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The map label for this gene is livH [H]

Identifier: 220916923

GI number: 220916923

Start: 2033506

End: 2034372

Strand: Reverse

Name: livH [H]

Synonym: A2cp1_1819

Alternate gene names: 220916923

Gene position: 2034372-2033506 (Counterclockwise)

Preceding gene: 220916924

Following gene: 220916922

Centisome position: 40.45

GC content: 70.93

Gene sequence:

>867_bases
ATGACCCAGGCGCTCTTCGGCCAGCTCTTCCTCGGCCTCATCAACGGCGCGTTCTACGCGCTCCTCTCGCTGGGCCTCGC
GGTCATCTTCGGCCTGCTCGACGTGGTGAACTTCGCCCACGGCGCGCAGTACATGATGGGCGCCTTCGCCGCGTGGATGG
GGCTCACGTACCTGGGCGTCCCCTACGGCTGGGCGCTCCTGCTCGCGCCGCTCGCGGTGGGCCTCGTCGGCATGGCCGTC
GAGCGGACGCTGCTGCGCCGCCTGCAGGGGCTGGATCCGCTCTACGGCCTGCTGCTCACGTTCGGCCTCACGCTCATCGC
GGAGGGGCTGTTCCATCACGCCTACGGCAACTCCGGCTTCGCCTACCCGGTGCCGGGCTGGCTGCGCGGCGGCGTGAACC
TCGGCTTCATGTTCCTGCCGCTGTACCGCGCCTGGGCGGTGGGCCTGTCGCTGGCGGTGTGCCTCGCCTGCTGGTTCGTC
ATCGAGCGGACCAAGCTGGGCGCGTACCTGCGCGCCGGCACGGAGAACCCGAAGCTGCTGCAGGCGTTCGGGGTGAACGT
GCCGCTCATGTTCACGCTCACCTACGGCTTCGGCGCGGCGCTCGCCGCGTTCGCCGGCGTGGTGGCCGCGCCGGTGTACC
AGGTGACGCCGCTCATGGGGTCGAGCGTCATCATGGTGGTGTTCGCGGTGGTGGTGATCGGCGGCATGGGGTCGATCGGC
GGCGCCATCGTCACCGGCCTCGGCGTCGGGCTGCTCGAGGGCCTGACGCGCTTCTGGTACCCGCCCGCCTCCAGCGTGGT
GGTGTTCGTGGTGATGGCGCTCGTGCTGCTGGTGCGCCCCGCCGGGCTGTTCGGGAGGGAGCGCTAG

Upstream 100 bases:

>100_bases
CCCCTCGGTCGAGGCCCAGGCCTGCCCGCTGGCGAAGAGGTAGCCCCGCGCGCCCGGCGCCGCGCCGCCCGCCGGCGGCG
CGCGCCGGGCCCCGTCCCCC

Downstream 100 bases:

>100_bases
ATGCCCGGGCGGCTCGTCACCTGGGGCTGGCTGGCCCTGCTCGCCGCGGGGCTGGCCGCGCCGTTCGTGGTGTACCCGGT
CTTCGCCATGAACGTGCTCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTQALFGQLFLGLINGAFYALLSLGLAVIFGLLDVVNFAHGAQYMMGAFAAWMGLTYLGVPYGWALLLAPLAVGLVGMAV
ERTLLRRLQGLDPLYGLLLTFGLTLIAEGLFHHAYGNSGFAYPVPGWLRGGVNLGFMFLPLYRAWAVGLSLAVCLACWFV
IERTKLGAYLRAGTENPKLLQAFGVNVPLMFTLTYGFGAALAAFAGVVAAPVYQVTPLMGSSVIMVVFAVVVIGGMGSIG
GAIVTGLGVGLLEGLTRFWYPPASSVVVFVVMALVLLVRPAGLFGRER

Sequences:

>Translated_288_residues
MTQALFGQLFLGLINGAFYALLSLGLAVIFGLLDVVNFAHGAQYMMGAFAAWMGLTYLGVPYGWALLLAPLAVGLVGMAV
ERTLLRRLQGLDPLYGLLLTFGLTLIAEGLFHHAYGNSGFAYPVPGWLRGGVNLGFMFLPLYRAWAVGLSLAVCLACWFV
IERTKLGAYLRAGTENPKLLQAFGVNVPLMFTLTYGFGAALAAFAGVVAAPVYQVTPLMGSSVIMVVFAVVVIGGMGSIG
GAIVTGLGVGLLEGLTRFWYPPASSVVVFVVMALVLLVRPAGLFGRER
>Mature_287_residues
TQALFGQLFLGLINGAFYALLSLGLAVIFGLLDVVNFAHGAQYMMGAFAAWMGLTYLGVPYGWALLLAPLAVGLVGMAVE
RTLLRRLQGLDPLYGLLLTFGLTLIAEGLFHHAYGNSGFAYPVPGWLRGGVNLGFMFLPLYRAWAVGLSLAVCLACWFVI
ERTKLGAYLRAGTENPKLLQAFGVNVPLMFTLTYGFGAALAAFAGVVAAPVYQVTPLMGSSVIMVVFAVVVIGGMGSIGG
AIVTGLGVGLLEGLTRFWYPPASSVVVFVVMALVLLVRPAGLFGRER

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=292, Percent_Identity=30.4794520547945, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30478; Mature: 30347

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TQALFGQLFLGLINGAFYALLSLGLAVIFGLLDVVNFAHGAQYMMGAFAAWMGLTYLGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PYGWALLLAPLAVGLVGMAVERTLLRRLQGLDPLYGLLLTFGLTLIAEGLFHHAYGNSGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AYPVPGWLRGGVNLGFMFLPLYRAWAVGLSLAVCLACWFVIERTKLGAYLRAGTENPKLL
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
QAFGVNVPLMFTLTYGFGAALAAFAGVVAAPVYQVTPLMGSSVIMVVFAVVVIGGMGSIG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHH
GAIVTGLGVGLLEGLTRFWYPPASSVVVFVVMALVLLVRPAGLFGRER
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]