGGTCGAGCTGTCCGGCGAGATCGCG
CACGAGCTGAAGAACCCGCTCGCCAGCGTGAAGGCGCTCGCGGGGCTGCTGAGGCAGCAGCTCCCGGACGGCAAGGGCGC
CGAGCGGCTCGAGGTCCTCCGCCACGAGGTGGACCGGATGCAGTCGGTGCTGGAGGACTTCCTCAACTTCTCGCGCCCGC
TCGTGCCGCTCTCGGTGGACGCGTGCGACCTCGCCGCGCTCTGCCAGGAGGTCGCGGCGCTGCACGAGGGCGTCGCCTCG
GAGCGCGGGCTGGAGCTGTCGGTGGAAGGCGACGGCGCGTCCGTCCGCGGCGATCGCCGCAAGCTGAAGCAGGTGCTCAT
CAACCTGGTCCAGAACGCGGTGGAGGCGAGCGCGCCGGGCGGCGAGGTGGTGCTCGAGGTCGCGCCCGCCGCGGACGGCG
GCGCGCGCGTGCGCGTGCTCGATCGCGGCGCAGGGGTGGACCCCGCGCTCGGCGACGCCGTGTTCCACCCCGGCGTGACC
AGCAAGGCGAAGGGCTCCGGCCTGGGCCTCACCGTGGCGCGGGCCATCGCCCGCCAGCACGGCGGTGACCTCGCGCTCGC
GCCCCGGCCGGACGGCGGCACCGCCGCGGAGCTGGTCCTGCCGGCGCGCCCCGCCGCGCCCGGGCCGTAG

Upstream 100 bases:

>100_bases
TGGCCGAGATCGGCCTCGCCGACGCGCGCGCGCGGCTCGCGCAGGCGCGGCTCGCGCTCGGGCGCGCGCTGGGGCGGGAC
CTGTAGCGCCGGGGGCGGCC

Downstream 100 bases:

>100_bases
CCGGGACGCCGCCGGGCGCAGGGCCTGGTCGGCGCGATCCGCGATCCCGGGACCGGATCGCGGATCGCGTGCCGCGCGCG
CTTACCGCGGCGCCGCGCCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRAAATLARRRVGSGPPLPERIQREEFSRLFGRLLTFRLWVLLPVLLLVGWVVWIDPSPWRRAVLLAALVAVSIFFVREL
LAFRAGGAGQRSVNRNVLLATFGQVVVSFATGGIDSPFLPAALVLAVIPAMLVEGPVRWLIPAMQISGVLTLAALGASGA
IPDLNLAAFGGGARVGAGTAYLWADAALLCLMLAGVHALGNGLRHAYQAVLRRQLAAQEDALRAHQERAAELVELSGEIA
HELKNPLASVKALAGLLRQQLPDGKGAERLEVLRHEVDRMQSVLEDFLNFSRPLVPLSVDACDLAALCQEVAALHEGVAS
ERGLELSVEGDGASVRGDRRKLKQVLINLVQNAVEASAPGGEVVLEVAPAADGGARVRVLDRGAGVDPALGDAVFHPGVT
SKAKGSGLGLTVARAIARQHGGDLALAPRPDGGTAAELVLPARPAAPGP

Sequences:

>Translated_449_residues
MRAAATLARRRVGSGPPLPERIQREEFSRLFGRLLTFRLWVLLPVLLLVGWVVWIDPSPWRRAVLLAALVAVSIFFVREL
LAFRAGGAGQRSVNRNVLLATFGQVVVSFATGGIDSPFLPAALVLAVIPAMLVEGPVRWLIPAMQISGVLTLAALGASGA
IPDLNLAAFGGGARVGAGTAYLWADAALLCLMLAGVHALGNGLRHAYQAVLRRQLAAQEDALRAHQERAAELVELSGEIA
HELKNPLASVKALAGLLRQQLPDGKGAERLEVLRHEVDRMQSVLEDFLNFSRPLVPLSVDACDLAALCQEVAALHEGVAS
ERGLELSVEGDGASVRGDRRKLKQVLINLVQNAVEASAPGGEVVLEVAPAADGGARVRVLDRGAGVDPALGDAVFHPGVT
SKAKGSGLGLTVARAIARQHGGDLALAPRPDGGTAAELVLPARPAAPGP
>Mature_449_residues
MRAAATLARRRVGSGPPLPERIQREEFSRLFGRLLTFRLWVLLPVLLLVGWVVWIDPSPWRRAVLLAALVAVSIFFVREL
LAFRAGGAGQRSVNRNVLLATFGQVVVSFATGGIDSPFLPAALVLAVIPAMLVEGPVRWLIPAMQISGVLTLAALGASGA
IPDLNLAAFGGGARVGAGTAYLWADAALLCLMLAGVHALGNGLRHAYQAVLRRQLAAQEDALRAHQERAAELVELSGEIA
HELKNPLASVKALAGLLRQQLPDGKGAERLEVLRHEVDRMQSVLEDFLNFSRPLVPLSVDACDLAALCQEVAALHEGVAS
ERGLELSVEGDGASVRGDRRKLKQVLINLVQNAVEASAPGGEVVLEVAPAADGGARVRVLDRGAGVDPALGDAVFHPGVT
SKAKGSGLGLTVARAIARQHGGDLALAPRPDGGTAAELVLPARPAAPGP

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=33.4728033472803, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790436, Length=246, Percent_Identity=32.520325203252, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=31.5352697095436, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081816, Length=289, Percent_Identity=29.0657439446367, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=28.2051282051282, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=28.8288288288288, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=208, Percent_Identity=25.9615384615385, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=30.316742081448, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=23.5537190082645, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082128, Length=220, Percent_Identity=27.7272727272727, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47034; Mature: 47034

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAATLARRRVGSGPPLPERIQREEFSRLFGRLLTFRLWVLLPVLLLVGWVVWIDPSPW
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
RRAVLLAALVAVSIFFVRELLAFRAGGAGQRSVNRNVLLATFGQVVVSFATGGIDSPFLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
AALVLAVIPAMLVEGPVRWLIPAMQISGVLTLAALGASGAIPDLNLAAFGGGARVGAGTA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHH
YLWADAALLCLMLAGVHALGNGLRHAYQAVLRRQLAAQEDALRAHQERAAELVELSGEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELKNPLASVKALAGLLRQQLPDGKGAERLEVLRHEVDRMQSVLEDFLNFSRPLVPLSVD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
ACDLAALCQEVAALHEGVASERGLELSVEGDGASVRGDRRKLKQVLINLVQNAVEASAPG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GEVVLEVAPAADGGARVRVLDRGAGVDPALGDAVFHPGVTSKAKGSGLGLTVARAIARQH
CCEEEEEECCCCCCCEEEEEECCCCCCCHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHC
GGDLALAPRPDGGTAAELVLPARPAAPGP
CCCEEECCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MRAAATLARRRVGSGPPLPERIQREEFSRLFGRLLTFRLWVLLPVLLLVGWVVWIDPSPW
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
RRAVLLAALVAVSIFFVRELLAFRAGGAGQRSVNRNVLLATFGQVVVSFATGGIDSPFLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
AALVLAVIPAMLVEGPVRWLIPAMQISGVLTLAALGASGAIPDLNLAAFGGGARVGAGTA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHH
YLWADAALLCLMLAGVHALGNGLRHAYQAVLRRQLAAQEDALRAHQERAAELVELSGEIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HELKNPLASVKALAGLLRQQLPDGKGAERLEVLRHEVDRMQSVLEDFLNFSRPLVPLSVD
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
ACDLAALCQEVAALHEGVASERGLELSVEGDGASVRGDRRKLKQVLINLVQNAVEASAPG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GEVVLEVAPAADGGARVRVLDRGAGVDPALGDAVFHPGVTSKAKGSGLGLTVARAIARQH
CCEEEEEECCCCCCCEEEEEECCCCCCCHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHC
GGDLALAPRPDGGTAAELVLPARPAAPGP
CCCEEECCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]