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The map label for this gene is zraS [C]

Identifier: 220916906

GI number: 220916906

Start: 2015721

End: 2017343

Strand: Reverse

Name: zraS [C]

Synonym: A2cp1_1802

Alternate gene names: 220916906

Gene position: 2017343-2015721 (Counterclockwise)

Preceding gene: 220916907

Following gene: 220916905

Centisome position: 40.11

GC content: 74.18

Gene sequence:

>1623_bases
GTGGTCGGTGGCGACCGCGACTACCCGCCCTACGAGTTCCTCGACCGCGACGGGAAGCCCGCCGGCTTCAACGTCGAGCT
GACCCGCGCCATCGCCGAGGTGACGGGGATGCGGGTGGAGATCCGCCTGGGCGCGTGGTCGGAGATGCGCGCCGCGCTCG
CCGCCGGGCGCATCGACGCGCTGCAGGGCATGTCCTGGTCGGAGCAGCGGGCCGCGGAGGTGGACTTCTCGCCGCCGCAC
CTCGTGGTGAACCACGCCATCTTCGCGCGCAAGGGCACGCCCGCGGTGGCGTCGCTGGAGGCGCTCCGGGGCCACGCGGT
GGCGGTCCACCGCGACGGGATCATGGACGACCAGCTCACCACCCTGGGCATGGGCGACCGCCTGCTGCGCACCGACACGC
CGGCGGACGCGCTGCGGCTGCTCGCGTCCGGCAAGGGCGAGTACGCGGTGGTGGCGGCGCTGCCCGGCACGTTCATCATC
CGCGAGCTGAAGCTCACCAACCTCGACCCGGTGGCGCATAGCGTCGCCTCGCAGCGCTACGGGTACGCGGTCCGCAAGGG
CGACGCGGCGCTCCGGTCCCGCTTCGACGAGGGGCTCGCCATCCTGAAACAGACCGGGCGCTACGAGGCGCTGCGGCAGC
GCTGGCTGGGGGTGCTCGAGCCGCAGCCCGTCTCCTGGGGGAAGTTCTTCCAGTACGGCGCGGTGGTGTTCGTGCCGCTG
CTGCTCGTGCTGGGCGGCACGGTGCTCTGGTCGCGCCAGCTCCAGCGCGAGGTGGCCGAGCGCACCGCCTCCCTCGCCGC
GGCGGTGGAGGAGCTGCGGCTCAACCAGGCCCAGCTCGTCCAGGCCGACAAGATGGCGGCGCTGGGCGTGCTGGTCTCCG
GCGTGGCCCACGAGATCAACAACCCCAACGGCTTCATCCTGCTCAACATGCCGGCGCTGAAGGACGTGTACCTCGACGCG
CTGGAGGCGCTCGACCGCGACCGGCCGGACGGCGCGCCCCCGCGGCTCGGCGGGCTGCCGTTCGCGACCGCGCGCGAGGA
GGTGCCGCGCATGCTCGACGAGATGCTGGACGGGGCGCGGCGCATCCGGCGCATCGTCGAGGACCTGAAGGACTTCGCGC
GGCGGGAGGACGCCCCCGCGCGCGCGCCGCTCGACCTCGACGAGGTGGTGCGGGCGGCGGTGCGGCTGGTGGAGAACCCC
ATCCGCAAGGCGACCACGCGGTTCGAGCTGGCCCTCGACGGCGCGCTCCCGCCGGTGGTGGGGAGCGCGCAGCGCATCGA
GCAGGTGATCGTGAACCTGGTGCTGAACGCCTGCCAGGCGCTGCCCTCGCCCGACCGCGCCGTGCGCGTCTCGACCCGCG
CCGACGGCGCCCGAGGCGTGGTGATCTGCGAGGTCCGGGACGAGGGCGTGGGGATCCCGCCCGAGCACCTGCCGCGCCTC
ACCGACCCGTTCTTCACCACCAAGCGCGACAGCGGCGGGACGGGTCTCGGCCTCTCGGTGTCGTCCGGGATCGTGAAGGA
GCACGGGGGGACGCTCGAGTTCCGCTCCGCGCCCGGCGCGGGGACCACCGCCACCGTCACGCTCCCGGCCGCGCCCGACG
CCGGCCCCCAGGGGATCCCATGA

Upstream 100 bases:

>100_bases
GCTCGGCCGCGCGGCGCTCGCGGCGCTCGTCGCCGCCGCGGCGAACGCCGGGGCCGTCCGCGCCGAGCCGCCCCCCGCCG
CGCCGCCGGCGCGGACCGTG

Downstream 100 bases:

>100_bases
GCGAGCCCGCGTCCACCTACCCCTCCTTCGCCGTGCTGCTGGTGGACGACGAGGCGGCCTGGCTGCGCTCCATGCGCGTG
GCGCTGCAGCGCGCCGGGGT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MVGGDRDYPPYEFLDRDGKPAGFNVELTRAIAEVTGMRVEIRLGAWSEMRAALAAGRIDALQGMSWSEQRAAEVDFSPPH
LVVNHAIFARKGTPAVASLEALRGHAVAVHRDGIMDDQLTTLGMGDRLLRTDTPADALRLLASGKGEYAVVAALPGTFII
RELKLTNLDPVAHSVASQRYGYAVRKGDAALRSRFDEGLAILKQTGRYEALRQRWLGVLEPQPVSWGKFFQYGAVVFVPL
LLVLGGTVLWSRQLQREVAERTASLAAAVEELRLNQAQLVQADKMAALGVLVSGVAHEINNPNGFILLNMPALKDVYLDA
LEALDRDRPDGAPPRLGGLPFATAREEVPRMLDEMLDGARRIRRIVEDLKDFARREDAPARAPLDLDEVVRAAVRLVENP
IRKATTRFELALDGALPPVVGSAQRIEQVIVNLVLNACQALPSPDRAVRVSTRADGARGVVICEVRDEGVGIPPEHLPRL
TDPFFTTKRDSGGTGLGLSVSSGIVKEHGGTLEFRSAPGAGTTATVTLPAAPDAGPQGIP

Sequences:

>Translated_540_residues
MVGGDRDYPPYEFLDRDGKPAGFNVELTRAIAEVTGMRVEIRLGAWSEMRAALAAGRIDALQGMSWSEQRAAEVDFSPPH
LVVNHAIFARKGTPAVASLEALRGHAVAVHRDGIMDDQLTTLGMGDRLLRTDTPADALRLLASGKGEYAVVAALPGTFII
RELKLTNLDPVAHSVASQRYGYAVRKGDAALRSRFDEGLAILKQTGRYEALRQRWLGVLEPQPVSWGKFFQYGAVVFVPL
LLVLGGTVLWSRQLQREVAERTASLAAAVEELRLNQAQLVQADKMAALGVLVSGVAHEINNPNGFILLNMPALKDVYLDA
LEALDRDRPDGAPPRLGGLPFATAREEVPRMLDEMLDGARRIRRIVEDLKDFARREDAPARAPLDLDEVVRAAVRLVENP
IRKATTRFELALDGALPPVVGSAQRIEQVIVNLVLNACQALPSPDRAVRVSTRADGARGVVICEVRDEGVGIPPEHLPRL
TDPFFTTKRDSGGTGLGLSVSSGIVKEHGGTLEFRSAPGAGTTATVTLPAAPDAGPQGIP
>Mature_540_residues
MVGGDRDYPPYEFLDRDGKPAGFNVELTRAIAEVTGMRVEIRLGAWSEMRAALAAGRIDALQGMSWSEQRAAEVDFSPPH
LVVNHAIFARKGTPAVASLEALRGHAVAVHRDGIMDDQLTTLGMGDRLLRTDTPADALRLLASGKGEYAVVAALPGTFII
RELKLTNLDPVAHSVASQRYGYAVRKGDAALRSRFDEGLAILKQTGRYEALRQRWLGVLEPQPVSWGKFFQYGAVVFVPL
LLVLGGTVLWSRQLQREVAERTASLAAAVEELRLNQAQLVQADKMAALGVLVSGVAHEINNPNGFILLNMPALKDVYLDA
LEALDRDRPDGAPPRLGGLPFATAREEVPRMLDEMLDGARRIRRIVEDLKDFARREDAPARAPLDLDEVVRAAVRLVENP
IRKATTRFELALDGALPPVVGSAQRIEQVIVNLVLNACQALPSPDRAVRVSTRADGARGVVICEVRDEGVGIPPEHLPRL
TDPFFTTKRDSGGTGLGLSVSSGIVKEHGGTLEFRSAPGAGTTATVTLPAAPDAGPQGIP

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=257, Percent_Identity=31.5175097276265, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1788549, Length=262, Percent_Identity=29.0076335877863, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788228, Length=219, Percent_Identity=25.5707762557078, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789149, Length=289, Percent_Identity=25.2595155709343, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=269, Percent_Identity=30.4832713754647, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI145693157, Length=200, Percent_Identity=29.5, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87081816, Length=283, Percent_Identity=27.208480565371, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1786600, Length=188, Percent_Identity=30.3191489361702, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787031, Length=225, Percent_Identity=27.1111111111111, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=169, Percent_Identity=29.585798816568, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58242; Mature: 58242

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGGDRDYPPYEFLDRDGKPAGFNVELTRAIAEVTGMRVEIRLGAWSEMRAALAAGRIDA
CCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCCHHH
LQGMSWSEQRAAEVDFSPPHLVVNHAIFARKGTPAVASLEALRGHAVAVHRDGIMDDQLT
HCCCCCCHHHCCCCCCCCCCEEEHHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCHH
TLGMGDRLLRTDTPADALRLLASGKGEYAVVAALPGTFIIRELKLTNLDPVAHSVASQRY
HCCCCCHHHCCCCCHHHHHHHHCCCCCEEEEEECCCHHEEEEHHCCCCCHHHHHHHHHHC
GYAVRKGDAALRSRFDEGLAILKQTGRYEALRQRWLGVLEPQPVSWGKFFQYGAVVFVPL
CCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LLVLGGTVLWSRQLQREVAERTASLAAAVEELRLNQAQLVQADKMAALGVLVSGVAHEIN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
NPNGFILLNMPALKDVYLDALEALDRDRPDGAPPRLGGLPFATAREEVPRMLDEMLDGAR
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RIRRIVEDLKDFARREDAPARAPLDLDEVVRAAVRLVENPIRKATTRFELALDGALPPVV
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
GSAQRIEQVIVNLVLNACQALPSPDRAVRVSTRADGARGVVICEVRDEGVGIPPEHLPRL
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCHHHCCCC
TDPFFTTKRDSGGTGLGLSVSSGIVKEHGGTLEFRSAPGAGTTATVTLPAAPDAGPQGIP
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MVGGDRDYPPYEFLDRDGKPAGFNVELTRAIAEVTGMRVEIRLGAWSEMRAALAAGRIDA
CCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCCHHH
LQGMSWSEQRAAEVDFSPPHLVVNHAIFARKGTPAVASLEALRGHAVAVHRDGIMDDQLT
HCCCCCCHHHCCCCCCCCCCEEEHHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCHH
TLGMGDRLLRTDTPADALRLLASGKGEYAVVAALPGTFIIRELKLTNLDPVAHSVASQRY
HCCCCCHHHCCCCCHHHHHHHHCCCCCEEEEEECCCHHEEEEHHCCCCCHHHHHHHHHHC
GYAVRKGDAALRSRFDEGLAILKQTGRYEALRQRWLGVLEPQPVSWGKFFQYGAVVFVPL
CCEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LLVLGGTVLWSRQLQREVAERTASLAAAVEELRLNQAQLVQADKMAALGVLVSGVAHEIN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
NPNGFILLNMPALKDVYLDALEALDRDRPDGAPPRLGGLPFATAREEVPRMLDEMLDGAR
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
RIRRIVEDLKDFARREDAPARAPLDLDEVVRAAVRLVENPIRKATTRFELALDGALPPVV
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
GSAQRIEQVIVNLVLNACQALPSPDRAVRVSTRADGARGVVICEVRDEGVGIPPEHLPRL
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCCHHHCCCC
TDPFFTTKRDSGGTGLGLSVSSGIVKEHGGTLEFRSAPGAGTTATVTLPAAPDAGPQGIP
CCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]