Click here to switch to the map view.

The map label for this gene is lipB [H]

Identifier: 220917212

GI number: 220917212

Start: 2351925

End: 2353022

Strand: Direct

Name: lipB [H]

Synonym: A2cp1_2109

Alternate gene names: 220917212

Gene position: 2351925-2353022 (Clockwise)

Preceding gene: 220917211

Following gene: 220917214

Centisome position: 46.76

GC content: 76.41

Gene sequence:

>1098_bases
ATGCCGCGCGTCCTGCGCACCTACCGCCTCGGCCGCGTCGAGTACGAGGACGGGCTCGCGCTCATGCGGCTCGCCGCCGA
CGCGGTCCGCGCCGGCACGCCCGCCGCGACCGACTTCTTGTTCCTGCTCGAGCACCCGCCGGTGCTGACGCTCGGCCGCA
GCGCCGGGCGCGAGCACATCGTGGCCGCGCCGGCCTGGCTCGAGAAGCAGGGCTTCGAGATCCACGAGACCGACCGCGGC
GGGGACGTCACCTACCACGGGCCCGGCCAGATCGTCGGCTACCCGGTGCTCGATCTGAACGGCCGCAAGGACGTGCGGCG
GTACGTGGGGGCGCTCGAGGAGGCGATGATCCGCACCTGCGCCGACTTCGGCGTGGAGGCGGGCCGCCACCCCGAGCACC
GGGGCTGCTGGGTGGGCCGCCGGAAGATCGGCGCGATCGGCGTGCACCTCTCGCGCTGGATCACCTCGCACGGCTTCGCG
TTCAACGCCCGCACCGACCTCGCGCACTTCCAGGTGATCGTCCCGTGCGGCATCGCGGATCCCCGCCTCGGCGTGACCAG
CCTCGAGGCCGAGCTGGCGGCGCGGGGCCGGGCCACGCCGGAGCAGGCCGAGATCGAGAACCGGCTGGCCGCGCACCTCG
CCGACGTCCTGGAGCTGGCCCGCGCCGACGCCGGGCCCGACCTGCGCACCATCTCGGTGGTCCCGGTGCGGCCGGACGGG
CGCGTGCTGCTGCTCCGGCGGAGCGTGGAGCGGGGCGGCTTCTGGCAGCAGGTGACCGGGCGGATCGAGCCGGGCGAGGC
GCCGGAGCAGGCCGCGCGGCGGGAGCTGCGCGAGGAGACCGGCGCCGATCTCCCGGTGGTGTCCCTCGGCTACCGGCACG
CGTTCGGGCTCGACCCCAGCGTCAACCGCGTCCGGCCCGGCGCGCTCGTGGTGGTCGAGGAGGTGGCGTTCGCGGCCCGG
GTGCCCGACGGGTTCGAGCCGCGCCTCTCCGGCGAGCACACCGAGCACGCCTGGGCCACCGGGGAGGAGGCGGCCGCGCA
GCTGCGCTTCCCCGGGCTGCGGCGGGCGGTGCGGCTCGCGCTCAGCGCCCGGCGCTGA

Upstream 100 bases:

>100_bases
AGAAGGGCGAGGCCGCCGCGGGCGCCCGGGCCTGACGCGCGCGCTCCGCCGGGCACCGGCGCCGCCACCCGGCGGTGCGC
GGTCCCGCGGGGAGGGATCG

Downstream 100 bases:

>100_bases
GCCCCTCGAGCGCCTGCGCCGTCGCGACGAAGCCCCCCGGCGCGTCGCGGACCCACTCCGCGATCCGGAACACCGCACCG
CCGGCGCGCCGCTCGTCCGG

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPRVLRTYRLGRVEYEDGLALMRLAADAVRAGTPAATDFLFLLEHPPVLTLGRSAGREHIVAAPAWLEKQGFEIHETDRG
GDVTYHGPGQIVGYPVLDLNGRKDVRRYVGALEEAMIRTCADFGVEAGRHPEHRGCWVGRRKIGAIGVHLSRWITSHGFA
FNARTDLAHFQVIVPCGIADPRLGVTSLEAELAARGRATPEQAEIENRLAAHLADVLELARADAGPDLRTISVVPVRPDG
RVLLLRRSVERGGFWQQVTGRIEPGEAPEQAARRELREETGADLPVVSLGYRHAFGLDPSVNRVRPGALVVVEEVAFAAR
VPDGFEPRLSGEHTEHAWATGEEAAAQLRFPGLRRAVRLALSARR

Sequences:

>Translated_365_residues
MPRVLRTYRLGRVEYEDGLALMRLAADAVRAGTPAATDFLFLLEHPPVLTLGRSAGREHIVAAPAWLEKQGFEIHETDRG
GDVTYHGPGQIVGYPVLDLNGRKDVRRYVGALEEAMIRTCADFGVEAGRHPEHRGCWVGRRKIGAIGVHLSRWITSHGFA
FNARTDLAHFQVIVPCGIADPRLGVTSLEAELAARGRATPEQAEIENRLAAHLADVLELARADAGPDLRTISVVPVRPDG
RVLLLRRSVERGGFWQQVTGRIEPGEAPEQAARRELREETGADLPVVSLGYRHAFGLDPSVNRVRPGALVVVEEVAFAAR
VPDGFEPRLSGEHTEHAWATGEEAAAQLRFPGLRRAVRLALSARR
>Mature_364_residues
PRVLRTYRLGRVEYEDGLALMRLAADAVRAGTPAATDFLFLLEHPPVLTLGRSAGREHIVAAPAWLEKQGFEIHETDRGG
DVTYHGPGQIVGYPVLDLNGRKDVRRYVGALEEAMIRTCADFGVEAGRHPEHRGCWVGRRKIGAIGVHLSRWITSHGFAF
NARTDLAHFQVIVPCGIADPRLGVTSLEAELAARGRATPEQAEIENRLAAHLADVLELARADAGPDLRTISVVPVRPDGR
VLLLRRSVERGGFWQQVTGRIEPGEAPEQAARRELREETGADLPVVSLGYRHAFGLDPSVNRVRPGALVVVEEVAFAARV
PDGFEPRLSGEHTEHAWATGEEAAAQLRFPGLRRAVRLALSARR

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=198, Percent_Identity=40.9090909090909, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI87081767, Length=199, Percent_Identity=35.678391959799, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323268, Length=119, Percent_Identity=37.8151260504202, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355483, Length=187, Percent_Identity=41.1764705882353, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF00293 NUDIX [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 39998; Mature: 39867

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00893 NUDIX ; PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVLRTYRLGRVEYEDGLALMRLAADAVRAGTPAATDFLFLLEHPPVLTLGRSAGREHI
CCCHHHHHHCCCEEHHCCHHHHHHHHHHHHCCCCCHHHEEEEECCCCEEEECCCCCCCEE
VAAPAWLEKQGFEIHETDRGGDVTYHGPGQIVGYPVLDLNGRKDVRRYVGALEEAMIRTC
EECCHHHHHCCCEEEECCCCCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
ADFGVEAGRHPEHRGCWVGRRKIGAIGVHLSRWITSHGFAFNARTDLAHFQVIVPCGIAD
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCC
PRLGVTSLEAELAARGRATPEQAEIENRLAAHLADVLELARADAGPDLRTISVVPVRPDG
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
RVLLLRRSVERGGFWQQVTGRIEPGEAPEQAARRELREETGADLPVVSLGYRHAFGLDPS
CEEEEEECHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCC
VNRVRPGALVVVEEVAFAARVPDGFEPRLSGEHTEHAWATGEEAAAQLRFPGLRRAVRLA
CCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LSARR
HHCCC
>Mature Secondary Structure 
PRVLRTYRLGRVEYEDGLALMRLAADAVRAGTPAATDFLFLLEHPPVLTLGRSAGREHI
CCHHHHHHCCCEEHHCCHHHHHHHHHHHHCCCCCHHHEEEEECCCCEEEECCCCCCCEE
VAAPAWLEKQGFEIHETDRGGDVTYHGPGQIVGYPVLDLNGRKDVRRYVGALEEAMIRTC
EECCHHHHHCCCEEEECCCCCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
ADFGVEAGRHPEHRGCWVGRRKIGAIGVHLSRWITSHGFAFNARTDLAHFQVIVPCGIAD
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCCCC
PRLGVTSLEAELAARGRATPEQAEIENRLAAHLADVLELARADAGPDLRTISVVPVRPDG
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCC
RVLLLRRSVERGGFWQQVTGRIEPGEAPEQAARRELREETGADLPVVSLGYRHAFGLDPS
CEEEEEECHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCC
VNRVRPGALVVVEEVAFAARVPDGFEPRLSGEHTEHAWATGEEAAAQLRFPGLRRAVRLA
CCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHH
LSARR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA