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The map label for this gene is typA [H]

Identifier: 220917079

GI number: 220917079

Start: 2230476

End: 2232323

Strand: Reverse

Name: typA [H]

Synonym: A2cp1_1976

Alternate gene names: 220917079

Gene position: 2232323-2230476 (Counterclockwise)

Preceding gene: 220917080

Following gene: 220917075

Centisome position: 44.39

GC content: 69.64

Gene sequence:

>1848_bases
ATGACCCCCCGCGAGCAGATCCGCAACGTGGCGATCGTCGCCCACGTCGACCACGGCAAGACCACCCTCGTCGATTTCAT
GCTGCGCCAGGCCGGCGTGTTCCGGGCCAACGAGCAGGTGGTCGAGCGGGTCATGGACTCGAACGACCTCGAGCGCGAGA
AGGGCATCACCATCCTCGCGAAGAACACCGCCGTCACGTACCAGGGCGTGAAGATCAACATCGTGGACACGCCCGGCCAC
GCCGACTTCGGCGGCGAGGTGGAGCGCGCGCTGCGCCTGGTCGACGGGGTGCTGCTGCTGGTGGACGCGGCCGAGGGGCC
GCTCCCGCAGACCCGCTTCGTGCTCTCCAAGGCGCTCTCGATGGGCCTGCCCTCGGTGCTGGTCGTCAACAAGGTGGACC
GGCAGGACGCGCGCGCGAAGGAGGTCCTCGACCTCGTCTACTCGCTCTACATCGACCTCGGCGCGAACGAGCGGCAGATC
GACTTCCCGGTCATCTACGCGATCGCGCGCGAGGGCAAGGCCGCCCACACCGTGCAGGGCGCGTTCGCGGCGGAGTCGCT
GAAGCCGCTGTTCGACGCGATCCTCACCCACGTCCCGCCTCCGCCCGCCGGCGAGCGCGAGACGCTGCAGATGCTGGTGG
ACAACCTCGACTACGACGACTACGTGGGCCGCCTCGCCATCGGCCGGGTCGCCTCCGGCCTGGCGCGCGAGGGCATGGCC
ATCTCGGTGCTGCGCGAGGAGGGCAAGGTCGTCCCCGCGAAGATCGTGCGGCTGTACGCCTACGACGGCCTGAAGCGCGT
CGAGGTGAAGGACGCCGGCCCGGGCGAGATCGTCTGCATCGCCGGCGCCGAGGAGATCGGGATCGGCGACACCATCGCCG
ACCCGGCCGCACCGGAGGCGCTCCCGCGCATCAGCGTGGAGGAGCCCACCATGTCGATGGTCTTCAAGGTCAACGACGGG
CCCTTCGCCGGACGCGAGGGCAAGTACGTGACCAGCCGCAACATCCGCGAGCGGCTCTACCGCGAGGCGTACCGCAACGT
GTCCATCCGCGTGGAGGACACCGACACCCCGGACGCGTTCAAGGTGGTGGGCCGCGGCGAGCTGCAGCTCGCGGTGATCG
TCGAGAACATGCGGCGCGAGGGCTACGAGGTCACCGTCTCGAACCCGGAGCCGATCCTGAAGACGGTCGAGGGCGAGGTG
CACGAGCCGATGGAGCTGCTCGTGTGCGACCTGCCCGACGACGGCGTGGGCGGCGTCACCCAGAGCATGGGCTCGCGCAA
GGGCCGCATGGTGGACATGCAGCCGCTCGGCTCGGGCCGCACGCGCCTCCAGTTCCGGGTGCCCGCCCGCGGCCTGATCG
GCTTCCGGGGCGACTTCCTCACGCTCACCCGCGGCGAGGGCATCATGTCCTCGCAGTTCGACGGCTACGAGCCGTGGCAG
GGCAAGATCGAGAAGCGGAAGAGCGGCGCCATCGTGGCCGACCGGATCGGCGACGTGGTCGCCTACGCCTGCTTCTACGC
GCAGGAGCGCGGGGCGCTGTTCGTGAGGCCCGGCGACAAGGTGTACCCGGGCATGATCGTGGGCGAGCACAGCCACGACA
ACGACCTCGACTTCAACATCTGCAAGGAGAAGAAGCTCACCAACATCCGCGCCGCCGGCCGCGACGAGAACGTCATCCTG
ACGCCGCCGCGCGAGCTGAGCCTGGAGGCGGCGCTGGAGTGGATCGCCGAGGACGAGCTGGTCGAGGTCACGCCGCAGTC
CATCCGGCTGCGCAAGAAGTTCCTCGACCCGACCGCGCGCTACAAGATCGAGCGCGACCGCAAGCGCGGCCAGGCCGAGG
CGTCGTAG

Upstream 100 bases:

>100_bases
GCGCGCCGCGCTTCCCCTTGCCCGCGCGGCATCAAAGGACTATAAGTTCCGGCCCTTTGCAGGCCGGCGTCCGTACCGGC
CCTTTCCAGGCCGGAGCCCA

Downstream 100 bases:

>100_bases
CCGGCCGCCCTCCTCCCCTCCCCGCAGCACCGACGCCGCCCGGCCCCCGGGCGGCGTTCGTCGTTCCGGGCCCGCGCTCG
CCCCGGCGGCCCGCCGTCCG

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MTPREQIRNVAIVAHVDHGKTTLVDFMLRQAGVFRANEQVVERVMDSNDLEREKGITILAKNTAVTYQGVKINIVDTPGH
ADFGGEVERALRLVDGVLLLVDAAEGPLPQTRFVLSKALSMGLPSVLVVNKVDRQDARAKEVLDLVYSLYIDLGANERQI
DFPVIYAIAREGKAAHTVQGAFAAESLKPLFDAILTHVPPPPAGERETLQMLVDNLDYDDYVGRLAIGRVASGLAREGMA
ISVLREEGKVVPAKIVRLYAYDGLKRVEVKDAGPGEIVCIAGAEEIGIGDTIADPAAPEALPRISVEEPTMSMVFKVNDG
PFAGREGKYVTSRNIRERLYREAYRNVSIRVEDTDTPDAFKVVGRGELQLAVIVENMRREGYEVTVSNPEPILKTVEGEV
HEPMELLVCDLPDDGVGGVTQSMGSRKGRMVDMQPLGSGRTRLQFRVPARGLIGFRGDFLTLTRGEGIMSSQFDGYEPWQ
GKIEKRKSGAIVADRIGDVVAYACFYAQERGALFVRPGDKVYPGMIVGEHSHDNDLDFNICKEKKLTNIRAAGRDENVIL
TPPRELSLEAALEWIAEDELVEVTPQSIRLRKKFLDPTARYKIERDRKRGQAEAS

Sequences:

>Translated_615_residues
MTPREQIRNVAIVAHVDHGKTTLVDFMLRQAGVFRANEQVVERVMDSNDLEREKGITILAKNTAVTYQGVKINIVDTPGH
ADFGGEVERALRLVDGVLLLVDAAEGPLPQTRFVLSKALSMGLPSVLVVNKVDRQDARAKEVLDLVYSLYIDLGANERQI
DFPVIYAIAREGKAAHTVQGAFAAESLKPLFDAILTHVPPPPAGERETLQMLVDNLDYDDYVGRLAIGRVASGLAREGMA
ISVLREEGKVVPAKIVRLYAYDGLKRVEVKDAGPGEIVCIAGAEEIGIGDTIADPAAPEALPRISVEEPTMSMVFKVNDG
PFAGREGKYVTSRNIRERLYREAYRNVSIRVEDTDTPDAFKVVGRGELQLAVIVENMRREGYEVTVSNPEPILKTVEGEV
HEPMELLVCDLPDDGVGGVTQSMGSRKGRMVDMQPLGSGRTRLQFRVPARGLIGFRGDFLTLTRGEGIMSSQFDGYEPWQ
GKIEKRKSGAIVADRIGDVVAYACFYAQERGALFVRPGDKVYPGMIVGEHSHDNDLDFNICKEKKLTNIRAAGRDENVIL
TPPRELSLEAALEWIAEDELVEVTPQSIRLRKKFLDPTARYKIERDRKRGQAEAS
>Mature_614_residues
TPREQIRNVAIVAHVDHGKTTLVDFMLRQAGVFRANEQVVERVMDSNDLEREKGITILAKNTAVTYQGVKINIVDTPGHA
DFGGEVERALRLVDGVLLLVDAAEGPLPQTRFVLSKALSMGLPSVLVVNKVDRQDARAKEVLDLVYSLYIDLGANERQID
FPVIYAIAREGKAAHTVQGAFAAESLKPLFDAILTHVPPPPAGERETLQMLVDNLDYDDYVGRLAIGRVASGLAREGMAI
SVLREEGKVVPAKIVRLYAYDGLKRVEVKDAGPGEIVCIAGAEEIGIGDTIADPAAPEALPRISVEEPTMSMVFKVNDGP
FAGREGKYVTSRNIRERLYREAYRNVSIRVEDTDTPDAFKVVGRGELQLAVIVENMRREGYEVTVSNPEPILKTVEGEVH
EPMELLVCDLPDDGVGGVTQSMGSRKGRMVDMQPLGSGRTRLQFRVPARGLIGFRGDFLTLTRGEGIMSSQFDGYEPWQG
KIEKRKSGAIVADRIGDVVAYACFYAQERGALFVRPGDKVYPGMIVGEHSHDNDLDFNICKEKKLTNIRAAGRDENVILT
PPRELSLEAALEWIAEDELVEVTPQSIRLRKKFLDPTARYKIERDRKRGQAEAS

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=531, Percent_Identity=25.9887005649718, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=42.4242424242424, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI18390331, Length=151, Percent_Identity=41.7218543046358, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=36.6666666666667, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI25306283, Length=140, Percent_Identity=37.8571428571429, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI19923640, Length=140, Percent_Identity=37.8571428571429, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI25306287, Length=140, Percent_Identity=37.8571428571429, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=39.6396396396396, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=39.6396396396396, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=39.6396396396396, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI217272892, Length=140, Percent_Identity=35.7142857142857, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI217272894, Length=140, Percent_Identity=35.7142857142857, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI34147630, Length=204, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI94966752, Length=128, Percent_Identity=33.59375, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI48994988, Length=602, Percent_Identity=49.5016611295681, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI1788922, Length=507, Percent_Identity=26.8244575936884, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1789738, Length=167, Percent_Identity=37.7245508982036, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1790835, Length=396, Percent_Identity=24.4949494949495, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790412, Length=131, Percent_Identity=34.3511450381679, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789737, Length=131, Percent_Identity=34.3511450381679, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=293, Percent_Identity=30.3754266211604, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17533571, Length=167, Percent_Identity=41.3173652694611, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71988811, Length=132, Percent_Identity=41.6666666666667, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988819, Length=132, Percent_Identity=41.6666666666667, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17556745, Length=143, Percent_Identity=37.7622377622378, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17506493, Length=164, Percent_Identity=35.3658536585366, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=35.5555555555556, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=284, Percent_Identity=26.7605633802817, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=512, Percent_Identity=27.734375, Blast_Score=137, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324707, Length=179, Percent_Identity=37.9888268156425, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=179, Percent_Identity=37.9888268156425, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323098, Length=243, Percent_Identity=32.9218106995885, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322359, Length=146, Percent_Identity=34.2465753424658, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=35.5555555555556, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=245, Percent_Identity=29.7959183673469, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324550, Length=127, Percent_Identity=33.0708661417323, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI78706572, Length=522, Percent_Identity=25.8620689655172, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24582462, Length=167, Percent_Identity=38.9221556886228, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574573, Length=140, Percent_Identity=41.4285714285714, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585711, Length=156, Percent_Identity=35.8974358974359, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585713, Length=156, Percent_Identity=35.8974358974359, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585709, Length=156, Percent_Identity=35.8974358974359, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=41.044776119403, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221458488, Length=134, Percent_Identity=44.7761194029851, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921738, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363316, Length=239, Percent_Identity=27.6150627615063, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17864358, Length=239, Percent_Identity=27.6150627615063, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67858; Mature: 67726

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPREQIRNVAIVAHVDHGKTTLVDFMLRQAGVFRANEQVVERVMDSNDLEREKGITILA
CCCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCEEEE
KNTAVTYQGVKINIVDTPGHADFGGEVERALRLVDGVLLLVDAAEGPLPQTRFVLSKALS
ECCEEEEECEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
MGLPSVLVVNKVDRQDARAKEVLDLVYSLYIDLGANERQIDFPVIYAIAREGKAAHTVQG
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHH
AFAAESLKPLFDAILTHVPPPPAGERETLQMLVDNLDYDDYVGRLAIGRVASGLAREGMA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCE
ISVLREEGKVVPAKIVRLYAYDGLKRVEVKDAGPGEIVCIAGAEEIGIGDTIADPAAPEA
EEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCC
LPRISVEEPTMSMVFKVNDGPFAGREGKYVTSRNIRERLYREAYRNVSIRVEDTDTPDAF
CCCCCCCCCCEEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHCCCEEEEECCCCCCCE
KVVGRGELQLAVIVENMRREGYEVTVSNPEPILKTVEGEVHEPMELLVCDLPDDGVGGVT
EEECCCCEEEEEEEHHHHCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHH
QSMGSRKGRMVDMQPLGSGRTRLQFRVPARGLIGFRGDFLTLTRGEGIMSSQFDGYEPWQ
HHHCCCCCCEEEECCCCCCCEEEEEECCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCC
GKIEKRKSGAIVADRIGDVVAYACFYAQERGALFVRPGDKVYPGMIVGEHSHDNDLDFNI
CHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCCCCCCCEE
CKEKKLTNIRAAGRDENVILTPPRELSLEAALEWIAEDELVEVTPQSIRLRKKFLDPTAR
ECCCHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCHHHH
YKIERDRKRGQAEAS
EEEHHHHHCCCCCCC
>Mature Secondary Structure 
TPREQIRNVAIVAHVDHGKTTLVDFMLRQAGVFRANEQVVERVMDSNDLEREKGITILA
CCHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHCCCEEEE
KNTAVTYQGVKINIVDTPGHADFGGEVERALRLVDGVLLLVDAAEGPLPQTRFVLSKALS
ECCEEEEECEEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHH
MGLPSVLVVNKVDRQDARAKEVLDLVYSLYIDLGANERQIDFPVIYAIAREGKAAHTVQG
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHH
AFAAESLKPLFDAILTHVPPPPAGERETLQMLVDNLDYDDYVGRLAIGRVASGLAREGMA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCE
ISVLREEGKVVPAKIVRLYAYDGLKRVEVKDAGPGEIVCIAGAEEIGIGDTIADPAAPEA
EEEECCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCC
LPRISVEEPTMSMVFKVNDGPFAGREGKYVTSRNIRERLYREAYRNVSIRVEDTDTPDAF
CCCCCCCCCCEEEEEEECCCCCCCCCCCEECHHHHHHHHHHHHHCCCEEEEECCCCCCCE
KVVGRGELQLAVIVENMRREGYEVTVSNPEPILKTVEGEVHEPMELLVCDLPDDGVGGVT
EEECCCCEEEEEEEHHHHCCCEEEEECCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHH
QSMGSRKGRMVDMQPLGSGRTRLQFRVPARGLIGFRGDFLTLTRGEGIMSSQFDGYEPWQ
HHHCCCCCCEEEECCCCCCCEEEEEECCCCCCEEECCCEEEEECCCCCCCCCCCCCCCCC
GKIEKRKSGAIVADRIGDVVAYACFYAQERGALFVRPGDKVYPGMIVGEHSHDNDLDFNI
CHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCCCCCCCEE
CKEKKLTNIRAAGRDENVILTPPRELSLEAALEWIAEDELVEVTPQSIRLRKKFLDPTAR
ECCCHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCHHHH
YKIERDRKRGQAEAS
EEEHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]