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The map label for this gene is hom [H]

Identifier: 220917410

GI number: 220917410

Start: 2559168

End: 2560493

Strand: Reverse

Name: hom [H]

Synonym: A2cp1_2310

Alternate gene names: 220917410

Gene position: 2560493-2559168 (Counterclockwise)

Preceding gene: 220917411

Following gene: 220917409

Centisome position: 50.91

GC content: 74.43

Gene sequence:

>1326_bases
ATGCGCGAGGTCGGGATCGGGATCGCCGGGTTCGGCGTGGTCGGCGGCGGGGTGCTGTCCATCCTGCGGCAGCACGCTGG
GGACATCGAGGCGCGGCTGGGCGGGCGGATCGTGGTCCGGCGCGTGGCGCTGCGCGACCTGGAGAAGGAGCGCTCGATCG
ACGTCGATCCGGCGCTGCTCACCACGCGGCTCGAGGACCTGCTCGAGGACCCCGGCATCCAGGTGGTGGTCGAGCTCATC
GGCGGCGTGGACCAGGCGTTCGAGCTGGTGTGCGGGGCGCTGCAGCGCGGCAAGCACGTGGTCACCGCCAACAAGGCGCT
GCTGGCCGCGCGCGGCGACGAGATCTTCCGGCTCGCCCGCGCCCGCGGCGTGGACGTCTACTACGAGGCCGCGGTCTGCG
GCGGCGTGCCCATCATCCGCACGCTCCGCGAGGCGCTCGCCTCCGACCGGATCACCGCGCTGCACGGCATCGTCAACGGC
ACCACCAACTTCATCCTCACCGCCATGGCCGAGAAGGGCGAGCCCATCGAGCGGGCGCTGGCCGAGGCGCAGCGGCTCGG
GTACGCCGAGGCGGACCCCACGCTCGACGTGTCGGGCGGCGACGCGGCGCAGAAGCTCTGCGTCCTCGCGCAGCTCGCGT
TCGGGGCGGCGCTCCTGCCCGCGGACGTGCTCACCGAGGGCATCATGGCGCTGAAGCCGGAGGACTTCCGGTGGGCGCGC
GAGTTCGGCTACGCGCTGAAGCTGCTGGCGGTGGCCCGGCGCTGCGGCCCGGCCGAGGGCGCCGCGCCCGGCGCGCAGGA
CCAGCTCGAGGCCCGCGTGCACCCCGCCTTCATCCCGGCAGGCTCGCTGCTCGCCGGCGTGCGCGGGGCCATGAACGCGG
TGGTGCTGCACTCGGAGGCGCTGGGCGCGTCCATGCTGTACGGGCAGGGCGCCGGCGCGATGCCCACCGGGAGCGCGGTG
GTGTCGGACATCATCGATCTCACCCGCAACATCCTGGCCGGGAGCCCCGGGCGCGTGCCGCTGCCGCCGGCCGAGCCGCT
CGTCTCGGTGCGGCCGCACGCCGAGGTGCGCTGCGCGTACTACCTGAACTTCTCGGTGCAGGACGCGCCCGGCGTGCTCG
CCCGCATCGCCTCGCAGCTCGCCGCCCGCCACATCTCCATCGCGGCGGTGCAGCAGCGGGAGCAGAACGACCAGGGCCAG
CCGGTGCCGCTCGTGATCGTGACGCACGTGGCCCGCGAGGCGGACCTGCGCGCCGCCATCGCCGACATCGACCGCGACCC
GACCACGCTCGCGCCGACGCGCCTCATCCGCATCGAGAGCGTCTGA

Upstream 100 bases:

>100_bases
GCGTCGGGCCGGTGCGGATCGAGACGTGGGCGGTGGTGGAGGGGAACGTGGCGCCGCAGGTGCGGGCGGTGCTCGGCTCG
TACCGGGTCGGAGGCAAGTG

Downstream 100 bases:

>100_bases
CCGCGCCGCGCGCCCGCCGCGACCGGCCCCGCGCCGGCCGCCGCGCCGCGCCGCGCCCAGGGTGAACGCATGGTGAAGAC
GGAGCTCCGAGTCATCTACG

Product: Homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MREVGIGIAGFGVVGGGVLSILRQHAGDIEARLGGRIVVRRVALRDLEKERSIDVDPALLTTRLEDLLEDPGIQVVVELI
GGVDQAFELVCGALQRGKHVVTANKALLAARGDEIFRLARARGVDVYYEAAVCGGVPIIRTLREALASDRITALHGIVNG
TTNFILTAMAEKGEPIERALAEAQRLGYAEADPTLDVSGGDAAQKLCVLAQLAFGAALLPADVLTEGIMALKPEDFRWAR
EFGYALKLLAVARRCGPAEGAAPGAQDQLEARVHPAFIPAGSLLAGVRGAMNAVVLHSEALGASMLYGQGAGAMPTGSAV
VSDIIDLTRNILAGSPGRVPLPPAEPLVSVRPHAEVRCAYYLNFSVQDAPGVLARIASQLAARHISIAAVQQREQNDQGQ
PVPLVIVTHVAREADLRAAIADIDRDPTTLAPTRLIRIESV

Sequences:

>Translated_441_residues
MREVGIGIAGFGVVGGGVLSILRQHAGDIEARLGGRIVVRRVALRDLEKERSIDVDPALLTTRLEDLLEDPGIQVVVELI
GGVDQAFELVCGALQRGKHVVTANKALLAARGDEIFRLARARGVDVYYEAAVCGGVPIIRTLREALASDRITALHGIVNG
TTNFILTAMAEKGEPIERALAEAQRLGYAEADPTLDVSGGDAAQKLCVLAQLAFGAALLPADVLTEGIMALKPEDFRWAR
EFGYALKLLAVARRCGPAEGAAPGAQDQLEARVHPAFIPAGSLLAGVRGAMNAVVLHSEALGASMLYGQGAGAMPTGSAV
VSDIIDLTRNILAGSPGRVPLPPAEPLVSVRPHAEVRCAYYLNFSVQDAPGVLARIASQLAARHISIAAVQQREQNDQGQ
PVPLVIVTHVAREADLRAAIADIDRDPTTLAPTRLIRIESV
>Mature_441_residues
MREVGIGIAGFGVVGGGVLSILRQHAGDIEARLGGRIVVRRVALRDLEKERSIDVDPALLTTRLEDLLEDPGIQVVVELI
GGVDQAFELVCGALQRGKHVVTANKALLAARGDEIFRLARARGVDVYYEAAVCGGVPIIRTLREALASDRITALHGIVNG
TTNFILTAMAEKGEPIERALAEAQRLGYAEADPTLDVSGGDAAQKLCVLAQLAFGAALLPADVLTEGIMALKPEDFRWAR
EFGYALKLLAVARRCGPAEGAAPGAQDQLEARVHPAFIPAGSLLAGVRGAMNAVVLHSEALGASMLYGQGAGAMPTGSAV
VSDIIDLTRNILAGSPGRVPLPPAEPLVSVRPHAEVRCAYYLNFSVQDAPGVLARIASQLAARHISIAAVQQREQNDQGQ
PVPLVIVTHVAREADLRAAIADIDRDPTTLAPTRLIRIESV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=28.1124497991968, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790376, Length=245, Percent_Identity=26.1224489795918, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46478; Mature: 46478

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVGIGIAGFGVVGGGVLSILRQHAGDIEARLGGRIVVRRVALRDLEKERSIDVDPALL
CCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHH
TTRLEDLLEDPGIQVVVELIGGVDQAFELVCGALQRGKHVVTANKALLAARGDEIFRLAR
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCEECCCHHHHHHHH
ARGVDVYYEAAVCGGVPIIRTLREALASDRITALHGIVNGTTNFILTAMAEKGEPIERAL
HCCCCEEEEHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHEEHHHHCCCHHHHHH
AEAQRLGYAEADPTLDVSGGDAAQKLCVLAQLAFGAALLPADVLTEGIMALKPEDFRWAR
HHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCCHHHHHH
EFGYALKLLAVARRCGPAEGAAPGAQDQLEARVHPAFIPAGSLLAGVRGAMNAVVLHSEA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEHHH
LGASMLYGQGAGAMPTGSAVVSDIIDLTRNILAGSPGRVPLPPAEPLVSVRPHAEVRCAY
HCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEEEE
YLNFSVQDAPGVLARIASQLAARHISIAAVQQREQNDQGQPVPLVIVTHVAREADLRAAI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHH
ADIDRDPTTLAPTRLIRIESV
HHCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MREVGIGIAGFGVVGGGVLSILRQHAGDIEARLGGRIVVRRVALRDLEKERSIDVDPALL
CCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHH
TTRLEDLLEDPGIQVVVELIGGVDQAFELVCGALQRGKHVVTANKALLAARGDEIFRLAR
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCEECCCHHHHHHHH
ARGVDVYYEAAVCGGVPIIRTLREALASDRITALHGIVNGTTNFILTAMAEKGEPIERAL
HCCCCEEEEHHHHCCCHHHHHHHHHHHHCCHHHHHHHHCCHHHHHEEHHHHCCCHHHHHH
AEAQRLGYAEADPTLDVSGGDAAQKLCVLAQLAFGAALLPADVLTEGIMALKPEDFRWAR
HHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHCCCCHHHHHH
EFGYALKLLAVARRCGPAEGAAPGAQDQLEARVHPAFIPAGSLLAGVRGAMNAVVLHSEA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHEEEHHH
LGASMLYGQGAGAMPTGSAVVSDIIDLTRNILAGSPGRVPLPPAEPLVSVRPHAEVRCAY
HCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCEEEEE
YLNFSVQDAPGVLARIASQLAARHISIAAVQQREQNDQGQPVPLVIVTHVAREADLRAAI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHH
ADIDRDPTTLAPTRLIRIESV
HHCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]