Click here to switch to the map view.

The map label for this gene is mutL [H]

Identifier: 220917323

GI number: 220917323

Start: 2464654

End: 2466477

Strand: Direct

Name: mutL [H]

Synonym: A2cp1_2223

Alternate gene names: 220917323

Gene position: 2464654-2466477 (Clockwise)

Preceding gene: 220917321

Following gene: 220917324

Centisome position: 49.01

GC content: 77.8

Gene sequence:

>1824_bases
ATGCCGCGCATCCACGTCCTCCCGCCCGGGCTCGTCAACCAGATCGCCGCGGGCGAGGTGGTCGAGCGGCCGGCCTCGAT
CGTCAAGGAGCTGGTCGAGAACGCGCTCGACGCCGGCGCCACCTCCGTCGGCGTGGACGTGGAGGAGGGCGGGCTCGCGC
TGGTCCGGGTGGCGGACGACGGGTCGGGCATGGACCGCGACGATGCGCTGCTCGCGCTCGAGCGCCACGCGACCAGCAAG
CTGCGCGACGCCGAGGGGCTCGCCGCCATCGGGACCATGGGCTTCCGGGGCGAGGCGGTGCCGGCCATCGCGTCGGTCTC
GCGCTTCCGCCTCGACACCTCGGCCGGCGAGGACGGCGCCGGCACGCGGGTGGAGATCGAGGGGGGCGTGCTGGGCGAGG
TGGCGCCGGTGGCCCGGCCGCGCGGCACCACCGTCGAGGTCCGGGACCTGTTCTTCAACACGCCGGCCCGCCGCAAGTTC
ATGCGCGCGGCCTCCACCGAGGCGGGGCACGTCTCCGAGGCGGTGATCCGGCTGGCGCTGGCGCGGCCGGACGTGGGGTT
CACGCTCCGCTCCGCCGGACGGCTGGTGCTGGGCGCGCGCGCGGGCGGCGGCCTGGCCGACCGGGCCGGGCAGGCGCTGG
GGCGGGAGGCGCACCGGCACCTGCTCCCGGTGGACGCCCGCCGCGGCGAGGTGCGCGTCCACGGGCTCATCTGCTCGCCG
GACCACTCCGAGGCCACCGGGCGGGCGCTCTACCTGTTCGTGAACGGGCGCTACGTGCGCGATCGCGCCGCCGCCCACGC
CGTGCTGCGCGCGTTCGCCGGCACGCTGCCGCCCGGGCGGCATCCCGCCGGCGTCCTGTTCGTGGAGCTGCCGCTCCACC
GCGTGGACGTGAACGTGCACCCGCAGAAGCTCGAGGTCCGGTTCGCGGAGGGGCGCGAGGTGTTCGACGCGCTGTTCCAC
ACCGTGGCCGGCGCCCTCCGCACCGCGCCCTGGCTGCGCGCGCGCCCGCAGCCGGGCGACGGCGTTCCGGCGGGGAACGG
CGGCGGGCCGGCCCCGGTGCCGGTGGCCGGCGAGGAGGCCGCCGAGGTGCTGGCCTGGGCGCGCGCGGCGCGGCCGCCGG
AGGGGAGCGGGGCGACGCTCGTCCAGCCCGCCCCGGGCGCCTGGGCGACCGGCCGGCTCGCGTTCCCGGTCGCGCCCGCG
CCCGGCGCCGGGCCGGAGGCGGGCCCGCGGCCGGAGGGATACTTCGCCGCGCTGCGCTACGTCGGGCAGCATGCGCGGAC
GTACCTGCTCTGCGAGGCGCCCGGCGGGACGTTGGTGGTGATCGACCAGCACGCCAGCCACGAGCGGATGCTGTTCCACC
GGCTTCGGGAGGCGTTCCGGGCGCGCCGCATCCCGGTGCAGCCGTTCCTGCTGCCGCAGGTGGTGACGCTCCCGCCCGCC
GCGGCGCGCGCCCTGGAGGCCGGGCTCGCGGAGCTGGGCCGGCTCGGGTTCGACGCGGAGCCGTTCGGCGGCGAGGCGTT
CGCCGTGAAGGGCGCGCCGGCAGCGCTCGCCGGGGTGGACCTCACCGCGCTGCTCACCGATCTCGGCAGCCAGCTCGCGG
AGGTGGAGCGCGGCAGCGCGGTGGACGATGCGTTCCACGACCTGCTCGCCACCATGGCTTGCCACGCGGCGGTGCGCGCC
AACCAGGACGTCTCGCCGGAGGAGGCGCGCGCGCTCCTCGACGGGCTCGACGCCATCGACTTCAAGGCGCGCTGCCCGCA
CGGCCGGCCGGTGGTCTTCGAGCTCTCGCTCGCGGACCTCGAGCGTCGCGTCGGCCGCCGCTAG

Upstream 100 bases:

>100_bases
CCTCCCGCCATCGCGTCCACATAGACGCACGCGGCGGCAGGCGTCAAACGTTCGCTGGGGGGAGCCGCCGCGTCGGATCG
CCGTGGTACGAACGGGCGCC

Downstream 100 bases:

>100_bases
GCGCCGCAGGATCCGGAGGGTCGAGGAAGAGGGCTGCTCTCGGCGCGGCTGAAGTCGGATCCGAGGTGAACGAGCGAACC
GCGCCGAGAGCGTCCCAGCG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MPRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADDGSGMDRDDALLALERHATSK
LRDAEGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGAGTRVEIEGGVLGEVAPVARPRGTTVEVRDLFFNTPARRKF
MRAASTEAGHVSEAVIRLALARPDVGFTLRSAGRLVLGARAGGGLADRAGQALGREAHRHLLPVDARRGEVRVHGLICSP
DHSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVHPQKLEVRFAEGREVFDALFH
TVAGALRTAPWLRARPQPGDGVPAGNGGGPAPVPVAGEEAAEVLAWARAARPPEGSGATLVQPAPGAWATGRLAFPVAPA
PGAGPEAGPRPEGYFAALRYVGQHARTYLLCEAPGGTLVVIDQHASHERMLFHRLREAFRARRIPVQPFLLPQVVTLPPA
AARALEAGLAELGRLGFDAEPFGGEAFAVKGAPAALAGVDLTALLTDLGSQLAEVERGSAVDDAFHDLLATMACHAAVRA
NQDVSPEEARALLDGLDAIDFKARCPHGRPVVFELSLADLERRVGRR

Sequences:

>Translated_607_residues
MPRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADDGSGMDRDDALLALERHATSK
LRDAEGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGAGTRVEIEGGVLGEVAPVARPRGTTVEVRDLFFNTPARRKF
MRAASTEAGHVSEAVIRLALARPDVGFTLRSAGRLVLGARAGGGLADRAGQALGREAHRHLLPVDARRGEVRVHGLICSP
DHSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVHPQKLEVRFAEGREVFDALFH
TVAGALRTAPWLRARPQPGDGVPAGNGGGPAPVPVAGEEAAEVLAWARAARPPEGSGATLVQPAPGAWATGRLAFPVAPA
PGAGPEAGPRPEGYFAALRYVGQHARTYLLCEAPGGTLVVIDQHASHERMLFHRLREAFRARRIPVQPFLLPQVVTLPPA
AARALEAGLAELGRLGFDAEPFGGEAFAVKGAPAALAGVDLTALLTDLGSQLAEVERGSAVDDAFHDLLATMACHAAVRA
NQDVSPEEARALLDGLDAIDFKARCPHGRPVVFELSLADLERRVGRR
>Mature_606_residues
PRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADDGSGMDRDDALLALERHATSKL
RDAEGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGAGTRVEIEGGVLGEVAPVARPRGTTVEVRDLFFNTPARRKFM
RAASTEAGHVSEAVIRLALARPDVGFTLRSAGRLVLGARAGGGLADRAGQALGREAHRHLLPVDARRGEVRVHGLICSPD
HSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVHPQKLEVRFAEGREVFDALFHT
VAGALRTAPWLRARPQPGDGVPAGNGGGPAPVPVAGEEAAEVLAWARAARPPEGSGATLVQPAPGAWATGRLAFPVAPAP
GAGPEAGPRPEGYFAALRYVGQHARTYLLCEAPGGTLVVIDQHASHERMLFHRLREAFRARRIPVQPFLLPQVVTLPPAA
ARALEAGLAELGRLGFDAEPFGGEAFAVKGAPAALAGVDLTALLTDLGSQLAEVERGSAVDDAFHDLLATMACHAAVRAN
QDVSPEEARALLDGLDAIDFKARCPHGRPVVFELSLADLERRVGRR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=33.434650455927, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI4505913, Length=358, Percent_Identity=27.0949720670391, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI310128478, Length=358, Percent_Identity=27.0949720670391, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=26.5243902439024, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=26.5243902439024, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI189458896, Length=326, Percent_Identity=26.9938650306748, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI263191589, Length=240, Percent_Identity=26.6666666666667, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI91992160, Length=353, Percent_Identity=26.9121813031161, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI91992162, Length=353, Percent_Identity=26.9121813031161, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310128480, Length=323, Percent_Identity=24.1486068111455, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790612, Length=332, Percent_Identity=46.6867469879518, Blast_Score=283, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.6875, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=352, Percent_Identity=25, Blast_Score=109, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323819, Length=342, Percent_Identity=33.0409356725146, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=366, Percent_Identity=26.2295081967213, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=707, Percent_Identity=21.9236209335219, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=157, Percent_Identity=32.484076433121, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136968, Length=333, Percent_Identity=36.3363363363363, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17136970, Length=167, Percent_Identity=36.5269461077844, Blast_Score=99, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 63793; Mature: 63662

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADD
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEECCCCEEEEEEECC
GSGMDRDDALLALERHATSKLRDAEGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGA
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHEEECCCCCCCC
GTRVEIEGGVLGEVAPVARPRGTTVEVRDLFFNTPARRKFMRAASTEAGHVSEAVIRLAL
CCEEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHH
ARPDVGFTLRSAGRLVLGARAGGGLADRAGQALGREAHRHLLPVDARRGEVRVHGLICSP
CCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECC
DHSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVH
CCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCCC
PQKLEVRFAEGREVFDALFHTVAGALRTAPWLRARPQPGDGVPAGNGGGPAPVPVAGEEA
CCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCHHH
AEVLAWARAARPPEGSGATLVQPAPGAWATGRLAFPVAPAPGAGPEAGPRPEGYFAALRY
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHH
VGQHARTYLLCEAPGGTLVVIDQHASHERMLFHRLREAFRARRIPVQPFLLPQVVTLPPA
HHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCH
AARALEAGLAELGRLGFDAEPFGGEAFAVKGAPAALAGVDLTALLTDLGSQLAEVERGSA
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
VDDAFHDLLATMACHAAVRANQDVSPEEARALLDGLDAIDFKARCPHGRPVVFELSLADL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHH
ERRVGRR
HHHHCCC
>Mature Secondary Structure 
PRIHVLPPGLVNQIAAGEVVERPASIVKELVENALDAGATSVGVDVEEGGLALVRVADD
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEECCCCEEEEEEECC
GSGMDRDDALLALERHATSKLRDAEGLAAIGTMGFRGEAVPAIASVSRFRLDTSAGEDGA
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHEEECCCCCCCC
GTRVEIEGGVLGEVAPVARPRGTTVEVRDLFFNTPARRKFMRAASTEAGHVSEAVIRLAL
CCEEEECCCCCCCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHH
ARPDVGFTLRSAGRLVLGARAGGGLADRAGQALGREAHRHLLPVDARRGEVRVHGLICSP
CCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECC
DHSEATGRALYLFVNGRYVRDRAAAHAVLRAFAGTLPPGRHPAGVLFVELPLHRVDVNVH
CCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCCC
PQKLEVRFAEGREVFDALFHTVAGALRTAPWLRARPQPGDGVPAGNGGGPAPVPVAGEEA
CCEEEEEECCCHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCHHH
AEVLAWARAARPPEGSGATLVQPAPGAWATGRLAFPVAPAPGAGPEAGPRPEGYFAALRY
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHH
VGQHARTYLLCEAPGGTLVVIDQHASHERMLFHRLREAFRARRIPVQPFLLPQVVTLPPA
HHHCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCH
AARALEAGLAELGRLGFDAEPFGGEAFAVKGAPAALAGVDLTALLTDLGSQLAEVERGSA
HHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
VDDAFHDLLATMACHAAVRANQDVSPEEARALLDGLDAIDFKARCPHGRPVVFELSLADL
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHH
ERRVGRR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA