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The map label for this gene is ilvC

Identifier: 220917090

GI number: 220917090

Start: 2244151

End: 2245176

Strand: Direct

Name: ilvC

Synonym: A2cp1_1987

Alternate gene names: 220917090

Gene position: 2244151-2245176 (Clockwise)

Preceding gene: 220917089

Following gene: 220917091

Centisome position: 44.62

GC content: 69.3

Gene sequence:

>1026_bases
ATGGCGACCATCTATTACGACAAGGACGCGAACCTCGACCTCCTGAAGAAGCGGAAGGTCGCGATCATCGGCTACGGCTC
GCAGGGCCACGCCCACGCGCTCAACCTGCGCGACTCCGGCGTGGACGTGCGGGTGGGCCTGGCGGCCGGCTCGAAGTCGA
AGGCCAAGGCCGAGGGCGCCGGGCTGCGCGTCCTCTCGGTCGCGGAGGCCTCGAAGGAGGCCGACGTGATCATGGTCCTC
ATCCCGGACCAGACGCAGAAGAAGGTCTACGACGAGGAGATCGCGCCGCACCTGTCCAAGGGCAAGGCGCTGCTCTTCGC
GCACGGCTTCAACATCCACTTCGTGCAGGTTCGCCCGCCGCCCGACGTGGACGTGCTCCTGGTCGCGCCGAAGGGCCCGG
GCCACATGGTCCGCCGCCAGTACCAGGACGGCCGCGGCATCCCCGGCCTCGTCGCGGTCCACCAGGACGCGACCGGCCAG
GCCAAGGCCGTCGGCCTCGCCTACGCCCGCGGCATCGGCTGCACCCGCGCCGGCGTGCTCGAGACCACGTTCAAGGAGGA
GACCGAGACCGACCTGTTCGGCGAGCAGGCCGTGCTGTGCGGCGGCGCGGCGGCGCTGGTGAAGAACGGGTTCGAGGTGC
TGGTCGAGGCCGGCTACCAGCCGGAGAGCGCCTACTTCGAGTGCCTCCACGAGCTGAAGCTCATCGTGGACCTCATGTAC
GAGGGCGGCCTGGCCTGGATGCGCCACTCCATCTCCGACACGGCGGAGTACGGCGACTACACCCGCGGTCCGCGGGTGGT
GGACGGCCGTTCCAAGGACGAGATGCGGAAGATCCTCAAGGAGATCCAGGGCGGCCACTTCGCCAAGGAGTTCATCCTCG
AGAACCAGGCGGGCGGTCCCACCATGGCCCGCTACCGCGCCGCCGAGGCCGCTCATCCCATCGAGGAGGTGGGCAAGCGC
CTCCGCGACATGATGAGCTGGATCCGCGAGGCGAAGAAGGACTCGTCGGACCCGGGCAGCCGCTAG

Upstream 100 bases:

>100_bases
CGCCCCTTCGGCATCCAGGAACTCTGCCGCTCGGGGCGCATCGCGCTCGAGCGGGGCTTCAAGACGCTGGCTCCCCCCTC
ACTGAAGTAGAGGAACGAAC

Downstream 100 bases:

>100_bases
GACCCGTCGCGCCGTCCCCTTCCCGCACGAGGGGAAGGGGACGCGCGCGCACGGGCGCACGGCCGCGTTGACATTGCGGC
CGAAATCCTTATTCTACAGC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MATIYYDKDANLDLLKKRKVAIIGYGSQGHAHALNLRDSGVDVRVGLAAGSKSKAKAEGAGLRVLSVAEASKEADVIMVL
IPDQTQKKVYDEEIAPHLSKGKALLFAHGFNIHFVQVRPPPDVDVLLVAPKGPGHMVRRQYQDGRGIPGLVAVHQDATGQ
AKAVGLAYARGIGCTRAGVLETTFKEETETDLFGEQAVLCGGAAALVKNGFEVLVEAGYQPESAYFECLHELKLIVDLMY
EGGLAWMRHSISDTAEYGDYTRGPRVVDGRSKDEMRKILKEIQGGHFAKEFILENQAGGPTMARYRAAEAAHPIEEVGKR
LRDMMSWIREAKKDSSDPGSR

Sequences:

>Translated_341_residues
MATIYYDKDANLDLLKKRKVAIIGYGSQGHAHALNLRDSGVDVRVGLAAGSKSKAKAEGAGLRVLSVAEASKEADVIMVL
IPDQTQKKVYDEEIAPHLSKGKALLFAHGFNIHFVQVRPPPDVDVLLVAPKGPGHMVRRQYQDGRGIPGLVAVHQDATGQ
AKAVGLAYARGIGCTRAGVLETTFKEETETDLFGEQAVLCGGAAALVKNGFEVLVEAGYQPESAYFECLHELKLIVDLMY
EGGLAWMRHSISDTAEYGDYTRGPRVVDGRSKDEMRKILKEIQGGHFAKEFILENQAGGPTMARYRAAEAAHPIEEVGKR
LRDMMSWIREAKKDSSDPGSR
>Mature_340_residues
ATIYYDKDANLDLLKKRKVAIIGYGSQGHAHALNLRDSGVDVRVGLAAGSKSKAKAEGAGLRVLSVAEASKEADVIMVLI
PDQTQKKVYDEEIAPHLSKGKALLFAHGFNIHFVQVRPPPDVDVLLVAPKGPGHMVRRQYQDGRGIPGLVAVHQDATGQA
KAVGLAYARGIGCTRAGVLETTFKEETETDLFGEQAVLCGGAAALVKNGFEVLVEAGYQPESAYFECLHELKLIVDLMYE
GGLAWMRHSISDTAEYGDYTRGPRVVDGRSKDEMRKILKEIQGGHFAKEFILENQAGGPTMARYRAAEAAHPIEEVGKRL
RDMMSWIREAKKDSSDPGSR

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=255, Percent_Identity=38.0392156862745, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=263, Percent_Identity=38.7832699619772, Blast_Score=144, Evalue=3e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_ANAD2 (B8J829)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492394.1
- ProteinModelPortal:   B8J829
- SMR:   B8J829
- GeneID:   7300114
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_1987
- HOGENOM:   HBG286525
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37128; Mature: 36997

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIYYDKDANLDLLKKRKVAIIGYGSQGHAHALNLRDSGVDVRVGLAAGSKSKAKAEGA
CEEEEECCCCCHHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCC
GLRVLSVAEASKEADVIMVLIPDQTQKKVYDEEIAPHLSKGKALLFAHGFNIHFVQVRPP
CEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCHHCCCCEEEEEECCEEEEEEECCC
PDVDVLLVAPKGPGHMVRRQYQDGRGIPGLVAVHQDATGQAKAVGLAYARGIGCTRAGVL
CCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCHH
ETTFKEETETDLFGEQAVLCGGAAALVKNGFEVLVEAGYQPESAYFECLHELKLIVDLMY
HHHHHHHHHHHHCCCCEEEECCHHHHHHCCHHEEHCCCCCCHHHHHHHHHHHHHHHHHHH
EGGLAWMRHSISDTAEYGDYTRGPRVVDGRSKDEMRKILKEIQGGHFAKEFILENQAGGP
HCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
TMARYRAAEAAHPIEEVGKRLRDMMSWIREAKKDSSDPGSR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATIYYDKDANLDLLKKRKVAIIGYGSQGHAHALNLRDSGVDVRVGLAAGSKSKAKAEGA
EEEEECCCCCHHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCC
GLRVLSVAEASKEADVIMVLIPDQTQKKVYDEEIAPHLSKGKALLFAHGFNIHFVQVRPP
CEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHCCHHCCCCEEEEEECCEEEEEEECCC
PDVDVLLVAPKGPGHMVRRQYQDGRGIPGLVAVHQDATGQAKAVGLAYARGIGCTRAGVL
CCCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCHH
ETTFKEETETDLFGEQAVLCGGAAALVKNGFEVLVEAGYQPESAYFECLHELKLIVDLMY
HHHHHHHHHHHHCCCCEEEECCHHHHHHCCHHEEHCCCCCCHHHHHHHHHHHHHHHHHHH
EGGLAWMRHSISDTAEYGDYTRGPRVVDGRSKDEMRKILKEIQGGHFAKEFILENQAGGP
HCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
TMARYRAAEAAHPIEEVGKRLRDMMSWIREAKKDSSDPGSR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA