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The map label for this gene is livM [H]

Identifier: 220916922

GI number: 220916922

Start: 2032564

End: 2033505

Strand: Reverse

Name: livM [H]

Synonym: A2cp1_1818

Alternate gene names: 220916922

Gene position: 2033505-2032564 (Counterclockwise)

Preceding gene: 220916923

Following gene: 220916921

Centisome position: 40.43

GC content: 73.04

Gene sequence:

>942_bases
ATGCCCGGGCGGCTCGTCACCTGGGGCTGGCTGGCCCTGCTCGCCGCGGGGCTGGCCGCGCCGTTCGTGGTGTACCCGGT
CTTCGCCATGAACGTGCTCTGCCTGGCGCTGTTCGCGAGCGCGTTCAACCTGCTGCTCGGCTACACCGGGCTGCTCTCCT
TCGGCCACGCCGCGTTCCTGGGCGCGTCCGCCTACGCCACCGGCTGGGCGCTGCGGAGCTGGGGGCTGCCGCCGGAGGTG
GCGGTGCTGCTCGGCACCGCGCTCGCCGCCGCGCTGGGCCTCGTGTTCGGGGCGCTCGCCATCCGGCGCTCCGGCATCTA
CTTCGCGATGATCACGCTGGGCTTCGCGCAGCTCGTGTACTTCCTGGTGGTCCAGCTGCCCTGGACCGGCGGCGAGGACG
GGCTGCAGGGCATCCCGCGCGGCCGCGCGCTCGGGCTGATCCCGCTCGACGACCCGCGCACCGCCTACTGGTTCGTGTAC
GCCGCGTTCCTGGCCGGCTTCTGGCTGCTCCACCGCGCCATCCACTCCCCGTTCGGCCACGTGCTCCGCGCCATCCGCGA
GAACGAGCCGCGCGCGGTCTCGCTCGGCTACGACGTGGCCCGCTACAAGCTGCTCGCGTTCGTGCTCTCGGCCGGCGTCT
CCGGCCTGGCGGGCGGGCTGAAGGCGGTGGTGCTCCAGTTCGCCTCGCTCTCCGACGTGCACTGGCACCGGTCGGGCGAG
GTGGTGCTCATGACCCTGCTCGGCGGCATGGGCACGGTGCTCGGGCCTTCGGTGGGGGCGCTGCTGGTGGTGGCGCTCGA
GAACTACCTTGCCGACACCGGCTCGTGGGTGACGGTGATCACCGGCGCGGTGTTCGTCGCCTGCGTGGTCGCGTTCCGCC
GCGGGATCGTGGGCGAGGTCCGCGCGCTGGTGCGGCGGTCGTTCACCGGAGGGAAGCCATGA

Upstream 100 bases:

>100_bases
GCGCTTCTGGTACCCGCCCGCCTCCAGCGTGGTGGTGTTCGTGGTGATGGCGCTCGTGCTGCTGGTGCGCCCCGCCGGGC
TGTTCGGGAGGGAGCGCTAG

Downstream 100 bases:

>100_bases
GCGCTGGGCTGGACGGGCGGGCCGCGCTGGTCACCGGCGCGGCGAGCGGCATCGGCCGCGAGATCGCGGAGCAGCTCGCG
CGGGAGGGCGCCCGGGTGGT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPGRLVTWGWLALLAAGLAAPFVVYPVFAMNVLCLALFASAFNLLLGYTGLLSFGHAAFLGASAYATGWALRSWGLPPEV
AVLLGTALAAALGLVFGALAIRRSGIYFAMITLGFAQLVYFLVVQLPWTGGEDGLQGIPRGRALGLIPLDDPRTAYWFVY
AAFLAGFWLLHRAIHSPFGHVLRAIRENEPRAVSLGYDVARYKLLAFVLSAGVSGLAGGLKAVVLQFASLSDVHWHRSGE
VVLMTLLGGMGTVLGPSVGALLVVALENYLADTGSWVTVITGAVFVACVVAFRRGIVGEVRALVRRSFTGGKP

Sequences:

>Translated_313_residues
MPGRLVTWGWLALLAAGLAAPFVVYPVFAMNVLCLALFASAFNLLLGYTGLLSFGHAAFLGASAYATGWALRSWGLPPEV
AVLLGTALAAALGLVFGALAIRRSGIYFAMITLGFAQLVYFLVVQLPWTGGEDGLQGIPRGRALGLIPLDDPRTAYWFVY
AAFLAGFWLLHRAIHSPFGHVLRAIRENEPRAVSLGYDVARYKLLAFVLSAGVSGLAGGLKAVVLQFASLSDVHWHRSGE
VVLMTLLGGMGTVLGPSVGALLVVALENYLADTGSWVTVITGAVFVACVVAFRRGIVGEVRALVRRSFTGGKP
>Mature_312_residues
PGRLVTWGWLALLAAGLAAPFVVYPVFAMNVLCLALFASAFNLLLGYTGLLSFGHAAFLGASAYATGWALRSWGLPPEVA
VLLGTALAAALGLVFGALAIRRSGIYFAMITLGFAQLVYFLVVQLPWTGGEDGLQGIPRGRALGLIPLDDPRTAYWFVYA
AFLAGFWLLHRAIHSPFGHVLRAIRENEPRAVSLGYDVARYKLLAFVLSAGVSGLAGGLKAVVLQFASLSDVHWHRSGEV
VLMTLLGGMGTVLGPSVGALLVVALENYLADTGSWVTVITGAVFVACVVAFRRGIVGEVRALVRRSFTGGKP

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=286, Percent_Identity=26.5734265734266, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 33133; Mature: 33001

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRLVTWGWLALLAAGLAAPFVVYPVFAMNVLCLALFASAFNLLLGYTGLLSFGHAAFL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GASAYATGWALRSWGLPPEVAVLLGTALAAALGLVFGALAIRRSGIYFAMITLGFAQLVY
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FLVVQLPWTGGEDGLQGIPRGRALGLIPLDDPRTAYWFVYAAFLAGFWLLHRAIHSPFGH
HHHHHCCCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHH
VLRAIRENEPRAVSLGYDVARYKLLAFVLSAGVSGLAGGLKAVVLQFASLSDVHWHRSGE
HHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VVLMTLLGGMGTVLGPSVGALLVVALENYLADTGSWVTVITGAVFVACVVAFRRGIVGEV
EEHHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHH
RALVRRSFTGGKP
HHHHHHHCCCCCC
>Mature Secondary Structure 
PGRLVTWGWLALLAAGLAAPFVVYPVFAMNVLCLALFASAFNLLLGYTGLLSFGHAAFL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GASAYATGWALRSWGLPPEVAVLLGTALAAALGLVFGALAIRRSGIYFAMITLGFAQLVY
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
FLVVQLPWTGGEDGLQGIPRGRALGLIPLDDPRTAYWFVYAAFLAGFWLLHRAIHSPFGH
HHHHHCCCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHH
VLRAIRENEPRAVSLGYDVARYKLLAFVLSAGVSGLAGGLKAVVLQFASLSDVHWHRSGE
HHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VVLMTLLGGMGTVLGPSVGALLVVALENYLADTGSWVTVITGAVFVACVVAFRRGIVGEV
EEHHHHHHCHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHH
RALVRRSFTGGKP
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]