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The map label for this gene is mdtA [H]

Identifier: 220917046

GI number: 220917046

Start: 2196584

End: 2197702

Strand: Reverse

Name: mdtA [H]

Synonym: A2cp1_1942

Alternate gene names: 220917046

Gene position: 2197702-2196584 (Counterclockwise)

Preceding gene: 220917047

Following gene: 220917045

Centisome position: 43.7

GC content: 78.55

Gene sequence:

>1119_bases
ATGACCGCCCCCCGCGCCGCGCCGCTCGCGCTCACCCTCCTCGCGCTCGCCGCCGCCTGCGGGCGGGGCGACGCCGGACC
GAAGGGCCCGCGCCCGGTGGCGGTTCGCGCCGCCGTGGCGGAGCGGCGCGACGTGCCGGTGGAGGTCCGCGCCGTCGGGC
GCATCGTGGCGAACCAGTCGGTGGCGGTGCGCGCGCAGGTGTCGGGCCCCATCGTCGCGGTGCGCTTCACCGAGGGCCAG
GCGGTGCGCCAGGGCGACGTGCTGCTCGAGCTCGACCCGCGCCCGTACCGCGCCGCGCTGGACGAGGCGCGGGCTCGCCT
CGCGCAGGACGAGGCGCGCGCCGCGAGCGCCCGGGACGACGCGCGCCGGTTCGCCGAGCTGGTGAAGAAGGAGTACGTCA
CGCAGCAGCAGGCCGAGCAGGCGGCGGCGGCCGCGACGGCCGCCGCGGCGGCGGTGGCGGGCGACCGCGCGCAGGTGGAG
CGGGCCGCGCTCGACCTCTCCTACTGCACCGTCCGCGCGCCGGCGGCGGGCCGCACCGGCCGCCTGCTCGTGCACGCCGG
CAACCTCGTCACCGCGTCGGCGCAGACGCCGCTGCTCACCATCGAGCAGGTGAAGCCGGTGTACGCGGCCTTCTCCATCC
CGGAGCGCCACCTCCCGGCGCTGCAGGGCTGGCGCGCCCACCCGCCGGCGGTGCGCGTGCGCGCAGGCGACGGGCCCGAG
ATCGCGGGCGTGCTCGACTTCGTGGACAACGCGGTGGACGCCGGCACCGGCACCATCCTGCTCAAGGCGCGCCTCGCCAA
CGCGGACGAGGCGCTCTGGCCCGGGCAGGTGGTGGACGTCGCGCTCCGGATCGGCGAGCGGCGCGGCGCGGTGGTGGTGC
CGGCCGCCGCGGTCGCGCAGGGCCAGCAGGGCGATTACGCCTACGTGGTCGGCGCGGACGGGAAGGCCGAGCTGCGCGGG
GTGACGGTGGAGCAGGCGGGCGACGCCGAGGCGGTGCTCTCGAAGGGAATCGCGCCCGGCGAGCGGGTGGTGATCGAGGG
CCAGCTGAAGCTGCGGCCGGGCGCGCCGGTGGAGGTGCAGGGGCCGCGCGAGGACGGGCGGAAGGCGCCGGGCACATGA

Upstream 100 bases:

>100_bases
ACTACCTGGTGGCACTGGCCCAGCTCGCCCGCGCCACCGGCCGCCTCGCGCCGCCGGCCCAGGCCGCCGCCGCGCCGACG
CCCGCGCCAGAAGGGAACCC

Downstream 100 bases:

>100_bases
ACCTCTCCGAGCCGTTCATCCGCCGGCCGGTCATGACGACGCTCGTCATGGCGAGCTTCATCGCGTTCGGCCTGGTCGCC
TACCAGAAGCTGCCGGTCTC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTAPRAAPLALTLLALAAACGRGDAGPKGPRPVAVRAAVAERRDVPVEVRAVGRIVANQSVAVRAQVSGPIVAVRFTEGQ
AVRQGDVLLELDPRPYRAALDEARARLAQDEARAASARDDARRFAELVKKEYVTQQQAEQAAAAATAAAAAVAGDRAQVE
RAALDLSYCTVRAPAAGRTGRLLVHAGNLVTASAQTPLLTIEQVKPVYAAFSIPERHLPALQGWRAHPPAVRVRAGDGPE
IAGVLDFVDNAVDAGTGTILLKARLANADEALWPGQVVDVALRIGERRGAVVVPAAAVAQGQQGDYAYVVGADGKAELRG
VTVEQAGDAEAVLSKGIAPGERVVIEGQLKLRPGAPVEVQGPREDGRKAPGT

Sequences:

>Translated_372_residues
MTAPRAAPLALTLLALAAACGRGDAGPKGPRPVAVRAAVAERRDVPVEVRAVGRIVANQSVAVRAQVSGPIVAVRFTEGQ
AVRQGDVLLELDPRPYRAALDEARARLAQDEARAASARDDARRFAELVKKEYVTQQQAEQAAAAATAAAAAVAGDRAQVE
RAALDLSYCTVRAPAAGRTGRLLVHAGNLVTASAQTPLLTIEQVKPVYAAFSIPERHLPALQGWRAHPPAVRVRAGDGPE
IAGVLDFVDNAVDAGTGTILLKARLANADEALWPGQVVDVALRIGERRGAVVVPAAAVAQGQQGDYAYVVGADGKAELRG
VTVEQAGDAEAVLSKGIAPGERVVIEGQLKLRPGAPVEVQGPREDGRKAPGT
>Mature_371_residues
TAPRAAPLALTLLALAAACGRGDAGPKGPRPVAVRAAVAERRDVPVEVRAVGRIVANQSVAVRAQVSGPIVAVRFTEGQA
VRQGDVLLELDPRPYRAALDEARARLAQDEARAASARDDARRFAELVKKEYVTQQQAEQAAAAATAAAAAVAGDRAQVER
AALDLSYCTVRAPAAGRTGRLLVHAGNLVTASAQTPLLTIEQVKPVYAAFSIPERHLPALQGWRAHPPAVRVRAGDGPEI
AGVLDFVDNAVDAGTGTILLKARLANADEALWPGQVVDVALRIGERRGAVVVPAAAVAQGQQGDYAYVVGADGKAELRGV
TVEQAGDAEAVLSKGIAPGERVVIEGQLKLRPGAPVEVQGPREDGRKAPGT

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=340, Percent_Identity=35.2941176470588, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1789929, Length=315, Percent_Identity=31.1111111111111, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1786668, Length=369, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1789665, Length=362, Percent_Identity=32.5966850828729, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1790519, Length=254, Percent_Identity=29.9212598425197, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081951, Length=169, Percent_Identity=28.9940828402367, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87081796, Length=337, Percent_Identity=27.893175074184, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 38586; Mature: 38455

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPRAAPLALTLLALAAACGRGDAGPKGPRPVAVRAAVAERRDVPVEVRAVGRIVANQS
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCCCCCEEHHHHHHHHCCCC
VAVRAQVSGPIVAVRFTEGQAVRQGDVLLELDPRPYRAALDEARARLAQDEARAASARDD
EEEEEECCCCEEEEEECCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHH
ARRFAELVKKEYVTQQQAEQAAAAATAAAAAVAGDRAQVERAALDLSYCTVRAPAAGRTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEEECCCCCCCC
RLLVHAGNLVTASAQTPLLTIEQVKPVYAAFSIPERHLPALQGWRAHPPAVRVRAGDGPE
EEEEEECCEEEECCCCCEEEHHHCCCCHHEECCCHHHCCHHCCCCCCCCEEEEECCCCCC
IAGVLDFVDNAVDAGTGTILLKARLANADEALWPGQVVDVALRIGERRGAVVVPAAAVAQ
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHC
GQQGDYAYVVGADGKAELRGVTVEQAGDAEAVLSKGIAPGERVVIEGQLKLRPGAPVEVQ
CCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEEECCCCCEEEE
GPREDGRKAPGT
CCHHCCCCCCCC
>Mature Secondary Structure 
TAPRAAPLALTLLALAAACGRGDAGPKGPRPVAVRAAVAERRDVPVEVRAVGRIVANQS
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCCCCCEEHHHHHHHHCCCC
VAVRAQVSGPIVAVRFTEGQAVRQGDVLLELDPRPYRAALDEARARLAQDEARAASARDD
EEEEEECCCCEEEEEECCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHH
ARRFAELVKKEYVTQQQAEQAAAAATAAAAAVAGDRAQVERAALDLSYCTVRAPAAGRTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEEEEEECCCCCCCC
RLLVHAGNLVTASAQTPLLTIEQVKPVYAAFSIPERHLPALQGWRAHPPAVRVRAGDGPE
EEEEEECCEEEECCCCCEEEHHHCCCCHHEECCCHHHCCHHCCCCCCCCEEEEECCCCCC
IAGVLDFVDNAVDAGTGTILLKARLANADEALWPGQVVDVALRIGERRGAVVVPAAAVAQ
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEECHHHHHC
GQQGDYAYVVGADGKAELRGVTVEQAGDAEAVLSKGIAPGERVVIEGQLKLRPGAPVEVQ
CCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEEECCCCCEEEE
GPREDGRKAPGT
CCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA