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The map label for this gene is luxQ [H]

Identifier: 220918232

GI number: 220918232

Start: 3464338

End: 3465876

Strand: Reverse

Name: luxQ [H]

Synonym: A2cp1_3135

Alternate gene names: 220918232

Gene position: 3465876-3464338 (Counterclockwise)

Preceding gene: 220918233

Following gene: 220918228

Centisome position: 68.91

GC content: 76.41

Gene sequence:

>1539_bases
ATGAGCGATCTGCACCGGTCCGAGCGCGTCCTGGTCCTCGCGCCCACCGGGCGCGACGCGGAGGTCGCGTCGAACGTGCT
GCGGACCGCGGGGCTGTCGGTCATGGTGTGCCGCGACGTCCCGGGGGCGCTCGAGGGCCTGCGCGAGGGCGCGGCGGTCC
TGCTGATCGCGCAGGAGGCGCTCGGCGACGGCGCGCGCGACGGGCTCGGGGAGTGGATCGCGCACCAGCCGCCCTGGTCC
GACATGCCGGTGTTCGTCGTCACCGGCGCCGCCCCCCGGCTGGACCACGCGCACGCGCTGCGCCGCCTCTCGTGGCTCGG
GAACGTGCTGCTGCTGGACCGGCCGCTGCGCCGCGCCACGCTGGTCAGCGTGGTGCGCTCCGCCATCCGCGCGCGGCAGC
GCCAGTACGCGGCCAGGGAGGTGCTCGCCGCGCGGGAGCGGGAGGTGGCGGCCCGCGACCAGTTCCTGGCCATGCTCGGC
CACGAGCTCCGCAACCCGCTCGGCGCCATCGTCCTCGCGCTGGACGTGATCGACCGGCGCGGCGCGGCCGAGCCGCGCCA
GCTCGACGTGGTGCGCCGGCAGTCTCGGCAGCTCTCGCGCCTCGTGGACGACCTGCTCGACGTGTCGCGCGTCACCTCGG
GGAAGATCGCGCTCCACAACCGCCCGGTGGACCTGGCCGGCCTGGTGATCCGCGCGGTCGAGGCCATGCAGCCTTCCGCC
GCGGCCGCGGGCGTCTCGCTGCGCGCGGAGGTCGCGCCGGGCGAGGTGCCGCTGGTGGGCGATCCGGTCCGGCTGGAGCA
GGTGGTCGCGAACCTGGTCGGGAACGCGCTCAAGTACAACCGGCCGGGCGGCCACGTGGTGGTCGCGCTGGAGGCGTCGG
GCGACGAGGCGGTGCTGCGCGTGCGCGACGACGGGATCGGCCTCGCCGAGCACGACCTGGAGCGCGTGTTCGACACGTTC
GTGCAGGTGGACACCGGGCTCGACCGTGCCCGCGGCGGGCTGGGGCTCGGGCTCACGCTGGTGAAGACGCTGGTGGCCAT
GCACGGCGGCCAGGTGCGCGCGGACAGCGCGGGCCCGGGCAAGGGCAGCACGTTCACCATCCGGCTGCCGCTGGCGGCGT
CGGCCGAGCGGGCCGCCGGCGCGGACCGCGACGGCGCGGGGTCCGGGGCCCGGTCGCGGCGCGTGCTGGTCATCGACGAC
AGCCCCGACAACCGCGAGGTGGCCCAGTCCGCGCTCGAGATGCTCGGGCACGTGGTGAGCGTCGCGGGCGACGGGCCGAG
CGGGATCGAGCAGGCGATCCGCGGCGATCCCGAGGTGGTGGTGATCGACATCGGCCTGCCGGGGCTGGACGGCTACGAGG
TGGCGCGCCGGCTGCGGGCCGCGCGCGGCCGGGGCATGACGCTCATCGCGCTGACGGGCTACGGCCAGCCGGACGATCGC
CAGCGCGCGCTGGAGGCCGGGTTCGACGTGCACCTGACGAAGCCGGTCGAGATCGAGGCGCTCCGCCGTGCCGTCGAGCG
GCCGCCGCCGGACGCGTGA

Upstream 100 bases:

>100_bases
GGCTCGGTGCCCCGCTGACGGCGTTCCGGGGCGTGCTCACCGGCGTGCCCGAGTTCGAGCCCGGCGCCGCCGGCGCGCAG
CTCCTGCCCGTCCAGTCTCC

Downstream 100 bases:

>100_bases
GCGGCCCTGCGGCCCCGCTCAGCCGCGCTGCCGGTGCGCCCCCGCCAGCAGCGCCTCGATGGCCTCGAAGCGCGCCGGCT
TGGCGAGGTGCGCGTCGAAG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSDLHRSERVLVLAPTGRDAEVASNVLRTAGLSVMVCRDVPGALEGLREGAAVLLIAQEALGDGARDGLGEWIAHQPPWS
DMPVFVVTGAAPRLDHAHALRRLSWLGNVLLLDRPLRRATLVSVVRSAIRARQRQYAAREVLAAREREVAARDQFLAMLG
HELRNPLGAIVLALDVIDRRGAAEPRQLDVVRRQSRQLSRLVDDLLDVSRVTSGKIALHNRPVDLAGLVIRAVEAMQPSA
AAAGVSLRAEVAPGEVPLVGDPVRLEQVVANLVGNALKYNRPGGHVVVALEASGDEAVLRVRDDGIGLAEHDLERVFDTF
VQVDTGLDRARGGLGLGLTLVKTLVAMHGGQVRADSAGPGKGSTFTIRLPLAASAERAAGADRDGAGSGARSRRVLVIDD
SPDNREVAQSALEMLGHVVSVAGDGPSGIEQAIRGDPEVVVIDIGLPGLDGYEVARRLRAARGRGMTLIALTGYGQPDDR
QRALEAGFDVHLTKPVEIEALRRAVERPPPDA

Sequences:

>Translated_512_residues
MSDLHRSERVLVLAPTGRDAEVASNVLRTAGLSVMVCRDVPGALEGLREGAAVLLIAQEALGDGARDGLGEWIAHQPPWS
DMPVFVVTGAAPRLDHAHALRRLSWLGNVLLLDRPLRRATLVSVVRSAIRARQRQYAAREVLAAREREVAARDQFLAMLG
HELRNPLGAIVLALDVIDRRGAAEPRQLDVVRRQSRQLSRLVDDLLDVSRVTSGKIALHNRPVDLAGLVIRAVEAMQPSA
AAAGVSLRAEVAPGEVPLVGDPVRLEQVVANLVGNALKYNRPGGHVVVALEASGDEAVLRVRDDGIGLAEHDLERVFDTF
VQVDTGLDRARGGLGLGLTLVKTLVAMHGGQVRADSAGPGKGSTFTIRLPLAASAERAAGADRDGAGSGARSRRVLVIDD
SPDNREVAQSALEMLGHVVSVAGDGPSGIEQAIRGDPEVVVIDIGLPGLDGYEVARRLRAARGRGMTLIALTGYGQPDDR
QRALEAGFDVHLTKPVEIEALRRAVERPPPDA
>Mature_511_residues
SDLHRSERVLVLAPTGRDAEVASNVLRTAGLSVMVCRDVPGALEGLREGAAVLLIAQEALGDGARDGLGEWIAHQPPWSD
MPVFVVTGAAPRLDHAHALRRLSWLGNVLLLDRPLRRATLVSVVRSAIRARQRQYAAREVLAAREREVAARDQFLAMLGH
ELRNPLGAIVLALDVIDRRGAAEPRQLDVVRRQSRQLSRLVDDLLDVSRVTSGKIALHNRPVDLAGLVIRAVEAMQPSAA
AAGVSLRAEVAPGEVPLVGDPVRLEQVVANLVGNALKYNRPGGHVVVALEASGDEAVLRVRDDGIGLAEHDLERVFDTFV
QVDTGLDRARGGLGLGLTLVKTLVAMHGGQVRADSAGPGKGSTFTIRLPLAASAERAAGADRDGAGSGARSRRVLVIDDS
PDNREVAQSALEMLGHVVSVAGDGPSGIEQAIRGDPEVVVIDIGLPGLDGYEVARRLRAARGRGMTLIALTGYGQPDDRQ
RALEAGFDVHLTKPVEIEALRRAVERPPPDA

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=370, Percent_Identity=27.8378378378378, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI48994928, Length=374, Percent_Identity=32.3529411764706, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=34.1772151898734, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789149, Length=260, Percent_Identity=31.1538461538462, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI87081816, Length=371, Percent_Identity=27.4932614555256, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790346, Length=235, Percent_Identity=32.3404255319149, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=29.7520661157025, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=30.4721030042918, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=31.7596566523605, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=30.8333333333333, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790436, Length=270, Percent_Identity=30, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=27.4774774774775, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=30.5164319248826, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788549, Length=232, Percent_Identity=26.7241379310345, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=264, Percent_Identity=26.8939393939394, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=28.2700421940928, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082012, Length=108, Percent_Identity=32.4074074074074, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786784, Length=108, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=221, Percent_Identity=26.2443438914027, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54472; Mature: 54341

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLHRSERVLVLAPTGRDAEVASNVLRTAGLSVMVCRDVPGALEGLREGAAVLLIAQEA
CCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCEEEEEEHHH
LGDGARDGLGEWIAHQPPWSDMPVFVVTGAAPRLDHAHALRRLSWLGNVLLLDRPLRRAT
HCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEECCCHHHHH
LVSVVRSAIRARQRQYAAREVLAAREREVAARDQFLAMLGHELRNPLGAIVLALDVIDRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
GAAEPRQLDVVRRQSRQLSRLVDDLLDVSRVTSGKIALHNRPVDLAGLVIRAVEAMQPSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCH
AAAGVSLRAEVAPGEVPLVGDPVRLEQVVANLVGNALKYNRPGGHVVVALEASGDEAVLR
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEE
VRDDGIGLAEHDLERVFDTFVQVDTGLDRARGGLGLGLTLVKTLVAMHGGQVRADSAGPG
ECCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCC
KGSTFTIRLPLAASAERAAGADRDGAGSGARSRRVLVIDDSPDNREVAQSALEMLGHVVS
CCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VAGDGPSGIEQAIRGDPEVVVIDIGLPGLDGYEVARRLRAARGRGMTLIALTGYGQPDDR
HCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHH
QRALEAGFDVHLTKPVEIEALRRAVERPPPDA
HHHHHCCCCEEECCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDLHRSERVLVLAPTGRDAEVASNVLRTAGLSVMVCRDVPGALEGLREGAAVLLIAQEA
CCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCEEEEEEHHH
LGDGARDGLGEWIAHQPPWSDMPVFVVTGAAPRLDHAHALRRLSWLGNVLLLDRPLRRAT
HCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEECCCHHHHH
LVSVVRSAIRARQRQYAAREVLAAREREVAARDQFLAMLGHELRNPLGAIVLALDVIDRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
GAAEPRQLDVVRRQSRQLSRLVDDLLDVSRVTSGKIALHNRPVDLAGLVIRAVEAMQPSA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCH
AAAGVSLRAEVAPGEVPLVGDPVRLEQVVANLVGNALKYNRPGGHVVVALEASGDEAVLR
HHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEE
VRDDGIGLAEHDLERVFDTFVQVDTGLDRARGGLGLGLTLVKTLVAMHGGQVRADSAGPG
ECCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCCCEEEECCCCCC
KGSTFTIRLPLAASAERAAGADRDGAGSGARSRRVLVIDDSPDNREVAQSALEMLGHVVS
CCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VAGDGPSGIEQAIRGDPEVVVIDIGLPGLDGYEVARRLRAARGRGMTLIALTGYGQPDDR
HCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHH
QRALEAGFDVHLTKPVEIEALRRAVERPPPDA
HHHHHCCCCEEECCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA