Click here to switch to the map view.

The map label for this gene is aceA [H]

Identifier: 220916830

GI number: 220916830

Start: 1925132

End: 1927378

Strand: Reverse

Name: aceA [H]

Synonym: A2cp1_1726

Alternate gene names: 220916830

Gene position: 1927378-1925132 (Counterclockwise)

Preceding gene: 220916833

Following gene: 220916829

Centisome position: 38.32

GC content: 72.99

Gene sequence:

>2247_bases
ATGGACTTCGAGCAGGAGGTCGCGGCCCTGCGCCGCTGGTTCGAGAGCCCACGGTTCGCGGGCATCCGGCGCATCCACAC
CGCCCGCGAGGTGATGGAGCAGCGCGGCACGATCCGCCAGGACTACCCGGTGGCGCGGGAGGCCGCCGAGGCGTTCCACG
CGCGCCTGCGCGAGCTGTTCCAGCAGCGGCGCTGCATCACCACGTTCGGCCCCTACTCGCCCGGGCAGGCCGTGGCCATG
AAGAAGATGGGCATCGAGGCCATCTACCTGGGCGGCTGGGCCACCTCGGCCAAGGGCTCGGTGCAGGAGGACCCCGGCCC
CGACCTCGCCAGCTACCCGCTCAGCCAGGTGCCCGACGAGGCGGCGCCCATCGTGCGCGCGCTGCTCACGGCGGACCGGA
ACCAGCACCACGCCCGCTCGCGCATGACCGAGGAGCAGCGGCGCGCCACCCCGGCGGTGGACTTCCGGCCGTTCATCATC
GCCGACGCCGACACCGGCCACGGCGGCGACGCGCAGGTGCGCAACCTCGTCCGCCGCTTCGTCGAGGTCGGGGTGCCCGG
CTACCACATCGAGGACCAGAAGCCGGGCGTGAAGAAGTGCGGGCACCAGGGCGGCAAGGTGCTGGTCGCCGAGGACGAGC
AGCTGAAGCGCCTCTCCGCGGCGCGGTTCCAGCTCGACCTCATGGGCGTGCCCGGGATCGTGGTGGCGCGCACCGACGCG
GAGTCGGCCACGCTGCTCGACGGCCGCGGCGACGAGCGCGACCAGCCGTTCATCCTGGGCGCGAGCAACCTCGCGGTCCC
GGCGTTCCGCGCGGCGTTCCTGGCGATCCTGCGCCGGTTCCGCCGCGCCGGCGTGGAGGAGCTCTCCGGCCACGAGCTGT
ACGCGGTGTGCGACGAGGAGTACGCGGCCGCCGACGCCTGGCTGGAGCGGACCGGCTTCGACAAGGCCATCGCCGCCGCC
GCCGCCGAGCACCAGCGCGGCGCGCTCGCGGTGGACGCCGCGCTCGACCGGGTGTTCGACCGGTTCGTGGACGCGTGGCA
GCAGGAGGCCGGCGTCTGCACCTACGCCGAGGCGGTGGCGCAGGCGATCGCGTTCCGCGAGCACGAGGGCGAGCACCCGA
CCATGCGGCGGGACGAGTGGATGGCGTTCGCAGCGCGCGCGCCGTTCTACCGGGCGCGCGAGAAGGCGCGCGCCATGGGG
ATCGACACGCCCTGGGACTGCGAGCACGCCAAGACGCCGGACGGCTACTACCAGGTGCGCGGCGGCATCGACTATGCCAT
CCAGAAGTCGCTCGCGGCGGCGCCGTTCGCCGACCTGCTCTGGATGGAGACCAAGACGGCCGACCTCGCCGACGCGCGGC
GCTTCGCCGACGCCATCCACGCGGTCCACCCGGACAAGATGCTCGCCTACAACCTGTCCCCGTCGTTCAACTGGGACACG
ACCGGCATGGACGACGAGCAGATGCGCCGCTTCCCCGAGGAGCTCGGCAAGCTCGGGTACGTCTTCGACTTCATCACCTA
CGGCGGCCACCAGATCGACGGGCTGGCGGCGGAGGAGTTCGCGACGGCGCTGCGCGAGGACGGCATGCTGGCGCTGGCGC
GGCTGCAGCGGAAGTTCCGCCTGCTCGAGTCGGGCTACCGGACGCCGCAGACGCTGGTGGGCGGACCGCGCCTCGACGCG
GCGCTCATGGCCGTCTCCGGCCGCACCGCCACCACCAAGGCCATGGGCCAGGGCTCGACCCAGCACCAGCACCTGGTCCA
GACCGAGGTGCCGCCGCGGCTGCTGGAGGACTGGCTCGACCTTTGGCGCGAGCGGCACGGCGTCCAGGGCAAGCTGCGCG
CGGCGCTCCGGCCGGTCACCGCGGGCTCCGACCTGCTCGAGCTGGTGGTCACCTCGGCCGACGGCGAGCGGAAGCTCGAC
GTCACCTTCGCGAGCATCACCGACCGGCGCGGGCGCAGCATCCTGTCGGTCCGCGACCAGAACACGCACGACCTGGCGCT
GCGGCGCAAGCGGCTCATGACGCTCGCGCAGCTGTTCCTGTTCCACCGCTACCGGGTGGACTCGGCGCACTACGTCACGC
CCACCGAGGACAACCAGCGGCAGGCGGAGGGCATGAAGGCGCTCGGGCTGTTCCGCTCGGTGGCGCAGGAGGTCGGTGCG
ATCATCGTCGCCGACGTGGACCGGGCGCGGGTGAAGGCGCTCGCCGCGCGGGACCACGTGGCGCTGAAGGCGCTCCTCGG
CGCCTGA

Upstream 100 bases:

>100_bases
GCCCGCACCCCGCGCGTGCGCCCCCGATGCGCGGTGGCCTCCCGGACCGTCTGGGTCCAGCCTGTCGGGACGCGCCGCCG
ACGGCGCCAGGAGACGACAC

Downstream 100 bases:

>100_bases
CGCCCGCCCCTGCGCGGGGCGCCCCGACCGGCGCGTTGCGGCGCCGGGTCACGTCCACCATGCGTGAGCCTCGCTTCCCC
GAGGCCCGCATGCCGCTCGT

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 748; Mature: 748

Protein sequence:

>748_residues
MDFEQEVAALRRWFESPRFAGIRRIHTAREVMEQRGTIRQDYPVAREAAEAFHARLRELFQQRRCITTFGPYSPGQAVAM
KKMGIEAIYLGGWATSAKGSVQEDPGPDLASYPLSQVPDEAAPIVRALLTADRNQHHARSRMTEEQRRATPAVDFRPFII
ADADTGHGGDAQVRNLVRRFVEVGVPGYHIEDQKPGVKKCGHQGGKVLVAEDEQLKRLSAARFQLDLMGVPGIVVARTDA
ESATLLDGRGDERDQPFILGASNLAVPAFRAAFLAILRRFRRAGVEELSGHELYAVCDEEYAAADAWLERTGFDKAIAAA
AAEHQRGALAVDAALDRVFDRFVDAWQQEAGVCTYAEAVAQAIAFREHEGEHPTMRRDEWMAFAARAPFYRAREKARAMG
IDTPWDCEHAKTPDGYYQVRGGIDYAIQKSLAAAPFADLLWMETKTADLADARRFADAIHAVHPDKMLAYNLSPSFNWDT
TGMDDEQMRRFPEELGKLGYVFDFITYGGHQIDGLAAEEFATALREDGMLALARLQRKFRLLESGYRTPQTLVGGPRLDA
ALMAVSGRTATTKAMGQGSTQHQHLVQTEVPPRLLEDWLDLWRERHGVQGKLRAALRPVTAGSDLLELVVTSADGERKLD
VTFASITDRRGRSILSVRDQNTHDLALRRKRLMTLAQLFLFHRYRVDSAHYVTPTEDNQRQAEGMKALGLFRSVAQEVGA
IIVADVDRARVKALAARDHVALKALLGA

Sequences:

>Translated_748_residues
MDFEQEVAALRRWFESPRFAGIRRIHTAREVMEQRGTIRQDYPVAREAAEAFHARLRELFQQRRCITTFGPYSPGQAVAM
KKMGIEAIYLGGWATSAKGSVQEDPGPDLASYPLSQVPDEAAPIVRALLTADRNQHHARSRMTEEQRRATPAVDFRPFII
ADADTGHGGDAQVRNLVRRFVEVGVPGYHIEDQKPGVKKCGHQGGKVLVAEDEQLKRLSAARFQLDLMGVPGIVVARTDA
ESATLLDGRGDERDQPFILGASNLAVPAFRAAFLAILRRFRRAGVEELSGHELYAVCDEEYAAADAWLERTGFDKAIAAA
AAEHQRGALAVDAALDRVFDRFVDAWQQEAGVCTYAEAVAQAIAFREHEGEHPTMRRDEWMAFAARAPFYRAREKARAMG
IDTPWDCEHAKTPDGYYQVRGGIDYAIQKSLAAAPFADLLWMETKTADLADARRFADAIHAVHPDKMLAYNLSPSFNWDT
TGMDDEQMRRFPEELGKLGYVFDFITYGGHQIDGLAAEEFATALREDGMLALARLQRKFRLLESGYRTPQTLVGGPRLDA
ALMAVSGRTATTKAMGQGSTQHQHLVQTEVPPRLLEDWLDLWRERHGVQGKLRAALRPVTAGSDLLELVVTSADGERKLD
VTFASITDRRGRSILSVRDQNTHDLALRRKRLMTLAQLFLFHRYRVDSAHYVTPTEDNQRQAEGMKALGLFRSVAQEVGA
IIVADVDRARVKALAARDHVALKALLGA
>Mature_748_residues
MDFEQEVAALRRWFESPRFAGIRRIHTAREVMEQRGTIRQDYPVAREAAEAFHARLRELFQQRRCITTFGPYSPGQAVAM
KKMGIEAIYLGGWATSAKGSVQEDPGPDLASYPLSQVPDEAAPIVRALLTADRNQHHARSRMTEEQRRATPAVDFRPFII
ADADTGHGGDAQVRNLVRRFVEVGVPGYHIEDQKPGVKKCGHQGGKVLVAEDEQLKRLSAARFQLDLMGVPGIVVARTDA
ESATLLDGRGDERDQPFILGASNLAVPAFRAAFLAILRRFRRAGVEELSGHELYAVCDEEYAAADAWLERTGFDKAIAAA
AAEHQRGALAVDAALDRVFDRFVDAWQQEAGVCTYAEAVAQAIAFREHEGEHPTMRRDEWMAFAARAPFYRAREKARAMG
IDTPWDCEHAKTPDGYYQVRGGIDYAIQKSLAAAPFADLLWMETKTADLADARRFADAIHAVHPDKMLAYNLSPSFNWDT
TGMDDEQMRRFPEELGKLGYVFDFITYGGHQIDGLAAEEFATALREDGMLALARLQRKFRLLESGYRTPQTLVGGPRLDA
ALMAVSGRTATTKAMGQGSTQHQHLVQTEVPPRLLEDWLDLWRERHGVQGKLRAALRPVTAGSDLLELVVTSADGERKLD
VTFASITDRRGRSILSVRDQNTHDLALRRKRLMTLAQLFLFHRYRVDSAHYVTPTEDNQRQAEGMKALGLFRSVAQEVGA
IIVADVDRARVKALAARDHVALKALLGA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=256, Percent_Identity=35.9375, Blast_Score=152, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17561814, Length=241, Percent_Identity=37.7593360995851, Blast_Score=157, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71982926, Length=241, Percent_Identity=37.7593360995851, Blast_Score=156, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320908, Length=586, Percent_Identity=32.4232081911263, Blast_Score=271, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6325263, Length=261, Percent_Identity=36.7816091954023, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 83263; Mature: 83263

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEQEVAALRRWFESPRFAGIRRIHTAREVMEQRGTIRQDYPVAREAAEAFHARLRELF
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QQRRCITTFGPYSPGQAVAMKKMGIEAIYLGGWATSAKGSVQEDPGPDLASYPLSQVPDE
HHCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHCCCH
AAPIVRALLTADRNQHHARSRMTEEQRRATPAVDFRPFIIADADTGHGGDAQVRNLVRRF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VEVGVPGYHIEDQKPGVKKCGHQGGKVLVAEDEQLKRLSAARFQLDLMGVPGIVVARTDA
HHHCCCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHHEEEEECCCEEEEEECCC
ESATLLDGRGDERDQPFILGASNLAVPAFRAAFLAILRRFRRAGVEELSGHELYAVCDEE
CCCEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECCH
YAAADAWLERTGFDKAIAAAAAEHQRGALAVDAALDRVFDRFVDAWQQEAGVCTYAEAVA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QAIAFREHEGEHPTMRRDEWMAFAARAPFYRAREKARAMGIDTPWDCEHAKTPDGYYQVR
HHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
GGIDYAIQKSLAAAPFADLLWMETKTADLADARRFADAIHAVHPDKMLAYNLSPSFNWDT
CCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
TGMDDEQMRRFPEELGKLGYVFDFITYGGHQIDGLAAEEFATALREDGMLALARLQRKFR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
LLESGYRTPQTLVGGPRLDAALMAVSGRTATTKAMGQGSTQHQHLVQTEVPPRLLEDWLD
HHHCCCCCCHHHCCCCCHHHHHHEECCCCHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHH
LWRERHGVQGKLRAALRPVTAGSDLLELVVTSADGERKLDVTFASITDRRGRSILSVRDQ
HHHHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEEHHHCCCCCCEEEECCC
NTHDLALRRKRLMTLAQLFLFHRYRVDSAHYVTPTEDNQRQAEGMKALGLFRSVAQEVGA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCE
IIVADVDRARVKALAARDHVALKALLGA
EEEECCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFEQEVAALRRWFESPRFAGIRRIHTAREVMEQRGTIRQDYPVAREAAEAFHARLRELF
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QQRRCITTFGPYSPGQAVAMKKMGIEAIYLGGWATSAKGSVQEDPGPDLASYPLSQVPDE
HHCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHCCCH
AAPIVRALLTADRNQHHARSRMTEEQRRATPAVDFRPFIIADADTGHGGDAQVRNLVRRF
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VEVGVPGYHIEDQKPGVKKCGHQGGKVLVAEDEQLKRLSAARFQLDLMGVPGIVVARTDA
HHHCCCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHHEEEEECCCEEEEEECCC
ESATLLDGRGDERDQPFILGASNLAVPAFRAAFLAILRRFRRAGVEELSGHELYAVCDEE
CCCEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECCH
YAAADAWLERTGFDKAIAAAAAEHQRGALAVDAALDRVFDRFVDAWQQEAGVCTYAEAVA
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QAIAFREHEGEHPTMRRDEWMAFAARAPFYRAREKARAMGIDTPWDCEHAKTPDGYYQVR
HHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEE
GGIDYAIQKSLAAAPFADLLWMETKTADLADARRFADAIHAVHPDKMLAYNLSPSFNWDT
CCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCC
TGMDDEQMRRFPEELGKLGYVFDFITYGGHQIDGLAAEEFATALREDGMLALARLQRKFR
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
LLESGYRTPQTLVGGPRLDAALMAVSGRTATTKAMGQGSTQHQHLVQTEVPPRLLEDWLD
HHHCCCCCCHHHCCCCCHHHHHHEECCCCHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHH
LWRERHGVQGKLRAALRPVTAGSDLLELVVTSADGERKLDVTFASITDRRGRSILSVRDQ
HHHHHCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEEHHHCCCCCCEEEECCC
NTHDLALRRKRLMTLAQLFLFHRYRVDSAHYVTPTEDNQRQAEGMKALGLFRSVAQEVGA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCE
IIVADVDRARVKALAARDHVALKALLGA
EEEECCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002 [H]