Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 220918248

GI number: 220918248

Start: 3482065

End: 3484290

Strand: Reverse

Name: luxQ [H]

Synonym: A2cp1_3151

Alternate gene names: 220918248

Gene position: 3484290-3482065 (Counterclockwise)

Preceding gene: 220918249

Following gene: 220918243

Centisome position: 69.28

GC content: 78.35

Gene sequence:

>2226_bases
ATGCGGTTCAGGTGGCGCCTCGTGGGTCTCACCGCGGGCGCGCTGCTGCCGGTGGCGCTGTTCTCCGCCGCGACGCTGAG
CCGGCTGGCGGCGGGCGAGCGCGAGGCGAACCGGCAGCGCCTGGTCGCCGACGCGCGCACGCTGGCCGAGGGCGTGGACC
GCGAGACCACCGCCACGTTCCGGGCGCTGCAGGCGCTCGGCGGGTCCGAGCGCCTGGAGCGCGGCGACCTGGATGGCTTC
CGCGAGGACGCGGTGCGCGTGCTCCGGACGCAGCCCACCTGGCACGCGGTGATCCTCGCGAGGCCGGACGGGCTGCGGCT
GCTCGACACGCGGAGGACCTCGGTCGCGGCCACGGCGCCGCCGCGCGACCCTCGCAGCCTGGCGGAGGCGGTCGGGACCG
GCGAGCCGGTGCTGGGCGACGTCTTCACCGGCCCGGACGGCGCGCTCCTGGTCGCCGCGCGGCTCCCGCTGATGCACCGG
GGACGGGTGCGGCACGTGCTGAGCGCGCTCATCCCGGCGGAGGCGCTGCGCGATCTCGTGCGGGTGCCCGGGACCGGCGA
GAACCCCTGGATCCGAACGCTGGTGGACCGGTCCGGCACGGTGGTGGCGCGGAGCCGGTCGCCGGAGCGCTTCGTGGGAC
AGCCCGCGTCGCCGCGCTTCCTGGAGGCCGCCCGCGCGGGCGGCGAGGGCGTGTACCGCGACACCAACCTCGACGGCGGG
CGCTCGTACGTCGCGTTCGGCCACTCGGCGCGCGCCGGCTGGACCGCAGCGGTGGTGGCGCCGGTGGACATGCTGGACGG
CGCCACCCGGCGCTCGGTGCTCACCATCGCGGCGCTGGGCGCGGCGGTGCTGCTCGTGAGCGCGGGCGGCGCGTTCCTGG
CGGCGGGCCGGTTCAACCGCGCCATCGCCTCCGCGGCAGCGTCCGCCGAGGCGCTCGCCCGCGGCGCCCGCCCGCGGGTC
GAGGCGGAGGGGATCGCGGAGGTGGCGCGGCTGGGCGAGGCGCTCGAGCGGTCCGCGGACCTGCTCGCCGCGCGCGAGCG
GGAGCGCGACCAGCACCTCGCGGTCGCCGAGGCCGCCCGCGCCGAGGCCGAGGCGGCCAGCCGGACCAAGGACGAGTTCC
TGGCCATGCTCGGCCACGAGCTGCGCAACCCGCTGTCGCCCATCGTGACCGCGCTGGAGCTGCAGGATCTCGGCGGGAGC
GGCGGGACGCGCGAGCACGCCGTCATCCGCCGGCAGGTGGATCACCTGGTGCGGCTGGTGGACGACCTGCTCGACGTCTC
GCGGATCACCCGCGGCAAGGTCGAGCTGCAGCCGGAGCGCATCGAGGTCCGGTCGTTCGTCGCGCGCGCGGTGGAGATGG
CGACGCCCCTCGTGGAGGAGCGCTCGCACCGGCTCACGGTCGACGTGCCGGAGGGCCTCGCGGTGGTCGGCGACCCGCAC
CGGCTCGCGCAGGTGGTCGCGAACCTGCTCACCAACGCGGCCCGGTACACGCCGCCCCGCGGCCACATCGGGGTCCGGGC
GGCGCTGCGCGGCGCCGAGGTGGAGCTGGCGGTCCGGGACGACGGCCGCGGGCTCGCGCCCGAGCTCCGCTCCCGCATCT
TCGAGCCGTTCGTGCAGGCGCCGCAGGGCCAGGATCGCCCGCAGGGCGGGCTCGGCATCGGCCTCGCGCTGGTGCGGAGC
CTGGTGGAGCTGCACGGCGGCCGGGTGGAGGCGTGCAGCGAGGGGCCGGGCAAGGGGAGCACGTTCGTGGTGGAGCTGCC
CGCCGCCCCGCGGGCCCCGGCCGCCTCGCCCCCGGCGCCGCGCCCCGCCGCCGCGGCCGCCGCCGCGCCGCTGCGGATCC
TGGTGGTGGACGACAACGAGGACGCGGCGGAGCTGCTCGCCGACGTGCTCGCGCACGCCGGGCACGAGGTCCGGGTGGCG
GGCGACGGCGGGCGCGGGCTCGAGCTGGCCGTACGGTTCCGGCCCGACGTCGCCCTCCTCGACATCGGCCTTCCGGTGCT
CGACGGCTACGAGCTCGCGGTCCAGCTCCGGCGGCGCCTGGGCGAGGCGGCCCCGGTGGTGATCGGTGTCAGCGGCTACG
GCCAGCCGAACGACCGCGCGCGCAGCGCCGCCGCCGGGTTCCGGCACCACTTCGTCAAGCCGGCCGACCTGGAGGCGCTG
CTCGCCGCGGTGGCCGCGGCGGGGCGGGAGCGCGGGCGCGCGCCGGCGACCGAGGAGCGCGCCTAG

Upstream 100 bases:

>100_bases
GAAGCCCCGCCTGAGCGTGGGAGGCGGGGGGCCGGCGCCCTATCGGTCACGCGTGCGGTCTCTTCGCCCCAGGGCGCTCC
GGCGCCGCCCTGCCCGGGTC

Downstream 100 bases:

>100_bases
CGGCGCTTCTTCGGGCCCCACGAGCCGACGCGGCGCGGCTTCGAGCCCGCGCCGGCGGCGGCGGGCGCGCTCCGTCGCGG
GGCGGACGCCGCGGGCTGCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MRFRWRLVGLTAGALLPVALFSAATLSRLAAGEREANRQRLVADARTLAEGVDRETTATFRALQALGGSERLERGDLDGF
REDAVRVLRTQPTWHAVILARPDGLRLLDTRRTSVAATAPPRDPRSLAEAVGTGEPVLGDVFTGPDGALLVAARLPLMHR
GRVRHVLSALIPAEALRDLVRVPGTGENPWIRTLVDRSGTVVARSRSPERFVGQPASPRFLEAARAGGEGVYRDTNLDGG
RSYVAFGHSARAGWTAAVVAPVDMLDGATRRSVLTIAALGAAVLLVSAGGAFLAAGRFNRAIASAAASAEALARGARPRV
EAEGIAEVARLGEALERSADLLAARERERDQHLAVAEAARAEAEAASRTKDEFLAMLGHELRNPLSPIVTALELQDLGGS
GGTREHAVIRRQVDHLVRLVDDLLDVSRITRGKVELQPERIEVRSFVARAVEMATPLVEERSHRLTVDVPEGLAVVGDPH
RLAQVVANLLTNAARYTPPRGHIGVRAALRGAEVELAVRDDGRGLAPELRSRIFEPFVQAPQGQDRPQGGLGIGLALVRS
LVELHGGRVEACSEGPGKGSTFVVELPAAPRAPAASPPAPRPAAAAAAAPLRILVVDDNEDAAELLADVLAHAGHEVRVA
GDGGRGLELAVRFRPDVALLDIGLPVLDGYELAVQLRRRLGEAAPVVIGVSGYGQPNDRARSAAAGFRHHFVKPADLEAL
LAAVAAAGRERGRAPATEERA

Sequences:

>Translated_741_residues
MRFRWRLVGLTAGALLPVALFSAATLSRLAAGEREANRQRLVADARTLAEGVDRETTATFRALQALGGSERLERGDLDGF
REDAVRVLRTQPTWHAVILARPDGLRLLDTRRTSVAATAPPRDPRSLAEAVGTGEPVLGDVFTGPDGALLVAARLPLMHR
GRVRHVLSALIPAEALRDLVRVPGTGENPWIRTLVDRSGTVVARSRSPERFVGQPASPRFLEAARAGGEGVYRDTNLDGG
RSYVAFGHSARAGWTAAVVAPVDMLDGATRRSVLTIAALGAAVLLVSAGGAFLAAGRFNRAIASAAASAEALARGARPRV
EAEGIAEVARLGEALERSADLLAARERERDQHLAVAEAARAEAEAASRTKDEFLAMLGHELRNPLSPIVTALELQDLGGS
GGTREHAVIRRQVDHLVRLVDDLLDVSRITRGKVELQPERIEVRSFVARAVEMATPLVEERSHRLTVDVPEGLAVVGDPH
RLAQVVANLLTNAARYTPPRGHIGVRAALRGAEVELAVRDDGRGLAPELRSRIFEPFVQAPQGQDRPQGGLGIGLALVRS
LVELHGGRVEACSEGPGKGSTFVVELPAAPRAPAASPPAPRPAAAAAAAPLRILVVDDNEDAAELLADVLAHAGHEVRVA
GDGGRGLELAVRFRPDVALLDIGLPVLDGYELAVQLRRRLGEAAPVVIGVSGYGQPNDRARSAAAGFRHHFVKPADLEAL
LAAVAAAGRERGRAPATEERA
>Mature_741_residues
MRFRWRLVGLTAGALLPVALFSAATLSRLAAGEREANRQRLVADARTLAEGVDRETTATFRALQALGGSERLERGDLDGF
REDAVRVLRTQPTWHAVILARPDGLRLLDTRRTSVAATAPPRDPRSLAEAVGTGEPVLGDVFTGPDGALLVAARLPLMHR
GRVRHVLSALIPAEALRDLVRVPGTGENPWIRTLVDRSGTVVARSRSPERFVGQPASPRFLEAARAGGEGVYRDTNLDGG
RSYVAFGHSARAGWTAAVVAPVDMLDGATRRSVLTIAALGAAVLLVSAGGAFLAAGRFNRAIASAAASAEALARGARPRV
EAEGIAEVARLGEALERSADLLAARERERDQHLAVAEAARAEAEAASRTKDEFLAMLGHELRNPLSPIVTALELQDLGGS
GGTREHAVIRRQVDHLVRLVDDLLDVSRITRGKVELQPERIEVRSFVARAVEMATPLVEERSHRLTVDVPEGLAVVGDPH
RLAQVVANLLTNAARYTPPRGHIGVRAALRGAEVELAVRDDGRGLAPELRSRIFEPFVQAPQGQDRPQGGLGIGLALVRS
LVELHGGRVEACSEGPGKGSTFVVELPAAPRAPAASPPAPRPAAAAAAAPLRILVVDDNEDAAELLADVLAHAGHEVRVA
GDGGRGLELAVRFRPDVALLDIGLPVLDGYELAVQLRRRLGEAAPVVIGVSGYGQPNDRARSAAAGFRHHFVKPADLEAL
LAAVAAAGRERGRAPATEERA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=376, Percent_Identity=28.7234042553192, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI87081816, Length=401, Percent_Identity=32.4189526184539, Blast_Score=146, Evalue=6e-36,
Organism=Escherichia coli, GI1789149, Length=396, Percent_Identity=28.030303030303, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=34.1666666666667, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI48994928, Length=376, Percent_Identity=28.9893617021277, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1786912, Length=268, Percent_Identity=33.5820895522388, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=32.8767123287671, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788393, Length=230, Percent_Identity=31.304347826087, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=31.7180616740088, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=31.6279069767442, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=30.9417040358744, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=29.8245614035088, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=27.8761061946903, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788549, Length=262, Percent_Identity=27.0992366412214, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1790861, Length=320, Percent_Identity=27.1875, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=290, Percent_Identity=26.2068965517241, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 78419; Mature: 78419

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS50885 HAMP ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRWRLVGLTAGALLPVALFSAATLSRLAAGEREANRQRLVADARTLAEGVDRETTATF
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
RALQALGGSERLERGDLDGFREDAVRVLRTQPTWHAVILARPDGLRLLDTRRTSVAATAP
HHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCEEEECCC
PRDPRSLAEAVGTGEPVLGDVFTGPDGALLVAARLPLMHRGRVRHVLSALIPAEALRDLV
CCCHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHCCHHHCHHHHHHHHHHHHHHHHHHHH
RVPGTGENPWIRTLVDRSGTVVARSRSPERFVGQPASPRFLEAARAGGEGVYRDTNLDGG
HCCCCCCCCHHHHHHCCCCCEEEECCCCHHHCCCCCCCHHHHHHHCCCCCCEECCCCCCC
RSYVAFGHSARAGWTAAVVAPVDMLDGATRRSVLTIAALGAAVLLVSAGGAFLAAGRFNR
CEEEEECCCCCCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHH
AIASAAASAEALARGARPRVEAEGIAEVARLGEALERSADLLAARERERDQHLAVAEAAR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEAEAASRTKDEFLAMLGHELRNPLSPIVTALELQDLGGSGGTREHAVIRRQVDHLVRLV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
DDLLDVSRITRGKVELQPERIEVRSFVARAVEMATPLVEERSHRLTVDVPEGLAVVGDPH
HHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCHH
RLAQVVANLLTNAARYTPPRGHIGVRAALRGAEVELAVRDDGRGLAPELRSRIFEPFVQA
HHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCC
PQGQDRPQGGLGIGLALVRSLVELHGGRVEACSEGPGKGSTFVVELPAAPRAPAASPPAP
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCCCC
RPAAAAAAAPLRILVVDDNEDAAELLADVLAHAGHEVRVAGDGGRGLELAVRFRPDVALL
CCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEE
DIGLPVLDGYELAVQLRRRLGEAAPVVIGVSGYGQPNDRARSAAAGFRHHFVKPADLEAL
ECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LAAVAAAGRERGRAPATEERA
HHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRFRWRLVGLTAGALLPVALFSAATLSRLAAGEREANRQRLVADARTLAEGVDRETTATF
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
RALQALGGSERLERGDLDGFREDAVRVLRTQPTWHAVILARPDGLRLLDTRRTSVAATAP
HHHHHCCCHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCEEEECCC
PRDPRSLAEAVGTGEPVLGDVFTGPDGALLVAARLPLMHRGRVRHVLSALIPAEALRDLV
CCCHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHCCHHHCHHHHHHHHHHHHHHHHHHHH
RVPGTGENPWIRTLVDRSGTVVARSRSPERFVGQPASPRFLEAARAGGEGVYRDTNLDGG
HCCCCCCCCHHHHHHCCCCCEEEECCCCHHHCCCCCCCHHHHHHHCCCCCCEECCCCCCC
RSYVAFGHSARAGWTAAVVAPVDMLDGATRRSVLTIAALGAAVLLVSAGGAFLAAGRFNR
CEEEEECCCCCCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHH
AIASAAASAEALARGARPRVEAEGIAEVARLGEALERSADLLAARERERDQHLAVAEAAR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEAEAASRTKDEFLAMLGHELRNPLSPIVTALELQDLGGSGGTREHAVIRRQVDHLVRLV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
DDLLDVSRITRGKVELQPERIEVRSFVARAVEMATPLVEERSHRLTVDVPEGLAVVGDPH
HHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCHH
RLAQVVANLLTNAARYTPPRGHIGVRAALRGAEVELAVRDDGRGLAPELRSRIFEPFVQA
HHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCC
PQGQDRPQGGLGIGLALVRSLVELHGGRVEACSEGPGKGSTFVVELPAAPRAPAASPPAP
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCCCC
RPAAAAAAAPLRILVVDDNEDAAELLADVLAHAGHEVRVAGDGGRGLELAVRFRPDVALL
CCHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCEEEE
DIGLPVLDGYELAVQLRRRLGEAAPVVIGVSGYGQPNDRARSAAAGFRHHFVKPADLEAL
ECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
LAAVAAAGRERGRAPATEERA
HHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]