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The map label for this gene is atoC [H]

Identifier: 220916812

GI number: 220916812

Start: 1901554

End: 1902945

Strand: Direct

Name: atoC [H]

Synonym: A2cp1_1708

Alternate gene names: 220916812

Gene position: 1901554-1902945 (Clockwise)

Preceding gene: 220916811

Following gene: 220916813

Centisome position: 37.81

GC content: 75.36

Gene sequence:

>1392_bases
ATGTCGCGCGTGCTGCTGGTGGATGACGAGCCGTCGGTCCGCGCCGCGCTCAAGGAGCTGGTGCAGGGCCGCGGCTGGGA
GCCGGTGCTCGCGTGCTCGGCCTCGGAGGCGCTGGAGCAGCTCGAGCGCGCCGACGTGCTGGTGACCGACTTCTCCATGC
CGGAGATGGACGGTCTCGCGCTGCTCCAGGCGGTGCGCGAGCGCGACGAGTGGCTGCCGGTCATCCTGCTCACCGCGCAC
GGCTCGGAGCGCCTGGCGGTGCGCGCCATGAAGGCGGGCGCGTACGAGTACGTGCCGAAGCCGTTCGACGTGGACGAGCT
GGCGCTGGCCATCGGCCGCGCGCTGGAGGCGCGGCTCCTGCGCCAGCGCAACCGCCAGCTCACGGTGGAGCACGCCATCG
GCCGGCGGCTGGTGTTCGAGTCCGCGAACATGCGCCAGGTGCTGGCCGCCACCGCCCGGGTGGCGGCGCGCGAGATCACC
GTGCTGGTGTGCGGCGAGACCGGCACCGGCAAGGAGCTCATCGGGACGCTGCTCCACGCGCTCAGCAAGCGGGCCGCCGG
GCCGCTCGTCCGGTTCAACTGCAGCGCCATCCCGGCCGAGCTGGCGGAGGCGGAGCTGTTCGGCCACGTGCGCGGCGCGT
TCACCGGCGCCGTGCAGGCGCGGCCCGGGTTCTTCGCGCAGGCCGACGGCGGGACGCTGGTGCTCGACGAGGTCGGCGAG
CTGCCGCTCGGGATCCAGGCGAAGCTGCTCCGGGCGCTGCAGGAGGGCGAGATCCAGCCGGTCGGCTCGGGCCGGGTGGA
GCGGGTGGACGTGCGGATCGTCGCGTGCACGCACCGCGACCTGCGCGCCGACGTGCAGGCGGGGAGGTTCCGCGAGGACC
TGTACTACCGGCTGGCGGTGGTGGAGCTGACCGTCCCGCCGCTCCGGGATCGCCGCGAGGACATCCCGGCGCTGGCCCAC
GAGTTCGCGCTGCGCTACGCCGAGCGCTTCGGGTCGGAGGACGTGCGGCTCGCGCCGGCCCTGATCGAGCGGCTGGTCGA
GGCGGACTGGCCCGGCAACGTGCGGCAGCTCGAGAACGTGGTGGCGCGGATGGTGGCCCTGAGCGGCGGGGGCGAGATCG
GCCCCGACGCGTTCGAGGCGACCAGCGTCCCGGCGGACCGGCCGGCCGCCGTCGCGCGCGGCGGCGAGGAGACGCGCACG
CTCCGCGAGCAGCTCGACGAGCTGGAGCGGGCCGTCATCGCGCGGACCATGGCCGCCGTCCGCGGGAACCAGTCCGAGGC
GGCGCGGCGGCTCGGCATCAGCCGGAACACGCTCACCGAGCGGCTGCGGCGCTACGAGCTCGTCACCGACGCCGTCGAGG
GCGCGGCGGCGACCGCCGGCGCCGTCCGCTGA

Upstream 100 bases:

>100_bases
GTGATCGTGCAGCACGGTGGTACCCTGCGCTACGAGAGCGAGCCGGGGAGCGGGACGAAGGTGCTCGTCACGTTGCCGCG
CGCCGCGAAGAGGAGCGGGG

Downstream 100 bases:

>100_bases
GCGCCGGATCGCGCCCGCATACCCGAACGCGGTGCTCAAGGGTTGAGCGGCCCCGTCGGACCTCGGTACGGCGGCGGCGC
GGGGGCGCCGCGCCGGGGCA

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSRVLLVDDEPSVRAALKELVQGRGWEPVLACSASEALEQLERADVLVTDFSMPEMDGLALLQAVRERDEWLPVILLTAH
GSERLAVRAMKAGAYEYVPKPFDVDELALAIGRALEARLLRQRNRQLTVEHAIGRRLVFESANMRQVLAATARVAAREIT
VLVCGETGTGKELIGTLLHALSKRAAGPLVRFNCSAIPAELAEAELFGHVRGAFTGAVQARPGFFAQADGGTLVLDEVGE
LPLGIQAKLLRALQEGEIQPVGSGRVERVDVRIVACTHRDLRADVQAGRFREDLYYRLAVVELTVPPLRDRREDIPALAH
EFALRYAERFGSEDVRLAPALIERLVEADWPGNVRQLENVVARMVALSGGGEIGPDAFEATSVPADRPAAVARGGEETRT
LREQLDELERAVIARTMAAVRGNQSEAARRLGISRNTLTERLRRYELVTDAVEGAAATAGAVR

Sequences:

>Translated_463_residues
MSRVLLVDDEPSVRAALKELVQGRGWEPVLACSASEALEQLERADVLVTDFSMPEMDGLALLQAVRERDEWLPVILLTAH
GSERLAVRAMKAGAYEYVPKPFDVDELALAIGRALEARLLRQRNRQLTVEHAIGRRLVFESANMRQVLAATARVAAREIT
VLVCGETGTGKELIGTLLHALSKRAAGPLVRFNCSAIPAELAEAELFGHVRGAFTGAVQARPGFFAQADGGTLVLDEVGE
LPLGIQAKLLRALQEGEIQPVGSGRVERVDVRIVACTHRDLRADVQAGRFREDLYYRLAVVELTVPPLRDRREDIPALAH
EFALRYAERFGSEDVRLAPALIERLVEADWPGNVRQLENVVARMVALSGGGEIGPDAFEATSVPADRPAAVARGGEETRT
LREQLDELERAVIARTMAAVRGNQSEAARRLGISRNTLTERLRRYELVTDAVEGAAATAGAVR
>Mature_462_residues
SRVLLVDDEPSVRAALKELVQGRGWEPVLACSASEALEQLERADVLVTDFSMPEMDGLALLQAVRERDEWLPVILLTAHG
SERLAVRAMKAGAYEYVPKPFDVDELALAIGRALEARLLRQRNRQLTVEHAIGRRLVFESANMRQVLAATARVAAREITV
LVCGETGTGKELIGTLLHALSKRAAGPLVRFNCSAIPAELAEAELFGHVRGAFTGAVQARPGFFAQADGGTLVLDEVGEL
PLGIQAKLLRALQEGEIQPVGSGRVERVDVRIVACTHRDLRADVQAGRFREDLYYRLAVVELTVPPLRDRREDIPALAHE
FALRYAERFGSEDVRLAPALIERLVEADWPGNVRQLENVVARMVALSGGGEIGPDAFEATSVPADRPAAVARGGEETRTL
REQLDELERAVIARTMAAVRGNQSEAARRLGISRNTLTERLRRYELVTDAVEGAAATAGAVR

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=455, Percent_Identity=40.6593406593407, Blast_Score=343, Evalue=9e-96,
Organism=Escherichia coli, GI1790437, Length=447, Percent_Identity=43.1767337807606, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790299, Length=461, Percent_Identity=41.4316702819957, Blast_Score=328, Evalue=6e-91,
Organism=Escherichia coli, GI1788905, Length=452, Percent_Identity=39.8230088495575, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI87082117, Length=358, Percent_Identity=41.8994413407821, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87082152, Length=299, Percent_Identity=45.4849498327759, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI1789233, Length=357, Percent_Identity=37.2549019607843, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789087, Length=320, Percent_Identity=44.0625, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=38.2911392405063, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87081872, Length=323, Percent_Identity=37.4613003095975, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1786524, Length=330, Percent_Identity=39.0909090909091, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789828, Length=374, Percent_Identity=32.620320855615, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI87081858, Length=296, Percent_Identity=33.1081081081081, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=37.3831775700935, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI2367329, Length=112, Percent_Identity=37.5, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789809, Length=108, Percent_Identity=31.4814814814815, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50498; Mature: 50367

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4 ; PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLLVDDEPSVRAALKELVQGRGWEPVLACSASEALEQLERADVLVTDFSMPEMDGLA
CCCEEEECCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCEEEEECCCCCCHHHH
LLQAVRERDEWLPVILLTAHGSERLAVRAMKAGAYEYVPKPFDVDELALAIGRALEARLL
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
RQRNRQLTVEHAIGRRLVFESANMRQVLAATARVAAREITVLVCGETGTGKELIGTLLHA
HHHCCCEEHHHHHCHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHH
LSKRAAGPLVRFNCSAIPAELAEAELFGHVRGAFTGAVQARPGFFAQADGGTLVLDEVGE
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCCEEEECCCCC
LPLGIQAKLLRALQEGEIQPVGSGRVERVDVRIVACTHRDLRADVQAGRFREDLYYRLAV
CCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHEEEE
VELTVPPLRDRREDIPALAHEFALRYAERFGSEDVRLAPALIERLVEADWPGNVRQLENV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
VARMVALSGGGEIGPDAFEATSVPADRPAAVARGGEETRTLREQLDELERAVIARTMAAV
HHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGNQSEAARRLGISRNTLTERLRRYELVTDAVEGAAATAGAVR
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRVLLVDDEPSVRAALKELVQGRGWEPVLACSASEALEQLERADVLVTDFSMPEMDGLA
CCEEEECCCCHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCEEEEECCCCCCHHHH
LLQAVRERDEWLPVILLTAHGSERLAVRAMKAGAYEYVPKPFDVDELALAIGRALEARLL
HHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
RQRNRQLTVEHAIGRRLVFESANMRQVLAATARVAAREITVLVCGETGTGKELIGTLLHA
HHHCCCEEHHHHHCHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHH
LSKRAAGPLVRFNCSAIPAELAEAELFGHVRGAFTGAVQARPGFFAQADGGTLVLDEVGE
HHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEECCCCCEEECCCCEEEECCCCC
LPLGIQAKLLRALQEGEIQPVGSGRVERVDVRIVACTHRDLRADVQAGRFREDLYYRLAV
CCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHEEEE
VELTVPPLRDRREDIPALAHEFALRYAERFGSEDVRLAPALIERLVEADWPGNVRQLENV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHH
VARMVALSGGGEIGPDAFEATSVPADRPAAVARGGEETRTLREQLDELERAVIARTMAAV
HHHHHHHCCCCCCCCCCHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RGNQSEAARRLGISRNTLTERLRRYELVTDAVEGAAATAGAVR
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]