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The map label for this gene is nudG [H]

Identifier: 220917389

GI number: 220917389

Start: 2539032

End: 2539430

Strand: Reverse

Name: nudG [H]

Synonym: A2cp1_2289

Alternate gene names: 220917389

Gene position: 2539430-2539032 (Counterclockwise)

Preceding gene: 220917390

Following gene: 220917386

Centisome position: 50.49

GC content: 76.69

Gene sequence:

>399_bases
GTGAAGCGGATCCGCGTCGTCGCGGCCGTCGTCCGGCGGGGCGACGCCATCCTCGTCACCCGCCGTCCCGACCGCGACGG
CCTGCGCGGCCAGTGGGAGTTCCCCGGCGGCAAGGTCGAGGCCGGCGAGTCCGAGCCCGACGCGCTCCGGCGCGAGATCC
GCGAGGAGCTGGGCTGCGAGCTCACCGTGGGCGCGCTCCTGCTCCGGCACGAGCACCGTTACCCGGAGCTCGAGGTCGAG
CTGGCGTTCTACGCCGGCGCGCTCGCCTCGGACCAGGTGCCGTGCGCGCTCGGCGTGGCCGAGATCGCCTGGGCGCCGGC
GGGCACGCTGGCCGGCTACGACTTCCTCGAGGCGGACCGGGCCGTGCTGGGCGAGCTCGAGCGCCGCTCGGCGCCCTGA

Upstream 100 bases:

>100_bases
TGCTCGACCCCGGCACCGGCATCTCCTCCACGCCGGGCGTCGGCGGCGAGCGCGTGTACGTGCTCTCCAACGGCGGCGAC
CTGCTCGCGCTCGACCTGCG

Downstream 100 bases:

>100_bases
CGCGCCCGTCACCGCGCCCGGCGCTTGCGCTTCGCGGGCTGCGGCTTCGGCTCGGGCGGCGGCGGCGTGCCGGCGACCAG
CACGCTGAGGCCGGCCGGCG

Product: NUDIX hydrolase

Products: CMP; diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MKRIRVVAAVVRRGDAILVTRRPDRDGLRGQWEFPGGKVEAGESEPDALRREIREELGCELTVGALLLRHEHRYPELEVE
LAFYAGALASDQVPCALGVAEIAWAPAGTLAGYDFLEADRAVLGELERRSAP

Sequences:

>Translated_132_residues
MKRIRVVAAVVRRGDAILVTRRPDRDGLRGQWEFPGGKVEAGESEPDALRREIREELGCELTVGALLLRHEHRYPELEVE
LAFYAGALASDQVPCALGVAEIAWAPAGTLAGYDFLEADRAVLGELERRSAP
>Mature_132_residues
MKRIRVVAAVVRRGDAILVTRRPDRDGLRGQWEFPGGKVEAGESEPDALRREIREELGCELTVGALLLRHEHRYPELEVE
LAFYAGALASDQVPCALGVAEIAWAPAGTLAGYDFLEADRAVLGELERRSAP

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=71, Percent_Identity=52.112676056338, Blast_Score=71, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 14507; Mature: 14507

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIRVVAAVVRRGDAILVTRRPDRDGLRGQWEFPGGKVEAGESEPDALRREIREELGCE
CCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHCCE
LTVGALLLRHEHRYPELEVELAFYAGALASDQVPCALGVAEIAWAPAGTLAGYDFLEADR
EHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
AVLGELERRSAP
HHHHHHHHCCCC
>Mature Secondary Structure
MKRIRVVAAVVRRGDAILVTRRPDRDGLRGQWEFPGGKVEAGESEPDALRREIREELGCE
CCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHCCE
LTVGALLLRHEHRYPELEVELAFYAGALASDQVPCALGVAEIAWAPAGTLAGYDFLEADR
EHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
AVLGELERRSAP
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; H2O [C]

Specific reaction: CTP + H2O = CMP + diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]